CN103947658A - Thifluzamide-containing bactericidal composition - Google Patents
Thifluzamide-containing bactericidal composition Download PDFInfo
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- CN103947658A CN103947658A CN201410212527.0A CN201410212527A CN103947658A CN 103947658 A CN103947658 A CN 103947658A CN 201410212527 A CN201410212527 A CN 201410212527A CN 103947658 A CN103947658 A CN 103947658A
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- thifluzamide
- piperazine mycin
- shen piperazine
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- bactericidal composition
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- WOSNCVAPUOFXEH-UHFFFAOYSA-N thifluzamide Chemical compound S1C(C)=NC(C(F)(F)F)=C1C(=O)NC1=C(Br)C=C(OC(F)(F)F)C=C1Br WOSNCVAPUOFXEH-UHFFFAOYSA-N 0.000 title claims abstract description 94
- 239000000203 mixture Substances 0.000 title claims abstract description 41
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 20
- 201000010099 disease Diseases 0.000 claims abstract description 27
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 27
- 235000013339 cereals Nutrition 0.000 claims abstract description 3
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 3
- 235000013311 vegetables Nutrition 0.000 claims abstract description 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 156
- 239000000375 suspending agent Substances 0.000 claims description 30
- 239000004480 active ingredient Substances 0.000 claims description 10
- 239000004562 water dispersible granule Substances 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 238000009736 wetting Methods 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 239000000839 emulsion Substances 0.000 claims 1
- 239000004530 micro-emulsion Substances 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 244000061456 Solanum tuberosum Species 0.000 abstract description 26
- 235000002595 Solanum tuberosum Nutrition 0.000 abstract description 26
- 235000007164 Oryza sativa Nutrition 0.000 abstract description 22
- 235000009566 rice Nutrition 0.000 abstract description 22
- 208000001840 Dandruff Diseases 0.000 abstract description 13
- 241000209140 Triticum Species 0.000 abstract description 4
- 235000021307 Triticum Nutrition 0.000 abstract description 4
- 241000233622 Phytophthora infestans Species 0.000 abstract description 3
- AMNAZJFEONUVTD-KEWDHRJRSA-N (2s,3s,4s,5r,6r)-6-(4-amino-2-oxopyrimidin-1-yl)-4,5-dihydroxy-3-[[(2s)-3-hydroxy-2-[[2-(methylamino)acetyl]amino]propanoyl]amino]oxane-2-carboxamide Chemical compound O1[C@H](C(N)=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC)[C@H](O)[C@@H](O)[C@@H]1N1C(=O)N=C(N)C=C1 AMNAZJFEONUVTD-KEWDHRJRSA-N 0.000 abstract 2
- FEACDOXQOYCHKU-UHFFFAOYSA-N Gougerotin Natural products CNCC(=O)NC1=NC(=O)N(C=C1)C2OC(C(O)C(NC(=O)C(N)CO)C2O)C(=O)N FEACDOXQOYCHKU-UHFFFAOYSA-N 0.000 abstract 2
- 240000007594 Oryza sativa Species 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 description 38
- 239000004615 ingredient Substances 0.000 description 36
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- 238000000034 method Methods 0.000 description 20
- 230000002195 synergetic effect Effects 0.000 description 19
- 239000002131 composite material Substances 0.000 description 15
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- 229940079593 drug Drugs 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000000080 wetting agent Substances 0.000 description 5
- 241000219109 Citrullus Species 0.000 description 4
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 4
- 239000000306 component Substances 0.000 description 4
- 238000003306 harvesting Methods 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- 244000052769 pathogen Species 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 238000009331 sowing Methods 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 231100000820 toxicity test Toxicity 0.000 description 4
- 235000002566 Capsicum Nutrition 0.000 description 3
- 240000008574 Capsicum frutescens Species 0.000 description 3
- 239000003905 agrochemical Substances 0.000 description 3
- 239000001390 capsicum minimum Substances 0.000 description 3
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- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
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- 238000002474 experimental method Methods 0.000 description 2
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- 239000003864 humus Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 238000010030 laminating Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
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- 235000010603 pastilles Nutrition 0.000 description 2
- 239000000575 pesticide Substances 0.000 description 2
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- 239000000126 substance Substances 0.000 description 2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 241000223600 Alternaria Species 0.000 description 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 1
- BHUAFRMKCZOACQ-UHFFFAOYSA-N C1=CC=C2N=C3C(C(=O)O)=CC=CC3=NC2=C1.C1=CC=C2N=C3C(C(=O)O)=CC=CC3=NC2=C1 Chemical group C1=CC=C2N=C3C(C(=O)O)=CC=CC3=NC2=C1.C1=CC=C2N=C3C(C(=O)O)=CC=CC3=NC2=C1 BHUAFRMKCZOACQ-UHFFFAOYSA-N 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 241000589540 Pseudomonas fluorescens Species 0.000 description 1
- 241000813090 Rhizoctonia solani Species 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- SYHPANJAVIEQQL-UHFFFAOYSA-N dicarboxy carbonate Chemical compound OC(=O)OC(=O)OC(O)=O SYHPANJAVIEQQL-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
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- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericidal composition which comprises effective components including thifluzamide and ningnanmycin, wherein the ratio of the thifluzamide to the ningnanmycin is 50:1-1:50. The bactericidal composition has obvious synergism, and can be used for controlling diseases such as rice sheath blight disease, rice false smut, wheat sharp eyespot, potato late blight and potato black scurf of vegetables, fruits, flowers and cereal crops.
Description
Technical field
The present invention relates to a kind of bactericidal composition that contains thifluzamide, specifically a kind of bactericidal composition that contains thifluzamide and Shen piperazine mycin.
Background technology
Thifluzamide ISO adopted name: thifluzamide; CA registration number: 130000-40-7
The bromo-2-methyl-4-of chemical name: 2,6-bis-trifluoromethoxy-4-Trifluoromethyl-1,3-thiazole-5-carbonyl acyl is for aniline; Molecular formula: C13H6Br2F6N2O2S; Relative molecular mass: 528.06 (by international relative atomic masses in 2007).Thifluzamide is that phenylamide has the systemic fungicide that therapeutic action is held concurrently in prevention, and the succinate dehydrase in Antifungi tricarbonic acid cycle, affects the transmission of pathogen respiratory chain electronics, causes that thalline is dead, and the lasting period is long.Thifluzamide, since 2000 Nian China obtain the interim registration of agricultural chemicals, has been mainly used in preventing and treating rice sheath blight disease; In some areas rice sheath blight disease, it is produced to resistance, need to strengthen consumption and just can reach desirable control efficiency.
By different pesticide active ingredient combinations; the obvious formula of synergistic effect can greatly improve preventive effect, reduces dosage, reduces costs, protection of the environment; can also avoid phytopathogen to produce the speed that resistance or delaying drug resistance produce, be a kind of effectively and efficiently mode that solves the alone resistance of current agricultural chemicals and Cost Problems simultaneously.
In sum, the Synergistic bactericidal composition that exploitation contains thifluzamide is significant.
Summary of the invention
The object of the invention is to: high-efficiency environment friendly, the wide spectrum using in a kind of applicable agricultural is provided and can delays the bactericidal composition that contains thifluzamide that pathogen resistance produces speed and reduces agricultural chemicals use cost.
For solving the problems of the technologies described above, we have carried out composition research to thifluzamide.By a large amount of biologicall tests, screen, unexpected discovery thifluzamide (A) is composite with certain proportion with Shen piperazine mycin (B), and the diseases such as rice sheath blight disease, potato late blight are had significant synergies.Shen piperazine mycin is the tunning by pseudomonas fluorescens strain M18, main component is phenazine-1-carboxylic acid (phenazine-1-carboxylic acid), and the various plants pathogens such as rice sheath blight disease, the climing rot of cucumber, watermelon blight are had to good inhibitory action.Shen piperazine mycin in Shanghai, the ground such as Hubei, Hainan, Henan, Gansu carried out large-area extend trial, and rice sheath blight disease, alternaria leaf spot of apple, watermelon blight, gummy stem blight of melon etc. are shown to good field efficacy.
Thifluzamide and Shen piperazine mycin belong to dissimilar bactericide, and its mechanism of action is different, and 2 are mixed can slow down the generation of germ resistance, simultaneously can expanding prevention spectrum.
On the basis of above-mentioned discovery, through composition is carried out to symphyogenetic quantitative analysis, formed technical scheme of the present invention, the thifluzamide (A) of take is active ingredient with Shen piperazine mycin (B), the mass ratio of the two is 50:1-1:50, and preferable quality is than being 20:1-1:20.
The present composition can be prepared into by known method the formulation that is applicable to agricultural use, and as wetting powder, suspending agent, suspension seed-coating agent, granule or water dispersible granules, in preparation, the total content of active ingredient is 1%-84%.
In composition of the present invention, also comprise that the auxiliary elements such as solvent, dispersant, wetting agent, antifreezing agent, bleeding agent and other are of value to the known substance of active ingredient stable and drug effect performance in storing and using, all various compositions conventional in pesticidal preparations or that allow to use, be not particularly limited, concrete composition and consumption require to determine by simple experiment according to formula.
Composition described in the invention can finished product preparation form provide, be that in composition, each material mixes, the composition of composition also can provide with single dose form, before use, directly in bucket or tank, directly mixes, and paste is smeared after scraping morbidity place off by related request.
A kind of bactericidal composition that contains thifluzamide of the present invention can be used for preventing and treating various fungus-caused plant diseases, be specially adapted to prevent and treat the disease of the crops such as vegetables, fruit, flowers and Cereal, as rice sheath blight disease, rice green smut, wheat sharp eyespot, capsicum epidemic disease, potato late blight, potato black scurf.
Compared with prior art, the beneficial effect that the present invention produces is: (1) is compared with single dose, and this kind of bactericidal composition that contains thifluzamide has obvious synergy to diseases such as rice sheath blight disease, potato black scurf, has improved control efficiency; (2) can reduce field dosage, effectively reduce environmental pollution and residue of pesticide, reduce and produce and use cost; (3) in bactericidal composition, the mechanism of action of active ingredient is different, is conducive to avoid and delays the drug-fast generation of germ; (4) compare with single dose and expanded control spectrum.
Embodiment
In order to make object of the present invention, technical scheme and advantage clearer, the present invention describes with following specific embodiment, but the present invention is limited to absolutely not these examples.
The present composition be take thifluzamide (A) as a kind of active ingredient, Shen piperazine mycin (B) is another kind of active ingredient, combination between them has obvious synergistic function to diseases such as rice sheath blight disease, capsicum epidemic diseases, and be not only the simple addition of two kinds of pharmacy effects, refer to biologicall test embodiment.
Biologicall test example 1: thifluzamide and the composite toxicity test to rice sheath blight disease of Shen piperazine mycin
Subjects: Rhizoctonia solani Kuhn
Test adopts growth rate method (Plating).On aseptic operating platform, according to test, process the sterilising medium melting in advance is quantitatively placed in aseptic conical flask, from low concentration to high concentration, getting successively 5mL liquid joins respectively the hot medium of 45mL (PDA medium is housed, 45-50 ℃) in conical flask, after shaking up, pour rapidly diameter 90mm glass culture dish into, each culture dish is poured band medicine medium 10mL into.Level is standing, makes flat board after cooling.Five repetitions of each concentration.Not contain the processing of medicament effective ingredient, make blank.By cultured pathogen, under aseptic condition, with the sterilizing card punch of diameter 4mm, from colony edge, cut bacterium cake, with inoculator by pure culture biscuits involvng inoculation in the dull and stereotyped central authorities of pastille, by facing down and medium laminating of having mycelia, cover ware lid.Above all operations all carries out sterile working at superclean bench.After processing, be placed in the constant temperature aseptic culture case of 26 ± 0.5 ℃ and cultivate, after 2d, take out.Adopt right-angled intersection method to measure respectively the colony diameter (take millimeter as unit) that each is processed, calculate the mean value of colony diameter.Take each logarithm value of processing effective ingredient concentration (μ g/mL) is independent variable X, and the probit value that inhibiting rate changes into is dependent variable Y, uses the DPS of expert data statistical software to process, and calculates concentration EC in inhibition
50, according to toxicity index and the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun medicament.
Actual measurement toxicity index (ATI)=(standard medicament EC
50/ reagent agent EC
50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] * 100
When CTC≤80, composition performance is for antagonism, and as 80 < CTC < 120, composition performance is for summation action, and when CTC >=120, composition performance is synergistic effect.
Toxicity test result is referring to table 1
The Toxicity Determination result of the serial proportioning of table 1 thifluzamide and Shen piperazine mycin to rice sheath blight disease
Result of the test shows, thifluzamide and the composite rice sheath blight disease of preventing and treating of Shen piperazine mycin, and proportioning is between 50:1-1:50 time, co-toxicity coefficient, all more than 140, has certain synergistic effect, and between 20:1-1:20 time, co-toxicity coefficient is all higher than 200, and synergistic effect is more obvious.
Biologicall test example 2: thifluzamide and the composite toxicity test to potato black scurf of Shen piperazine mycin
Subjects: potato black scurf
Test adopts growth rate method (Plating).On aseptic operating platform, according to test, process the sterilising medium melting in advance is quantitatively placed in aseptic conical flask, from low concentration to high concentration, getting successively 5mL liquid joins respectively the hot medium of 45mL (PDA medium is housed, 45-50 ℃) in conical flask, after shaking up, pour rapidly diameter 90mm glass culture dish into, each culture dish is poured band medicine medium 10mL into.Level is standing, makes flat board after cooling.Five repetitions of each concentration.Not contain the processing of medicament effective ingredient, make blank.By cultured pathogen, under aseptic condition, with the sterilizing card punch of diameter 4mm, from colony edge, cut bacterium cake, with inoculator by pure culture biscuits involvng inoculation in the dull and stereotyped central authorities of pastille, by facing down and medium laminating of having mycelia, cover ware lid.Above all operations all carries out sterile working at superclean bench.After processing, be placed in the constant temperature aseptic culture case of 25 ± 0.5 ℃ and cultivate, after 2d, take out.Adopt right-angled intersection method to measure respectively the colony diameter (take millimeter as unit) that each is processed, calculate the mean value of colony diameter.Take each logarithm value of processing effective ingredient concentration (μ g/mL) is independent variable X, and the probit value that inhibiting rate changes into is dependent variable Y, uses the DPS of expert data statistical software to process, and calculates concentration EC in inhibition
50, according to toxicity index and the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun medicament.
Drug effect calculating, toxicity index and co-toxicity coefficient (CTC) calculate, analytical method is the same.
Toxicity test the results are shown in Table 2.
The Toxicity Determination result of the serial proportioning of table 2 thifluzamide and Shen piperazine mycin to potato black scurf
Result of the test shows, thifluzamide and the composite potato black scurf of preventing and treating of Shen piperazine mycin, and proportioning is between 50:1-1:50 time, co-toxicity coefficient, all more than 170.0, shows to have certain synergistic effect, and between 20:1-1:20 time, co-toxicity coefficient is all higher than 200.0, and synergistic effect is more obvious.
Above measurement result shows, when in thifluzamide (A) and Shen piperazine mycin (B), a kind of composite proportioning of preventing and treating rice sheath blight disease and potato black scurf is between 50:1-1:50, co-toxicity coefficient is all more than 120.0, there is certain synergistic effect, in the time of between 20:1-1:20, co-toxicity coefficient is more than 200, and synergistic effect is more obvious.
A kind of bactericidal composition that contains thifluzamide of the present invention can be prepared into by known method wetting powder, suspending agent, granule or the water dispersible granules that is applicable to agricultural use.With specific embodiment, describe below, in formula, percentage is mass percent, and the former medicine effective content of thifluzamide is 96%, piperazine mycin former medicine effective content in Shen is 95%, during use, all by effective content folding hundred, calculates.A kind of in active component present specification middle finger thifluzamide (A) and Shen piperazine mycin (B), below repeat no more.
Embodiment 1:51% thifluzamide Shen piperazine mycin wetting powder
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of formula, after ultra-fine pulverizer disintegrating, make 100 gram of 51% thifluzamide Shen piperazine mycin wetting powder.
This embodiment is applied to prevent and treat rice sheath blight disease.By 51% thifluzamide Shen piperazine mycin wetting powder, by 8 grams/acre, preparation, (wherein thifluzamide effective ingredient consumption is 60 grams/ha, Shen piperazine mycin effective ingredient consumption is 1.2 grams/ha) be watered dilution spraying 2 times, after 2 medicines, the control efficiency of 14 days is 85.6%.Said preparation is used safety, and poisoning phenomenon is not found in field.240 grams per liter thifluzamide suspending agents by 20 milliliters/mu, preparation (thifluzamide effective ingredient consumption is 72 grams/ha) and 1% Shen piperazine mycin suspending agent by 70 grams/acre, preparation (Shen piperazine mycin effective ingredient consumption is 10.5 grams/ha), with same method, use, after 2 medicines, the control efficiency of 14 days is respectively 80.1% and 80.8%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of rice sheath blight disease significantly better than single dose.
Embodiment 2:31% thifluzamide Shen piperazine mycin suspending agent
Each components such as active component, wetting agent, dispersant, thickener, defoamer, antifreezing agent and water are mixed in the ratio of formula, after grinding and/or high speed shear, obtain 100 grams of 31% thifluzamide Shen piperazine mycin suspending agents.
This embodiment is applied to prevent and treat rice green smut.By 31% thifluzamide Shen piperazine mycin suspending agent, by 15 milliliters/mu, preparation, (wherein thifluzamide effective ingredient consumption is 67.5 grams/ha, Shen piperazine mycin effective ingredient consumption is 2.25 grams/ha) be watered dilution spraying 2 times, after 2 medicines, the control efficiency of 15 days is 86.7%.Said preparation is used safety, and poisoning phenomenon is not found in field.240 grams per liter thifluzamide suspending agents by 20 milliliters/mu, preparation (thifluzamide effective ingredient consumption is 72 grams/ha) and 1% Shen piperazine mycin suspending agent by 60 grams/acre, preparation (Shen piperazine mycin effective ingredient consumption is 9 grams/ha), with same method, use, after 2 medicines, the preventive effect of 7 days is respectively 83.4% and 80.2%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of rice green smut significantly better than single dose.
Embodiment 3:84% thifluzamide Shen piperazine mycin water dispersible granules
Active component, dispersant, wetting agent and filler are mixed in the ratio of formula, through air-flow crushing, become wetting powder, then add a certain amount of water mixing extruding to make material.After drying screening, obtain 100 gram of 84% thifluzamide Shen piperazine mycin water dispersible granules for field trial.
This embodiment is applied to potato black scurf.By 84% thifluzamide Shen piperazine mycin water dispersible granules, by 25 grams/acre, preparation, (wherein thifluzamide effective ingredient consumption is 300 grams/ha, Shen piperazine mycin effective ingredient consumption is 15 grams/ha) when potato sowing, to ditch and spray 1 time, potato harvest phase investigation prevention effect is 87.4%.Said preparation is used safety, and poisoning phenomenon is not found in field.240 grams per liter thifluzamide suspending agents by 120 milliliters/mu, preparation (thifluzamide effective ingredient consumption is 432 grams/ha) and 1% Shen piperazine mycin suspending agent by 120 grams/acre, preparation (Shen piperazine mycin effective ingredient consumption is 18 grams/ha), with same method, use, potato harvest phase investigation preventive effect is respectively 79.1% and 60.4%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of potato black scurf significantly better than single dose.
Embodiment 4:33% thifluzamide Shen piperazine mycin suspending agent
Each components such as active component, wetting agent, dispersant, thickener, defoamer, antifreezing agent and water are mixed in the ratio of formula, after grinding and/or high speed shear, obtain 100 grams of 33% thifluzamide Shen piperazine mycin suspending agents.
This embodiment is applied to prevent and treat capsicum epidemic disease.By 33% thifluzamide Shen piperazine mycin suspending agent, by 20 milliliters/mu, preparation, (wherein thifluzamide effective ingredient consumption is 90 grams/ha, Shen piperazine mycin effective ingredient consumption is 9 grams/ha) be watered dilution spraying 2 times, after 2 medicines, the control efficiency of 15 days is 75.4%.Said preparation is used safety, and poisoning phenomenon is not found in field.240 grams per liter thifluzamide suspending agents by 20 milliliters/mu, preparation (thifluzamide effective ingredient consumption is 72 grams/ha) and 1% Shen piperazine mycin suspending agent by 70 grams/acre, preparation (Shen piperazine mycin effective ingredient consumption is 10.5 grams/ha), with same method, use, after 2 medicines, the preventive effect of 15 days is respectively 60.2% and 70.3%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of rice green smut significantly better than single dose.
Embodiment 5:90% thifluzamide Shen piperazine mycin water dispersible granules
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of formula, after ultra-fine pulverizer disintegrating, make 100 gram of 90% thifluzamide Shen piperazine mycin water dispersible granules.
This embodiment is applied to prevent and treat wheat sharp eyespot.By 90% thifluzamide Shen piperazine mycin water dispersible granules, by 2 grams/acre, preparation, (wherein thifluzamide effective ingredient consumption is 13.5 grams/ha, Shen piperazine mycin effective ingredient consumption is 13.5 grams/ha) be watered dilution spraying, after medicine, the control efficiency of 20 days is 83.5%.Said preparation is used safety, and poisoning phenomenon is not found in field.240 grams per liter thifluzamide suspending agents by 20 milliliters/mu, preparation (thifluzamide effective ingredient consumption is 72 grams/ha) and 1% Shen piperazine mycin suspending agent by 100 grams/acre, preparation (Shen piperazine mycin effective ingredient consumption is 15 grams/ha), with same method, use, after medicine, the control efficiency of 20 days is respectively 80.2% and 81.3%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of wheat sharp eyespot significantly better than single dose.
Embodiment 6:5.5% thifluzamide Shen piperazine mycin granule
Active component, various auxiliary agents etc. are fully mixed in the ratio of formula, after ultra-fine pulverizer disintegrating, add humus and carrier, use granulator granulation, obtain 100 gram of 5.5% thifluzamide Shen piperazine mycin granule.
This embodiment is applied to potato haulm basal stem rot.When potato sowing, 5.5% thifluzamide Shen piperazine mycin granule is adopted to the method dispenser of ditch spread, every mu of preparation consumption 2.0kg, the potato " Invest, Then Investigate " drug effect of emerging, control efficiency can reach more than 88%.Said preparation is used safety, and poisoning phenomenon is not found in field; The humus simultaneously adding in medicament can improve soil property, increases soil fertility, and increases crop yield.Check experiment is 240 grams per liter thifluzamide suspending agents by 20 milliliters/mu, preparation (thifluzamide effective ingredient consumption is 72 grams/ha) and 1% Shen piperazine mycin suspending agent by 120 grams/acre, preparation (Shen piperazine mycin effective ingredient consumption is 18 grams/ha), in potato post-emergence spraying, use, after medicine, the preventive effect of 15 days is respectively 81.3% and 83.5%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of potato haulm basal stem rot significantly better than single dose.
Embodiment 7:1% thifluzamide Shen piperazine mycin effervescent tablet
Active component, various auxiliary agents etc. are fully mixed in the ratio of formula, after ultra-fine pulverizer disintegrating, use tablet press machine to be pressed into suitable size, obtain 100 gram of 1% thifluzamide Shen piperazine mycin effervescent tablet.
This embodiment is applied to prevent and treat rice sheath blight disease.By 1% thifluzamide Shen piperazine mycin effervescent tablet, by 200 grams/acre, preparation, (wherein thifluzamide effective ingredient consumption is 7.5 grams/ha, Shen piperazine mycin effective ingredient consumption is 7.5 grams/ha) be watered dilution spraying 2 times, after 2 medicines, the control efficiency of 14 days is 86.7%.Said preparation is used safety, and poisoning phenomenon is not found in field.240 grams per liter thifluzamide suspending agents by 20 milliliters/mu, preparation (thifluzamide effective ingredient consumption is 72 grams/ha) and 1% Shen piperazine mycin suspending agent by 70 grams/acre, preparation (Shen piperazine mycin effective ingredient consumption is 10.5 grams/ha), with same method, use, after 2 medicines, the control efficiency of 14 days is respectively 80.1% and 80.8%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of rice sheath blight disease significantly better than single dose.
Embodiment 8:10.5% thifluzamide Shen piperazine mycin suspending agent
Each components such as active component, wetting agent, dispersant, thickener, defoamer, antifreezing agent and water are mixed in the ratio of formula, through grind and/or high speed shear after obtain 100 grams of 10.5% thifluzamide Shen piperazine mycin suspending agents for field trial.
This embodiment is applied to prevent and treat watermelon blight.By 10.5% thifluzamide Shen piperazine mycin suspending agent, by 6000 times of preparation dilutions, (wherein thifluzamide effective ingredient consumption is 0.8 mg/kg, Shen piperazine mycin effective ingredient consumption is 17 mg/kg) be watered dilution spraying 3 times, after 3 medicines, the control efficiency of 14 days is 88.9%.Said preparation is used safety, and poisoning phenomenon is not found in field.240 grams per liter thifluzamide suspending agents are by preparation dilution 2000 times of (thifluzamide effective ingredient consumption is 120 mg/kg) and 500 times (Shen piperazine mycin effective ingredient consumption is 20 mg/kg) of 1% Shen piperazine mycin suspending agent dilution, with same method, use, after 3 medicines, the control efficiency of 14 days is respectively 63.4% and 77.9%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of watermelon blight significantly better than single dose.
Embodiment 9:31% thifluzamide Shen piperazine mycin suspension seed-coating agent
This product is mixed and is reached certain index by sand milling by standard compliant former medicine, auxiliary agent, water etc., is deployed into finished product, obtains 100 gram of 31% thifluzamide Shen piperazine mycin suspension seed-coating agent for field trial.
This embodiment is applied to potato black scurf.31% thifluzamide Shen piperazine mycin is suspended kind and to be dressed seed when the potato sowing by 1000 grams/100 kilograms potato seeds of preparation, and potato harvest phase investigation prevention effect is 96.7%.Said preparation is used safety, and poisoning phenomenon is not found in field.Contrast medicament is 240 grams per liter thifluzamide suspending agents by 120 milliliters/mu, preparation (thifluzamide effective ingredient consumption is 432 grams/ha) and 1% Shen piperazine mycin suspending agent by 1200 grams/acre, preparation (Shen piperazine mycin effective ingredient consumption is 180 grams/ha), when potato sowing, potato and soil are sprayed to processing, potato harvest phase investigation preventive effect is respectively 90.3% and 69.4%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of potato black scurf significantly better than single dose.
Claims (5)
1. a bactericidal composition that contains thifluzamide, is characterized in that: in described bactericidal composition, active ingredient is thifluzamide (A) and Shen piperazine mycin (B), is (A) 50:1-1:50 with mass ratio (B).
2. bactericidal composition according to claim 1, is characterized in that: active ingredient (A) is 20:1-1:20 with mass ratio (B).
3. according to bactericidal composition described in claim 1 or 2, it is characterized in that: active ingredient (A) is 1%-90% with gross mass percentage composition (B).
4. bactericidal composition according to claim 3, is characterized in that: described a kind of bactericidal composition that contains thifluzamide is mixed with suspending agent, wetting powder, seed coat agent, aqueous emulsion, microemulsion, missible oil, granule or water dispersible granules.
Described in claim 1 bactericidal composition for preventing and treating the purposes of vegetables, fruit, flowers, cereal crop disease.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105104385A (en) * | 2015-09-01 | 2015-12-02 | 河北中天邦正生物科技股份公司 | Bactericide composition and application thereof |
| CN105248425A (en) * | 2015-01-12 | 2016-01-20 | 四川利尔作物科学有限公司 | Sterilization composition and application thereof |
| CN106922689A (en) * | 2017-04-03 | 2017-07-07 | 佛山市瑞生通科技有限公司 | A kind of bactericidal composition of the mycin of second containing fen and thifluzamide |
| CN107306980A (en) * | 2016-04-26 | 2017-11-03 | 上海农乐生物制品股份有限公司 | A kind of shenqinmycin composite bactericide and its application |
| CN107361080A (en) * | 2017-08-31 | 2017-11-21 | 广西沙田仙人滩农业投资有限公司 | A kind of black scurf of potato bactericide containing tolelofos-methyl |
| CN107950552A (en) * | 2017-11-23 | 2018-04-24 | 安徽丰乐农化有限责任公司 | A kind of compounding seed coat agent containing shenqinmycin |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101637164A (en) * | 2009-09-03 | 2010-02-03 | 浙江省桐庐汇丰生物化工有限公司 | Compound pesticide for protecting and curing rice sheath blight |
| CN102249799A (en) * | 2011-04-27 | 2011-11-23 | 上海农安生物科技发展有限公司 | Method for controlling crop diseases with shenqinmycin and shenqinmycin preparation |
-
2014
- 2014-05-20 CN CN201410212527.0A patent/CN103947658B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101637164A (en) * | 2009-09-03 | 2010-02-03 | 浙江省桐庐汇丰生物化工有限公司 | Compound pesticide for protecting and curing rice sheath blight |
| CN102249799A (en) * | 2011-04-27 | 2011-11-23 | 上海农安生物科技发展有限公司 | Method for controlling crop diseases with shenqinmycin and shenqinmycin preparation |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105248425A (en) * | 2015-01-12 | 2016-01-20 | 四川利尔作物科学有限公司 | Sterilization composition and application thereof |
| CN105248424A (en) * | 2015-01-12 | 2016-01-20 | 四川利尔作物科学有限公司 | Sterilization composition and application thereof |
| CN105432620A (en) * | 2015-01-12 | 2016-03-30 | 四川利尔作物科学有限公司 | Bactericidal composition and application thereof |
| CN105432620B (en) * | 2015-01-12 | 2017-11-14 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN105104385A (en) * | 2015-09-01 | 2015-12-02 | 河北中天邦正生物科技股份公司 | Bactericide composition and application thereof |
| CN107306980A (en) * | 2016-04-26 | 2017-11-03 | 上海农乐生物制品股份有限公司 | A kind of shenqinmycin composite bactericide and its application |
| CN106922689A (en) * | 2017-04-03 | 2017-07-07 | 佛山市瑞生通科技有限公司 | A kind of bactericidal composition of the mycin of second containing fen and thifluzamide |
| CN107361080A (en) * | 2017-08-31 | 2017-11-21 | 广西沙田仙人滩农业投资有限公司 | A kind of black scurf of potato bactericide containing tolelofos-methyl |
| CN107950552A (en) * | 2017-11-23 | 2018-04-24 | 安徽丰乐农化有限责任公司 | A kind of compounding seed coat agent containing shenqinmycin |
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