CN103918672B - Bactericidal composition - Google Patents
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- CN103918672B CN103918672B CN201410173143.2A CN201410173143A CN103918672B CN 103918672 B CN103918672 B CN 103918672B CN 201410173143 A CN201410173143 A CN 201410173143A CN 103918672 B CN103918672 B CN 103918672B
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Abstract
The invention discloses a bactericidal composition of which effective components are coumoxystrobin and tridemorph in a mass ratio of 50:1-1:50. The composition has an obvious synergistic action, and can be used for controlling diseases of vegetables, fruits and cereal crops, especially apple rot, wheat powdery mildew, powdery mildew of garden pea, rice sheath blight disease, gray mold of tomato, gray mold of cucumber, gray mold of strawberry, gray mold of grape and the like.
Description
Technical field
The present invention relates to a kind of bactericidal composition, especially a kind of bactericidal composition containing SYP-3375.
Technical background
SYP-3375, English common name coumoxystrobin is a kind of methoxy acrylic bactericide that China is newly developed, effective to powdery mildew, downy mildew, gray mold, very high to apple canker spore germination activity, but lower to Valsa mali mycelial growth inhibit activities.Along with being all the Fluoxastrobin of methoxy acrylic bactericide, kresoxim-methyl, pyraclostrobin, oxime bacterium ester spread use, and the resistance problem of this series bactericidal agent is more and more outstanding.In addition, SYP-3375 is the compound of new synthesis, and it is higher to be used alone cost, and exploitation compound synergic composition can improve cost performance.
Different pesticide active ingredients is combined, synergistic effect is significantly filled a prescription and greatly can be improved preventive effect, reduce dosage, reduce costs, speed phytopathogen simultaneously can also being avoided to produce resistance or delaying drug resistance produce is the one effectively and efficiently mode solving the alone resistance of current agricultural chemicals and Cost Problems.
In sum, the Synergistic bactericidal composition of exploitation containing SYP-3375 is significant.
Summary of the invention
The object of the invention is to: a kind of high-efficiency environment friendly, the wide spectrum and can delay pathogen resistance and produce speed and reduce the bactericidal composition of Pesticide use cost that are applicable to agriculturally using are provided.
For solving the problems of the technologies described above, we have carried out composition research to SYP-3375.By a large amount of biologicall tests screening, surprisingly find that SYP-3375 (A) and tridemorph (B) are composite with certain proportion, the disease such as apple canker, wheat powdery mildew is had significant synergies.
Tridemorph, English common name Tridemorph is a kind of interior absorption wide-spectrum bactericide; suppress the biosynthesis of germ ergosterol; there is protection and treatment double action, can be absorbed in plant corpus by the root of plant, stem, leaf, move up through xylem.Tridemorph can suppress Valsa mali mycelial growth preferably, also has certain inhibitory action to the formation of germ spore.Tridemorph is conventional dose, and drug cost is relatively low.But tridemorph be used alone dosage larger time there is security risks, and long-term single continuous use, the same with triazole bactericidal agent also exist resistance risk.SYP-3375 and the composite deficiency that also can solve tridemorph preferably of tridemorph.
On the basis of above-mentioned discovery, through carrying out symphyogenetic quantitative analysis to composition, define technical scheme of the present invention, namely with SYP-3375 (A) and tridemorph (B) for active ingredient, the mass ratio of the two is 50: 1-1: 50, and preferable quality ratio is 10: 1-1: 10.
The present composition can be prepared into the formulation of applicable agricultural use by known method, in preparation, the total content of active ingredient is 3%-90%.
The auxiliary elements such as dispersant, wetting agent, antifreezing agent, bleeding agent are also comprised and other is of value to active ingredient at storage and known substance that in using, stable and drug effect plays in composition of the present invention, all various compositions that are conventional in pesticidal preparations or permission use, be not particularly limited, concrete composition and consumption are determined by simple experiment according to recipe requirements.
Composition described in the invention can finished product preparation form provide, namely in composition, each material mixes, the composition of composition also can provide with unit dose form, and directly directly mix in bucket or tank before using, paste is smeared after scraping morbidity place off by related request.
Bactericidal composition of the present invention can be used for preventing and treating various fungus-caused plant disease, be specially adapted to the disease of preventing and treating the crop such as veterinary antibiotics, Cereal, as apple canker, wheat powdery mildew, powdery mildew of pea, gray mold of cucumber, graw mold of tomato, Botrytis cinerea, grey mould fruit rot of strawberry, grape grey mould, cucumber downy mildew, rice sheath blight disease etc.
Compared with prior art, the beneficial effect that the present invention produces is: (1), compared with single dose, this bactericidal composition has obvious synergy to the disease such as apple canker, wheat powdery mildew, improves control efficiency; (2) field dosage can be reduced, effectively reduce environmental pollution and residue of pesticide, reduce and produce and use cost; (3) in bactericidal composition, the mechanism of action of active ingredient is different, is conducive to avoiding and delay the drug-fast generation of germ; (4) control spectrum is expanded compared with single dose.
Embodiment
In order to make object of the present invention, technical scheme and advantage clearly understand, the following specific embodiment of the present invention is described, but the present invention is limited to absolutely not these examples.
The present composition with SYP-3375 (A) for a kind of active ingredient, tridemorph (B) is another kind of active ingredient, combination between them has obvious synergistic function to diseases such as apple canker, and be not only the simple addition of two kinds of pharmacy effects, refer to Assays Example.
Biologicall test example 1: SYP-3375 and the composite Toxicity Determination to Valsa mali of tridemorph
Subjects: apple canker (pick up from field, and through separation and purification)
Test method: test is with reference to " farm-chemical indoor determination test rule NY/T1156.2-2006 and 1156.6-2006 ", and test adopts growth rate method (Plating).The liquid diluted is added in quantitative culture medium and makes band medicine PDA medium, inoculation diameter is 4mm bacterium cake, and to add the medium of aqua sterilisa for blank, 4 repetitions are established in each process, are put in 25 DEG C of constant incubators and cultivate.Until contrast colony diameter surveys each process colony diameter by right-angled intersection method when reaching about 7CM, and record its data and carry out interpretation of result, carry out statistical analysis with DPS data processing software, calculate the EC of each medicament
50, then press the abundant method of Sun Yun and calculate co-toxicity coefficient (CTC).Inhibitory action computing formula is as follows:
Inhibiting rate is converted into probability value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, calculates virulence equation and concentration EC in suppressing with method of least squares
50, toxicity index and the co-toxicity coefficient (CTC) of medicament is calculated according to the abundant method of Sun Yun.Computational methods are with biologicall test example 1.Toxicity test the results are shown in Table 2.
Table 2 SYP-3375 and the composite Toxicity Determination result to Valsa mali of tridemorph
The result of table 2 shows, SYP-3375 and tridemorph are proportioning 50: 1-1: 50 time, and have obvious synergistic effect to the sick germ of apple canker, time especially between 10: 1-1: 10, listed proportioning co-toxicity coefficient is all higher than 172.7, and synergistic effect is more obvious.
Bactericidal composition of the present invention can be prepared into the suspending agent of applicable agricultural use, missible oil, aqueous emulsion, microemulsion, wetting powder, water dispersible granules or paste by known method.Be described with specific embodiment below, in present specification, active component or active ingredient refer to SYP-3375 and tridemorph, and in formula, percentage is mass percent, below repeat no more.
Embodiment 1:20.4% SYP-3375 tridemorph suspending agent
The ratio of each components such as former for active component medicine, dispersant, wetting agent and water in formula is mixed, after grinding and/or high speed shear, obtains 20.4% SYP-3375 tridemorph suspending agent.
This embodiment is applied to control graw mold of tomato.Sprayed by 20.4% SYP-3375 tridemorph suspending agent thin up 4000 times (SYP-3375 valid density is 50 μ g/ml, and tridemorph valid density is 1 μ g/ml), after medicine, the control efficiency of 7 days and 15 days is respectively 85.7%, 80.1%.20% SYP-3375 suspending agent by 2500 times (valid density is 80 μ g/ml) and 50% tridemorph missible oil by 1000 times (valid density is 500 μ g/ml), use with same method, after medicine, the preventive effect of 7 days is respectively 75.2% and 66.2%; After medicine, 15 days preventive effects are respectively 72.5% and 61.1%.SYP-3375 and the composite rear preventive effect to graw mold of tomato of tridemorph are significantly better than single dose.
Embodiment 2:15% SYP-3375 tridemorph microemulsion
Former medicine, solvent, emulsifier are added together, make to be dissolved into homogeneous oil phase; By water-soluble component and the obtained aqueous phase of water mixing; Under high velocity agitation, oil phase is mixed with water, obtained 15% SYP-3375 tridemorph microemulsion.
This embodiment is applied to prevents and treats apple canker.15% SYP-3375 tridemorph microemulsion is smeared disease scar by 100 times of liquid, and after medicine, the control efficiency of 15 days and 30 days is respectively 100%, 100%.20% SYP-3375 suspending agent presses 200 times by 100 times of liquid and 50% tridemorph missible oil, and use with same method, after medicine, the preventive effect of 15 days is respectively 87.0% and 83.7%; After medicine, 15 days preventive effects are respectively 84.1% and 80.7%.SYP-3375 and tridemorph composite rear to preventing and treating the preventive effect of apple canker significantly better than single dose.
Embodiment 3:51% SYP-3375 tridemorph missible oil
Active component, emulsifier and the auxiliary agent ratio in formula is added in mixing kettle successively, stirs, obtained 51% SYP-3375 tridemorph missible oil.
This embodiment is applied to powdery mildew of pea.Sprayed by 2000 times of (SYP-3375 valid density is 5 μ g/ml, and tridemorph valid density is 250 μ g/ml) thin ups by 51% SYP-3375 tridemorph missible oil, after medicine, the control efficiency of 7 days and 15 days is respectively 92.8%, 87.6%.20% SYP-3375 suspending agent by 2500 times (valid density is 80 μ g/ml) and 50% tridemorph missible oil by 1000 times (valid density is 500 μ g/ml), use with same method, after medicine, the preventive effect of 7 days is respectively 66.1% and 83.7%; After medicine, 15 days preventive effects are respectively 60.2% and 77.3%.SYP-3375 and the composite rear preventive effect to powdery mildew of pea of tridemorph are significantly better than single dose.
Embodiment 4:3% SYP-3375 tridemorph paste
Get said ratio raw material, first in water, slowly add polyvinyl alcohol and bentonite, limit edged is stirred to fully swelling, high fat film and potassium sorbate is added during fast cooling, limit edged stirs, and adds SYP-3375 and tridemorph, complement to 100% with water after cooling, till stirring, obtained 3% SYP-3375 tridemorph paste.
This embodiment is applied to apple canker.Morbidity place of strain bar scraped off, by 3% SYP-3375 tridemorph paste application, in morbidity place, (SYP-3375 dosage is 3g/m
2, tridemorph dosage is 3g/m
2), after medicine, the control efficiency of 15 days, 30 days, 60 days is respectively 100%, 100%, 86.2%.6g/m pressed by 3% SYP-3375 paste
26g/m is pressed with 3% tridemorph paste
2, use with same method, after medicine, the preventive effect of 15 days is respectively 91.4% and 90.2%; After medicine, 30 days preventive effects are respectively 85.3% and 83.5%, and after medicine, 60 days preventive effects are respectively 80.8% and 75.7%.SYP-3375 and the composite rear preventive effect to apple canker of tridemorph are significantly better than single dose.
Embodiment 5:30% SYP-3375 tridemorph aqueous emulsion
Former medicine, solvent, emulsifier are added together, make to be dissolved into homogeneous oil phase; By water-soluble component and the obtained aqueous phase of water mixing; Under high velocity agitation, oil phase is mixed with water, obtained 30% SYP-3375 tridemorph aqueous emulsion.
This embodiment is applied to prevents and treats powdery mildew of cucumber.Sprayed by 2000 times of (SYP-3375 valid density is 25 μ g/ml, and tridemorph valid density is 125 μ g/ml) thin ups by 30% SYP-3375 tridemorph aqueous emulsion, after medicine, the control efficiency of 7 days and 15 days is respectively 96.4%, 91.5%.20% SYP-3375 suspending agent by 2000 times (valid density is 100 μ g/ml) and 50% tridemorph missible oil by 2500 times (valid density is 200 μ g/ml), use with same method, after medicine, the preventive effect of 7 days is respectively 66.1% and 80.4%; After medicine, 15 days preventive effects are respectively 61.2% and 76.3%.SYP-3375 and the composite rear preventive effect to powdery mildew of cucumber of tridemorph are significantly better than single dose.
Embodiment 6:55% SYP-3375 tridemorph missible oil
Active component, emulsifier and the auxiliary agent ratio in formula is added in mixing kettle successively, stirs, obtained 55% SYP-3375 tridemorph missible oil.
This embodiment is applied to control grape grey mould.Sprayed by 2500 times of (SYP-3375 valid density is 20 μ g/ml, and tridemorph valid density is 200 μ g/ml) thin ups by 55% SYP-3375 tridemorph missible oil, after medicine, the control efficiency of 7 days and 15 days is respectively 87.6%, 81.3%.20% SYP-3375 suspending agent by 2500 times (valid density is 80 μ g/ml) and 50% tridemorph missible oil by 2000 times (valid density is 250 μ g/ml), use with same method, after medicine, the preventive effect of 7 days is respectively 75.2% and 67.3%; After medicine, 15 days preventive effects are respectively 72.7% and 61.6%.SYP-3375 and the composite rear preventive effect to grape grey mould of tridemorph are significantly better than single dose.
Embodiment 7:11% SYP-3375 tridemorph missible oil
Active component, emulsifier and the auxiliary agent ratio in formula is added in mixing kettle successively, stirs, obtained 11% SYP-3375 tridemorph missible oil.
This embodiment is for preventing and treating cucumber downy mildew.Sprayed by 4000 times of (SYP-3375 valid density is 25 μ g/ml, and tridemorph valid density is 2.5 μ g/ml) thin ups by 11% SYP-3375 tridemorph microemulsion, after medicine, the control efficiency of 7 days and 15 days is respectively 96.3%, 92.8%.20% SYP-3375 suspending agent by 5000 times (valid density is 40 μ g/ml) and 50% tridemorph missible oil by 2000 times (valid density is 250 μ g/ml), use with same method, after medicine, the preventive effect of 7 days is respectively 86.7% and 47.1%; After medicine, 15 days preventive effects are respectively 80.2% and 34.3%.SYP-3375 and the composite rear preventive effect to cucumber downy mildew of tridemorph are significantly better than single dose.
Embodiment 8:30% SYP-3375 tridemorph wetting powder
The ratio in formula such as active component, various auxiliary agent and filler is fully mixed, after ultra-fine pulverizer disintegrating, obtains 30% SYP-3375 tridemorph wetting powder.
This embodiment is applied to rice sheath blight disease.By 30% SYP-3375 tridemorph wetting powder, (SYP-3375 valid density is 25 μ g/ml by 10000 times, tridemorph valid density is 50 μ g/ml) thin up spraying, after medicine, the control efficiency of 7 days and 15 days is respectively 88.2%, 85.3%.20% SYP-3375 suspending agent by 5000 times (valid density is 40 μ g/ml) and 50% tridemorph missible oil by 2500 times (valid density is 200 μ g/ml), use with same method, after medicine, the preventive effect of 7 days is respectively 78.9% and 66.3%; After medicine, 15 days preventive effects are respectively 76.3% and 58.5%.SYP-3375 and the composite rear preventive effect to rice sheath blight disease of tridemorph are significantly better than single dose.
Embodiment 9:90% SYP-3375 tridemorph water dispersible granules
Active component, dispersant, wetting agent, disintegrant and the filler ratio in formula is mixed, becomes wetting powder through air-flow crushing, then add a certain amount of water mixing extruding and make material.90% SYP-3375 tridemorph water dispersible granules is obtained after drying screening.
This embodiment is applied to control wheat powdery mildew.By 90% SYP-3375 tridemorph water dispersible granules 5000 times, (SYP-3375 valid density is 40 μ g/ml, tridemorph valid density is 140 μ g/ml) thin up spraying, after medicine, the control efficiency of 7 days and 15 days is respectively 94.5%, 90.4%.20% SYP-3375 suspending agent by 2000 times (valid density is 100 μ g/ml) and 50% tridemorph missible oil by 2500 times (valid density is 200 μ g/ml), use with same method, after medicine, the preventive effect of 7 days is respectively 69.3% and 84.5%; After medicine, 15 days preventive effects are respectively 64.7% and 80.4%.SYP-3375 and the composite rear preventive effect to wheat powdery mildew of tridemorph are significantly better than single dose.
Embodiment 10:40% SYP-3375 tridemorph water dispersible granules
Active component, dispersant, wetting agent, disintegrant and the filler ratio in formula is mixed, wetting powder is become through air-flow crushing, add a certain amount of water mixing extruding again and make material, after drying screening, obtain 40% SYP-3375 tridemorph water dispersible granules.
This embodiment is applied to control grey mould fruit rot of strawberry.By 40% SYP-3375 tridemorph water dispersible granules thin up 8000 times, (SYP-3375 valid density is 25 μ g/ml, tridemorph valid density is 25 μ g/ml) spraying, after medicine, the control efficiency of 7 days and 15 days is respectively 86.2%, 82.5%.20% SYP-3375 suspending agent by 4000 times (valid density is 50 μ g/ml) and 50% tridemorph missible oil by 2000 times (valid density is 250 μ g/ml), use with same method, after medicine, the preventive effect of 7 days is respectively 75.2% and 65.8%; After medicine, 15 days preventive effects are respectively 68.7% and 60.3%.SYP-3375 and the composite rear preventive effect to grey mould fruit rot of strawberry of tridemorph are significantly better than single dose.
Embodiment 11:60% SYP-3375 tridemorph water dispersible granules
Active component, dispersant, wetting agent, disintegrant and the filler ratio in formula is mixed, wetting powder is become through air-flow crushing, add a certain amount of water mixing extruding again and make material, after drying screening, obtain 60% SYP-3375 tridemorph water dispersible granules.
This embodiment is applied to control Rubber Red Root Disease.Filled with by active ingredient 24g/ strain by 60% SYP-3375 tridemorph water dispersible granules and drench, after medicine, the control efficiency of 15 days and 30 days is respectively 100%, 95.7%.20% SYP-3375 suspending agent is by active ingredient 30g/ strain, and 50% tridemorph missible oil is by active ingredient 30g/ strain, and use with same method, after medicine, the preventive effect of 15 days is respectively 69.2% and 89.3%; After medicine, 30 days preventive effects are respectively 61.7% and 84.3%.SYP-3375 and the composite rear preventive effect to Rubber Red Root Disease of tridemorph are significantly better than single dose.
Claims (5)
1. a bactericidal composition, is characterized in that: in described bactericidal composition, active ingredient is SYP-3375 (A) and tridemorph (B), and (A) is 50: 1-1: 50 with the mass ratio of (B).
2. bactericidal composition according to claim 1, is characterized in that: active ingredient (A) is 10: 1-1: 10 with the mass ratio of (B).
3. bactericidal composition according to claim 1 or 2, is characterized in that: active ingredient (A) is 3%-90% with the gross mass percentage composition of (B).
4. bactericidal composition according to claim 3, is characterized in that: the formulation of described bactericidal composition is suspending agent, missible oil, aqueous emulsion, microemulsion, wetting powder, water dispersible granules or paste.
5. bactericidal composition according to claim 1 is for preventing and treating the purposes of veterinary antibiotics, cereal diseases.
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| CN101999375A (en) * | 2010-12-08 | 2011-04-06 | 陕西美邦农药有限公司 | Antibacterial composition containing tridemorph |
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| CN101999375A (en) * | 2010-12-08 | 2011-04-06 | 陕西美邦农药有限公司 | Antibacterial composition containing tridemorph |
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| Title |
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| 杀菌剂丁香菌酯的创制经纬;关爱莹等;《农药》;20110228;第50卷(第2期);第91-92页 * |
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Address after: 518102 No. 113 Reservoir Road, Baoan District, Guangdong, Shenzhen, Xixiang Patentee after: Shenzhen Novozon Crop Science Co.,Ltd. Country or region after: China Address before: 518102 No. 113 Reservoir Road, Baoan District, Guangdong, Shenzhen, Xixiang Patentee before: SHENZHEN NOPOSION AGROCHEMICALS Co.,Ltd. Country or region before: China |