CN103947658B - Thifluzamide-containing bactericidal composition - Google Patents
Thifluzamide-containing bactericidal composition Download PDFInfo
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- CN103947658B CN103947658B CN201410212527.0A CN201410212527A CN103947658B CN 103947658 B CN103947658 B CN 103947658B CN 201410212527 A CN201410212527 A CN 201410212527A CN 103947658 B CN103947658 B CN 103947658B
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- thifluzamide
- piperazine mycin
- shen piperazine
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- WOSNCVAPUOFXEH-UHFFFAOYSA-N thifluzamide Chemical compound S1C(C)=NC(C(F)(F)F)=C1C(=O)NC1=C(Br)C=C(OC(F)(F)F)C=C1Br WOSNCVAPUOFXEH-UHFFFAOYSA-N 0.000 title claims abstract description 94
- 239000000203 mixture Substances 0.000 title claims abstract description 43
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 20
- 201000010099 disease Diseases 0.000 claims abstract description 23
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 23
- 235000013339 cereals Nutrition 0.000 claims abstract description 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 156
- 239000000375 suspending agent Substances 0.000 claims description 30
- 239000004480 active ingredient Substances 0.000 claims description 10
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- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 7
- 238000009736 wetting Methods 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims 1
- 239000004530 micro-emulsion Substances 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 244000061456 Solanum tuberosum Species 0.000 abstract description 26
- 235000002595 Solanum tuberosum Nutrition 0.000 abstract description 26
- 235000007164 Oryza sativa Nutrition 0.000 abstract description 22
- 235000009566 rice Nutrition 0.000 abstract description 22
- 208000001840 Dandruff Diseases 0.000 abstract description 12
- 235000002566 Capsicum Nutrition 0.000 abstract description 4
- 241000209140 Triticum Species 0.000 abstract description 4
- 235000021307 Triticum Nutrition 0.000 abstract description 4
- 241000233622 Phytophthora infestans Species 0.000 abstract description 3
- JGCSKOVQDXEQHI-UHFFFAOYSA-N phenazine-1-carboxylic acid Chemical compound C1=CC=C2N=C3C(C(=O)O)=CC=CC3=NC2=C1 JGCSKOVQDXEQHI-UHFFFAOYSA-N 0.000 abstract 4
- 240000007594 Oryza sativa Species 0.000 abstract 2
- 239000006002 Pepper Substances 0.000 abstract 1
- 241000233614 Phytophthora Species 0.000 abstract 1
- 235000016761 Piper aduncum Nutrition 0.000 abstract 1
- 235000017804 Piper guineense Nutrition 0.000 abstract 1
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- 239000002131 composite material Substances 0.000 description 15
- 230000003449 preventive effect Effects 0.000 description 15
- 230000001988 toxicity Effects 0.000 description 11
- 231100000419 toxicity Toxicity 0.000 description 11
- 229940079593 drug Drugs 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 231100000572 poisoning Toxicity 0.000 description 9
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- 238000012360 testing method Methods 0.000 description 9
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- 239000002270 dispersing agent Substances 0.000 description 5
- 239000000080 wetting agent Substances 0.000 description 5
- 241000219109 Citrullus Species 0.000 description 4
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 4
- 239000000306 component Substances 0.000 description 4
- 238000003306 harvesting Methods 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- 244000052769 pathogen Species 0.000 description 4
- 238000009331 sowing Methods 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 231100000820 toxicity test Toxicity 0.000 description 4
- 240000008574 Capsicum frutescens Species 0.000 description 3
- 239000001390 capsicum minimum Substances 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
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- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 235000015895 biscuits Nutrition 0.000 description 2
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- 238000005516 engineering process Methods 0.000 description 2
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- 239000011521 glass Substances 0.000 description 2
- 239000003864 humus Substances 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 238000010030 laminating Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
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- 239000007921 spray Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 241000223600 Alternaria Species 0.000 description 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 1
- BHUAFRMKCZOACQ-UHFFFAOYSA-N C1=CC=C2N=C3C(C(=O)O)=CC=CC3=NC2=C1.C1=CC=C2N=C3C(C(=O)O)=CC=CC3=NC2=C1 Chemical group C1=CC=C2N=C3C(C(=O)O)=CC=CC3=NC2=C1.C1=CC=C2N=C3C(C(=O)O)=CC=CC3=NC2=C1 BHUAFRMKCZOACQ-UHFFFAOYSA-N 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241000813090 Rhizoctonia solani Species 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- SYHPANJAVIEQQL-UHFFFAOYSA-N dicarboxy carbonate Chemical compound OC(=O)OC(=O)OC(O)=O SYHPANJAVIEQQL-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
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- 230000000361 pesticidal effect Effects 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericidal composition which comprises effective components including thifluzamide and phenazine-1-carboxylic acid, wherein the ratio of the thifluzamide to the phenazine-1-carboxylic acid is 50:1-1:50. The bactericidal composition has obvious synergism, and can be used for controlling diseases such as rice sheath blight disease, rice false smut, wheat sharp eyespot, pepper phytophthora blight, potato late blight and potato black scurf of vegetables, fruits, flowers and cereal crops.
Description
Technical field
The present invention relates to a kind of bactericidal composition containing thifluzamide, specifically a kind of bactericidal composition containing thifluzamide and Shen piperazine mycin.
Background technology
Thifluzamide ISO adopted name: thifluzamide; CA registration number: 130000-40-7
The bromo-2-methyl of chemical name: 2,6-bis--4-trifluoromethoxy-4-Trifluoromethyl-1,3-thiazole-5-carbonyl acyl is for aniline; Molecular formula: C13H6Br2F6N2O2S; Relative molecular mass: 528.06 (by international relative atomic masses in 2007).Thifluzamide is the systemic fungicide that phenylamide has the double therapeutic action of prevention, and the succinate dehydrase in Antifungi tricarbonic acid cycle, affects pathogen respiratory chain electron transmission, and cause thalline dead, the lasting period is long.Thifluzamide had obtained since agricultural chemicals registers temporarily from 2000 in China, was mainly used in the water prevention rice sheath blight; Resistance is produced to it in some areas rice sheath blight disease, need to strengthen consumption and just can reach desirable control efficiency.
Different pesticide active ingredients is combined; synergistic effect significantly fill a prescription can greatly improve preventive effect, reduce dosage, reduce costs, protection of the environment; speed phytopathogen simultaneously can also being avoided to produce resistance or delaying drug resistance produce is the one effectively and efficiently mode solving the alone resistance of current agricultural chemicals and Cost Problems.
In sum, the Synergistic bactericidal composition of exploitation containing thifluzamide is significant.
Summary of the invention
The object of the invention is to: a kind of high-efficiency environment friendly, the wide spectrum and can delay pathogen resistance and produce speed and reduce the bactericidal composition containing thifluzamide of Pesticide use cost that are applicable to agriculturally using are provided.
For solving the problems of the technologies described above, we have carried out composition research to thifluzamide.By a large amount of biologicall tests screening, surprisingly find that thifluzamide (A) and Shen piperazine mycin (B) are composite with certain proportion, the disease such as rice sheath blight disease, potato late blight is had significant synergies.Shen piperazine mycin is by the tunning of Pseudomonas bacterial strain M18, main component is phenazine-1-carboxylic acid (phenazine-1-carboxylic acid), has good inhibitory action to various plants pathogens such as rice sheath blight disease, cucumber blight dis-ease, watermelon blights.Shen piperazine mycin in Shanghai, Hubei, Hainan, Henan, the ground such as Gansu carried out large-area extend trial, shows good field efficacy to rice sheath blight disease, alternaria leaf spot of apple, watermelon blight, gummy stem blight of melon etc.
Thifluzamide and Shen piperazine mycin belong to dissimilar bactericide, and its mechanism of action is different, and 2 mixtures can slow down the generation of germ resistance, simultaneously can expanding prevention spectrum.
On the basis of above-mentioned discovery, through carrying out symphyogenetic quantitative analysis to composition, define technical scheme of the present invention, namely with thifluzamide (A) and Shen piperazine mycin (B) for active ingredient, the mass ratio of the two is 50:1-1:50, and preferable quality is than being 20:1-1:20.
The present composition can be prepared into the formulation of applicable agricultural use by known method, as wetting powder, suspending agent, suspension seed-coating agent, granule or water dispersible granules, in preparation, the total content of active ingredient is 1%-84%.
The auxiliary elements such as solvent, dispersant, wetting agent, antifreezing agent, bleeding agent are also comprised and other is of value to active ingredient at storage and known substance that in using, stable and drug effect plays in composition of the present invention, all various compositions that are conventional in pesticidal preparations or permission use, be not particularly limited, concrete composition and consumption are determined by simple experiment according to recipe requirements.
Composition described in the invention can finished product preparation form provide, namely in composition, each material mixes, the composition of composition also can provide with unit dose form, and directly directly mix in bucket or tank before using, paste is smeared after scraping morbidity place off by related request.
A kind of bactericidal composition containing thifluzamide of the present invention can be used for preventing and treating various fungus-caused plant disease, be specially adapted to the disease of preventing and treating the crops such as veterinary antibiotics, flowers and Cereal, as rice sheath blight disease, rice green smut, wheat sharp eyespot, capsicum epidemic disease, potato late blight, potato black scurf.
Compared with prior art, the beneficial effect that the present invention produces is: (1), compared with single dose, this kind of bactericidal composition containing thifluzamide has obvious synergy to the disease such as rice sheath blight disease, potato black scurf, improves control efficiency; (2) field dosage can be reduced, effectively reduce environmental pollution and residue of pesticide, reduce and produce and use cost; (3) in bactericidal composition, the mechanism of action of active ingredient is different, is conducive to avoiding and delay the drug-fast generation of germ; (4) control spectrum is expanded compared with single dose.
Embodiment
In order to make object of the present invention, technical scheme and advantage clearly understand, the following specific embodiment of the present invention is described, but the present invention is limited to absolutely not these examples.
The present composition with thifluzamide (A) for a kind of active ingredient, Shen piperazine mycin (B) is another kind of active ingredient, combination between them has obvious synergistic function to the disease such as rice sheath blight disease, capsicum epidemic disease, and be not only the simple addition of two kinds of pharmacy effects, refer to Assays Example.
Biologicall test example 1: thifluzamide and the composite toxicity test to rice sheath blight disease of Shen piperazine mycin
Subjects: Rhizoctonia solani Kuhn
Test adopts growth rate method (Plating).On aseptic operating platform, according to test process, the sterilising medium melted in advance is quantitatively placed in aseptic conical flask, from low concentration to high concentration, get 5mL liquid successively join respectively the hot medium of 45mL (PDA medium is housed, 45-50 DEG C) conical flask in, after shaking up, pour rapidly diameter 90mm glass culture dish into, band medicine medium 10mL poured into by each culture dish.Horizontal rest, makes flat board after cooling.Each concentration five repetition.Blank is made with the process not containing medicament effective ingredient.By cultured pathogen, aseptically use the sterilizing card punch of diameter 4mm, cut bacterium cake from colony edge, with inoculator, pure culture biscuits involvng inoculation is dull and stereotyped central in pastille, facing down having one of mycelia and medium laminating, covering ware lid.Above all operations all carries out sterile working at superclean bench.Be placed on after process in the constant temperature aseptic culture case of 26 ± 0.5 DEG C and cultivate, take out after 2d.Adopt right-angled intersection method to measure the colony diameter (in units of millimeter) of each process respectively, calculate the mean value of colony diameter.The logarithm value processing effective ingredient concentration (μ g/mL) with each is independent variable X, and the probit value that inhibiting rate changes into is dependent variable Y, uses expert data statistical software DPS process, calculates concentration EC in suppression
50, toxicity index and the co-toxicity coefficient (CTC) of medicament is calculated according to the abundant method of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent EC
50/ reagent agent EC
50) × 100
In theoretical toxicity index (TTI)=A medicament toxicity index × mixture A percentage composition+B medicament toxicity index × mixture in the percentage composition of B
Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] × 100
When CTC≤80, then composition shows as antagonism, and as 80 < CTC < 120, then composition shows as summation action, and when CTC >=120, then composition shows as synergistic effect.
Toxicity test result is see table 1
The serial proportioning of table 1 thifluzamide and Shen piperazine mycin is to the Toxicity Determination result of rice sheath blight disease
Result of the test shows, thifluzamide and the composite water prevention rice sheath blight of Shen piperazine mycin, when proportioning is between 50:1-1:50, co-toxicity coefficient, all more than 140, has certain synergistic effect, and time between 20:1-1:20, co-toxicity coefficient is all higher than 200, and synergistic effect is more obvious.
Biologicall test example 2: thifluzamide and the composite toxicity test to potato black scurf of Shen piperazine mycin
Subjects: potato black scurf
Test adopts growth rate method (Plating).On aseptic operating platform, according to test process, the sterilising medium melted in advance is quantitatively placed in aseptic conical flask, from low concentration to high concentration, get 5mL liquid successively join respectively the hot medium of 45mL (PDA medium is housed, 45-50 DEG C) conical flask in, after shaking up, pour rapidly diameter 90mm glass culture dish into, band medicine medium 10mL poured into by each culture dish.Horizontal rest, makes flat board after cooling.Each concentration five repetition.Blank is made with the process not containing medicament effective ingredient.By cultured pathogen, aseptically use the sterilizing card punch of diameter 4mm, cut bacterium cake from colony edge, with inoculator, pure culture biscuits involvng inoculation is dull and stereotyped central in pastille, facing down having one of mycelia and medium laminating, covering ware lid.Above all operations all carries out sterile working at superclean bench.Be placed on after process in the constant temperature aseptic culture case of 25 ± 0.5 DEG C and cultivate, take out after 2d.Adopt right-angled intersection method to measure the colony diameter (in units of millimeter) of each process respectively, calculate the mean value of colony diameter.The logarithm value processing effective ingredient concentration (μ g/mL) with each is independent variable X, and the probit value that inhibiting rate changes into is dependent variable Y, uses expert data statistical software DPS process, calculates concentration EC in suppression
50, toxicity index and the co-toxicity coefficient (CTC) of medicament is calculated according to the abundant method of Sun Yun.
Drug effect calculating, toxicity index and co-toxicity coefficient (CTC) calculate, analytical method is the same.
Toxicity test the results are shown in Table 2.
The serial proportioning of table 2 thifluzamide and Shen piperazine mycin is to the Toxicity Determination result of potato black scurf
Result of the test shows, thifluzamide and Shen piperazine mycin is composite prevents and treats potato black scurf, when proportioning is between 50:1-1:50, co-toxicity coefficient, all more than 170.0, shows to have certain synergistic effect, and time between 20:1-1:20, co-toxicity coefficient is all higher than 200.0, and synergistic effect is more obvious.
Above measurement result shows, when in thifluzamide (A) and Shen piperazine mycin (B), the proportioning of a kind of composite water prevention rice sheath blight and potato black scurf is between 50:1-1:50, co-toxicity coefficient is all more than 120.0, there is certain synergistic effect, time between 20:1-1:20, co-toxicity coefficient is more than 200, and synergistic effect is more obvious.
A kind of bactericidal composition containing thifluzamide of the present invention can be prepared into the wetting powder of applicable agricultural use, suspending agent, granule or water dispersible granules by known method.Be described with specific embodiment below, in formula, percentage is mass percent, and thifluzamide former medicine effective content is 96%, piperazine mycin former medicine effective content in Shen is 95%, all calculates by effective content folding hundred during use.Active component present specification middle finger thifluzamide (A) and one in Shen piperazine mycin (B), below repeat no more.
Embodiment 1:51% thifluzamide Shen piperazine mycin wetting powder
The ratio in formula such as active component, various auxiliary agent and filler is fully mixed, after ultra-fine pulverizer disintegrating, makes 100 gram of 51% thifluzamide Shen piperazine mycin wetting powder.
This embodiment is applied to the water prevention rice sheath blight.By 51% thifluzamide Shen piperazine mycin wetting powder, by 8 grams/acre, preparation, (wherein thifluzamide effective ingredient consumption is 60 grams/ha, Shen piperazine mycin effective ingredient consumption is 1.2 grams/ha) be watered dilution spraying 2 times, after 2 medicines, the control efficiency of 14 days is 85.6%.Said preparation use safety, field does not find poisoning phenomenon.240 grams per liter thifluzamide suspending agents by 20 milliliters/mu, preparation (thifluzamide effective ingredient consumption is 72 grams/ha) and 1% Shen piperazine mycin suspending agent by 70 grams/acre, preparation (Shen piperazine mycin effective ingredient consumption is 10.5 grams/ha), use with same method, after 2 medicines, the control efficiency of 14 days is respectively 80.1% and 80.8%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of rice sheath blight disease significantly better than single dose.
Embodiment 2:31% thifluzamide Shen piperazine mycin suspending agent
The ratio of each components such as active component, wetting agent, dispersant, thickener, defoamer, antifreezing agent and water in formula is mixed, after grinding and/or high speed shear, obtains 31% thifluzamide Shen piperazine mycin suspending agent 100 grams.
This embodiment is applied to control rice green smut.By 31% thifluzamide Shen piperazine mycin suspending agent, by 15 milliliters/mu, preparation, (wherein thifluzamide effective ingredient consumption is 67.5 grams/ha, Shen piperazine mycin effective ingredient consumption is 2.25 grams/ha) be watered dilution spraying 2 times, after 2 medicines, the control efficiency of 15 days is 86.7%.Said preparation use safety, field does not find poisoning phenomenon.240 grams per liter thifluzamide suspending agents by 20 milliliters/mu, preparation (thifluzamide effective ingredient consumption is 72 grams/ha) and 1% Shen piperazine mycin suspending agent by 60 grams/acre, preparation (Shen piperazine mycin effective ingredient consumption is 9 grams/ha), use with same method, after 2 medicines, the preventive effect of 7 days is respectively 83.4% and 80.2%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of rice green smut significantly better than single dose.
Embodiment 3:84% thifluzamide Shen piperazine mycin water dispersible granules
Active component, dispersant, wetting agent and the filler ratio in formula is mixed, becomes wetting powder through air-flow crushing, then add a certain amount of water mixing extruding and make material.100 gram of 84% thifluzamide Shen piperazine mycin water dispersible granules is obtained for field trial after drying screening.
This embodiment is applied to potato black scurf.By 84% thifluzamide Shen piperazine mycin water dispersible granules, by 25 grams/acre, preparation, (wherein thifluzamide effective ingredient consumption is 300 grams/ha, Shen piperazine mycin effective ingredient consumption is 15 grams/ha) when potato sowing, trench digging sprays 1 time, and potato harvest phase investigation prevention effect is 87.4%.Said preparation use safety, field does not find poisoning phenomenon.240 grams per liter thifluzamide suspending agents by 120 milliliters/mu, preparation (thifluzamide effective ingredient consumption is 432 grams/ha) and 1% Shen piperazine mycin suspending agent by 120 grams/acre, preparation (Shen piperazine mycin effective ingredient consumption is 18 grams/ha), use with same method, potato harvest phase investigation preventive effect is respectively 79.1% and 60.4%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of potato black scurf significantly better than single dose.
Embodiment 4:33% thifluzamide Shen piperazine mycin suspending agent
The ratio of each components such as active component, wetting agent, dispersant, thickener, defoamer, antifreezing agent and water in formula is mixed, after grinding and/or high speed shear, obtains 33% thifluzamide Shen piperazine mycin suspending agent 100 grams.
This embodiment is applied to control capsicum epidemic disease.By 33% thifluzamide Shen piperazine mycin suspending agent, by 20 milliliters/mu, preparation, (wherein thifluzamide effective ingredient consumption is 90 grams/ha, Shen piperazine mycin effective ingredient consumption is 9 grams/ha) be watered dilution spraying 2 times, after 2 medicines, the control efficiency of 15 days is 75.4%.Said preparation use safety, field does not find poisoning phenomenon.240 grams per liter thifluzamide suspending agents by 20 milliliters/mu, preparation (thifluzamide effective ingredient consumption is 72 grams/ha) and 1% Shen piperazine mycin suspending agent by 70 grams/acre, preparation (Shen piperazine mycin effective ingredient consumption is 10.5 grams/ha), use with same method, after 2 medicines, the preventive effect of 15 days is respectively 60.2% and 70.3%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of rice green smut significantly better than single dose.
Embodiment 5:90% thifluzamide Shen piperazine mycin water dispersible granules
The ratio in formula such as active component, various auxiliary agent and filler is fully mixed, after ultra-fine pulverizer disintegrating, obtained 100 gram of 90% thifluzamide Shen piperazine mycin water dispersible granules.
This embodiment is applied to control wheat sharp eyespot.By 90% thifluzamide Shen piperazine mycin water dispersible granules, by 2 grams/acre, preparation, (wherein thifluzamide effective ingredient consumption is 13.5 grams/ha, Shen piperazine mycin effective ingredient consumption is 13.5 grams/ha) be watered dilution spraying, after medicine, the control efficiency of 20 days is 83.5%.Said preparation use safety, field does not find poisoning phenomenon.240 grams per liter thifluzamide suspending agents by 20 milliliters/mu, preparation (thifluzamide effective ingredient consumption is 72 grams/ha) and 1% Shen piperazine mycin suspending agent by 100 grams/acre, preparation (Shen piperazine mycin effective ingredient consumption is 15 grams/ha), use with same method, after medicine, the control efficiency of 20 days is respectively 80.2% and 81.3%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of wheat sharp eyespot significantly better than single dose.
Embodiment 6:5.5% thifluzamide Shen piperazine mycin granule
The ratio in formula such as active component, various auxiliary agents is fully mixed, after ultra-fine pulverizer disintegrating, adds humus and carrier, use granulator granulation, obtain 100 gram of 5.5% thifluzamide Shen piperazine mycin granule.
This embodiment is applied to potato haulm basal stem rot.When potato sowing, 5.5% thifluzamide Shen piperazine mycin granule is adopted the method dispenser of ditch spread, every mu of preparation consumption 2.0kg, potato emerges " Invest, Then Investigate " drug effect, and control efficiency can reach more than 88%.Said preparation use safety, field does not find poisoning phenomenon; The humus simultaneously added in medicament can improve soil property, increases soil fertility, and increases crop yield.Check experiment is 240 grams per liter thifluzamide suspending agents by 20 milliliters/mu, preparation (thifluzamide effective ingredient consumption is 72 grams/ha) and 1% Shen piperazine mycin suspending agent by 120 grams/acre, preparation (Shen piperazine mycin effective ingredient consumption is 18 grams/ha), use in potato post-emergence spraying, after medicine, the preventive effect of 15 days is respectively 81.3% and 83.5%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of potato haulm basal stem rot significantly better than single dose.
Embodiment 7:1% thifluzamide Shen piperazine mycin effervescent tablet
The ratio in formula such as active component, various auxiliary agents is fully mixed, after ultra-fine pulverizer disintegrating, uses tablet press machine to be pressed into suitable size, obtain 100 gram of 1% thifluzamide Shen piperazine mycin effervescent tablet.
This embodiment is applied to the water prevention rice sheath blight.By 1% thifluzamide Shen piperazine mycin effervescent tablet, by 200 grams/acre, preparation, (wherein thifluzamide effective ingredient consumption is 7.5 grams/ha, Shen piperazine mycin effective ingredient consumption is 7.5 grams/ha) be watered dilution spraying 2 times, after 2 medicines, the control efficiency of 14 days is 86.7%.Said preparation use safety, field does not find poisoning phenomenon.240 grams per liter thifluzamide suspending agents by 20 milliliters/mu, preparation (thifluzamide effective ingredient consumption is 72 grams/ha) and 1% Shen piperazine mycin suspending agent by 70 grams/acre, preparation (Shen piperazine mycin effective ingredient consumption is 10.5 grams/ha), use with same method, after 2 medicines, the control efficiency of 14 days is respectively 80.1% and 80.8%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of rice sheath blight disease significantly better than single dose.
Embodiment 8:10.5% thifluzamide Shen piperazine mycin suspending agent
The ratio of each components such as active component, wetting agent, dispersant, thickener, defoamer, antifreezing agent and water in formula is mixed, after grinding and/or high speed shear, obtains 10.5% thifluzamide Shen piperazine mycin suspending agent 100 grams for field trial.
This embodiment is applied to control watermelon blight.By 10.5% thifluzamide Shen piperazine mycin suspending agent, by preparation diluent 6000 times, (wherein thifluzamide effective ingredient consumption is 0.8 mg/kg, Shen piperazine mycin effective ingredient consumption is 17 mg/kg) be watered dilution spraying 3 times, after 3 medicines, the control efficiency of 14 days is 88.9%.Said preparation use safety, field does not find poisoning phenomenon.240 grams per liter thifluzamide suspending agents dilute 500 times (Shen piperazine mycin effective ingredient consumption is 20 mg/kg) by preparation diluent 2000 times (thifluzamide effective ingredient consumption is 120 mg/kg) and 1% Shen piperazine mycin suspending agent, use with same method, after 3 medicines, the control efficiency of 14 days is respectively 63.4% and 77.9%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of watermelon blight significantly better than single dose.
Embodiment 9:31% thifluzamide Shen piperazine mycin suspension seed-coating agent
This product reaches certain index through sand milling after being mixed by standard compliant former medicine, auxiliary agent, water etc., is deployed into finished product, obtains 100 gram of 31% thifluzamide Shen piperazine mycin suspension seed-coating agent for field trial.
This embodiment is applied to potato black scurf.To be suspended by 31% thifluzamide Shen piperazine mycin kind and to dress seed when potato sowing by preparation 1000 grams/100 kilograms potato seeds, potato harvest phase investigation prevention effect is 96.7%.Said preparation use safety, field does not find poisoning phenomenon.Contrast medicament is 240 grams per liter thifluzamide suspending agents by 120 milliliters/mu, preparation (thifluzamide effective ingredient consumption is 432 grams/ha) and 1% Shen piperazine mycin suspending agent by 1200 grams/acre, preparation (Shen piperazine mycin effective ingredient consumption is 180 grams/ha), spray process when potato sowing to potato and soil, potato harvest phase investigation preventive effect is respectively 90.3% and 69.4%.Thifluzamide and the composite rear synergistic effect of Shen piperazine mycin are obvious, to the preventive effect of potato black scurf significantly better than single dose.
Claims (5)
1. the bactericidal composition containing thifluzamide, is characterized in that: in described bactericidal composition, active ingredient is thifluzamide (A) and Shen piperazine mycin (B), and (A) is 50:1-1:50 with the mass ratio of (B).
2. bactericidal composition according to claim 1, is characterized in that: active ingredient (A) is 20:1-1:20 with the mass ratio of (B).
3. bactericidal composition according to claim 1 or 2, is characterized in that: active ingredient (A) is 1%-90% with the gross mass percentage composition of (B).
4. bactericidal composition according to claim 3, is characterized in that: described a kind of bactericidal composition containing thifluzamide is mixed with suspending agent, wetting powder, seed coat agent, aqueous emulsion, microemulsion, missible oil, granule or water dispersible granules.
5. bactericidal composition described in claim 1 is for preventing and treating the purposes of veterinary antibiotics, flowers, cereal diseases.
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| CN105432620B (en) * | 2015-01-12 | 2017-11-14 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN105104385A (en) * | 2015-09-01 | 2015-12-02 | 河北中天邦正生物科技股份公司 | Bactericide composition and application thereof |
| CN107306980A (en) * | 2016-04-26 | 2017-11-03 | 上海农乐生物制品股份有限公司 | A kind of shenqinmycin composite bactericide and its application |
| CN106922689A (en) * | 2017-04-03 | 2017-07-07 | 佛山市瑞生通科技有限公司 | A kind of bactericidal composition of the mycin of second containing fen and thifluzamide |
| CN107361080A (en) * | 2017-08-31 | 2017-11-21 | 广西沙田仙人滩农业投资有限公司 | A kind of black scurf of potato bactericide containing tolelofos-methyl |
| CN107950552A (en) * | 2017-11-23 | 2018-04-24 | 安徽丰乐农化有限责任公司 | A kind of compounding seed coat agent containing shenqinmycin |
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| CN101637164A (en) * | 2009-09-03 | 2010-02-03 | 浙江省桐庐汇丰生物化工有限公司 | Compound pesticide for protecting and curing rice sheath blight |
| CN102249799A (en) * | 2011-04-27 | 2011-11-23 | 上海农安生物科技发展有限公司 | Method for controlling crop diseases with shenqinmycin and shenqinmycin preparation |
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| CN101637164A (en) * | 2009-09-03 | 2010-02-03 | 浙江省桐庐汇丰生物化工有限公司 | Compound pesticide for protecting and curing rice sheath blight |
| CN102249799A (en) * | 2011-04-27 | 2011-11-23 | 上海农安生物科技发展有限公司 | Method for controlling crop diseases with shenqinmycin and shenqinmycin preparation |
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