CN103946225B - 用于制备和分离伐地那非与酸的盐的方法 - Google Patents

用于制备和分离伐地那非与酸的盐的方法 Download PDF

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Publication number
CN103946225B
CN103946225B CN201280057517.3A CN201280057517A CN103946225B CN 103946225 B CN103946225 B CN 103946225B CN 201280057517 A CN201280057517 A CN 201280057517A CN 103946225 B CN103946225 B CN 103946225B
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vardenafil
acid
solution
salt
water
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Chinese (zh)
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CN103946225A (zh
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A·哈拉马
I·斯特莱克
O·达马
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Zentiva KS
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Zentiva KS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201280057517.3A 2011-11-24 2012-11-26 用于制备和分离伐地那非与酸的盐的方法 Active CN103946225B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZ20110767A CZ2011767A3 (cs) 2011-11-24 2011-11-24 Zpusob prípravy a izolace solí vardenafilu s kyselinami
CZPV2011-767 2011-11-24
PCT/CZ2012/000120 WO2013075680A1 (en) 2011-11-24 2012-11-26 A method for the preparation and isolation of salts of vardenafil with acids

Publications (2)

Publication Number Publication Date
CN103946225A CN103946225A (zh) 2014-07-23
CN103946225B true CN103946225B (zh) 2016-06-15

Family

ID=47435673

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280057517.3A Active CN103946225B (zh) 2011-11-24 2012-11-26 用于制备和分离伐地那非与酸的盐的方法

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Country Link
CN (1) CN103946225B (cg-RX-API-DMAC7.html)
BR (1) BR112014012430A2 (cg-RX-API-DMAC7.html)
CZ (1) CZ2011767A3 (cg-RX-API-DMAC7.html)
HU (1) HUP1400334A3 (cg-RX-API-DMAC7.html)
IL (1) IL232652A (cg-RX-API-DMAC7.html)
IN (1) IN2014KN01308A (cg-RX-API-DMAC7.html)
WO (1) WO2013075680A1 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160317542A1 (en) 2013-12-09 2016-11-03 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
PL223869B1 (pl) 2013-12-16 2016-11-30 Starogardzkie Zakłady Farm Polpharma Spółka Akcyjna Sposób otrzymywania wardenafilu i jego soli
CN107445964A (zh) * 2017-07-29 2017-12-08 合肥创新医药技术有限公司 一种盐酸伐地那非杂质的合成方法
MX2020005890A (es) 2017-12-20 2020-10-19 Klaria Pharma Holding Ab Formulacion de pelicula que comprende vardenafil, metodo para su preparacion y uso de la misma.
BR112021009958A2 (pt) * 2018-11-28 2021-08-17 Topadur Pharma Ag modo duplo de ação de ativadores de guanilato ciclase solúveis e inibidores de fosfodiesterase e seus usos
CN114085225A (zh) * 2021-06-04 2022-02-25 广东西捷药业有限公司 一种伐地那非类似物及其合成方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1278822A (zh) * 1997-11-12 2001-01-03 拜尔公司 用作磷酸二酯酶抑制剂的2－苯基取代的咪唑并三嗪酮
US20070197535A1 (en) * 2006-03-13 2007-08-23 Eswaraiah Sajja Polymorphic forms of vardenafil
WO2011079935A2 (en) * 2009-12-30 2011-07-07 Zaklady Farmaceutyczne Polpharma Sa A process for the preparation and isolation of vardenafil and salts thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10063108A1 (de) * 2000-12-18 2002-06-20 Bayer Ag Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
DE102004023069A1 (de) 2004-05-11 2005-12-08 Bayer Healthcare Ag Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil
DE102007027067A1 (de) 2007-06-12 2008-12-18 Ratiopharm Gmbh Verfahren zur Herstellung eines Arzneimittels enthaltend Vardenafil Hydrochlorid Trihydrat
CN101965348B (zh) 2007-09-06 2013-11-13 上海特化医药科技有限公司 伐地那非的制备方法及其中间体
PL2228370T3 (pl) 2007-12-28 2012-10-31 Topharman Shanghai Co Ltd N-{1-[3-(2-etoksy-5-(4-etylopiperazynylo)benzenosulfonylo)-4,5-dihydro-5-okso-1,2,4-triazyn-6-yl]etylo}butyroamid, sposób jego wytwarzania i zastosowanie
DE102009020888A1 (de) 2009-05-12 2010-11-18 Ratiopharm Gmbh Schmelztablette, enthaltend ein Vardenafil-Salz
CN101870698B (zh) * 2010-04-02 2012-10-17 漆又毛 磺酰苯基咪唑并三嗪衍生物及制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1278822A (zh) * 1997-11-12 2001-01-03 拜尔公司 用作磷酸二酯酶抑制剂的2－苯基取代的咪唑并三嗪酮
CN1508137A (zh) * 1997-11-12 2004-06-30 用作磷酸二酯酶抑制剂的2-苯基取代的咪唑并三嗪酮
US20070197535A1 (en) * 2006-03-13 2007-08-23 Eswaraiah Sajja Polymorphic forms of vardenafil
WO2011079935A2 (en) * 2009-12-30 2011-07-07 Zaklady Farmaceutyczne Polpharma Sa A process for the preparation and isolation of vardenafil and salts thereof

Also Published As

Publication number Publication date
BR112014012430A2 (pt) 2017-06-06
CZ303877B6 (cs) 2013-06-05
IN2014KN01308A (cg-RX-API-DMAC7.html) 2015-10-16
CN103946225A (zh) 2014-07-23
WO2013075680A1 (en) 2013-05-30
IL232652A (en) 2017-05-29
CZ2011767A3 (cs) 2013-06-05
HUP1400334A2 (hu) 2014-10-28
HUP1400334A3 (en) 2014-12-29
IL232652A0 (en) 2014-06-30

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