BR112014012430A2 - métodos para a preparação e isolamento de sais de vardenafila e para a preparação de vardenafila, e, uso de sais de vardenafila com ácidos - Google Patents

métodos para a preparação e isolamento de sais de vardenafila e para a preparação de vardenafila, e, uso de sais de vardenafila com ácidos

Info

Publication number
BR112014012430A2
BR112014012430A2 BR112014012430A BR112014012430A BR112014012430A2 BR 112014012430 A2 BR112014012430 A2 BR 112014012430A2 BR 112014012430 A BR112014012430 A BR 112014012430A BR 112014012430 A BR112014012430 A BR 112014012430A BR 112014012430 A2 BR112014012430 A2 BR 112014012430A2
Authority
BR
Brazil
Prior art keywords
vardenafil
preparation
salts
isolation
acids
Prior art date
Application number
BR112014012430A
Other languages
English (en)
Inventor
Halama Ales
Strelec Ivo
Dammer Ondrej
Original Assignee
Zentiva Ks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva Ks filed Critical Zentiva Ks
Publication of BR112014012430A2 publication Critical patent/BR112014012430A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
BR112014012430A 2011-11-24 2012-11-26 métodos para a preparação e isolamento de sais de vardenafila e para a preparação de vardenafila, e, uso de sais de vardenafila com ácidos BR112014012430A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20110767A CZ2011767A3 (cs) 2011-11-24 2011-11-24 Zpusob prípravy a izolace solí vardenafilu s kyselinami
PCT/CZ2012/000120 WO2013075680A1 (en) 2011-11-24 2012-11-26 A method for the preparation and isolation of salts of vardenafil with acids

Publications (1)

Publication Number Publication Date
BR112014012430A2 true BR112014012430A2 (pt) 2017-06-06

Family

ID=47435673

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014012430A BR112014012430A2 (pt) 2011-11-24 2012-11-26 métodos para a preparação e isolamento de sais de vardenafila e para a preparação de vardenafila, e, uso de sais de vardenafila com ácidos

Country Status (7)

Country Link
CN (1) CN103946225B (pt)
BR (1) BR112014012430A2 (pt)
CZ (1) CZ2011767A3 (pt)
HU (1) HUP1400334A3 (pt)
IL (1) IL232652A (pt)
IN (1) IN2014KN01308A (pt)
WO (1) WO2013075680A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3082428A4 (en) 2013-12-09 2017-08-02 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
PL223869B1 (pl) 2013-12-16 2016-11-30 Starogardzkie Zakłady Farm Polpharma Spółka Akcyjna Sposób otrzymywania wardenafilu i jego soli
CN107445964A (zh) * 2017-07-29 2017-12-08 合肥创新医药技术有限公司 一种盐酸伐地那非杂质的合成方法
BR112020012239A2 (pt) 2017-12-20 2020-11-24 Klaria Pharma Holding Ab método para preparar um filme mucoadesivo, e, filme mucoadesivo
EP3887376A1 (en) * 2018-11-28 2021-10-06 Topadur Pharma AG Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
CN114085225A (zh) * 2021-06-04 2022-02-25 广东西捷药业有限公司 一种伐地那非类似物及其合成方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU230154B1 (hu) * 1997-11-12 2015-09-28 Bayer Intellectual Property Gmbh Eljárás 2-es helyzetben fenil-szubszituenst hordozó imidazo-triazinon-származékok előállítására
DE10063108A1 (de) 2000-12-18 2002-06-20 Bayer Ag Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
DE102004023069A1 (de) 2004-05-11 2005-12-08 Bayer Healthcare Ag Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil
US7977478B2 (en) 2006-03-13 2011-07-12 Dr. Reddy's Laboratories Limited Polymorphic forms of vardenafil
DE102007027067A1 (de) 2007-06-12 2008-12-18 Ratiopharm Gmbh Verfahren zur Herstellung eines Arzneimittels enthaltend Vardenafil Hydrochlorid Trihydrat
CN101965348B (zh) 2007-09-06 2013-11-13 上海特化医药科技有限公司 伐地那非的制备方法及其中间体
JP5411161B2 (ja) 2007-12-28 2014-02-12 上海特化医薬科技有限公司 Ｎ−｛１−［３−（２−エトキシ−５−（４−エチルピペラジニル）スルホニルフェニル）−４，５−ジヒドロ−５−オキソ−１，２，４−トリアジン−６−イル］エチル｝ブチルアミド、その調製方法及び用途
DE102009020888A1 (de) 2009-05-12 2010-11-18 Ratiopharm Gmbh Schmelztablette, enthaltend ein Vardenafil-Salz
PL390079A1 (pl) * 2009-12-30 2011-07-04 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Sposób otrzymywania wardenafilu i jego izolacji jako soli z kwasem cytrynowym oraz krystaliczna postać tej soli
CN101870698B (zh) * 2010-04-02 2012-10-17 漆又毛 磺酰苯基咪唑并三嗪衍生物及制备方法

Also Published As

Publication number Publication date
HUP1400334A2 (hu) 2014-10-28
CZ303877B6 (cs) 2013-06-05
CN103946225A (zh) 2014-07-23
HUP1400334A3 (en) 2014-12-29
CZ2011767A3 (cs) 2013-06-05
WO2013075680A1 (en) 2013-05-30
IL232652A0 (en) 2014-06-30
IN2014KN01308A (pt) 2015-10-16
IL232652A (en) 2017-05-29
CN103946225B (zh) 2016-06-15

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]