HUP1400334A3 - A method for the preparation and isolation of salts of vardenafil with acids - Google Patents
A method for the preparation and isolation of salts of vardenafil with acidsInfo
- Publication number
- HUP1400334A3 HUP1400334A3 HU1400334A HUP1400334A HUP1400334A3 HU P1400334 A3 HUP1400334 A3 HU P1400334A3 HU 1400334 A HU1400334 A HU 1400334A HU P1400334 A HUP1400334 A HU P1400334A HU P1400334 A3 HUP1400334 A3 HU P1400334A3
- Authority
- HU
- Hungary
- Prior art keywords
- vardenafil
- isolation
- salts
- acids
- preparation
- Prior art date
Links
- SECKRCOLJRRGGV-UHFFFAOYSA-N Vardenafil Chemical class CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 SECKRCOLJRRGGV-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 238000002955 isolation Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 229960002381 vardenafil Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gynecology & Obstetrics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ20110767A CZ2011767A3 (cs) | 2011-11-24 | 2011-11-24 | Zpusob prípravy a izolace solí vardenafilu s kyselinami |
| PCT/CZ2012/000120 WO2013075680A1 (en) | 2011-11-24 | 2012-11-26 | A method for the preparation and isolation of salts of vardenafil with acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP1400334A2 HUP1400334A2 (hu) | 2014-10-28 |
| HUP1400334A3 true HUP1400334A3 (en) | 2014-12-29 |
Family
ID=47435673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU1400334A HUP1400334A3 (en) | 2011-11-24 | 2012-11-26 | A method for the preparation and isolation of salts of vardenafil with acids |
Country Status (7)
| Country | Link |
|---|---|
| CN (1) | CN103946225B (hu) |
| BR (1) | BR112014012430A2 (hu) |
| CZ (1) | CZ2011767A3 (hu) |
| HU (1) | HUP1400334A3 (hu) |
| IL (1) | IL232652A (hu) |
| IN (1) | IN2014KN01308A (hu) |
| WO (1) | WO2013075680A1 (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160317542A1 (en) | 2013-12-09 | 2016-11-03 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
| PL223869B1 (pl) | 2013-12-16 | 2016-11-30 | Starogardzkie Zakłady Farm Polpharma Spółka Akcyjna | Sposób otrzymywania wardenafilu i jego soli |
| CN107445964A (zh) * | 2017-07-29 | 2017-12-08 | 合肥创新医药技术有限公司 | 一种盐酸伐地那非杂质的合成方法 |
| CN111655229A (zh) | 2017-12-20 | 2020-09-11 | 卡里亚制药控股有限公司 | 包含伐地那非的薄膜制剂、其制备方法及其用途 |
| CN113166157A (zh) * | 2018-11-28 | 2021-07-23 | 托帕杜制药公司 | 新型双作用模式可溶性鸟苷酸环化酶活化剂和磷酸二酯酶抑制剂及其用途 |
| CN114085225A (zh) * | 2021-06-04 | 2022-02-25 | 广东西捷药业有限公司 | 一种伐地那非类似物及其合成方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2295436A1 (de) * | 1997-11-12 | 2011-03-16 | Bayer Schering Pharma AG | 2-Phenyl-substituierte Imidazotriazinone als Phosphodiesterase V Inhibitoren |
| DE10063108A1 (de) | 2000-12-18 | 2002-06-20 | Bayer Ag | Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen |
| DE10232113A1 (de) | 2002-07-16 | 2004-01-29 | Bayer Ag | Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel |
| DE102004023069A1 (de) | 2004-05-11 | 2005-12-08 | Bayer Healthcare Ag | Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil |
| US7977478B2 (en) * | 2006-03-13 | 2011-07-12 | Dr. Reddy's Laboratories Limited | Polymorphic forms of vardenafil |
| DE102007027067A1 (de) | 2007-06-12 | 2008-12-18 | Ratiopharm Gmbh | Verfahren zur Herstellung eines Arzneimittels enthaltend Vardenafil Hydrochlorid Trihydrat |
| WO2009030095A1 (en) | 2007-09-06 | 2009-03-12 | Topharman Shanghai Co., Ltd. | Process for preparing vardenafil and its intermediates |
| WO2009082845A1 (en) | 2007-12-28 | 2009-07-09 | Topharman Shanghai Co., Ltd. | N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)benzenesulfonyl)-4,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl}butyramide, the preparation method and use thereof |
| DE102009020888A1 (de) | 2009-05-12 | 2010-11-18 | Ratiopharm Gmbh | Schmelztablette, enthaltend ein Vardenafil-Salz |
| PL390079A1 (pl) * | 2009-12-30 | 2011-07-04 | Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna | Sposób otrzymywania wardenafilu i jego izolacji jako soli z kwasem cytrynowym oraz krystaliczna postać tej soli |
| CN101870698B (zh) * | 2010-04-02 | 2012-10-17 | 漆又毛 | 磺酰苯基咪唑并三嗪衍生物及制备方法 |
-
2011
- 2011-11-24 CZ CZ20110767A patent/CZ2011767A3/cs not_active IP Right Cessation
-
2012
- 2012-11-26 HU HU1400334A patent/HUP1400334A3/hu unknown
- 2012-11-26 WO PCT/CZ2012/000120 patent/WO2013075680A1/en active Application Filing
- 2012-11-26 IN IN1308KON2014 patent/IN2014KN01308A/en unknown
- 2012-11-26 BR BR112014012430A patent/BR112014012430A2/pt not_active Application Discontinuation
- 2012-11-26 CN CN201280057517.3A patent/CN103946225B/zh active Active
-
2014
- 2014-05-15 IL IL232652A patent/IL232652A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN103946225A (zh) | 2014-07-23 |
| BR112014012430A2 (pt) | 2017-06-06 |
| CZ303877B6 (cs) | 2013-06-05 |
| IN2014KN01308A (hu) | 2015-10-16 |
| HUP1400334A2 (hu) | 2014-10-28 |
| CZ2011767A3 (cs) | 2013-06-05 |
| IL232652A0 (en) | 2014-06-30 |
| WO2013075680A1 (en) | 2013-05-30 |
| CN103946225B (zh) | 2016-06-15 |
| IL232652A (en) | 2017-05-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201305972B (en) | Method for the preparation of biphephos | |
| PL2697345T3 (pl) | Sposób izolacji fosfolipidu | |
| PT2734536T (pt) | Processo para a preparação de estetrol | |
| PL2675539T3 (pl) | Sposób wytwarzania poli(kwasu hydroksykarboksylowego) | |
| GB2491003B (en) | Method and system of a compound buoy | |
| IL232652A0 (en) | A method for the preparation and isolation of salts of vardenafil with acids | |
| SG11201403150PA (en) | Mixtures of diphosphinic acids and alkylphosphinic acids, a process for the preparation thereof and the use thereof | |
| PT2683361E (pt) | Método para a preparação de uma solução de levotiroxina | |
| SG10201802011WA (en) | Mixtures of diphosphinic acids and alkylphosphonic acids, a process for the preparation thereof and the use thereof | |
| EP2875348A4 (en) | METHOD OF ISOLATING MICROVESICLES | |
| SI2736909T1 (sl) | Proces za pripravo sitagliptina in njegovih farmacevtsko sprejemljivih soli | |
| EP2663646A4 (en) | METHOD FOR PRODUCING NICOTIC ACID | |
| IL231645A (en) | Process for making isoxazolyl - methoxy - nicotinic acids | |
| PL2681199T3 (pl) | Sposób wytwarzania (-)-hupercyny A | |
| HK1186172A1 (zh) | 製備 -氟- -羥基亞甲基－ -氧代丁酸酯的烯醇鹽方法 | |
| EP2751074A4 (en) | 5-SULPHISOPHTHALIC ACID SALTS AND PROCESS FOR THE PREPARATION THEREOF | |
| IL228851A0 (en) | A method for preparing a concentrate of factor xi | |
| PL2673282T3 (pl) | Nowy sposób wytwarzania kwasów dronowych | |
| PL393959A1 (pl) | Sposób wytwarzania syropu i syrop | |
| IL229602A0 (en) | Method for the production of fluoromethyl esters of androstene-17-beta carboxylic acids | |
| HK1201063A1 (en) | Process for the preparation of a thioprecursor for statins | |
| PL396137A1 (pl) | Sposób otrzymywania tadalafilu | |
| GB201107625D0 (en) | Method of forming a coupling | |
| PL2757953T3 (pl) | Sposób wytrawiania z maską elementu nakłuwającego | |
| PL396120A1 (pl) | Sposób wytwarzania kremu ochronnego do pielegnacji twarzy i ciala |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |