CN103930551B - 猴腺病毒和杂合腺病毒载体 - Google Patents

猴腺病毒和杂合腺病毒载体 Download PDF

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CN103930551B
CN103930551B CN201280036659.1A CN201280036659A CN103930551B CN 103930551 B CN103930551 B CN 103930551B CN 201280036659 A CN201280036659 A CN 201280036659A CN 103930551 B CN103930551 B CN 103930551B
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immunogenic composition
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CN103930551A (zh
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马修·道格拉斯·詹姆斯·迪克斯
马修·盖伊·科廷汉姆
阿德里安·薇薇安·辛顿·希尔
莎拉·吉尔伯特
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Oxford University Innovation Ltd
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CN201280036659.1A 2011-05-25 2012-05-25 猴腺病毒和杂合腺病毒载体 Active CN103930551B (zh)

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GB1108879.6 2011-05-25
GBGB1108879.6A GB201108879D0 (en) 2011-05-25 2011-05-25 Vector
PCT/GB2012/000467 WO2012172277A1 (en) 2011-05-25 2012-05-25 Simian adenovirus and hybrid adenoviral vectors

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CN103930551B true CN103930551B (zh) 2017-05-24

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US (4) US9714435B2 (https=)
EP (2) EP2714916B1 (https=)
JP (1) JP6230527B2 (https=)
CN (1) CN103930551B (https=)
AU (1) AU2012270144B2 (https=)
BR (1) BR112013030222A2 (https=)
CA (1) CA2837274C (https=)
DK (1) DK2714916T3 (https=)
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FR (1) FR21C1026I1 (https=)
GB (1) GB201108879D0 (https=)
NO (2) NO2714916T3 (https=)
RU (1) RU2013152648A (https=)
SG (2) SG10201604179VA (https=)
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Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201108879D0 (en) * 2011-05-25 2011-07-06 Isis Innovation Vector
SG11201407343XA (en) * 2012-05-18 2014-12-30 Univ Pennsylvania Subfamily e simian adenoviruses a1302, a1320, a1331 and a1337 and uses thereof
SG11201507393TA (en) 2013-03-14 2015-10-29 Salk Inst For Biological Studi Oncolytic adenovirus compositions
GB201413530D0 (en) 2014-07-30 2014-09-10 Isis Innovation Treatment and prevention of malaria
KR102608590B1 (ko) 2014-09-24 2023-12-01 솔크 인스티튜트 포 바이올로지칼 스터디즈 종양 살상 바이러스 및 이의 사용방법
BR112017026523A2 (pt) * 2015-06-12 2018-08-14 Glaxosmithkline Biologicals Sa vetor recombinante, adenovírus recombinante, composição, uso de um vetor recombinante, de um adenovírus recombinante ou de uma composição, método para induzir uma resposta imune em um indivíduo, e, polinucleotídeo isolado.
WO2017147269A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
GB2549809C (en) 2016-06-23 2022-11-30 Univ Oxford Innovation Ltd Vector
EP3532082A4 (en) 2016-12-12 2020-08-26 Salk Institute for Biological Studies SYNTHETIC ADENOVIRUS TUMOR TARGETING AND THEIR USES
CN106916851A (zh) * 2017-03-01 2017-07-04 广州恩宝生物医药科技有限公司 一种复制缺陷型人14型腺病毒载体及其制备方法和应用
KR20230166145A (ko) 2017-03-15 2023-12-06 옥스포드 바이오메디카(유케이) 리미티드 방법
EP3634449A4 (en) 2017-05-08 2021-03-17 Gritstone Oncology, Inc. ALPHAVIRUS NEOANTIGEN VECTORS
GB201708444D0 (en) 2017-05-26 2017-07-12 Univ Oxford Innovation Ltd Compositions and methods for inducing an immune response
MX2020007077A (es) 2018-01-04 2020-10-28 Iconic Therapeutics Inc Anticuerpos anti-factor tisular, conjugados anticuerpo-farmaco y metodos relacionados.
CN112292449A (zh) 2018-04-09 2021-01-29 萨克生物研究学院 具有增强的复制特性的溶瘤腺病毒组合物
GB201812647D0 (en) 2018-08-03 2018-09-19 Chancellor Masters And Scholars Of The Univ Of Oxford Viral vectors and methods for the prevention or treatment of cancer
GB201814141D0 (en) * 2018-08-30 2018-10-17 Univ Oxford Innovation Ltd Method and compositions for producing a virus
CN109797168A (zh) * 2018-09-28 2019-05-24 广州佰芮慷生物科技有限公司 一种重组腺病毒的表达载体SAd23-L
US12377138B2 (en) 2018-10-10 2025-08-05 Oxford University Innovation Limited Treatment and prevention of malaria
GB201818084D0 (en) 2018-11-06 2018-12-19 Univ Oxford Innovation Ltd Compositions and methods
CN109602901B (zh) * 2019-01-08 2022-05-27 成都迈科康生物科技有限公司 一种带状疱疹病毒疫苗及其制备方法和应用
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
TWI810456B (zh) 2019-05-22 2023-08-01 美商基利科學股份有限公司 Tlr7調節化合物及hiv疫苗之組合
AU2020279988A1 (en) 2019-05-22 2021-12-23 Aelix Therapeutics, S.L. Dosage regimens for vaccines
MX2021014525A (es) 2019-05-30 2022-03-17 Gritstone Bio Inc Adenovirus modificados.
DK4037708T3 (da) 2019-09-30 2024-09-30 Gilead Sciences Inc HBV-vacciner og fremgangsmåder til at behandle HBV
AU2020384323A1 (en) 2019-11-14 2022-06-02 Aelix Therapeutics, S.L. Dosage regimens for vaccines
CR20220220A (es) 2019-11-18 2022-09-20 Janssen Biotech Inc Vacunas basadas en calr y jak2 mutantes y sus usos
JP2023512519A (ja) 2020-01-31 2023-03-27 ベス イスラエル ディーコネス メディカル センター インコーポレイテッド コロナウイルス感染症を予防および処置するための組成物および方法-sars-cov-2ワクチン
GB2594683A (en) 2020-02-17 2021-11-10 Vaxbio Ltd Vaccine
GB202003611D0 (en) 2020-03-12 2020-04-29 Univ Oxford Innovation Ltd Stabilised viral fusion proteins
JP2023517286A (ja) 2020-03-13 2023-04-25 オックスフォード ユニヴァーシティ イノヴェーション リミテッド 免疫応答を誘導するための組成物及び方法
RU2720614C9 (ru) * 2020-04-23 2021-02-09 федеральное государственное бюджетное учреждение «Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи» Министерства здравоохранения Российской Федерации Иммунобиологическое средство и способ его использования для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2 (варианты)
CA3183086A1 (en) 2020-05-11 2021-11-18 Janssen Pharmaceuticals, Inc. Stabilized coronavirus spike protein fusion proteins
TWI867224B (zh) * 2020-06-08 2024-12-21 中央研究院 重組抗體或片段,以及其用途
US20230233661A1 (en) 2020-06-29 2023-07-27 Janssen Vaccines & Prevention B.V. Vaccine combination against repiratory syncytial virus infection
US20230302119A1 (en) 2020-07-06 2023-09-28 Janssen Pharmaceuticals, Inc. Stabilized Corona Virus Spike Protein Fusion Proteins
EP4175664A2 (en) 2020-07-06 2023-05-10 Janssen Biotech, Inc. Prostate neoantigens and their uses
GB2596820A (en) 2020-07-07 2022-01-12 Spicona Inc Combination vaccine
CN116438308A (zh) 2020-08-06 2023-07-14 磨石生物公司 多表位疫苗盒
JP7369276B2 (ja) * 2020-08-22 2023-10-25 フェデラル ステート バジェタリー インスティテューション“ナショナル リサーチ センター フォー エピデミオロジー アンド マイクロバイオロジー ネームド アフター ザ オナラリー アカデミシャン エヌ.エフ.ガマレヤ”オブ ザ ミニストリー オブ ヘルス オブ ザ ロシアン フェデレーション 重症急性呼吸器症候群ウイルスsars-cov-2に対する発現ベクター
JP2023541632A (ja) 2020-09-15 2023-10-03 インペリアル・カレッジ・イノベーションズ・リミテッド 特発性肺線維症の処置
GB202016604D0 (en) 2020-10-20 2020-12-02 Univ Of Oxford Compositions and methods for inducing an immune response
GB202017673D0 (en) 2020-11-09 2020-12-23 Imperial College Innovations Ltd Treatment of pulmonary arterial hypertensive
WO2022120176A2 (en) * 2020-12-04 2022-06-09 Gritstone Bio, Inc. Compositions and methods of use thereof
GB202019455D0 (en) 2020-12-10 2021-01-27 Chancellor Masters And Scholars Of The Univ Of Oxford Method for producing virus
GB202019454D0 (en) 2020-12-10 2021-01-27 Chancellor Masters And Scholars Of The Univ Of Oxford Method for purifying virus
WO2022175479A1 (en) 2021-02-19 2022-08-25 Janssen Vaccines & Prevention B.V. Vaccine combinations against respiratory syncytial virus strain a and b infections
WO2022175477A1 (en) 2021-02-19 2022-08-25 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion rsv fb antigens
JP2024509769A (ja) 2021-02-23 2024-03-05 ヤンセン ファッシンズ アンド プリベンション ベーフェー 三量体安定化hivエンベロープタンパク質変異
KR20230165275A (ko) 2021-04-01 2023-12-05 얀센 백신스 앤드 프리벤션 비.브이. 안정화된 융합 전 piv3 f 단백질
GB202105277D0 (en) 2021-04-13 2021-05-26 Imperial College Innovations Ltd Signal peptides
WO2022234283A1 (en) 2021-05-07 2022-11-10 Astrazeneca Uk Limited Compositions and methods for inducing an immune response
WO2023020939A1 (en) 2021-08-17 2023-02-23 Janssen Pharmaceuticals, Inc. Sars-cov-2 vaccines
WO2023026182A1 (en) 2021-08-24 2023-03-02 Janssen Pharmaceuticals, Inc. Sars-cov-2 vaccines
WO2023047348A1 (en) 2021-09-24 2023-03-30 Janssen Pharmaceuticals, Inc. Stabilized corona virus spike protein fusion proteins
WO2023047349A1 (en) 2021-09-24 2023-03-30 Janssen Pharmaceuticals, Inc. Stabilized coronavirus spike protein fusion proteins
EP4444347A1 (en) 2021-12-07 2024-10-16 Barinthus Biotherapeutics (UK) Limited Vaccine boost methods and compositions
WO2023111725A1 (en) 2021-12-14 2023-06-22 Janssen Pharmaceuticals, Inc. Sars-cov-2 vaccines
EP4448802A1 (en) 2021-12-16 2024-10-23 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion hmpv fusion proteins
WO2023156505A1 (en) 2022-02-17 2023-08-24 Janssen Vaccines & Prevention B.V. Trimer stabilizing hiv envelope protein mutations r304v, n302m and t320l
WO2024061757A1 (en) 2022-09-23 2024-03-28 Janssen Vaccines & Prevention B.V. Pre-fusion human piv1 f proteins
WO2024061759A1 (en) 2022-09-23 2024-03-28 Janssen Vaccines & Prevention B.V. Stabilized coronavirus s proteins
WO2024074584A1 (en) 2022-10-06 2024-04-11 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion piv3 f proteins
WO2024084441A1 (en) 2022-10-19 2024-04-25 Aelix Therapeutics, S.L. Combination hiv vaccine
WO2024092028A2 (en) 2022-10-25 2024-05-02 Vaccitech North America, Inc. Combination treatment regimes for treating cancer
GB202301244D0 (en) 2023-01-27 2023-03-15 Univ Oxford Innovation Ltd Vaccine
GB202303328D0 (en) 2023-03-07 2023-04-19 Imperial College Innovations Ltd Synthetic promoters
GB202305535D0 (en) 2023-04-14 2023-05-31 Imperial College Innovations Ltd Oligonucleotide decoy
WO2024218165A1 (en) 2023-04-17 2024-10-24 Barinthus Biotherapeutics (Uk) Limited Hpv viral vector vaccine
WO2025017540A1 (en) 2023-07-20 2025-01-23 Aelix Therapeutics, S.L. Method of treatment of hiv infection with vaccine
CN117089577B (zh) * 2023-08-21 2024-06-25 暨南大学 重组的猴腺病毒、病毒载体及构建方法
WO2025052130A1 (en) 2023-09-05 2025-03-13 Oxford University Innovation Limited Monoclonal antibody directed to reticulocyte-binding protein homologue 5 (pfrh5)
GB202400424D0 (en) 2024-01-11 2024-02-28 Cancer Research Tech Ltd Treatment and prevention of lung cancer
WO2025168946A1 (en) 2024-02-09 2025-08-14 Oxford University Innovation Limited Pfrh5 immunogen

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101883858A (zh) * 2007-11-28 2010-11-10 宾夕法尼亚州立大学托管会 猿猴亚家族E腺病毒SAdV-39、-25.2、-26、-30、-37和-38及其应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3650939A (en) 1964-11-12 1972-03-21 Ppg Industries Inc Alkali chlorine cell
CA2271450A1 (en) 1999-05-12 2000-11-12 Stuart Energy Systems Inc. Hydrogen fuel replenishment process and apparatus
US20040136963A1 (en) * 2001-06-22 2004-07-15 The Trustees Of The University Of Pennsylvania Simian adenovirus vectors and methods of use
AU2002365366B2 (en) * 2001-11-21 2007-05-10 The Trustees Of The University Of Pennsylvania Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
US20070205342A1 (en) 2002-01-23 2007-09-06 Edward Gabriel Slip drive for leveling devices
US7481858B2 (en) 2005-02-25 2009-01-27 Societe Bic Hydrogen generating fuel cell cartridges
DE602005017743D1 (de) * 2004-01-23 2009-12-31 Angeletti P Ist Richerche Bio Impfstoffträger für schimpansen-adenovirus
US7617018B2 (en) 2004-10-18 2009-11-10 Innovative Design Solutions Platform attitude adjustment augmentation method and apparatus
US7178337B2 (en) 2004-12-23 2007-02-20 Tassilo Pflanz Power plant system for utilizing the heat energy of geothermal reservoirs
CN100578676C (zh) * 2005-01-12 2010-01-06 明基电通股份有限公司 可调式升降支撑装置
WO2007104792A2 (en) * 2006-03-16 2007-09-20 Crucell Holland B.V. Recombinant adenoviruses based on serotype 26 and 48, and use thereof
EP1998804B1 (en) * 2006-03-27 2014-04-16 Crucell Holland B.V. Compositions comprising a recombinant adenovirus and an adjuvant
EP2333091B1 (en) * 2007-05-29 2017-06-21 Nature Technology Corporation Vectors and methods for genetic immunization
DK2406289T3 (en) * 2009-03-10 2017-05-01 Baylor Res Inst ANTIGEN PRESENTING CELL TARGETED ANTIVIRUS VACCINES
GB201108879D0 (en) * 2011-05-25 2011-07-06 Isis Innovation Vector

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101883858A (zh) * 2007-11-28 2010-11-10 宾夕法尼亚州立大学托管会 猿猴亚家族E腺病毒SAdV-39、-25.2、-26、-30、-37和-38及其应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
serologic classification of chimpanzee adenoviruses by hemagglutination and hemagglution inhibition;WILLIAM D. HILLIS and ROSANNE GOODMAN;《The journal of immunology》;19691231;第103卷(第5期);表1 *
Simian adenovirus 25, complete genome;Farina,S.F. et al.;《GenBank: AF394196.1》;20011127;全文 *

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