CN103919893B - The Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease and preparation method - Google Patents
The Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease and preparation method Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease, take off the primary raw material stating weight proportion and be prepared from: melilotus 20-60 part, Cortex Dictamni 15 ~ 20 parts, Cortex Phellodendri 25-55 part, Radix Sanguisorbae 15 ~ 28 parts, Radix Aristolochiae Fangchi 30-60 part, the Fructus Kochiae 15 ~ 30 parts, Herba Zornia Diphyllae 30-50 part.Chinese medicine preparation Be very effective of the present invention, Most patients medication after 5 days symptom be clearly better, use spray of the present invention, by the direct administration in affected part, significantly reduce the misery of patient, sterilizing can also be carried out to indoor, control the source of infection, be exactly comparatively serious patient medication after 10 days malaise symptoms substantially disappear.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to and a kind ofly treat Chinese medicine preparation of serious symptom hand-foot-mouth disease and preparation method thereof.
Background technology
Hand-foot-mouth disease is the infectious disease caused by enterovirus, is multiplely born in less than 5 years old child, and can cause the herpes at the position such as hands, foot, oral cavity, minority infant can cause the complication such as myocarditis, pulmonary edema, AME.If indivedual children with serious disease PD is fast, cause death.The enterovirus causing hand-foot-mouth disease has kind more than 20 (type), 16,4,5,9,10 types of CA group, 2,5 types of B group, and enterovirns type 71, be the pathogen that hand-foot-mouth disease is more common, wherein with coxsackie virus A 16-type (Cox A16) and enterovirns type 71 (EV 71) the most common.Several viral is had to cause hand-foot-mouth disease.Modal is coxsackie virus A 16-type, and other strains of CA or enterovirns type 71 also can cause hand-foot-mouth disease in addition.Coxsackie virus is the one of enterovirus.Enterovirus comprises poliovirus, Coxsackie virus and echovirus.Its infection site is the whole digestive tract comprising oral cavity, enters in body, and breed at intestinal by the per os such as food, beverage, fruit polluted.
Clinical manifestation: hand-foot-mouth disease mainly occurs in the child of less than 4 years old, but adult also likely falls ill, and therefore can say that everyone is susceptible.Only obtaining the immunity of this type virus after infection, other type viruses are infected without cross immunity again, after namely suffering from hand-foot-mouth disease, also again may suffer from hand-foot-mouth disease because infecting other type viruses.Incubation period: mostly be 2 ~ 10 days, average 3 ~ 5 days.1. average case performance: Acute onset, heating, oral mucosa occurs being dispersed in herpes, and maculopapule, herpes appear in hands, foot and buttocks, and can have inflammatory blush around herpes, in bleb, liquid is less.Can with symptoms such as cough, watery nasal discharge, inappetence.Some cases only shows as erythra or herpangina.Many recoveries from illness in a week, prognosis bona.The performance of some cases erythra is not true to type, as single position or only show as maculopapule.2. severe cases performance: minority case (being especially less than 3 years old person) disease progression is rapid, within about 1 ~ 5 day, there are meningitis, encephalitis (the most dangerous with brain stem encephalitis), encephalomyelitis, pulmonary edema, circulatory disturbance etc. in morbidity, the only a few case state of an illness is critical, can lethally die, survival case can leave sequela.(1) Manifestations of nervous system: spirit is poor, drowsiness, easily frightened, headache, vomit, delirium even goes into a coma; Limb shaking, myoclonus, nystagmus, ataxia, ocular motility disorder; Unable or AFP Cases; Faint from fear.Have a medical check-up visible meningeal irritation sign, tendon reflex weakens or disappears, and the pathology such as babinski sign levy the positive.(2) respiratory system performance: shortness of breath, dyspnea or the rhythm and pace of moving things change, lip cyanosis, cough, coughs white, pink or courageous and upright frothy sputum liquid; Pulmonary's audible and moist rales or rale sound.(3) blood circulation performance: the grey ash of complexion, skin pattern, coolness of extremities, refer to (toe) cyanosis; Be in a cold sweat; Prolonged capillary refill time.Increased heart rate or slow down, the shallow speed of pulse or weaken even disappears; Blood pressure raises or declines.Acute onset, heating; There is loose shape herpes in oral mucosa, grain of rice size, and pain is obvious; There is the large exanthema vesiculosum of the grain of rice in palm or foot palm part, buttocks or knee occasionally can be got involved.Have inflammatory blush around herpes, in bleb, liquid is less.Part infant can with shapes such as cough, watery nasal discharge, inappetence, Nausea and vomiting, headaches.Doctor according to the symptom told of the age of patient, patient or the head of a family, and can check that erythra and ulcer differentiate the oral ulcer caused by hand-foot-mouth disease and other reasons usually.Throat swab or stool sample can be delivered to test in laboratory virus, but Viral diagnosis needs just can go out result in 2 ~ 4 weeks, therefore doctor does not propose to do this inspection usually.According to epidemiologic data, clinical manifestation, lab testing, make a definite diagnosis time must have etiologic inspection foundation.
The traditional Chinese medical science is particular about dialectical treating in treatment hand-foot-mouth disease process, and the different situations according to patient carry out dialectical treatment, patient can be allowed like this to start with from the cause of disease and treat, obtain the effect of good symptomatic treatment.Publication number Authorization Notice No. CN 102423447 B(application number 201110378341.9) Chinese patent literature disclose a kind of Chinese medicine composition of prevention and therapy Hand-Food-Mouth Disease, by Retinervus Luffae Fructus 10g, Radix Et Rhizoma Rhei 30g, Galla Chinensis 10g, Fructus Cnidii 35g, Calamina 20g, Umbrella Rhopilema esculenta 8g, Herba Pogostemonis 5g, Mirabilitum crystallina 4g, Ramulus Cinnamomi 15g, Rhizoma Et Radix Notopterygii 20g, Radix Angelicae Pubescentis 18g, Radix Clematidis 15g, Cortex erythrinae 10g, Fructus Amomi 8g, Fructus Amomi Rotundus 8g, Semen Coicis 20g, Herba Hyperici Japonici 15g, Herba Abri 10g, Borax 12g, Mylabris 5g is prepared from.Authorization Notice No. CN 102499965 B(application number 201110443224.6) Chinese patent literature disclose a kind of fumigation Chinese medicinal composition of preventing hand-foot-mouth disease, it is formulated by the raw material of Chinese medicine of following weight parts, Styrax 30, dry Herba Spirodelae 30, Folium Artemisiae Argyi 30, Aloe 20, Fructus Xanthii 25, Rhizoma Cyperi 25, Fructus Artemisiae Annuae 30, Herba Pogostemonis 30, Herba Eupatorii 20, Camphora 15, its using method is, by Styrax 30, dry Herba Spirodelae 30, Folium Artemisiae Argyi 30, Aloe 20, Fructus Xanthii 25, Rhizoma Cyperi 25, Fructus Artemisiae Annuae 30, Herba Pogostemonis 30, Herba Eupatorii 20, Camphora 15 be placed on altogether in a large marmite add water cross medicine high 5 centimetres soak within 20 minutes, endure out with high heat after, then 30-45 minute is endured with moderate heat, 1 point set by small field, large-scalely divide 3-5 point, within every 2 days, fumigate once.
The medicine of various treatment serious symptom hand-foot-mouth disease above, no matter be that different curative effect all appears in Chinese medicine or Western medicine, significantly reduce the misery of patient, weak point is that the medication cycle is long, easily recurs.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease, it has heat-clearing and toxic substances removing, dampness removing is antipruritic, the function of bactericidal antiphlogistic, there is no pain, easily acceptance, feature evident in efficacy, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.
Another object of the present invention is just to provide the preparation method of above-mentioned Chinese medicine preparation.
The Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease, takes off the primary raw material stating weight proportion and is prepared from:
Melilotus 20-60 part Cortex Dictamni 15 ~ 20 parts
Cortex Phellodendri 25-55 part Radix Sanguisorbae 15 ~ 28 parts
Radix Stephaniae Tetrandrae 30-60 part Fructus Kochiae 15 ~ 30 parts
Herba Zornia Diphyllae 30-50 part.
According to the Chinese medicine preparation of foregoing treatment serious symptom hand-foot-mouth disease, preferred scheme is: take off the primary raw material stating weight proportion and be prepared from:
Melilotus 35-50 part Cortex Dictamni 17-19 part
Cortex Phellodendri 35-45 part Radix Sanguisorbae 22-26 part
Radix Stephaniae Tetrandrae 40-50 part Fructus Kochiae 20-22 part
Herba Zornia Diphyllae 35-45 part.
According to the Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease above, better preferred scheme is: take off the primary raw material stating weight proportion and be prepared from:
Melilotus 45 parts of Cortex Dictamni 18 parts
Cortex Phellodendri 40 portions of Radix Sanguisorbaes 24 parts
Radix Stephaniae Tetrandrae 45 parts of Fructus Kochiae 21 parts
Herba Zornia Diphyllae 40 parts.
According to the preparation method of the Chinese medicine preparation of serious symptom hand-foot-mouth disease described arbitrarily above, preferred scheme is, step is as follows:
(1) melilotus, Radix Stephaniae Tetrandrae and Herba Zornia Diphyllae are placed on tile, dry 2-6 minute with low baking temperature, to take out after giving out fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 80-120 mesh sieve;
(3) Cortex Phellodendri, Cortex Dictamni, Radix Sanguisorbae and the Fructus Kochiae are cleaned mixing, add raw material weight 1-5 warm water doubly, soak 10-40min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 15-35 minute, filter and remove residue, obtains filtrate for subsequent use;
(4) add in step (3) gained filtrate by step (2) gained smalls, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
According to foregoing preparation method, preferred scheme is: step (1) low baking temperature dries 3-5 minute (preferably drying 4 minutes).
According to foregoing preparation method, preferred scheme is: step (2) smalls crosses 90-110 mesh sieve (preferred mistake 100 mesh sieve).
According to foregoing preparation method, preferred scheme is, step (3) adds raw material weight 2-4 warm water (preferably 3 times) doubly.
According to foregoing preparation method, preferred scheme is, the time of step (3) crude drug warm water soaking is the time that 20-30min(preferably soaks is 25 min).
According to foregoing preparation method, preferred scheme is, the time that step (3) keeps slight boiling condition to decoct is 20-30 minute (preferably 25 minutes).
According to the application of the Chinese medicine preparation above described in any one when the medicine of heating caused by preparation treatment hand-foot-mouth disease, herpes, eczema, urticaria disease.
Using method: gained Chinese medicine preparation of the present invention both can also can take orally in external, can also be sprayed on indoor and prevent from infecting, the outer used time, first by affected part wash clean, towel off dry, Chinese medicine preparation of the present invention is sprayed on affected part, one for several times, each appropriate, time for oral administration, Chinese medicine preparation of the present invention is sprayed in mouth, under each spray 3-5,6-9 time on the one 5 days is a course for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Melilotus: base is former: be the herb of pulse family melilot serration melilotus.Composition: herb, containing volatile oil, includes coumarin.The property of medicine: " Inner Mongol Chinese herbal medicine ": " acrid in the mouth, property is put down." function cures mainly: " Inner Mongol Chinese herbal medicine ": " with middle stomach invigorating, clearing away heat and eliminating dampness, diuresis.Cure mainly heat-damp in summer uncomfortable in chest, greasy taste in the mouth, halitosis, dysentery with red and white feces, gonorrhea, furuncle.”
Herba Zornia Diphyllae: be the herb of pulse family Herba Zornia Diphyllae platymiscium Herba Zornia Diphyllae.Composition: herb is containing coumarin.The property of medicine: bitter, sweet, cool.Function cures mainly: heat-clearing and toxic substances removing, cool the blood dissipate blood stasis, dehumidifying diuresis.Cure mainly anemopyretic cold, pharyngalgia, skin infection swells and ache, venom, and jaundice is had loose bowels, dysentery, infantile malnutrition.
Radix Aristolochiae Fangchi: be the root of Aristolochiaceae birthwort Radix Aristolochiae Fangchi.Another name Radix cocculi laurifolii, rattan Radix Stephaniae Tetrandrae, large acute diseases such as cholera and sunstroke medicine.Micro-bitter, acrid, cold.Function cures mainly: wind-expelling pain-stopping, clearing away heat and promoting diuresis.Cure mainly damp and hot general pain, rheumatic arthralgia, lower limbs edema, dysuria, beriberi.
Cortex Phellodendri: nature and flavor: bitter, cold.Gui Jing: return kidney, urinary bladder channel.Effect: heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.Cure mainly: for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi ， flaccidity of feet with lamenness, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
The Fructus Kochiae, nature and flavor: pungent, bitter, cold.Gui Jing: return kidney, urinary bladder channel.Effect: clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.Cure mainly: for difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Radix Sanguisorbae, nature and flavor: bitter, sour, puckery, are slightly cold.Gui Jing: return liver, large intestine channel.Effect: cooling blood for hemostasis, removing toxic substances sore.Cure mainly: for having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle sore tumefacting virus.
Cortex Dictamni, nature and flavor: bitter, cold.Gui Jing: return spleen, stomach, urinary bladder channel.Effect: heat clearing and damp drying. removing toxic substances of dispeling the wind.Cure mainly: for damp and hot sore, yellow fluid is dripping, eczema, rubella, scabies skin ulcer leprosy, beriberoid pyretic arthralgia, yellow cellulitis dark coloured urine.
The invention provides Chinese medicine preparation scientific formula, the preparation method of dosage form is simple, and products obtained therefrom is easy to use, be easy to carry, and can effectively prevent herpes ulceration, and reduce children's painful, in addition, excellent results of the present invention also shows:
1,selected materials is all Chinese medicine material, without any side effects, is applicable to any skin quality, hypo-allergenic;
2,this prescription meets Chinese medicine principle and serious symptom hand-foot-mouth disease patient body and mind feature completely, under the prerequisite of general principle, can have different prescription according to different crowd, and function is different.
3,medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part):
Melilotus 20 parts of Cortex Dictamni 15 parts
Cortex Phellodendri 25 portions of Radix Sanguisorbaes 15 parts
Radix Aristolochiae Fangchi 30 parts of Fructus Kochiae 15 parts
Herba Zornia Diphyllae 30 parts.
The preparation method of the Chinese medicine preparation of above-mentioned treatment serious symptom hand-foot-mouth disease:
(1) melilotus, Radix Aristolochiae Fangchi and Herba Zornia Diphyllae are placed on tile, dry 2 minutes with low baking temperature, to take out after giving out fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 80 mesh sieves;
(3) Cortex Phellodendri, Cortex Dictamni, Radix Sanguisorbae and the Fructus Kochiae are cleaned mixing, add the warm water of raw material weight 1 times, soak 10min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 15 minutes, filter and remove residue, obtain filtrate for subsequent use;
(4) add in step (3) gained filtrate by step (2) gained smalls, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
model case one: woods ××, female, 23 years old, Jinan, Shandong Province people from Jiyang, within 2012, autumn has set in, and face, axillary fossa and medial thigh skin have exanthema vesiculosum, dry pharynx pharyngalgia, also slight cough, thinks and is that just autumn has set in caused by dry weather, just do not take notice of always, spent 3 days, what exanthema vesiculosum had breaks, some suppurations, pain very, learns that Chinese medicine preparation of the present invention was gone to a doctor in here afterwards.
Use the Chinese medicine preparation of the present embodiment 1 gained treatment serious symptom hand-foot-mouth disease, first by affected part wash clean, towel off dry, Chinese medicine preparation of the present invention is sprayed on affected part, and one for several times, at every turn in right amount, time for oral administration, Chinese medicine preparation of the present invention is sprayed in mouth, each spray 5 times, 9 times on the one, use 3 days, pharyngalgia, the transference cures such as cough, the herpes of breaking has healed, and continues a course for the treatment of of use, patient's self-induction is fully recovered, and does not recur so far.
embodiment 2the Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease, takes off the primary raw material stating weight proportion and is prepared from (getting 15g for every part):
Melilotus 60 parts of Cortex Dictamni 20 parts
Cortex Phellodendri 55 portions of Radix Sanguisorbaes 28 parts
Radix Aristolochiae Fangchi 60 parts of Fructus Kochiae 30 parts
Herba Zornia Diphyllae 50 parts.
The preparation method of the Chinese medicine preparation of above-mentioned treatment serious symptom hand-foot-mouth disease:
(1) melilotus, Radix Aristolochiae Fangchi and Herba Zornia Diphyllae are placed on tile, dry 6 minutes with low baking temperature, to take out after giving out fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 120 mesh sieves;
(3) Cortex Phellodendri, Cortex Dictamni, Radix Sanguisorbae and the Fructus Kochiae are cleaned mixing, add the warm water of raw material weight 5 times, soak 40min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 35 minutes, filter and remove residue, obtain filtrate for subsequent use;
(4) add in step (3) gained filtrate by step (2) gained smalls, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
typical case two,liu's ××, man, 5 years old, Jining of Shandong Province people, in July, 2013 examines, father patient describes and says: his son of 5 years old is before one month, eat the brochette bought on beach, roadside, after 5 days, child says that whole body is felt bad, the severity of pharyngalgia, there is herpes in trick, pruritus is obvious, and with burning sensation, child cries always, household looks after children examination in hospital, be dermatitis aestivale at Yantai hospital diagnosis, and opened some antihistaminic oral medicine and antipruritic ointment external, originally symptom slows down, drug withdrawal one day after above-mentioned symptom has occurred again, and herpes is suppurated, child also has slight fever, grandparents afterwards in native place brings Chinese medicine preparation of the present invention to it.
Use the embodiment of the present invention 2 gained Chinese medicine preparation, first by affected part wash clean, towel off dry, Chinese medicine preparation of the present invention is sprayed on affected part, and one for several times, at every turn in right amount, time for oral administration, Chinese medicine preparation of the present invention is sprayed in mouth, each spray 3 times, 6 times on the one, symptom after 3 days is used to take a turn for the better, the transference cure such as pharyngalgia, heating, herpes deliquescing, after continuing use course for the treatment of, patient's self-induction is cured.
embodiment 3treatment serious symptom hand-foot-mouth disease Chinese medicine preparation, takes off the primary raw material stating weight proportion and is prepared from (getting 25g for every part):
Melilotus 35 parts of Cortex Dictamni 17 parts
Cortex Phellodendri 35 portions of Radix Sanguisorbaes 22 parts
Radix Aristolochiae Fangchi 40 parts of Fructus Kochiae 20 parts
Herba Zornia Diphyllae 35 parts.
The preparation method of above-mentioned treatment serious symptom hand-foot-mouth disease Chinese medicine preparation:
(1) melilotus, Radix Aristolochiae Fangchi and Herba Zornia Diphyllae are placed on tile, dry 3 minutes with low baking temperature, to take out after giving out fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 90 mesh sieves;
(3) Cortex Phellodendri, Cortex Dictamni, Radix Sanguisorbae and the Fructus Kochiae are cleaned mixing, add the warm water of raw material weight 2 times, soak 20min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 20 minutes, filter and remove residue, obtain filtrate for subsequent use;
(4) add in step (3) gained filtrate by step (2) gained smalls, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
model case three: money ××, man, 10 years old,, from last year during summer has set in, there is Acute onset suddenly in Distributions in Liaocheng of Shandong Province people, heating is serious, oral mucosa, and occur being dispersed in herpes, there is maculopapule, herpes in hands, foot and buttocks, originally do not take notice of time incipient, spent 3 days and had inflammatory blush around herpes, in bleb, liquid is less, also with symptoms such as cough, watery nasal discharge, inappetence.In in July, 2013 here go to a doctor, opened the Chinese medicine preparation of the present invention of a course for the treatment of to her.
Use the Chinese medicine preparation of the present embodiment 3 gained treatment serious symptom hand-foot-mouth disease, first by affected part wash clean, towel off dry, Chinese medicine preparation of the present invention is sprayed on affected part, and one for several times, at every turn in right amount, time for oral administration, Chinese medicine preparation of the present invention is sprayed in mouth, each spray 4 times, 7 times on the one, symptom after 5 days is used to take a turn for the better, heating, pharyngalgia transference cure, continue to take 3 days, herpes deliquescing, has bought again a course for the treatment of and has consolidated, without recurrence after drug withdrawal.
embodiment 4the Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease, takes off the primary raw material stating weight proportion and is prepared from (getting 20g for every part):
Melilotus 50 parts of Cortex Dictamni 19 parts
Cortex Phellodendri 45 portions of Radix Sanguisorbaes 26 parts
Radix Aristolochiae Fangchi 50 parts of Fructus Kochiae 22 parts
Herba Zornia Diphyllae 45 parts.
The preparation method of the Chinese medicine preparation of above-mentioned treatment serious symptom hand-foot-mouth disease:
(1) melilotus, Radix Aristolochiae Fangchi and Herba Zornia Diphyllae are placed on tile, dry 5 minutes with low baking temperature, to take out after giving out fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 110 mesh sieves;
(3) Cortex Phellodendri, Cortex Dictamni, Radix Sanguisorbae and the Fructus Kochiae are cleaned mixing, add the warm water of raw material weight 4 times, soak 30min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 30 minutes, filter and remove residue, obtain filtrate for subsequent use;
(4) add in step (3) gained filtrate by step (2) gained smalls, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
embodiment 5the Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part):
Melilotus 45 parts of Cortex Dictamni 18 parts
Cortex Phellodendri 40 portions of Radix Sanguisorbaes 24 parts
Radix Aristolochiae Fangchi 45 parts of Fructus Kochiae 21 parts
Herba Zornia Diphyllae 40 parts.
The preparation method of the Chinese medicine preparation of above-mentioned treatment serious symptom hand-foot-mouth disease:
(1) melilotus, Radix Aristolochiae Fangchi and Herba Zornia Diphyllae are placed on tile, dry 4 minutes with low baking temperature, to take out after giving out fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 100 mesh sieves;
(3) Cortex Phellodendri, Cortex Dictamni, Radix Sanguisorbae and the Fructus Kochiae are cleaned mixing, add the warm water of raw material weight 3 times, soak 25min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 25 minutes, filter and remove residue, obtain filtrate for subsequent use;
(4) add in step (3) gained filtrate by step (2) gained smalls, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
test example 1object is to verify whether the present invention (embodiment 5 gained) Chinese medicine preparation has curative effect to treatment serious symptom hand-foot-mouth disease." the new Chinese medicine guideline of clinical investigations " within 1993, formulated according to Ministry of Public Health is equally diagnosis basis, totally 100 example ages 1-30 year between suffer from the patient of serious symptom hand-foot-mouth disease, wherein, male 50 people, female 50 people, random division is administration group and matched group.Before the experiments first 3 days, the health of record patient, comprise the symptom whether having heating, pharyngalgia, skin surface situation, herpes blisters distribution and emotion changes (being determined by question and answer and answer test problem), look over patient body symptom every day, guarantee administration group and matched group situation basically identical.Administration group uses embodiment 5 gained Chinese medicine preparation every day, the outer used time, first by affected part wash clean, towel off dry, Chinese medicine preparation of the present invention is sprayed on affected part, one for several times, at every turn in right amount, time for oral administration, Chinese medicine preparation of the present invention is sprayed in mouth, under each spray 3-5,6-9 time on the one 10 days is a course for the treatment of.Check patient body situation every day, make a record.Criterion: cure: after using 1 course for the treatment of of gained Chinese medicine preparation of the present invention, malaise symptoms disappearance; Effective: after using 1 course for the treatment of of gained Chinese medicine preparation of the present invention, malaise symptoms disappears substantially; Invalid: after using 1 course for the treatment of of gained Chinese medicine preparation of the present invention, malaise symptoms is unchanged, and result is as following table 1:
Table 1:
Self-induction symptom and emotion changes result are as table 2:
Table 2:
efficacy analysis:experimentally routine the data obtained is known, and the present invention treats the Chinese medicine preparation effective percentage of serious symptom hand-foot-mouth disease up to 96%, and cure rate is up to 92%.When administration group (Chinese medicine preparation of the present invention) uses 3 days, most patient sensory symptoms obviously alleviates, pharyngalgia, the symptoms such as heating are improved, and herpes blisters reduces, scratchiness is no longer strong, patient's emotion takes a turn for the better, and during medication 5 days, patient is almost recovered, the transference cure such as pharyngalgia, heating, herpes blisters disappears, the existence of imperceptible pruritus, spiritual cephalopodium, in a good humor.Drug withdrawal a period of time has no repeatedly, and the state of an illness is better controlled.Matched group take medicine after curative effect obvious, but after drug withdrawal, the patient of 96% is recurred again.Chinese medicine preparation Be very effective of the present invention, Most patients medication after 3 days symptom be clearly better, use Chinese medicine preparation of the present invention, by the direct administration in affected part, significantly reduce the misery of patient, sterilizing can also be carried out to indoor, control the source of infection, comparatively serious patient medication after 10 days malaise symptoms also substantially disappear.
Claims (6)
1.
the preparation method of the Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease, is characterized in that: take off the crude drug stating weight proportion:
Melilotus 35-50 part Cortex Dictamni 17-19 part
Cortex Phellodendri 35-45 part Radix Sanguisorbae 22-26 part
Radix Stephaniae Tetrandrae 40-50 part Fructus Kochiae 20-22 part
Herba Zornia Diphyllae 35-45 part;
Step is as follows:
(1) melilotus, Radix Stephaniae Tetrandrae and Herba Zornia Diphyllae are placed on tile, dry 3-5 minute with low baking temperature, to take out after giving out fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 90-110 mesh sieve;
(3) Cortex Phellodendri, Cortex Dictamni, Radix Sanguisorbae and the Fructus Kochiae are cleaned mixing, add raw material weight 2-4 warm water doubly, soak 20-30min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 20-30 minute, filter and remove residue, obtains filtrate for subsequent use;
(4) add in step (3) gained filtrate by step (2) gained smalls, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
2. preparation method according to claim 1, is characterized in that: take off the crude drug stating weight proportion:
Melilotus 45 parts of Cortex Dictamni 18 parts
Cortex Phellodendri 40 portions of Radix Sanguisorbaes 24 parts
Radix Stephaniae Tetrandrae 45 parts of Fructus Kochiae 21 parts
Herba Zornia Diphyllae 40 parts.
3. preparation method according to claim 1, is characterized in that: step (1) dries 4 minutes with low baking temperature.
4. preparation method according to claim 1, is characterized in that: step (2) smalls crosses 100 mesh sieves.
5. preparation method according to claim 1, is characterized in that: step (3) adds the warm water of raw material weight 3 times.
6. preparation method according to claim 1, is characterized in that: the time of step (3) crude drug warm water soaking is 25 min.
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| 杨爱国等,.手足口病治疗1号方体外抗EV71 实验研究.《齐鲁药事》.2009,第28卷(第8期),第476-477页. * |
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