CN103919893A - Traditional Chinese medicinal preparation for treating severe hand-foot-mouth disease and preparation method thereof - Google Patents
Traditional Chinese medicinal preparation for treating severe hand-foot-mouth disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal preparation for treating a severe hand-foot-mouth disease. The traditional Chinese medicinal preparation is mainly prepared from the following raw materials in parts by weight: 20-60 parts of melilotus suavcolen, 15-20 parts of cortex dictamni, 25-55 parts of amur cork tree bark, 15-28 parts of sanguisorba officinalis, 30-60 parts of aristolochia fangchi, 15-30 parts of radish seeds and 30-50 parts of zornia diphylla pers. The traditional Chinese medicinal preparation disclosed by the invention is significant in effect, and capable of remarkably improving symptoms of most patients after being applied for 5 days; the spray disclosed by the invention is directly applied to an affected part, thus greatly relieving pain of patients; moreover, the preparation can sterilize and disinfect an indoor environment and control an infection source; and even for relatively severe patients, the preparation can basically eliminate discomfort symptoms after being applied for 10 days.
Description
Technical field
The present invention relates to Chinese medicine field, particularly relate to a kind of Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease and preparation method thereof.
Background technology
Hand-foot-mouth disease is the infectious disease being caused by enterovirus, is multiplely born in 5 years old following child, can cause the herpes at the positions such as hands, foot, oral cavity, and minority infant can cause the complication such as myocarditis, pulmonary edema, AME.If indivedual children with serious disease PD are fast, cause death.The enterovirus that causes hand-foot-mouth disease has kind more than 20 (type), 16,4,5,9,10 types of CA group, 2,5 types of B group, and enterovirns type 71, be the more common pathogen of hand-foot-mouth disease, wherein common with coxsackie virus A 16-type (Cox A16) and enterovirns type 71 (EV 71).There are several viruses can cause hand-foot-mouth disease.Modal is coxsackie virus A 16-type, and other strains of CA or enterovirns type 71 also can cause hand-foot-mouth disease in addition.Coxsackie virus is a kind of of enterovirus.Enterovirus comprises poliovirus, Coxsackie virus and echovirus.Its infection site is the whole digestive tract that comprises oral cavity, and the per os such as the food by polluting, beverage, fruit enter in body, and breed at intestinal.
Clinical manifestation: hand-foot-mouth disease mainly occurs in 4 years old following child, also likely falls ill but be grown up, and therefore can say that everyone is susceptible.After infection, only obtain the immunity of this type virus, other type viruses are infected without cross immunity again, suffer from after hand-foot-mouth disease and also may again suffer from hand-foot-mouth disease because infecting other types viruses.Incubation period: mostly be 2～10 days, average 3～5 days.1. common case performance: Acute onset, heating, there is being dispersed in herpes in oral mucosa, and there is maculopapule, herpes in hands, foot and buttocks, and herpes can have inflammatory blush around, and in bleb, liquid is less.Can be with symptoms such as cough, watery nasal discharge, inappetence.Some cases only shows as erythra or herpangina.How in one week, to fully recover, prognosis bona.Some cases erythra performance is not true to type, as single position or only show as maculopapule.2. severe cases performance: minority case (being especially less than 3 years old person) disease progression is rapid, in morbidity, within about 1～5 day, there are meningitis, encephalitis (the most dangerous with brain stem encephalitis), encephalomyelitis, pulmonary edema, circulatory disturbance etc., the only a few case state of an illness is critical, can lethally die, survival case can leave sequela.(1) Manifestations of nervous system: spirit is poor, drowsiness, easily shy, headache, vomiting, delirium are even gone into a coma; Limb shaking, myoclonus, nystagmus, ataxia, ocular motility disorder; Unable or AFP Cases; Faint from fear.The visible meningeal irritation sign of having a medical check-up, tendon reflex weakens or disappears, and the pathology such as babinski sign are levied the positive.(2) respiratory system performance: shortness of breath, dyspnea or the rhythm and pace of moving things change, lip cyanosis, cough, coughs white, pink or courageous and upright frothy sputum liquid; Pulmonary's audible and moist rales or rale sound.(3) blood circulation performance: the grey ash of complexion, skin pattern, coolness of extremities, refer to (toe) cyanosis; Be in a cold sweat; Prolonged capillary refill time.Increased heart rate or slow down, the shallow speed of pulse or weaken even disappears; Hypertension or decline.Acute onset, heating; There is loose shape herpes in oral mucosa, grain of rice size, and pain is obvious; There is the large exanthema vesiculosum of the grain of rice in palm or foot palm part, buttocks or knee occasionally can be got involved.Herpes has inflammatory blush around, and in bleb, liquid is less.The shapes such as part infant can be with cough, watery nasal discharge, inappetence, feel sick, vomiting, headache.Doctor conventionally can be according to patient's age, patient or the head of a family's the symptom of telling, and checks that erythra and ulcer differentiates the oral ulcer due to hand-foot-mouth disease and other reasons.Throat swab or stool sample can be delivered to laboratory detection virus, but virus detection need to just can go out result in 2～4 weeks, so doctor does not propose to do this inspection conventionally.According to epidemiologic data, clinical manifestation, lab testing, while making a definite diagnosis, must there is etiologic inspection foundation.
The traditional Chinese medical science is particular about dialectical treating in treatment hand-foot-mouth disease process, according to patient's different situations, carries out dialectical treatment, can allow like this patient start with and treat from the cause of disease, obtains the effect of good symptomatic treatment.Publication number Granted publication CN 102423447 B(application numbers 201110378341.9) Chinese patent literature discloses the Chinese medicine composition of a kind of prevention and treatment Hand-Food-Mouth Disease, by Retinervus Luffae Fructus 10g, and Radix Et Rhizoma Rhei 30g, Galla Chinensis 10g, Fructus Cnidii 35g, Calamina 20g, Umbrella Rhopilema esculenta 8g, Herba Pogostemonis 5g, Mirabilitum crystallina 4g, Ramulus Cinnamomi 15g, Rhizoma Et Radix Notopterygii 20g, Radix Angelicae Pubescentis 18g, Radix Clematidis 15g, Cortex erythrinae 10g, Fructus Amomi 8g, Fructus Amomi Rotundus 8g, Semen Coicis 20g, Herba Hyperici Japonici 15g, Herba Abri 10g, Borax 12g, Mylabris 5g is prepared from.Granted publication CN 102499965 B(application numbers 201110443224.6) Chinese patent literature discloses a kind of Traditional Chinese medicine fumigant compositions of preventing hand-foot-mouth disease, it is formulated by the raw material of Chinese medicine of following weight parts, Styrax 30, dry Herba Spirodelae 30, Folium Artemisiae Argyi 30, Aloe 20, Fructus Xanthii 25, Rhizoma Cyperi 25, Fructus Artemisiae Annuae 30, Herba Pogostemonis 30, Herba Eupatorii 20, Camphora 15, its using method is, by Styrax 30, dry Herba Spirodelae 30, Folium Artemisiae Argyi 30, Aloe 20, Fructus Xanthii 25, Rhizoma Cyperi 25, Fructus Artemisiae Annuae 30, Herba Pogostemonis 30, Herba Eupatorii 20, Camphora 15 be placed on altogether in a large marmite, add water cross medicine high 5 centimetres soak and endure out with high heat for 20 minutes after, then with moderate heat, endure 30-45 minute, set 1 point of small field, large-scalely divide 3-5 point, within every 2 days, fumigate once.
The medicine of various treatment serious symptom hand-foot-mouth disease, no matter be that different curative effects all appear in Chinese medicine or Western medicine, has alleviated patient's misery greatly above, and weak point is that the medication cycle is long, easily recurrence.
Summary of the invention
For the deficiencies in the prior art, one of object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease, it has heat-clearing and toxic substances removing, dampness removing is antipruritic, the function of bactericidal antiphlogistic, there is no pain, easily accept, feature evident in efficacy, and it adopts comparatively common in the localities Chinese crude drug as raw material, with low cost.
Another object of the present invention is just to provide the preparation method of above-mentioned Chinese medicine preparation.
The Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease, takes off the primary raw material of stating weight proportion and is prepared from:
15 ~ 20 parts of melilotus 20-60 part Cortex Dictamni
15 ~ 28 parts of Cortex Phellodendri 25-55 part Radix Sanguisorbaes
15 ~ 30 parts of Radix Aristolochiae Fangchi 30-60 part Fructus Kochiae
Herba Zornia Diphyllae 30-50 part.
According to the Chinese medicine preparation of foregoing treatment serious symptom hand-foot-mouth disease, preferred scheme is: take off the primary raw material of stating weight proportion and be prepared from:
Melilotus 35-50 part Cortex Dictamni 17-19 part
Cortex Phellodendri 35-45 part Radix Sanguisorbae 22-26 part
Radix Aristolochiae Fangchi 40-50 part Fructus Kochiae 20-22 part
Herba Zornia Diphyllae 35-45 part.
According to the Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease above, better preferred scheme is: take off the primary raw material of stating weight proportion and be prepared from:
18 parts of 45 parts of Cortex Dictamni of melilotus
24 parts of 40 portions of Radix Sanguisorbaes of Cortex Phellodendri
21 parts of 45 parts of Fructus Kochiae of Radix Aristolochiae Fangchi
40 parts of Herba Zornia Diphyllae.
According to any preparation method of the Chinese medicine preparation of described serious symptom hand-foot-mouth disease above, preferred scheme is, step is as follows:
(1) melilotus, Radix Aristolochiae Fangchi and Herba Zornia Diphyllae are placed on tile, with low baking temperature, dry 2-6 minute, to give out take out after fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 80-120 mesh sieve;
(3) Cortex Phellodendri, Cortex Dictamni, Radix Sanguisorbae and the Fructus Kochiae are cleaned and mixed, add raw material weight 1-5 warm water doubly, soak 10-40min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 15-35 minute, filter and remove residue, obtains filtrate for later use;
(4) step (2) gained smalls is added in step (3) gained filtrate, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
According to foregoing preparation method, preferred scheme is: step (1) is dried 3-5 minute (preferably drying 4 minutes) with low baking temperature.
According to foregoing preparation method, preferred scheme is: step (2) smalls is crossed 90-110 mesh sieve (preferred mistake 100 mesh sieves).
According to foregoing preparation method, preferred scheme is, step (3) interpolation raw material weight 2-4 warm water (preferably 3 times) doubly.
According to foregoing preparation method, preferably scheme is, step (3) crude drug is that the time that 20-30min(preferably soaks is 25 min with the time of warm water soaking).
According to foregoing preparation method, preferably scheme is, the time that step (3) keeps slight boiling condition to decoct is 20-30 minute (preferably 25 minutes).
Application according to the Chinese medicine preparation described in any one above when the medicine of heating due to preparation treatment hand-foot-mouth disease, herpes, eczema, urticaria disease.
Using method: gained Chinese medicine preparation of the present invention both can also can take orally in external, can also be sprayed on indoor preventing and infect, the outer used time, first by affected part wash clean, towel off dryly, Chinese medicine preparation of the present invention is sprayed on to affected part, one for several times, each appropriate, when for oral administration, Chinese medicine preparation of the present invention is sprayed in mouth, sprays under 3-5 at every turn, 6-9 time on the one 5 days is a course for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Melilotus: base is former: be the herb of pulse family melilot serration melilotus.Composition: herb, containing volatile oil, includes coumarin.The property of medicine: < < Inner Mongol Chinese herbal medicine > >: " acrid in the mouth, property is flat." function cures mainly: < < Inner Mongol Chinese herbal medicine > >: " with middle stomach invigorating, clearing away heat and eliminating dampness, diuresis.Cure mainly heat-damp in summer uncomfortable in chest, greasy taste in the mouth, halitosis, dysentery with red and white feces, gonorrhea, furuncle.”
Herba Zornia Diphyllae: be the herb of pulse family Herba Zornia Diphyllae platymiscium Herba Zornia Diphyllae.Composition: herb is containing coumarin.The property of medicine: bitter, sweet, cool.Function cures mainly: heat-clearing and toxic substances removing, cool the blood dissipate blood stasis, dehumidifying diuresis.Cure mainly anemopyretic cold, pharyngalgia, skin infection swells and ache, venom, jaundice, has loose bowels, dysentery, infantile malnutrition.
Radix Aristolochiae Fangchi: be the root of Aristolochiaceae birthwort Radix Aristolochiae Fangchi.Another name Radix cocculi laurifolii, rattan Radix Stephaniae Tetrandrae, large acute diseases such as cholera and sunstroke medicine.Micro-bitter, acrid, cold.Function cures mainly: wind-expelling pain-stopping, clearing away heat and promoting diuresis.Cure mainly damp and hot general pain, rheumatic arthralgia, lower limbs edema, dysuria, beriberi.
Cortex Phellodendri: nature and flavor: hardship, cold.Gui Jing: return kidney, urinary bladder channel.Effect: heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment.Cure mainly: for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi ， flaccidity of feet with lamenness, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
The Fructus Kochiae, nature and flavor: pungent, bitter, cold.Gui Jing: return kidney, urinary bladder channel.Effect: clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.Cure mainly: for difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Radix Sanguisorbae, nature and flavor: bitter, acid, puckery, is slightly cold.Gui Jing: return liver, large intestine channel.Effect: cooling blood for hemostasis, removing toxic substances sore.Cure mainly: for having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle sore tumefacting virus.
Cortex Dictamni, nature and flavor: hardship, cold.Gui Jing: return spleen, stomach, urinary bladder channel.Effect: heat clearing and damp drying. the removing toxic substances of dispeling the wind.Cure mainly: for damp and hot sore, yellow fluid is dripping eczema, rubella, scabies skin ulcer leprosy, rheumatism pyretic arthralgia, yellow cellulitis dark coloured urine.
The invention provides Chinese medicine preparation prescription science, the preparation method of dosage form is simple, and products obtained therefrom is easy to use, be easy to carry, and can effectively prevent herpes ulceration, reduces children's painful, and in addition, excellent results of the present invention also shows:
1,selected materials is all Chinese medicine material, without any side effects, is applicable to any skin quality, hypo-allergenic;
2,this prescription meets Chinese medicine principle and serious symptom hand-foot-mouth disease patient body and mind feature completely, under the prerequisite of general principle, can have different prescriptions according to different crowd, and function is different.
3,medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
The specific embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not limited to this.
embodiment 1the Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease, takes off the primary raw material of stating weight proportion and is prepared from (getting 10g for every part):
15 parts of 20 parts of Cortex Dictamni of melilotus
15 parts of 25 portions of Radix Sanguisorbaes of Cortex Phellodendri
15 parts of 30 parts of Fructus Kochiae of Radix Aristolochiae Fangchi
30 parts of Herba Zornia Diphyllae.
The preparation method of the Chinese medicine preparation of above-mentioned treatment serious symptom hand-foot-mouth disease:
(1) melilotus, Radix Aristolochiae Fangchi and Herba Zornia Diphyllae are placed on tile, with low baking temperature, dry 2 minutes, to give out take out after fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 80 mesh sieves;
(3) Cortex Phellodendri, Cortex Dictamni, Radix Sanguisorbae and the Fructus Kochiae are cleaned and mixed, add the warm water of 1 times of raw material weight, soak 10min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 15 minutes, filter and remove residue, obtains filtrate for later use;
(4) step (2) gained smalls is added in step (3) gained filtrate, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
model case one: woods * *, female, 23 years old, Jinan, Shandong Province people from Jiyang, within 2012, autumn has set in, on face, axillary fossa and medial thigh skin, has exanthema vesiculosum, dry pharynx pharyngalgia, also slight cough, thinks due to the dry weather that is that just autumn has set in, just do not take notice of always, spent 3 days, what exanthema vesiculosum had breaks, some suppurations, pain very, here was medical afterwards to learn Chinese medicine preparation of the present invention.
The Chinese medicine preparation that uses the present embodiment 1 gained treatment serious symptom hand-foot-mouth disease, first by affected part wash clean, towels off dry, Chinese medicine preparation of the present invention is sprayed on to affected part, and one for several times, at every turn appropriate, when for oral administration, Chinese medicine preparation of the present invention is sprayed in mouth, sprays 5 times at every turn, 9 times on the one, use pharyngalgia 3 days, the transference cures such as cough, the herpes of breaking has healed, and continues to use a course for the treatment of, the recovery from illness of patient's self-induction, so far not recurrence.
embodiment 2the Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease, takes off the primary raw material of stating weight proportion and is prepared from (getting 15g for every part):
20 parts of 60 parts of Cortex Dictamni of melilotus
28 parts of 55 portions of Radix Sanguisorbaes of Cortex Phellodendri
30 parts of 60 parts of Fructus Kochiae of Radix Aristolochiae Fangchi
50 parts of Herba Zornia Diphyllae.
The preparation method of the Chinese medicine preparation of above-mentioned treatment serious symptom hand-foot-mouth disease:
(1) melilotus, Radix Aristolochiae Fangchi and Herba Zornia Diphyllae are placed on tile, with low baking temperature, dry 6 minutes, to give out take out after fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 120 mesh sieves;
(3) Cortex Phellodendri, Cortex Dictamni, Radix Sanguisorbae and the Fructus Kochiae are cleaned and mixed, add the warm water of 5 times of raw material weights, soak 40min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 35 minutes, filter and remove residue, obtains filtrate for later use;
(4) step (2) gained smalls is added in step (3) gained filtrate, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
typical case two,liu * *, man, 5 years old, Jining of Shandong Province people, examine in July, 2013, father patient narrates: his son of 5 years old is before one month, eaten the brochette of buying on beach, roadside, after 5 days, child says that whole body feels bad, the severity of pharyngalgia, there is herpes in trick, pruritus is obvious, and with burning sensation, child cries always, household's examination in hospital of looking after children, at Yantai hospital diagnosis, it is dermatitis aestivale, and some antihistaminic oral medicine and antipruritic ointment external have been opened, originally symptom slows down, drug withdrawal one day after above-mentioned symptom has occurred again, and herpes is suppurated, child also has slight fever, grandparents in native place had brought Chinese medicine preparation of the present invention to it afterwards.
Use the embodiment of the present invention 2 gained Chinese medicine preparation, first by affected part wash clean, towel off dry, Chinese medicine preparation of the present invention is sprayed on to affected part, and one for several times, at every turn appropriate, when for oral administration, Chinese medicine preparation of the present invention is sprayed in mouth, sprays 3 times at every turn, 6 times on the one, use symptom after 3 days to take a turn for the better, the transference cure such as pharyngalgia, heating, herpes deliquescing, after a course for the treatment of is used in continuation, patient's self-induction is cured.
embodiment 3treatment serious symptom hand-foot-mouth disease Chinese medicine preparation, takes off the primary raw material of stating weight proportion and is prepared from (getting 25g for every part):
17 parts of 35 parts of Cortex Dictamni of melilotus
22 parts of 35 portions of Radix Sanguisorbaes of Cortex Phellodendri
20 parts of 40 parts of Fructus Kochiae of Radix Aristolochiae Fangchi
35 parts of Herba Zornia Diphyllae.
The preparation method of above-mentioned treatment serious symptom hand-foot-mouth disease Chinese medicine preparation:
(1) melilotus, Radix Aristolochiae Fangchi and Herba Zornia Diphyllae are placed on tile, with low baking temperature, dry 3 minutes, to give out take out after fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 90 mesh sieves;
(3) Cortex Phellodendri, Cortex Dictamni, Radix Sanguisorbae and the Fructus Kochiae are cleaned and mixed, add the warm water of 2 times of raw material weights, soak 20min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 20 minutes, filter and remove residue, obtains filtrate for later use;
(4) step (2) gained smalls is added in step (3) gained filtrate, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
model case three: money * *, man, 10 years old,, during since last year summer has set in, there is suddenly Acute onset in Distributions in Liaocheng of Shandong Province people, heating is serious, oral mucosa, and there is being dispersed in herpes, there is maculopapule, herpes in hands, foot and buttocks, originally in the time of incipient, do not take notice of, having crossed 3 days herpess has inflammatory blush around, and in bleb, liquid is less, also with symptoms such as cough, watery nasal discharge, inappetence.In in July, 2013 here medical, to her, opened the Chinese medicine preparation of the present invention of a course for the treatment of.
The Chinese medicine preparation that uses the present embodiment 3 gained treatment serious symptom hand-foot-mouth disease, first by affected part wash clean, towels off dry, Chinese medicine preparation of the present invention is sprayed on to affected part, and one for several times, at every turn appropriate, when for oral administration, Chinese medicine preparation of the present invention is sprayed in mouth, sprays 4 times at every turn, 7 times on the one, use symptom after 5 days to take a turn for the better, heating, pharyngalgia transference cure, continue to take 3 days, herpes deliquescing, has bought again a course for the treatment of and has consolidated, nothing recurrence after drug withdrawal.
embodiment 4the Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease, takes off the primary raw material of stating weight proportion and is prepared from (getting 20g for every part):
19 parts of 50 parts of Cortex Dictamni of melilotus
26 parts of 45 portions of Radix Sanguisorbaes of Cortex Phellodendri
22 parts of 50 parts of Fructus Kochiae of Radix Aristolochiae Fangchi
45 parts of Herba Zornia Diphyllae.
The preparation method of the Chinese medicine preparation of above-mentioned treatment serious symptom hand-foot-mouth disease:
(1) melilotus, Radix Aristolochiae Fangchi and Herba Zornia Diphyllae are placed on tile, with low baking temperature, dry 5 minutes, to give out take out after fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 110 mesh sieves;
(3) Cortex Phellodendri, Cortex Dictamni, Radix Sanguisorbae and the Fructus Kochiae are cleaned and mixed, add the warm water of 4 times of raw material weights, soak 30min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 30 minutes, filter and remove residue, obtains filtrate for later use;
(4) step (2) gained smalls is added in step (3) gained filtrate, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
embodiment 5the Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease, takes off the primary raw material of stating weight proportion and is prepared from (getting 30g for every part):
18 parts of 45 parts of Cortex Dictamni of melilotus
24 parts of 40 portions of Radix Sanguisorbaes of Cortex Phellodendri
21 parts of 45 parts of Fructus Kochiae of Radix Aristolochiae Fangchi
40 parts of Herba Zornia Diphyllae.
The preparation method of the Chinese medicine preparation of above-mentioned treatment serious symptom hand-foot-mouth disease:
(1) melilotus, Radix Aristolochiae Fangchi and Herba Zornia Diphyllae are placed on tile, with low baking temperature, dry 4 minutes, to give out take out after fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 100 mesh sieves;
(3) Cortex Phellodendri, Cortex Dictamni, Radix Sanguisorbae and the Fructus Kochiae are cleaned and mixed, add the warm water of 3 times of raw material weights, soak 25min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 25 minutes, filter and remove residue, obtains filtrate for later use;
(4) step (2) gained smalls is added in step (3) gained filtrate, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
test example 1object is to verify whether the present invention (embodiment 5 gained) Chinese medicine preparation has curative effect to treatment serious symptom hand-foot-mouth disease.The < < new Chinese medicine guideline of clinical investigations > > formulating for 1993 according to Ministry of Public Health is equally diagnosis basis, totally 100 example ages are the patient who suffers from serious symptom hand-foot-mouth disease between 1-30 year, wherein, man 50 people, female 50 people, random division is administration group and matched group.Experiment before first 3 days, record patient's health, comprise the symptom that whether has heating, pharyngalgia, skin surface situation, herpes vesicle distributes and emotion changes (determining by question and answer and answer test problem), look over patient body symptom every day, guarantee that administration group and matched group situation are basically identical.Administration group is used embodiment 5 gained Chinese medicine preparation every day, the outer used time, first by affected part wash clean, towel off dry, Chinese medicine preparation of the present invention is sprayed on to affected part, one for several times, at every turn appropriate, when for oral administration, Chinese medicine preparation of the present invention is sprayed in mouth, under each spray 3-5,6-9 time on the one 10 days is a course for the treatment of.Check patient body situation every day, make a record.Criterion: cure: use gained Chinese medicine preparation of the present invention after 1 course for the treatment of, malaise symptoms disappears; Effective: use gained Chinese medicine preparation of the present invention after 1 course for the treatment of, malaise symptoms disappears substantially; Invalid: use gained Chinese medicine preparation of the present invention after 1 course for the treatment of, malaise symptoms is unchanged, result is as following table 1:
Table 1:
Self-induction symptom and emotion changes result are as table 2:
Table 2:
efficacy analysis:known according to experimental example the data obtained, the present invention treats the Chinese medicine preparation effective percentage of serious symptom hand-foot-mouth disease up to 96%, and cure rate is up to 92%.When administration group (Chinese medicine preparation of the present invention) is used 3 days, most patient sensory symptoms obviously alleviates, pharyngalgia, the symptoms such as heating are improved, and herpes vesicle reduces, scratchiness is no longer strong, patient's emotion takes a turn for the better, medication in the time of 5 days patient be almost recovered, the transference cures such as pharyngalgia, heating, herpes vesicle disappears, the existence of imperceptible pruritus, spiritual cephalopodium, in a good humor.Drug withdrawal a period of time has no repeatedly, and the state of an illness is better controlled.Matched group take medicine after curative effect obvious, but after drug withdrawal, 96% patient is recurred again.Chinese medicine preparation effect of the present invention is remarkable, Most patients medication after 3 days symptom be clearly better, use Chinese medicine preparation of the present invention, by the direct administration in affected part, greatly alleviated patient's misery, can also control the source of infection to the indoor sterilizing that carries out, comparatively serious patient is in medication also disappearance substantially of malaise symptoms after 10 days.
Claims (10)
1. the Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease, is characterized in that: take off the primary raw material of stating weight proportion and be prepared from:
15 ~ 20 parts of melilotus 20-60 part Cortex Dictamni
15 ~ 28 parts of Cortex Phellodendri 25-55 part Radix Sanguisorbaes
15 ~ 30 parts of Radix Aristolochiae Fangchi 30-60 part Fructus Kochiae
Herba Zornia Diphyllae 30-50 part.
2. the Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease according to claim 1, is characterized in that: take off the primary raw material of stating weight proportion and be prepared from:
Melilotus 35-50 part Cortex Dictamni 17-19 part
Cortex Phellodendri 35-45 part Radix Sanguisorbae 22-26 part
Radix Aristolochiae Fangchi 40-50 part Fructus Kochiae 20-22 part
Herba Zornia Diphyllae 35-45 part.
3. the Chinese medicine preparation for the treatment of serious symptom hand-foot-mouth disease according to claim 1, is characterized in that: take off the primary raw material of stating weight proportion and be prepared from:
18 parts of 45 parts of Cortex Dictamni of melilotus
24 parts of 40 portions of Radix Sanguisorbaes of Cortex Phellodendri
21 parts of 45 parts of Fructus Kochiae of Radix Aristolochiae Fangchi
40 parts of Herba Zornia Diphyllae.
4. according to the preparation method of the Chinese medicine preparation of the treatment serious symptom hand-foot-mouth disease described in claim 1-3 any one, it is characterized in that, step is as follows:
(1) melilotus, Radix Aristolochiae Fangchi and Herba Zornia Diphyllae are placed on tile, with low baking temperature, dry 2-6 minute, to give out take out after fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 80-120 mesh sieve;
(3) Cortex Phellodendri, Cortex Dictamni, Radix Sanguisorbae and the Fructus Kochiae are cleaned and mixed, add raw material weight 1-5 warm water doubly, soak 10-40min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 15-35 minute, filter and remove residue, obtains filtrate for later use;
(4) step (2) gained smalls is added in step (3) gained filtrate, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
5. preparation method according to claim 4, is characterized in that: step (1) is dried 3-5 minute (preferably drying 4 minutes) with low baking temperature.
6. preparation method according to claim 4, is characterized in that: step (2) smalls is crossed 90-110 mesh sieve (preferred mistake 100 mesh sieves).
7. preparation method according to claim 4, is characterized in that, step (3) is added raw material weight 2-4 warm water (preferably 3 times) doubly.
8. preparation method according to claim 4, is characterized in that, step (3) crude drug is that the time that 20-30min(preferably soaks is 25 min with the time of warm water soaking).
9. preparation method according to claim 4, is characterized in that, the time that step (3) keeps slight boiling condition to decoct is 20-30 minute (preferably 25 minutes).
10. the application when the medicine of heating due to preparation treatment hand-foot-mouth disease, herpes, eczema, urticaria disease according to the Chinese medicine preparation described in claim 1-3 any one.
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| CN105617211A (en) * | 2015-12-30 | 2016-06-01 | 李雷 | Traditional Chinese medicine for treating hand-foot-and-mouth diseases |
| CN105998787A (en) * | 2016-06-15 | 2016-10-12 | 邹城众达知识产权咨询服务有限公司 | Drug for treating hand-foot-mouth disease |
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| CN103041246A (en) * | 2012-12-25 | 2013-04-17 | 黄天双 | Traditional Chinese medicine composition for treating hand-foot-mouth disease |
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| CN103041246A (en) * | 2012-12-25 | 2013-04-17 | 黄天双 | Traditional Chinese medicine composition for treating hand-foot-mouth disease |
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| CN105617211A (en) * | 2015-12-30 | 2016-06-01 | 李雷 | Traditional Chinese medicine for treating hand-foot-and-mouth diseases |
| CN105998787A (en) * | 2016-06-15 | 2016-10-12 | 邹城众达知识产权咨询服务有限公司 | Drug for treating hand-foot-mouth disease |
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