CN103919938A - Traditional Chinese medicine spray for treating acute attack of hand-foot-and-mouth disease and preparation method of spray - Google Patents
Traditional Chinese medicine spray for treating acute attack of hand-foot-and-mouth disease and preparation method of spray Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine spray for treating acute attack of hand-foot-and-mouth disease. The spray is mainly prepared from the following raw material medicines in parts by weight: 30-50 parts of circium japonicum, 15-20 parts of fructus kochiae, 10-30 parts of golden cypress, 15-28 parts of cortex dictamni, 15-45 parts of aristolochia fangchi, 10-40 parts of lithospermum and 20-40 parts of pipewort. The traditional Chinese medicine spray disclosed by the invention is remarkable in effect, and symptoms of almost patients are remarkably improved after medication 3 days. The traditional Chinese medicine spray disclosed by the invention is directly delivered to the affected part to greatly alleviate pain of the patient and further can sterilize and disinfect the indoor environment to control the infection source. For relatively severe patients, the symptoms are further remarkably improved after medication 5 days.
Description
Technical field
The present invention relates to Chinese medicine field, particularly relate to a kind of medicinal herb spray for the treatment of hand-foot-mouth disease acute attack and preparation method thereof.
Background technology
Hand-foot-mouth disease is the infectious disease being caused by enterovirus, is multiplely born in 5 years old following child, can cause the herpes at the positions such as hands, foot, oral cavity, and minority infant can cause the complication such as myocarditis, pulmonary edema, AME.If indivedual children with serious disease PD are fast, cause death.The enterovirus that causes hand-foot-mouth disease has kind more than 20 (type), 16,4,5,9,10 types of CA group, 2,5 types of B group, and enterovirns type 71, be the more common pathogen of hand-foot-mouth disease, wherein common with coxsackie virus A 16-type (Cox A16) and enterovirns type 71 (EV 71).There are several viruses can cause hand-foot-mouth disease.Modal is coxsackie virus A 16-type, and other strains of CA or enterovirns type 71 also can cause hand-foot-mouth disease in addition.Coxsackie virus is a kind of of enterovirus.Enterovirus comprises poliovirus, Coxsackie virus and echovirus.Its infection site is the whole digestive tract that comprises oral cavity, and the per os such as the food by polluting, beverage, fruit enter in body, and breed at intestinal.
Clinical manifestation: hand-foot-mouth disease mainly occurs in 4 years old following child, also likely falls ill but be grown up, and therefore can say that everyone is susceptible.After infection, only obtain the immunity of this type virus, other type viruses are infected without cross immunity again, suffer from after hand-foot-mouth disease and also may again suffer from hand-foot-mouth disease because infecting other types viruses.Incubation period: mostly be 2～10 days, average 3～5 days.1. common case performance: Acute onset, heating, there is being dispersed in herpes in oral mucosa, and there is maculopapule, herpes in hands, foot and buttocks, and herpes can have inflammatory blush around, and in bleb, liquid is less.Can be with symptoms such as cough, watery nasal discharge, inappetence.Some cases only shows as erythra or herpangina.How in one week, to fully recover, prognosis bona.Some cases erythra performance is not true to type, as single position or only show as maculopapule.2. severe cases performance: minority case (being especially less than 3 years old person) disease progression is rapid, in morbidity, within about 1～5 day, there are meningitis, encephalitis (the most dangerous with brain stem encephalitis), encephalomyelitis, pulmonary edema, circulatory disturbance etc., the only a few case state of an illness is critical, can lethally die, survival case can leave sequela.(1) Manifestations of nervous system: spirit is poor, drowsiness, easily shy, headache, vomiting, delirium are even gone into a coma; Limb shaking, myoclonus, nystagmus, ataxia, ocular motility disorder; Unable or AFP Cases; Faint from fear.The visible meningeal irritation sign of having a medical check-up, tendon reflex weakens or disappears, and the pathology such as babinski sign are levied the positive.(2) respiratory system performance: shortness of breath, dyspnea or the rhythm and pace of moving things change, lip cyanosis, cough, coughs white, pink or courageous and upright frothy sputum liquid; Pulmonary's audible and moist rales or rale sound.(3) blood circulation performance: the grey ash of complexion, skin pattern, coolness of extremities, refer to (toe) cyanosis; Be in a cold sweat; Prolonged capillary refill time.Increased heart rate or slow down, the shallow speed of pulse or weaken even disappears; Hypertension or decline.Acute onset, heating; There is loose shape herpes in oral mucosa, grain of rice size, and pain is obvious; There is the large exanthema vesiculosum of the grain of rice in palm or foot palm part, buttocks or knee occasionally can be got involved.Herpes has inflammatory blush around, and in bleb, liquid is less.The shapes such as part infant can be with cough, watery nasal discharge, inappetence, feel sick, vomiting, headache.Doctor conventionally can be according to patient's age, patient or the head of a family's the symptom of telling, and checks that erythra and ulcer differentiates the oral ulcer due to hand-foot-mouth disease and other reasons.Throat swab or stool sample can be delivered to laboratory detection virus, but virus detection need to just can go out result in 2～4 weeks, so doctor does not propose to do this inspection conventionally.According to epidemiologic data, clinical manifestation, lab testing, while making a definite diagnosis, must there is etiologic inspection foundation.
The traditional Chinese medical science is particular about dialectical treating in treatment hand-foot-mouth disease process, according to patient's different situations, carries out dialectical treatment, can allow like this patient start with and treat from the cause of disease, obtains the effect of good symptomatic treatment.Publication number Granted publication CN 102423447 B(application numbers 201110378341.9) Chinese patent literature discloses the Chinese medicine composition of a kind of prevention and treatment Hand-Food-Mouth Disease, by Retinervus Luffae Fructus 10g, and Radix Et Rhizoma Rhei 30g, Galla Chinensis 10g, Fructus Cnidii 35g, Calamina 20g, Umbrella Rhopilema esculenta 8g, Herba Pogostemonis 5g, Mirabilitum crystallina 4g, Ramulus Cinnamomi 15g, Rhizoma Et Radix Notopterygii 20g, Radix Angelicae Pubescentis 18g, Radix Clematidis 15g, Cortex erythrinae 10g, Fructus Amomi 8g, Fructus Amomi Rotundus 8g, Semen Coicis 20g, Herba Hyperici Japonici 15g, Herba Abri 10g, Borax 12g, Mylabris 5g is prepared from.Granted publication CN 102499965 B(application numbers 201110443224.6) Chinese patent literature discloses a kind of Traditional Chinese medicine fumigant compositions of preventing hand-foot-mouth disease, it is formulated by the raw material of Chinese medicine of following weight parts, Styrax 30, dry Herba Spirodelae 30, Folium Artemisiae Argyi 30, Aloe 20, Fructus Xanthii 25, Rhizoma Cyperi 25, Fructus Artemisiae Annuae 30, Herba Pogostemonis 30, Herba Eupatorii 20, Camphora 15, its using method is, by Styrax 30, dry Herba Spirodelae 30, Folium Artemisiae Argyi 30, Aloe 20, Fructus Xanthii 25, Rhizoma Cyperi 25, Fructus Artemisiae Annuae 30, Herba Pogostemonis 30, Herba Eupatorii 20, Camphora 15 be placed on altogether in a large marmite, add water cross medicine high 5 centimetres soak and endure out with high heat for 20 minutes after, then with moderate heat, endure 30-45 minute, set 1 point of small field, large-scalely divide 3-5 point, within every 2 days, fumigate once.
The medicine of various treatment hand-foot-mouth disease acute attack, no matter be that different curative effects all appear in Chinese medicine or Western medicine, has alleviated patient's misery greatly above, and weak point is that the medication cycle is long, easily recurrence.
Summary of the invention
For the deficiencies in the prior art, one of object of the present invention is to provide a kind of medicinal herb spray for the treatment of hand-foot-mouth disease acute attack, it has heat-clearing and toxic substances removing, dampness removing is antipruritic, the function of bactericidal antiphlogistic, there is no pain, easily accept, feature evident in efficacy, and it adopts comparatively common in the localities Chinese crude drug as raw material, with low cost.
Another object of the present invention is just to provide the preparation method of above-mentioned medicinal herb spray.
The medicinal herb spray for the treatment of hand-foot-mouth disease acute attack, takes off the primary raw material of stating weight proportion and is prepared from:
15 ~ 20 parts of Radix Cirsii Japonici 30-50 part Fructus Kochiae
15 ~ 28 parts of Cortex Phellodendri 10-30 part Cortex Dictamni
Radix Aristolochiae Fangchi 15-45 part Radix Arnebiae (Radix Lithospermi) 10-40 part
Flos Eriocauli 20-40 part.
According to the medicinal herb spray of foregoing hand-foot-mouth disease acute attack, preferred scheme is: take off the primary raw material of stating weight proportion and be prepared from:
Radix Cirsii Japonici 35-45 part Fructus Kochiae 17-19 part
Cortex Phellodendri 15-25 part Cortex Dictamni 22-26 part
Radix Aristolochiae Fangchi 25-35 part Radix Arnebiae (Radix Lithospermi) 20-30 part
Flos Eriocauli 25-35 part.
According to the medicinal herb spray for the treatment of hand-foot-mouth disease acute attack above, better preferred scheme is: take off the primary raw material of stating weight proportion and be prepared from:
18 parts of 40 parts of Fructus Kochiae of Radix Cirsii Japonici
24 parts of 20 parts of Cortex Dictamni of Cortex Phellodendri
25 parts of 30 portions of Radix Arnebiae (Radix Lithospermi)s of Radix Aristolochiae Fangchi
30 parts of Flos Eriocaulis.
According to any preparation method of the medicinal herb spray of described hand-foot-mouth disease acute attack above, preferred scheme is, step is as follows:
(1) Radix Cirsii Japonici, Radix Aristolochiae Fangchi and Flos Eriocauli are placed on tile, with low baking temperature, dry 3-8 minute, to give out take out after fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 60-100 mesh sieve;
(3) Cortex Phellodendri, the Fructus Kochiae, Cortex Dictamni and Radix Arnebiae (Radix Lithospermi) are cleaned and mixed, add raw material weight 2-7 warm water doubly, soak 20-60min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 20-40 minute, filter and remove residue, obtains filtrate for later use;
(4) step (2) gained smalls is added in step (3) gained filtrate, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
According to foregoing preparation method, preferred scheme is: step (1) is dried 4-7 minute (preferably drying 6 minutes) with low baking temperature.
According to foregoing preparation method, preferred scheme is: step (2) smalls is crossed 70-90 mesh sieve (preferred mistake 80 mesh sieves).
According to foregoing preparation method, preferred scheme is, step (3) interpolation raw material weight 3-6 warm water (preferably 5 times) doubly.
According to foregoing preparation method, preferably scheme is, step (3) crude drug is that the time that 30-50min(preferably soaks is 40 min with the time of warm water soaking).
According to foregoing preparation method, preferably scheme is, the time that step (3) keeps slight boiling condition to decoct is 25-35 minute (preferably 30 minutes).
Application according to the medicinal herb spray described in any one above when the medicine of herpes, eczema, urticaria disease due to preparation treatment hand-foot-mouth disease.
Using method: gained medicinal herb spray of the present invention both can also can take orally in external, can also be sprayed on indoor preventing and infect, the outer used time, first by affected part wash clean, towel off dryly, medicinal herb spray of the present invention is sprayed on to affected part, one for several times, each appropriate, when for oral administration, medicinal herb spray of the present invention is sprayed in mouth, sprays under 3-5 at every turn, 6-9 time on the one 10 days is a course for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Cirsii Japonici: having another name called horse Ji, wild thorn dish, thatch mustard, is aerial parts or the root of Compositae artichoke plant Radix Cirsii Japonici.The property of medicine: sweet in the mouth, slightly cool in nature.Composition: fresh leaf contains pectolinarin; Root is containing volatile oil component aplotaxene, Rhizoma Cyperi alkene, Flos Caryophylli alkene.According to modern pharmacological research, find, this medical instrument has the effect of hemostasis, blood pressure lowering, antibacterial, clots absorbing detumescence, for spitting blood, and spitting of blood, epistaxis, has blood in stool, hematuria, skin infection swells and ache, nephritis, eczema etc.
Flos Eriocauli: having another name called Dai Xingcao, Wen Xingcao, move star grass, is the head inflorescence of Eriocaulaceae eriocaulon buergerianum plant Flos Eriocauli band scape.The property of medicine: this product head inflorescence is hemispherical, bract close-packed arrays is layer by layer arranged at bottom, and matter is soft, odorless, acrid in the mouth, sweet, property is flat.According to modern pharmacological research, find, that this medical instrument has is antibacterial, the effect of wind and heat eliminating, improving acuity of vision and removing nebula, for conjunctival congestion cataracta, and headache, nasal sinusitis, laryngalgia, rubella pruritus etc.
Radix Aristolochiae Fangchi: be the root of Aristolochiaceae birthwort Radix Aristolochiae Fangchi.Another name Radix cocculi laurifolii, rattan Radix Stephaniae Tetrandrae, large acute diseases such as cholera and sunstroke medicine.Micro-bitter, acrid, cold.Function cures mainly: wind-expelling pain-stopping, clearing away heat and promoting diuresis.Cure mainly damp and hot general pain, rheumatic arthralgia, lower limbs edema, dysuria, beriberi.
Cortex Phellodendri: nature and flavor: hardship, cold.Gui Jing: return kidney, urinary bladder channel.Effect: heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment.Cure mainly: for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi ， flaccidity of feet with lamenness, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
Radix Arnebiae (Radix Lithospermi): nature and flavor: sweet, salty, cold.Gui Jing: GUIXIN, Liver Channel.Effect: removing heat from blood, invigorate blood circulation, removing toxic substances rash.Cure mainly: for heat in blood poison, contain, class's rash purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.
Cortex Dictamni, nature and flavor: hardship, cold.Gui Jing: return spleen, stomach, urinary bladder channel.Effect: heat clearing and damp drying. the removing toxic substances of dispeling the wind.Cure mainly: for damp and hot sore, yellow fluid is dripping eczema, rubella, scabies skin ulcer leprosy, rheumatism pyretic arthralgia, yellow cellulitis dark coloured urine.
The Fructus Kochiae, nature and flavor: pungent, bitter, cold.Gui Jing: return kidney, urinary bladder channel.Effect: clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.Cure mainly: for difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
The invention provides medicinal herb spray prescription science, the preparation method of dosage form is simple, and products obtained therefrom is easy to use, be easy to carry, and can effectively prevent herpes ulceration, reduces children's painful, and in addition, excellent results of the present invention also shows:
1,selected materials is all Chinese medicine material, without any side effects, is applicable to any skin quality, hypo-allergenic;
2,this prescription meets Chinese medicine principle and hand-foot-mouth disease acute attack patient body and mind feature completely, under the prerequisite of general principle, can have different prescriptions according to different crowd, and function is different.
3,medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
The specific embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not limited to this.
embodiment 1the medicinal herb spray for the treatment of hand-foot-mouth disease acute attack, is mainly prepared from (getting 10g for every part) by following bulk drugs:
15 parts of 30 parts of Fructus Kochiae of Radix Cirsii Japonici
15 parts of 10 parts of Cortex Dictamni of Cortex Phellodendri
10 parts of 15 portions of Radix Arnebiae (Radix Lithospermi)s of Radix Aristolochiae Fangchi
20 parts of Flos Eriocaulis.
The preparation method of the medicinal herb spray of above-mentioned treatment hand-foot-mouth disease acute attack:
(1) Radix Cirsii Japonici, Radix Aristolochiae Fangchi and Flos Eriocauli are placed on tile, with low baking temperature, dry 3 minutes, to give out take out after fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 60 mesh sieves;
(3) Cortex Phellodendri, the Fructus Kochiae, Cortex Dictamni and Radix Arnebiae (Radix Lithospermi) are cleaned and mixed, add the warm water of 2 times of raw material weights, soak 20min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 20 minutes, filter and remove residue, obtains filtrate for later use;
(4) step (2) gained smalls is added in step (3) gained filtrate, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
model case one:liu * *, female, 5 years old, the student of Distributions in Liaocheng of Shandong Province * * kindergarten, in June, 2013, start to examine, the heating of son's unknown cause before 5 hours, dry pharynx, also slight cough are said in patient father and mother's narration, child cries always, think at the beginning it is flu, to child, taken infantile common cold spirit granule after symptom without significant change, moreover under child's axillary fossa, find red exanthema vesiculosum, doctor is through finding patient's observation, be the above-mentioned symptom that hand-foot-mouth disease causes, because child is too little, doctor advised is taken medicinal herb spray of the present invention.
The medicinal herb spray that uses the present embodiment 1 gained treatment hand-foot-mouth disease acute attack, first by affected part wash clean, towels off dry, medicinal herb spray of the present invention is sprayed on to affected part, and one for several times, at every turn appropriate, when for oral administration, medicinal herb spray of the present invention is sprayed in mouth, sprays 5 times at every turn, 9 times on the one, use pharyngalgia 1 day, the transference cures such as cough, herpes deliquescing, continue to use a course for the treatment of, the recovery from illness of patient's self-induction, so far not recurrence.
embodiment 2the medicinal herb spray for the treatment of hand-foot-mouth disease acute attack, is prepared from (getting 15g for every part) by following bulk drugs:
20 parts of 50 parts of Fructus Kochiae of Radix Cirsii Japonici
28 parts of 30 parts of Cortex Dictamni of Cortex Phellodendri
40 parts of 45 portions of Radix Arnebiae (Radix Lithospermi)s of Radix Aristolochiae Fangchi
40 parts of Flos Eriocaulis.
The preparation method of the medicinal herb spray of above-mentioned treatment hand-foot-mouth disease acute attack:
(1) Radix Cirsii Japonici, Radix Aristolochiae Fangchi and Flos Eriocauli are placed on tile, with low baking temperature, dry 38 minutes, to give out take out after fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 100 mesh sieves;
(3) Cortex Phellodendri, the Fructus Kochiae, Cortex Dictamni and Radix Arnebiae (Radix Lithospermi) are cleaned and mixed, add the warm water of 7 times of raw material weights, soak 60min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 40 minutes, filter and remove residue, obtains filtrate for later use;
(4) step (2) gained smalls is added in step (3) gained filtrate, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
embodiment 3treatment hand-foot-mouth disease acute attack medicinal herb spray, is prepared from (getting 25g for every part) by following bulk drugs:
17 parts of 35 parts of Fructus Kochiae of Radix Cirsii Japonici
22 parts of 15 parts of Cortex Dictamni of Cortex Phellodendri
20 parts of 25 portions of Radix Arnebiae (Radix Lithospermi)s of Radix Aristolochiae Fangchi
25 parts of Flos Eriocaulis.
The preparation method of above-mentioned treatment hand-foot-mouth disease acute attack medicinal herb spray:
(1) Radix Cirsii Japonici, Radix Aristolochiae Fangchi and Flos Eriocauli are placed on tile, with low baking temperature, dry 4 minutes, to give out take out after fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 70 mesh sieves;
(3) Cortex Phellodendri, the Fructus Kochiae, Cortex Dictamni and Radix Arnebiae (Radix Lithospermi) are cleaned and mixed, add the warm water of 3 times of raw material weights, soak 30min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 25 minutes, filter and remove residue, obtains filtrate for later use;
(4) step (2) gained smalls is added in step (3) gained filtrate, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
embodiment 4the medicinal herb spray for the treatment of hand-foot-mouth disease acute attack, is prepared from (getting 20g for every part) by following bulk drugs:
19 parts of 45 parts of Fructus Kochiae of Radix Cirsii Japonici
26 parts of 25 parts of Cortex Dictamni of Cortex Phellodendri
30 parts of 35 portions of Radix Arnebiae (Radix Lithospermi)s of Radix Aristolochiae Fangchi
35 parts of Flos Eriocaulis.
The preparation method of the medicinal herb spray of above-mentioned treatment hand-foot-mouth disease acute attack:
(1) Radix Cirsii Japonici, Radix Aristolochiae Fangchi and Flos Eriocauli are placed on tile, with low baking temperature, dry 7 minutes, to give out take out after fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 90 mesh sieves;
(3) Cortex Phellodendri, the Fructus Kochiae, Cortex Dictamni and Radix Arnebiae (Radix Lithospermi) are cleaned and mixed, add the warm water of 6 times of raw material weights, soak 50min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 35 minutes, filter and remove residue, obtains filtrate for later use;
(4) step (2) gained smalls is added in step (3) gained filtrate, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
model case three:* *, female, 8 years old, Jinan, Shandong Province people, last year is while starting summer has set in, the unexpected Acute onset of child, heating, oral mucosa, and there is being dispersed in herpes, there is maculopapule, herpes in hands, foot and buttocks, originally in the time of incipient, do not take notice of, having crossed 1 day herpes has inflammatory blush around, and in bleb, liquid is less, also with symptoms such as cough, watery nasal discharge, inappetence.In in July, 2013 here medical, to her, opened the medicinal herb spray of the present invention of a course for the treatment of.
The medicinal herb spray that uses the present embodiment 3 gained treatment hand-foot-mouth disease acute attacks, first by affected part wash clean, towels off dry, medicinal herb spray of the present invention is sprayed on to affected part, and one for several times, at every turn appropriate, when for oral administration, medicinal herb spray of the present invention is sprayed in mouth, sprays 4 times at every turn, 7 times on the one, use symptom after 2 days to take a turn for the better, heating, pharyngalgia transference cure, continue to take 3 days, herpes deliquescing, has bought again a course for the treatment of and has consolidated, nothing recurrence after drug withdrawal.
embodiment 5the medicinal herb spray for the treatment of hand-foot-mouth disease acute attack, is prepared from (getting 30g for every part) by following bulk drugs:
18 parts of 40 parts of Fructus Kochiae of Radix Cirsii Japonici
24 parts of 20 parts of Cortex Dictamni of Cortex Phellodendri
25 parts of 30 portions of Radix Arnebiae (Radix Lithospermi)s of Radix Aristolochiae Fangchi
30 parts of Flos Eriocaulis.
The preparation method of the medicinal herb spray of above-mentioned treatment hand-foot-mouth disease acute attack:
(1) Radix Cirsii Japonici, Radix Aristolochiae Fangchi and Flos Eriocauli are placed on tile, with low baking temperature, dry 6 minutes, to give out take out after fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 80 mesh sieves;
(3) Cortex Phellodendri, the Fructus Kochiae, Cortex Dictamni and Radix Arnebiae (Radix Lithospermi) are cleaned and mixed, add the warm water of 5 times of raw material weights, soak 40min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 30 minutes, filter and remove residue, obtains filtrate for later use;
(4) step (2) gained smalls is added in step (3) gained filtrate, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
test example 1object is to verify whether acute attack has curative effect to the present invention (embodiment 5 gained) medicinal herb spray to treatment hand-foot-mouth disease.The < < new Chinese medicine guideline of clinical investigations > > formulating for 1993 according to Ministry of Public Health is equally diagnosis basis, totally 100 example ages are the patient who suffers from hand-foot-mouth disease acute attack between 1-25 year, wherein, man 50 people, female 50 people, random division is administration group and matched group.Before experiment, record patient's health, comprise the symptom that whether has heating, pharyngalgia, skin surface situation, herpes vesicle distributes and emotion changes (determining by question and answer and answer test problem), look over patient body symptom every day, guarantee that administration group and matched group situation are basically identical.Administration group is used embodiment 5 gained medicinal herb spray every day, the outer used time, first by affected part wash clean, towel off dry, medicinal herb spray of the present invention is sprayed on to affected part, one for several times, at every turn appropriate, when for oral administration, medicinal herb spray of the present invention is sprayed in mouth, under each spray 3-5,6-9 time on the one 3 days is a course for the treatment of.Check patient body situation every day, make a record.Criterion: cure: use gained medicinal herb spray of the present invention after 1 course for the treatment of, malaise symptoms disappears; Effective: use gained medicinal herb spray of the present invention after 1 course for the treatment of, malaise symptoms disappears substantially; Invalid: use gained medicinal herb spray of the present invention after 1 course for the treatment of, malaise symptoms is unchanged, result is as following table 1:
Table 1:
Self-induction symptom and emotion changes result are as table 2:
Table 2:
Efficacy analysis: known according to experimental example the data obtained, the present invention treats the spray effective percentage of hand-foot-mouth disease up to 96%, and cure rate is up to 90%.When administration group (medicinal herb spray of the present invention) is used 3 days, most patient sensory symptoms obviously alleviates, pharyngalgia, the symptoms such as heating are improved, and herpes vesicle reduces, scratchiness is no longer strong, patient's emotion takes a turn for the better, medication in the time of 5 days patient be almost recovered, the transference cures such as pharyngalgia, heating, herpes vesicle disappears, the existence of imperceptible pruritus, spiritual cephalopodium, in a good humor.Drug withdrawal a period of time has no repeatedly, and the state of an illness is better controlled.Matched group take medicine after curative effect obvious, but after drug withdrawal, 96% patient is recurred again.Medicinal herb spray effect of the present invention is remarkable, uses medicinal herb spray of the present invention, by the direct administration in affected part, has greatly alleviated patient's misery, can also, to the indoor sterilizing that carries out, control the source of infection.
Claims (10)
1. the medicinal herb spray for the treatment of hand-foot-mouth disease acute attack, is characterized in that: take off the primary raw material of stating weight proportion and be prepared from:
15 ~ 20 parts of Radix Cirsii Japonici 30-50 part Fructus Kochiae
15 ~ 28 parts of Cortex Phellodendri 10-30 part Cortex Dictamni
Radix Aristolochiae Fangchi 15-45 part Radix Arnebiae (Radix Lithospermi) 10-40 part
Flos Eriocauli 20-40 part.
2. the medicinal herb spray for the treatment of hand-foot-mouth disease according to claim 1 acute attack, is characterized in that: take off the primary raw material of stating weight proportion and be prepared from:
Radix Cirsii Japonici 35-45 part Fructus Kochiae 17-19 part
Cortex Phellodendri 15-25 part Cortex Dictamni 22-26 part
Radix Aristolochiae Fangchi 25-35 part Radix Arnebiae (Radix Lithospermi) 20-30 part
Flos Eriocauli 25-35 part.
3. the medicinal herb spray for the treatment of hand-foot-mouth disease according to claim 1 acute attack, is characterized in that: take off the primary raw material of stating weight proportion and be prepared from:
18 parts of 40 parts of Fructus Kochiae of Radix Cirsii Japonici
24 parts of 20 parts of Cortex Dictamni of Cortex Phellodendri
25 parts of 30 portions of Radix Arnebiae (Radix Lithospermi)s of Radix Aristolochiae Fangchi
30 parts of Flos Eriocaulis.
4. according to the preparation method of the medicinal herb spray of the treatment hand-foot-mouth disease acute attack described in claim 1-3 any one, it is characterized in that, step is as follows:
(1) Radix Cirsii Japonici, Radix Aristolochiae Fangchi and Flos Eriocauli are placed on tile, with low baking temperature, dry 3-8 minute, to give out take out after fragrance dry in the air cool stand-by;
(2) step (1) gained medicament mixed is even, pulverization, crosses 60-100 mesh sieve;
(3) Cortex Phellodendri, the Fructus Kochiae, Cortex Dictamni and Radix Arnebiae (Radix Lithospermi) are cleaned and mixed, add raw material weight 2-7 warm water doubly, soak 20-60min, be fried open with high heat, use slow fire instead, keep slight boiling condition to decoct 20-40 minute, filter and remove residue, obtains filtrate for later use;
(4) step (2) gained smalls is added in step (3) gained filtrate, mix homogeneously, is aided with pharmaceutically acceptable carrier package and obtains.
5. preparation method according to claim 4, is characterized in that: step (1) is dried 4-7 minute (preferably drying 6 minutes) with low baking temperature.
6. preparation method according to claim 4, is characterized in that: step (2) smalls is crossed 70-90 mesh sieve (preferred mistake 80 mesh sieves).
7. preparation method according to claim 4, is characterized in that, step (3) is added raw material weight 3-6 warm water (preferably 5 times) doubly.
8. preparation method according to claim 4, is characterized in that, step (3) crude drug is that the time that 30-50min(preferably soaks is 40 min with the time of warm water soaking).
9. preparation method according to claim 4, is characterized in that, the time that step (3) keeps slight boiling condition to decoct is 25-35 minute (preferably 30 minutes).
10. the application when the medicine of herpes, eczema, urticaria disease due to preparation treatment hand-foot-mouth disease according to the medicinal herb spray described in claim 1-3 any one.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873598A (en) * | 2015-06-18 | 2015-09-02 | 万海峡 | Chinese medicinal composition for treating infantile hand-foot-mouth disease |
| CN105617211A (en) * | 2015-12-30 | 2016-06-01 | 李雷 | Traditional Chinese medicine for treating hand-foot-and-mouth diseases |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102784335A (en) * | 2012-08-23 | 2012-11-21 | 徐慧 | Traditional Chinese medicine compound lotion for treating urticaria papulosa and preparation method thereof |
-
2014
- 2014-04-12 CN CN201410144804.9A patent/CN103919938A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102784335A (en) * | 2012-08-23 | 2012-11-21 | 徐慧 | Traditional Chinese medicine compound lotion for treating urticaria papulosa and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 周德生等主编: "《中医验方全书（珍藏本）》", 31 January 2011, 湖南科学技术出版社 * |
| 薛梅红: "朱良春临床应用汉防己经验举隅", 《现代中西医结合杂志》 * |
| 魏彦等: "大蓟、小蓟的鉴别与临床应用", 《北京中医杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873598A (en) * | 2015-06-18 | 2015-09-02 | 万海峡 | Chinese medicinal composition for treating infantile hand-foot-mouth disease |
| CN105617211A (en) * | 2015-12-30 | 2016-06-01 | 李雷 | Traditional Chinese medicine for treating hand-foot-and-mouth diseases |
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Application publication date: 20140716 |