CN103906500B - 无酒精漱口水 - Google Patents
无酒精漱口水 Download PDFInfo
- Publication number
- CN103906500B CN103906500B CN201180074787.0A CN201180074787A CN103906500B CN 103906500 B CN103906500 B CN 103906500B CN 201180074787 A CN201180074787 A CN 201180074787A CN 103906500 B CN103906500 B CN 103906500B
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- oral care
- care composition
- liquid oral
- flavoring ingredient
- oil
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- 239000002324 mouth wash Substances 0.000 title abstract description 11
- 229940051866 mouthwash Drugs 0.000 title abstract description 9
- 239000000203 mixture Substances 0.000 claims abstract description 115
- 239000003921 oil Substances 0.000 claims abstract description 40
- 239000007788 liquid Substances 0.000 claims abstract description 37
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 10
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims abstract description 9
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims abstract description 9
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 7
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 43
- 229940041616 menthol Drugs 0.000 claims description 43
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 39
- 239000004615 ingredient Substances 0.000 claims description 36
- 235000019198 oils Nutrition 0.000 claims description 31
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 30
- 235000019477 peppermint oil Nutrition 0.000 claims description 30
- 235000013599 spices Nutrition 0.000 claims description 26
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 20
- 239000001683 mentha spicata herb oil Substances 0.000 claims description 19
- 235000019721 spearmint oil Nutrition 0.000 claims description 17
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 16
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 10
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical group CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 10
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 9
- 239000004530 micro-emulsion Substances 0.000 claims description 8
- 235000013024 sodium fluoride Nutrition 0.000 claims description 8
- 239000011775 sodium fluoride Substances 0.000 claims description 8
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 7
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 7
- 229920001983 poloxamer Polymers 0.000 claims description 7
- 229940085605 saccharin sodium Drugs 0.000 claims description 7
- NEUSVAOJNUQRTM-UHFFFAOYSA-N cetylpyridinium Chemical compound CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 NEUSVAOJNUQRTM-UHFFFAOYSA-N 0.000 claims description 6
- 229960000502 poloxamer Drugs 0.000 claims description 6
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 5
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims description 5
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims description 5
- 239000005770 Eugenol Substances 0.000 claims description 5
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims description 5
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- 235000013985 cinnamic acid Nutrition 0.000 claims description 5
- 229960002217 eugenol Drugs 0.000 claims description 5
- -1 gaultherolin Chemical compound 0.000 claims description 5
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims description 5
- 239000000080 wetting agent Substances 0.000 claims description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- 229940011037 anethole Drugs 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 claims description 4
- 238000005352 clarification Methods 0.000 claims description 4
- 239000000975 dye Substances 0.000 claims description 4
- 235000011194 food seasoning agent Nutrition 0.000 claims description 4
- 239000000693 micelle Substances 0.000 claims description 4
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 claims description 4
- 229920001993 poloxamer 188 Polymers 0.000 claims description 4
- 229940044519 poloxamer 188 Drugs 0.000 claims description 4
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 3
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- 238000004040 coloring Methods 0.000 claims description 3
- 235000003599 food sweetener Nutrition 0.000 claims description 3
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- 235000019640 taste Nutrition 0.000 claims description 3
- ULDHMXUKGWMISQ-VIFPVBQESA-N (S)-(+)-Carvone Natural products CC(=C)[C@H]1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-VIFPVBQESA-N 0.000 claims description 2
- 229940081974 saccharin Drugs 0.000 claims description 2
- 235000019204 saccharin Nutrition 0.000 claims description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 2
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000000668 oral spray Substances 0.000 abstract description 3
- 229940041678 oral spray Drugs 0.000 abstract description 3
- 238000005507 spraying Methods 0.000 abstract description 3
- 239000000606 toothpaste Substances 0.000 abstract description 3
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- 238000002360 preparation method Methods 0.000 abstract 1
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 10
- 239000003755 preservative agent Substances 0.000 description 6
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 6
- 239000005844 Thymol Substances 0.000 description 5
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- 229960000790 thymol Drugs 0.000 description 5
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 4
- VUNOFAIHSALQQH-UHFFFAOYSA-N Ethyl menthane carboxamide Chemical compound CCNC(=O)C1CC(C)CCC1C(C)C VUNOFAIHSALQQH-UHFFFAOYSA-N 0.000 description 4
- 235000019658 bitter taste Nutrition 0.000 description 4
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 4
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
- 206010006326 Breath odour Diseases 0.000 description 3
- CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical compound CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 description 3
- 208000032139 Halitosis Diseases 0.000 description 3
- 208000007565 gingivitis Diseases 0.000 description 3
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 3
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 3
- 229960003415 propylparaben Drugs 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 244000246386 Mentha pulegium Species 0.000 description 2
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- 235000004357 Mentha x piperita Nutrition 0.000 description 2
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- 239000002304 perfume Substances 0.000 description 2
- 229920001992 poloxamer 407 Polymers 0.000 description 2
- 239000003507 refrigerant Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000007762 w/o emulsion Substances 0.000 description 2
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- GHEZNRQAMLNCNT-UHFFFAOYSA-N C(=O)OCCC.OC1=CC=CC=C1 Chemical compound C(=O)OCCC.OC1=CC=CC=C1 GHEZNRQAMLNCNT-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 239000004278 EU approved seasoning Substances 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 240000006927 Foeniculum vulgare Species 0.000 description 1
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000014743 Mentha arvensis var villosa Nutrition 0.000 description 1
- 244000220832 Mentha arvensis var. villosa Species 0.000 description 1
- 244000024873 Mentha crispa Species 0.000 description 1
- 235000014749 Mentha crispa Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 description 1
- 229940117916 cinnamic aldehyde Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 210000004261 periodontium Anatomy 0.000 description 1
- XCRBXWCUXJNEFX-UHFFFAOYSA-N peroxybenzoic acid Chemical class OOC(=O)C1=CC=CC=C1 XCRBXWCUXJNEFX-UHFFFAOYSA-N 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Classifications
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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Landscapes
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- Cosmetics (AREA)
- Medicinal Preparation (AREA)
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Abstract
本发明提供无不可接受的苦味的包含氯化十六烷基吡啶的无酒精液体口腔护理组合物,例如基本无酒清的漱口水、牙膏、咽喉喷雾剂和口腔喷雾剂,例如,其包含(i)抗微生物有效量的氯化十六烷基吡啶
Description
发明领域
本发明涉及包含氯化十六烷基吡啶的新型液体无酒精口腔护理组合物。
发明背景
传统的漱口水组合物常包含高达27%体积的酒精,作为防腐剂和抗微生物剂。在一些个体中,酒精可加重口干燥症(口干),其反过来可导致口臭和严重蛀牙,因为降低唾液的再矿化釉质的保护作用。口干燥症还使口腔的粘膜和牙周组织更易受到感染并增加牙龈炎的风险。包含高水平酒精的漱口水还可对酗酒者、儿童和某些宗教信仰的成员的使用是非所需的,并且一些消费者可能反对相对高酒精的组合物的烧灼感。
氯化十六烷基吡啶 (CPC)为阳离子季铵化合物,常用于与酒精一同或代替酒精作为漱口水、牙膏、锭剂、咽喉喷雾剂、口腔喷雾剂和鼻喷雾剂中的抗菌剂和防腐剂。在有效浓度,例如约0.07%,CPC杀死细菌及其他微生物,并已显示出有效防止牙菌斑并减少牙龈炎。据认为其通过结合细菌细胞膜带负电的磷酸酯来杀死细菌。但因其苦味且其与很多组合物赋形剂的不兼容性所致,配制CPC有挑战。酒精在此类组合物中可以为有帮助的,因为其作为许多成分的增溶剂起作用并其是增味剂,但如上所述,含酒清的口腔护理产品存在缺点。
有对具有可接受味道的无酒精液体口腔护理组合物的需要。
发明简述
本发明提供无不可接受的苦味的包含CPC的无酒精液体口腔护理组合物。这是通过将相对不溶的调味油与CPC以特定比例掺混来实现的。例如,本发明提供基本上无酒清的液体口腔护理组合物,其包含(i)抗微生物有效量的氯化十六烷基吡啶 (CPC)和(ii)在室温下基本不溶于水的一种或多种调味油,其中CPC与所述一种或多种调味油的比例为1:1.5-1:2.5。在不意图受理论束缚的情况下,认为在最佳浓度,在室温下在存在水时CPC和一种或多种调味油自发地或在温和混合下可形成稳定的胶束或油包水微乳剂,这有助于掩盖CPC的苦味,而不会影响其作为抗菌剂的功效,并且同时,CPC的表面活性剂性质允许本身可具有抗菌性的难溶油的升高的水平。
本发明的适用性的其它范围将根据下文提供的详细描述而变得显而易见。应当理解的是,详细描述和特定实施例虽然指示本发明优选的实施方案,但仅旨在用于说明的目的而并不意图限制本发明的范围。
发明详述
在一个实施方案中,本发明提供基本无酒清、例如少于5%酒精液体口腔护理组合物(组合物1),其包含(i)抗微生物有效量的氯化十六烷基吡啶 (CPC),和(ii)在室温下基本不溶于水(例如少于1%溶于水)的一种或多种调味油,其中CPC与所述一种或多种调味油的比例为1:1.5-1:2.5。例如,本发明提供:
1.1. 组合物1的液体口腔护理组合物,其中CPC与所述一种或多种调味油的比例为1:1.6-1:1.9。
1.2. 组合物1或1.1的液体口腔护理组合物,其中在室温下CPC与所述一种或多种调味油在含水介质中形成胶束或油包水微乳剂。
1.3. 前述组合物中任一种的液体口腔护理组合物,其中所述一种或多种调味油包含薄荷醇。
1.4. 前述组合物中任一种的液体口腔护理组合物,其中所述一种或多种调味油包含薄荷醇、留兰香油、薄荷油或任何这些物质的组合。
1.5. 前述组合物中任一种的液体口腔护理组合物,其中所述一种或多种调味油选自薄荷醇、留兰香油、薄荷油、香芹酮、水杨酸甲酯、茴香脑、百里酚、丁子香酚、清凉剂、肉桂醛及其混合物中的一种或多种。
1.6. 前述组合物中任一种的液体口腔护理组合物,其中所述一种或多种调味油包含与CPC的比例如下的薄荷醇、留兰香油和薄荷油的组合:
1份CPC:
0.3-0.9份薄荷醇:
0.4-1.2份留兰香油:
0.1-0.5份薄荷油。
1.7. 前述组合物中任一种的液体口腔护理组合物,其基本无酒清且其包含
抗微生物有效量的氯化十六烷基吡啶 (例如0.05-0.1%/重量,例如,0.07-0.08%,约0.075%重量),和
有效量的调味组分(例如占总组合物重量的0.05-0.3%,例如,0.1-0.2%,例如约0.12%),所述调味组分包含:
薄荷醇,例如占调味组分重量的至少15%,例如15-25%,例如约20%的量;
薄荷油(例如天然薄荷油、合成薄荷油、亚洲薄荷油或其混合物),例如占调味组分重量的至少10%,例如10-20%,例如约15%的量;
留兰香油,例如占调味组分重量的30-55%,例如40-50%,约45%的量;
1.8. 前述组合物中任一种的液体口腔护理组合物(例如漱口水、牙膏、咽喉喷雾剂和口腔喷雾剂),其基本无酒清且包含以下比例的抗微生物有效量的CPC和香料:
1份CPC:
0.3-0.9,例如0.5-0.7份薄荷醇:
0.4-1.2,例如0.5-0.8份留兰香油:
0.1-0.5,例如0.2-0.4份薄荷油;
并任选包含另外的成分,例如另外包含一种或多种其它的香料,例如包含茴香脑(例如反式茴香脑)、百里酚、水杨酸甲酯、清凉剂(例如N-乙基-p-薄荷烷-3-甲酰胺(N-ethyl-p-menthane-3-carboxamide),Optacool®)、肉桂醛及其混合物中的一种或多种;
其它的防腐剂,例如对羟基苯甲酸酯类防腐剂,例如对羟基苯甲酸甲酯、对羟基苯甲酸丙酯及其混合物;
无热量甜味剂,例如包含糖精、糖醇(例如,山梨糖醇)或其混合物;
湿润剂,例如包含丙二醇、甘油或其混合物;
非离子表面活性剂,例如泊洛沙姆,例如泊洛沙姆470;
氟离子源,例如氟化钠;和水。
1.9. 呈漱口水形式的前述组合物中任一种的液体口腔护理组合物;
1.10. 前述组合物中任一种的液体口腔护理组合物,其包含CPC和含香料的调味组分,CPC和香料的比例按重量计为约1份CPC:约0.3份薄荷醇:约0.7份留兰香油:约0.24份薄荷油;其中所述组合物除包含调味组分外还可任选包含清凉剂和/或甜味剂。
1.11. 前述组合物中任一种的液体口腔护理组合物,其中调味组分包含按调味组分重量计约20%薄荷醇、约45%留兰香油和约15%薄荷油;
1.12. 前述组合物中任一种的液体口腔护理组合物,其包含L-薄荷醇;
1.13. 前述组合物中任一种的液体口腔护理组合物,其除包含调味组分中的薄荷醇外还包含薄荷醇,例如除包含调味组分中的薄荷醇外还包含占总组合物重量的0.01-0.04、例如约0.02%的薄荷醇。
1.14. 前述组合物中任一种的组合物,其包含0.05-0.07%总薄荷醇,例如包含添加的薄荷醇和来自薄荷油和留兰香油的薄荷醇。
1.15. 前述实施方案中任一项的组合物,其中调味组分另外包含占调味组分重量的1-10%、例如2-6%、例如约4%的量,或占总组合物重量的0.001-0.01%、例如0.002-0.006%、例如约0.004%的量的茴香脑、例如反式茴香脑。
1.16. 前述实施方案中任一项的组合物,其是水溶液、油包水乳剂、油包水微乳剂或胶束体系;
1.17. 前述实施方案中任一项的组合物,其是油包水微乳剂;
1.18. 前述实施方案中任一项的组合物,其是胶束体系;
1.19. 前述实施方案中任一项的组合物,其另外包含其它的香料,例如,包含茴香脑(例如,反式茴香脑)、百里酚、清凉剂(例如包含薄荷醇、N-乙基-p-薄荷烷-3-甲酰胺及其组合)、肉桂醛及其混合物中的一种或多种,例如市售的清凉剂混合物,例如Optacool®(Symrise);
1.20. 前述实施方案中任一项的组合物,其另外包含附加的防腐剂,例如对羟基苯甲酸酯类防腐剂,例如对羟基苯甲酸甲酯、对羟基苯甲酸丙酯及其混合物;
1.21. 前述实施方案中任一项的组合物,其另外包含无热量甜味剂,例如,包含糖精、糖醇(例如,山梨糖醇)或其混合物;
1.22. 前述实施方案中任一项的组合物,其另外包含湿润剂,例如,包含丙二醇、甘油或其混合物;
1.23. 前述实施方案中任一项的组合物,其包含水、着色剂、糖精钠、氟化钠、CPC、泊洛沙姆、例如,Pluronic F-127、山梨糖醇、甘油、丙二醇、对羟基苯甲酸酯类和薄荷醇,其中所述组合物是基本澄清的。
1.24. 前述实施方案中任一项的组合物,其另外包含非离子表面活性剂,例如,泊洛沙姆,例如,泊洛沙姆470;
1.25. 前述实施方案中任一项的组合物,其另外包含氟离子源,例如氟化钠;
1.26. 前述实施方案中任一项的组合物,其为水溶液、油包水乳剂或油包水微乳剂;
1.27. 前述实施方案中任一项的组合物,其以重量计包含下列组分:
i) 山梨糖醇 4-7%,
ii) 润湿剂例如甘油、丙二醇及其组合 12-18%
iii) 氟化钠 0.04-0.06%
iv) 氯化十六烷基吡啶0.05-0.1%
v) 糖精钠 0.01-0.03%
vi) 泊洛沙姆407 0.3-0.5%
vii) 调味组分0.05-0.5%,例如0.1-0.3%
viii) 薄荷醇/清凉剂(除调味组分之外) 0.02-0.06%
ix) 染料 0.0-0.01%
x) 对羟基苯甲酸酯类 0.02-0.06%
xi) 水 75-85%
其中所述调味组分包含85-100%不溶性调味油。
1.28. 前述实施方案中任一项的组合物,其以重量计包含下列组分:
山梨糖醇3-5%,例如,约4%
甘油6-9%,例如,约7.5%
丙二醇6-8%,例如,约7%
氟化钠0.04-0.06%,例如,约0.05%
氯化十六烷基吡啶0.05-0.1%,例如,约0.075%
糖精钠0.01-0.03%,例如,约0.2%
泊洛沙姆407 0.3-0.5%,例如,约0.4%
调味组分0.05-0.5,例如,0.1-0.3%,例如,约0.12%
薄荷醇/清凉剂(除调味组分之外)0.02-0.06%,例如,约0.045%
染料0.0-0.01,例如,约0.001%
对羟基苯甲酸酯类,例如,(约3:1对羟基苯甲酸甲酯:对羟基苯甲酸丙酯) 0.02-0.06%,例如,约0.04%
水75-85%,例如,余量
其中所述调味组分包含:
L-薄荷醇15-25%,例如约20%
N-乙基-p-薄荷烷-3-甲酰胺1-3%,例如,约2%
反式茴香脑2-6%,例如,约4%
丁子香酚0.1-0.3%,例如,约0.2%
薄荷油(例如,2:1亚洲薄荷油:合成薄荷油) 10-20%,例如,约15%
百里酚0.2-0.6%,例如,约0.4%
水杨酸甲酯10-15%,例如,约13%
肉桂醛0.1-0.3%,例如,约0.2%
留兰香油35-55%,例如,约45%
本发明另外提供预防和/或治疗选自口干、口臭、牙龈炎、蛀牙和龋齿中的一种或多种的疾病或病症的方法,所述方法包括将有效量的如之前所述的组合物(例如组合物1、1.1及以下各组合物中任一种)给予有需要的受试者。
本发明另外提供呈1:1.5-1:2.5比例的氯化十六烷基吡啶 (CPC)和在室温下基本不溶于水的一种或多种调味油在制备液体口腔护理组合物(例如组合物1、1.1及以下各组合物中任一种)中的用途,所述液体口腔护理组合物用于预防和/或治疗选自口干、口臭、牙龈炎、蛀牙和龋齿中的一种或多种的疾病或病症。
本发明另外提供制备组合物、例如组合物1、1.1及以下各组合物中的任一种的方法,所述方法包括添加调味油至含氯化十六烷基吡啶的水溶液并混合直至混合物澄清;例如,以下方法,其包括添加着色剂至水中并混合,接着加入糖精钠、氟化钠和CPC并混合,然后加入泊洛沙姆例如Pluronic F-127并混合,接着加入山梨糖醇和甘油并混合,并接着加入丙二醇、对羟基苯甲酸酯类和薄荷醇的混合物和其他香料,并混合直至组合物澄清。
如全文所用,范围用作用于描述在该范围内各个和所有值的简写。在该范围内的任何值可选作该范围的终点。另外,本文引用的所有参考文献在此通过引用以其全部内容并入。在本公开内容中的定义和引用的参考文献的定义冲突的情况下,以本公开内容为准。
除非另外说明,否则本说明书此处和别处表述的所有百分数和量应理解为指按重量计的百分数。给定的量基于材料的有效重量。
实施例1-对比组合物
组合物用如下的不同调味油来制备:
表1-漱口剂组合物
成分 | 配方A (%) | 配方B (%) |
山梨糖醇(70%溶液) | 5.5 | 5.5 |
甘油 | 7.5 | 7.5` |
丙二醇 | 7.0 | 7.0 |
氟化钠 | 0.05 | 0.05 |
氯化十六烷基吡啶 | 0.075 | 0.075 |
糖精钠 | 0.022 | 0.022 |
泊洛沙姆407 | 0.4 | 0.4 |
香料A | 0.12 | -- |
香料B | -- | 0.12 |
薄荷醇 | 0.02 | 0.02 |
清凉剂混合物(Optacool®) | 0.025 | 0.025 |
染料 | 0.001 | 0.001 |
对羟基苯甲酸甲酯 | 0.03 | 0.03 |
对羟基苯甲酸丙酯 | 0.01 | 0.01 |
水 | 余量 | 余量 |
表2-调味组分
成分 | 香料A (%) | 香料B (%) |
L-薄荷醇 | 20 | 15 |
北美薄荷油 | -- | 9 |
北美留兰香油 | 45 | 56 |
合成薄荷油 | 5 | -- |
亚洲薄荷油 | 10 | -- |
N-乙基-p-薄荷烷-3-甲酰胺 | 2 | 2 |
反式茴香脑 | 4 | 4 |
丁子香酚 | 0.2 | 0.2 |
百里酚 | 0.4 | 0.4 |
肉桂醛 | 0.2 | 0.2 |
水杨酸甲酯 | 13.2 | 13.2 |
实施例2-消费者测试
用消费者测试之前实施例所述的组合物以测量香料喜好和购买意向。
表3-消费者测试结果
配方A | 配方B | |
购买意向(肯定会买-Top Box) | 85% | 76% |
有我喜欢的味道 | 87% | 80% |
给人持久的新鲜感 | 85% | 74% |
香料强度-很喜欢 | 87% | 74% |
通常,更可接受的组合物配方A具有相对于留兰香油而言更高水平的薄荷醇和薄荷油。留兰香油和薄荷油尤其不同之处在于,薄荷油有更高量的薄荷醇。这种差异结合更高水平的添加薄荷醇,意味着配方A比配方B有明显更多的薄荷醇
不被理论束缚,假定配方A中相对较高水平的难溶薄荷醇允许掺有CPC的自发微乳剂或胶束体系的形成,从而减少来自CPC的苦味的感知。同时,CPC允许组合物含有较高水平的难溶性油,如薄荷醇,其本身具有抗菌性,因而提高组合物的功效。
实施例3-香料精细化
在以上漱口水组合物中测试了另外的香料,证实含有更高水平的不溶性或难溶性油的CPC组合物是消费者优选的。含下面的调味组分的漱口水是经消费者测试的(成分按香料的重量百分数给出):
表3-调味组分
成分 | 香料C | 香料D | 香料E | 香料F |
L-薄荷醇 | 20 | 43 | 18 | 14 |
N-乙基-p-薄荷烷-3-甲酰胺 | 7 | 1 | 2 | 1.6 |
2-异丙基-N,2,3-三甲基丁酰胺 | 7 | |||
反式茴香脑 | 5 | 6 | 2 | 1.6 |
丁子香酚 | 1 | 1 | ||
Optacool Special C香料 | 10 | 7 | ||
Optamint香料 | 20 | 12 | ||
BrightStar 7.0 | 20 | |||
亚洲薄荷油 | 10 | 13 | ||
水杨酸甲酯 | 14 | 14.2 | ||
薄荷香料 | 3 | 2.4 | ||
留兰香混合物 | 12 | 9.6 | ||
L-香芹酮 | 33 | 30 | ||
软薄荷组合 | 16 | 13.8 | ||
人工酒精替代物 | 12 | |||
除添加的薄荷醇外的总难溶性油% | 66 | 37 | 80 | 71.6 |
含添加的薄荷醇在内的总难溶性油% | 86 | 80 | 98 | 85.6 |
将含香料C的漱口剂与含香料D的漱口剂对比,且将含香料E的漱口剂与含香料F的漱口剂对比。消费者显示出相对于D对C明显的偏爱以及相对于F对E明显的偏爱,这证实具有较高水平的不溶性或难溶性油的产品是优选的,并且在香料中对于薄荷醇有优选的范围,例如大于15%但少于43%,优选约18-20%,除薄荷油和基料配方中存在的薄荷醇之外。在所用的基料配方(其包含0.12%香料和0.02%添加的薄荷醇)中,这相当于配方中总计0.042-0.044%薄荷醇,加上薄荷油中存在的薄荷醇。因而配方中CPC(0.075%)与不溶性油(0.12-0.14%)的整体比例为1:1.6-1:1.9。
Claims (17)
1.一种具有少于5%重量酒精的液体口腔护理组合物,其包含(i)抗微生物有效量的氯化十六烷基吡啶(CPC),和(ii)在室温下基本不溶于水的一种或多种调味油,其中所述一种或多种调味油包含调味组分,其含有薄荷醇、薄荷油和留兰香油,并且其中所述调味组分包含占调味组分重量的18-20%的量的薄荷醇、占调味组分重量的10-20%的量的薄荷油和占调味组分重量的30-55%的量的留兰香油,其中CPC与所述一种或多种调味油的比例为1:1.5-1:2.5。
2.权利要求1的液体口腔护理组合物,其中CPC和所述一种或多种调味油在室温下在含水介质中形成胶束或油包水微乳剂。
3.前述权利要求中任一项的液体口腔护理组合物,其中所述组合物除包含调味组分外还包含清凉剂和/或甜味剂。
4.权利要求1的液体口腔护理组合物,其中所述一种或多种调味油包含与CPC的重量比例如下的薄荷醇、留兰香油和薄荷油的组合:
1份CPC:
0.3-0.9份薄荷醇:
0.4-1.2份留兰香油:
0.1-0.5份薄荷油。
5.权利要求1的液体口腔护理组合物,其中所述调味组分含有:
i)占调味组分重量的18-20%的量的薄荷醇;
ii)占调味组分重量的10-20%的量的薄荷油;
iii)占调味组分重量的40-50%的量的留兰香油。
6.权利要求5的液体口腔护理组合物,其中所述薄荷油为天然薄荷油、合成薄荷油、亚洲薄荷油或其混合物。
7.权利要求5的液体口腔护理组合物,其中所述调味组分含有占调味组分重量的约15%的量的薄荷油。
8.权利要求5的液体口腔护理组合物,其中所述调味组分含有占调味组分重量的约45%的量的留兰香油。
9.呈漱口剂的形式的权利要求1的液体口腔护理组合物。
10.权利要求1的液体口腔护理组合物,其包含0.05-0.07%重量的总薄荷醇。
11.权利要求1的液体口腔护理组合物,其为油包水微乳剂或胶束体系。
12.权利要求1的液体口腔护理组合物,其另外包含香芹酮、水杨酸甲酯、茴香脑、百里酚、丁子香酚、清凉剂、肉桂醛及其混合物中的一种或多种。
13.权利要求1的液体口腔护理组合物,其另外包含一种或多种对羟基苯甲酸酯类。
14.权利要求1的液体口腔护理组合物,其另外包含:选自糖精、糖醇及其混合物的无热量甜味剂;湿润剂,所述湿润剂选自丙二醇、甘油或其混合物;一种或多种泊洛沙姆;和有效浓度的氟离子源。
15.权利要求1的液体口腔护理组合物,其按重量计包含以下成分:
i) 山梨糖醇 4-7%,
ii) 甘油、丙二醇及其组合 12-18%
iii) 氟化钠 0.04-0.06%
iv) 氯化十六烷基吡啶 0.05-0.1%
v) 糖精钠 0.01-0.03%
vi) 泊洛沙姆407 0.3-0.5%
vii) 调味组分 0.1-0.3%
viii) 除调味组分之外的薄荷醇/清凉剂 0.02-0.06%
ix) 染料 0.0-0.01%
x) 对羟基苯甲酸酯类 0.02-0.06%
xi) 水 75-85%
其中所述调味组分(vii)包含85-100%不溶性调味油。
16.制备权利要求1-15中任一项的液体口腔护理组合物的方法,所述方法包括添加调味油至包含氯化十六烷基吡啶的水溶液中并混合直至组合物澄清。
17.权利要求16的方法,所述方法包括添加着色剂至水中并混合,然后加入糖精钠、氟化钠和CPC并混合,然后加入泊洛沙姆并混合,然后加入山梨糖醇和甘油并混合,并接着加入丙二醇、对羟基苯甲酸酯类和薄荷醇的混合物和其它的香料,并混合直至组合物澄清。
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WO2016006647A1 (ja) * | 2014-07-11 | 2016-01-14 | ライオン株式会社 | 口腔用組成物 |
CN107007539A (zh) * | 2017-04-17 | 2017-08-04 | 江苏恩为众心生物医药有限公司 | 益生菌含漱液生产工艺 |
WO2019121660A1 (en) | 2017-12-20 | 2019-06-27 | Firmenich Sa | Oral care compositions |
EP4216918A1 (en) * | 2020-09-24 | 2023-08-02 | Medline Industries, LP | Oral rinse composition, oral cleansing kit, method of cleansing oral cavity and method of making oral rinse composition |
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