CN103890580B - 用于处理单分子的设备 - Google Patents

用于处理单分子的设备 Download PDF

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Publication number
CN103890580B
CN103890580B CN201280047984.8A CN201280047984A CN103890580B CN 103890580 B CN103890580 B CN 103890580B CN 201280047984 A CN201280047984 A CN 201280047984A CN 103890580 B CN103890580 B CN 103890580B
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layer
elongated slit
top layer
slit
nucleic acid
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Chinese (zh)
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CN103890580A (zh
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P·J·范德扎格
R·库霍恩
F·C·M·J·M·范德尔夫特
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Koninklijke Philips NV
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Koninklijke Philips Electronics NV
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Nanotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201280047984.8A 2011-09-28 2012-09-25 用于处理单分子的设备 Active CN103890580B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161540014P 2011-09-28 2011-09-28
US61/540,014 2011-09-28
EP11191966A EP2574923A1 (en) 2011-09-28 2011-12-05 Apparatus for the processing of single molecules
EP11191966.8 2011-12-05
PCT/IB2012/055091 WO2013046116A1 (en) 2011-09-28 2012-09-25 Apparatus for the processing of single molecules

Publications (2)

Publication Number Publication Date
CN103890580A CN103890580A (zh) 2014-06-25
CN103890580B true CN103890580B (zh) 2017-06-27

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CN201280047984.8A Active CN103890580B (zh) 2011-09-28 2012-09-25 用于处理单分子的设备

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Country Link
US (1) US10281453B2 (https=)
EP (2) EP2574923A1 (https=)
JP (1) JP6302836B2 (https=)
CN (1) CN103890580B (https=)
WO (1) WO2013046116A1 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9475709B2 (en) 2010-08-25 2016-10-25 Lockheed Martin Corporation Perforated graphene deionization or desalination
EP2574923A1 (en) 2011-09-28 2013-04-03 Koninklijke Philips Electronics N.V. Apparatus for the processing of single molecules
US10653824B2 (en) 2012-05-25 2020-05-19 Lockheed Martin Corporation Two-dimensional materials and uses thereof
US10376845B2 (en) 2016-04-14 2019-08-13 Lockheed Martin Corporation Membranes with tunable selectivity
US9744617B2 (en) 2014-01-31 2017-08-29 Lockheed Martin Corporation Methods for perforating multi-layer graphene through ion bombardment
US9834809B2 (en) 2014-02-28 2017-12-05 Lockheed Martin Corporation Syringe for obtaining nano-sized materials for selective assays and related methods of use
US9844757B2 (en) 2014-03-12 2017-12-19 Lockheed Martin Corporation Separation membranes formed from perforated graphene and methods for use thereof
KR20140028602A (ko) * 2012-08-29 2014-03-10 삼성전자주식회사 그래핀을 포함하는 나노 센서 및 이의 제조 방법
TW201504140A (zh) 2013-03-12 2015-02-01 Lockheed Corp 形成具有均勻孔尺寸之多孔石墨烯之方法
SG11201510807VA (en) 2013-05-01 2016-02-26 Koninkl Philips Nv Method of manufacturing a partially freestanding graphene crystal film and device comprising such a film
US9572918B2 (en) 2013-06-21 2017-02-21 Lockheed Martin Corporation Graphene-based filter for isolating a substance from blood
CN105940479A (zh) 2014-01-31 2016-09-14 洛克希德马丁公司 使用宽离子场穿孔二维材料
CN106029596A (zh) 2014-01-31 2016-10-12 洛克希德马丁公司 采用多孔非牺牲性支撑层的二维材料形成复合结构的方法
US9869658B2 (en) 2014-07-22 2018-01-16 International Business Machines Corporation Electronic label free detection of DNA complexes using nanogap
JP2017534311A (ja) 2014-09-02 2017-11-24 ロッキード・マーチン・コーポレーション 二次元膜材料をベースとする血液透析膜および血液濾過膜、ならびにそれを用いた方法
JP2018528144A (ja) 2015-08-05 2018-09-27 ロッキード・マーチン・コーポレーション グラフェン系材料の穿孔可能なシート
WO2017023377A1 (en) 2015-08-06 2017-02-09 Lockheed Martin Corporation Nanoparticle modification and perforation of graphene
EP3394612A1 (en) 2015-12-22 2018-10-31 Koninklijke Philips N.V. Method of creating a nano-sized recess
US20170191912A1 (en) 2016-01-06 2017-07-06 International Business Machines Corporation Semiconductor manufactured nano-structures for microbe or virus trapping or destruction
WO2017180134A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
EP3442697A4 (en) 2016-04-14 2020-03-18 Lockheed Martin Corporation SELECTIVE INTERFACE REDUCTION OF GRAPH DEFECTS
EP3442739A4 (en) * 2016-04-14 2020-03-04 Lockheed Martin Corporation PROCESS FOR PROCESSING GRAPHENE SHEETS FOR LARGE SCALE TRANSFER USING A FREE FLOATING PROCESS
KR20180133430A (ko) 2016-04-14 2018-12-14 록히드 마틴 코포레이션 결함 형성 또는 힐링의 인 시츄 모니터링 및 제어를 위한 방법
EP3442786A4 (en) 2016-04-14 2020-03-18 Lockheed Martin Corporation TWO-DIMENSIONAL MEMBRANE STRUCTURES HAVING FLOW PASSAGES
CN107058082A (zh) * 2017-04-22 2017-08-18 天津智巧数据科技有限公司 一种基于近场光学技术的单分子dna无损检测芯片

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101171345A (zh) * 2005-04-12 2008-04-30 454生命科学公司 用ultra-deep测序法测定序列变体的方法
US7468271B2 (en) * 2005-04-06 2008-12-23 President And Fellows Of Harvard College Molecular characterization with carbon nanotube control
US7582490B2 (en) * 1999-06-22 2009-09-01 President And Fellows Of Harvard College Controlled fabrication of gaps in electrically conducting structures
WO2011046706A1 (en) * 2009-09-18 2011-04-21 President And Fellows Of Harvard College Bare single-layer graphene membrane having a nanopore enabling high-sensitivity molecular detection and analysis
WO2011047582A1 (zh) * 2009-10-22 2011-04-28 浙江大学 一种纳米孔电学传感器
CN102076871A (zh) * 2008-11-07 2011-05-25 财团法人工业技术研究院 精确序列信息及修饰碱基位置确定的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08315760A (ja) 1995-05-23 1996-11-29 Hitachi Ltd ビーム成形絞りとその作成方法およびこれを用いた荷電粒子ビーム露光装置
JP3051099B2 (ja) 1997-05-14 2000-06-12 株式会社東芝 マーク基板，マーク基板の製造方法，電子ビーム描画装置及び電子ビーム描画装置の光学系の調整方法
WO2000009757A1 (en) 1998-08-13 2000-02-24 U.S. Genomics, Inc. Optically characterizing polymers
AU2001259128A1 (en) 2000-04-24 2001-11-07 Eagle Research And Development, Llc An ultra-fast nucleic acid sequencing device and a method for making and using the same
US6503409B1 (en) * 2000-05-25 2003-01-07 Sandia Corporation Lithographic fabrication of nanoapertures
WO2004085609A2 (en) * 2003-02-28 2004-10-07 Brown University Nanopores, methods for using same, methods for making same and methods for characterizing biomolecules using same
WO2009035647A1 (en) 2007-09-12 2009-03-19 President And Fellows Of Harvard College High-resolution molecular graphene sensor comprising an aperture in the graphene layer
AU2008307486B2 (en) 2007-10-02 2014-08-14 President And Fellows Of Harvard College Carbon nanotube synthesis for nanopore devices
WO2010042514A1 (en) * 2008-10-06 2010-04-15 Arizona Board Of Regents Nanopore and carbon nanotube based dna sequencer and a serial recognition elements
KR101127579B1 (ko) 2009-08-28 2012-03-23 삼성모바일디스플레이주식회사 헤테로아릴아민 화합물 및 이를 이용한 유기 발광 소자
EP2574923A1 (en) 2011-09-28 2013-04-03 Koninklijke Philips Electronics N.V. Apparatus for the processing of single molecules

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7582490B2 (en) * 1999-06-22 2009-09-01 President And Fellows Of Harvard College Controlled fabrication of gaps in electrically conducting structures
US7468271B2 (en) * 2005-04-06 2008-12-23 President And Fellows Of Harvard College Molecular characterization with carbon nanotube control
CN101171345A (zh) * 2005-04-12 2008-04-30 454生命科学公司 用ultra-deep测序法测定序列变体的方法
CN102076871A (zh) * 2008-11-07 2011-05-25 财团法人工业技术研究院 精确序列信息及修饰碱基位置确定的方法
WO2011046706A1 (en) * 2009-09-18 2011-04-21 President And Fellows Of Harvard College Bare single-layer graphene membrane having a nanopore enabling high-sensitivity molecular detection and analysis
WO2011047582A1 (zh) * 2009-10-22 2011-04-28 浙江大学 一种纳米孔电学传感器

Also Published As

Publication number Publication date
EP2748603A1 (en) 2014-07-02
US10281453B2 (en) 2019-05-07
WO2013046116A1 (en) 2013-04-04
US20140349892A1 (en) 2014-11-27
EP2574923A1 (en) 2013-04-03
JP2014529082A (ja) 2014-10-30
JP6302836B2 (ja) 2018-03-28
EP2748603B1 (en) 2021-01-27
CN103890580A (zh) 2014-06-25

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