CN103889981B - 作为抗癌剂的三环化合物 - Google Patents

作为抗癌剂的三环化合物 Download PDF

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CN103889981B
CN103889981B CN201280050818.3A CN201280050818A CN103889981B CN 103889981 B CN103889981 B CN 103889981B CN 201280050818 A CN201280050818 A CN 201280050818A CN 103889981 B CN103889981 B CN 103889981B
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mmol
dibenzo
dihydro
mixture
nmr
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CN103889981A (zh
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迈克尔·奥尔迈尔
古塔姆·纳尔拉
尼尔·达万
大卫·卡斯特里斯基
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Xi Naishanyikan Medical College
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    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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CN201280050818.3A 2011-08-16 2012-08-16 作为抗癌剂的三环化合物 Expired - Fee Related CN103889981B (zh)

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US201161523897P 2011-08-16 2011-08-16
US61/523,897 2011-08-16
PCT/US2012/051097 WO2013025882A2 (en) 2011-08-16 2012-08-16 Tricyclic compounds as anticancer agents

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AU (2) AU2012296528B2 (enExample)
BR (1) BR112014003567A2 (enExample)
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RU2015139700A (ru) 2013-02-19 2017-03-27 Икан Скул Оф Медсин Эт Маунт Синай Трициклические гетероциклические соединения в качестве противораковых средств
CN103232447B (zh) * 2013-04-02 2015-06-03 陕西科技大学 3-乙酰基-5-乙酰亚氨基-2-(n-吩噻嗪基)-1,3,4-噻二唑及其制备方法和应用
EP3116857B1 (en) * 2014-03-11 2019-02-06 Icahn School of Medicine at Mount Sinai Constrained tricyclic sulfonamides
CN106458936A (zh) * 2014-03-11 2017-02-22 西奈山伊坎医学院 作为抗癌药的三环‑2‑氨基环烷醇衍生的磺酰胺
CA2954764A1 (en) 2014-07-15 2016-01-21 Ontario Institute For Cancer Research Methods and devices for predicting anthracycline treatment efficacy
CN104529898B (zh) * 2015-01-15 2016-07-27 成都丽凯手性技术有限公司 氮杂二苯并环辛炔类化合物及其制备方法
AU2016281646A1 (en) * 2015-06-23 2018-02-01 Case Western Reserve University Compositions and methods for treating cancer
CA2994830A1 (en) * 2015-08-06 2017-02-09 Icahn School Of Medicine At Mount Sinai Stereospecific process for 3-heterocyclylcycloaliphatic-1,2-diols
WO2017044571A1 (en) * 2015-09-09 2017-03-16 Icahn School Of Medicine At Mount Sinai Tricyclic sultam sulfonamides as anticancer and neuroprotective agents
WO2017044572A1 (en) * 2015-09-09 2017-03-16 Icahn School Of Medicine At Mount Sinai Ring constrained diarylamino sulfonamides as anti-cancer agents
JP6966425B2 (ja) * 2015-09-09 2021-11-17 アイカーン スクール オブ メディスン アット マウント サイナイIcahn School of Medicine at Mt. Sinai 抗がん剤としての複素環式の限定された三環系スルホンアミド
WO2017044575A1 (en) * 2015-09-09 2017-03-16 Icahn School Of Medicine At Mount Sinai Constrained benzhydryl sulfonamides as anticancer and neuroprotective agents
US10759790B2 (en) 2015-09-09 2020-09-01 Ichan School Of Medicine At Mount Sinai Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents
CN111171006B (zh) * 2020-01-29 2023-05-12 成都睿智化学研究有限公司 一种3-取代亚氨基二苄氨基类化合物的工艺方法
US12398103B2 (en) * 2020-03-20 2025-08-26 Atux Iskay Llc 3-diarylmethylenes and uses thereof
GB2597446A (en) 2020-07-21 2022-02-02 Demuris Ltd Compounds and their uses
CN115554303B (zh) * 2021-09-18 2024-07-09 上海科技大学 一种三环类化合物、其制备方法及其应用
WO2024182363A1 (en) * 2023-02-27 2024-09-06 Atux Iskay Llc N,n'-sulfonimidamides as anticancer, antiinflammatory, antifibrotic and neuroprotective agents
CN118026942B (zh) * 2024-04-11 2024-06-28 江西师范大学 11-碘-二苯并[b,e][1,4]二氮杂卓化合物及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK88606C (da) 1958-05-09 1960-02-29 Kefalas As Fremgangsmåde til fremstilling af i 9-stillingen substituerede thiaxantener eller deres syreadditionssalte.
GB8510680D0 (en) 1985-04-26 1985-06-05 Smith Kline French Lab Pyridine derivatives
US4882351A (en) 1987-10-14 1989-11-21 Roussel Uclaf Tricyclic compounds
CA2144854A1 (en) 1993-07-26 1995-02-02 Hiroshi Yoshino Tricyclic heterocyclic sulfonamide and sulfonic ester derivatives
GB9703992D0 (en) 1997-02-26 1997-04-16 Rolabo Sl Process
AR036492A1 (es) 2001-09-06 2004-09-15 Schering Corp Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3, composiciones farmaceuticas y el uso de dichos inhibidores para la elaboracion de un medicamento para el tratamiento de enfermedades androgeno dependientes
JP4428053B2 (ja) * 2002-02-05 2010-03-10 味の素株式会社 ガバペンチン若しくはプレガバリンおよびｎ型カルシウムチャンネル拮抗剤を含有する医薬組成物
TW200400816A (en) 2002-06-26 2004-01-16 Lilly Co Eli Tricyclic steroid hormone nuclear receptor modulators
CA2587664A1 (en) * 2004-12-21 2006-06-29 Devgen N.V. Compounds with kv4 ion channel activity
MX2007011453A (es) 2005-04-22 2008-02-12 Alantos Pharmaceuticals Holding Inc Inhibidores de la dipeptidil peptidasa-iv.
GB0508992D0 (en) 2005-05-03 2005-06-08 Novartis Ag Organic compounds
WO2008121859A1 (en) * 2007-03-30 2008-10-09 Xenon Pharmaceuticals Inc. Methods of using tricyclic compounds in treating sodium channel-mediated diseases or conditions

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JP6105585B2 (ja) 2017-03-29
WO2013025882A3 (en) 2013-04-25
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US9540358B2 (en) 2017-01-10
AU2012296528A1 (en) 2014-03-20
AU2012296528B2 (en) 2017-07-06
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