CN103889981B - 作为抗癌剂的三环化合物 - Google Patents

作为抗癌剂的三环化合物 Download PDF

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CN103889981B
CN103889981B CN201280050818.3A CN201280050818A CN103889981B CN 103889981 B CN103889981 B CN 103889981B CN 201280050818 A CN201280050818 A CN 201280050818A CN 103889981 B CN103889981 B CN 103889981B
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mmol
dibenzo
dihydro
mixture
nmr
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CN103889981A (zh
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迈克尔·奥尔迈尔
古塔姆·纳尔拉
尼尔·达万
大卫·卡斯特里斯基
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Xi Naishanyikan Medical College
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CN201280050818.3A 2011-08-16 2012-08-16 作为抗癌剂的三环化合物 Expired - Fee Related CN103889981B (zh)

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US201161523897P 2011-08-16 2011-08-16
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PCT/US2012/051097 WO2013025882A2 (en) 2011-08-16 2012-08-16 Tricyclic compounds as anticancer agents

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KR20150119390A (ko) * 2013-02-19 2015-10-23 이칸 스쿨 오브 메디슨 엣 마운트 시나이 항암제로서의 삼환식 헤테로사이클
CN103232447B (zh) * 2013-04-02 2015-06-03 陕西科技大学 3-乙酰基-5-乙酰亚氨基-2-(n-吩噻嗪基)-1,3,4-噻二唑及其制备方法和应用
CN106458936A (zh) * 2014-03-11 2017-02-22 西奈山伊坎医学院 作为抗癌药的三环‑2‑氨基环烷醇衍生的磺酰胺
WO2015138496A1 (en) * 2014-03-11 2015-09-17 Icahn School Of Medicine At Mount Sinai Constrained tricyclic sulfonamides
DK3169815T3 (da) 2014-07-15 2021-02-15 Ontario Institute For Cancer Res Fremgangsmåder og indretninger til forudsigelse af anthracyclinbehandlingseffektivitet
CN104529898B (zh) * 2015-01-15 2016-07-27 成都丽凯手性技术有限公司 氮杂二苯并环辛炔类化合物及其制备方法
EP3313819A1 (en) * 2015-06-23 2018-05-02 Case Western Reserve University Compositions and methods for treating cancer
CA2994830A1 (en) 2015-08-06 2017-02-09 Icahn School Of Medicine At Mount Sinai Stereospecific process for 3-heterocyclylcycloaliphatic-1,2-diols
WO2017044571A1 (en) * 2015-09-09 2017-03-16 Icahn School Of Medicine At Mount Sinai Tricyclic sultam sulfonamides as anticancer and neuroprotective agents
US10221158B2 (en) 2015-09-09 2019-03-05 Icahn School Of Medicine At Mount Sinai Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents
EP3347355B1 (en) * 2015-09-09 2022-07-13 Icahn School of Medicine at Mount Sinai Heterotricyclic sulfonamides as anti-cancer agents
WO2017044575A1 (en) * 2015-09-09 2017-03-16 Icahn School Of Medicine At Mount Sinai Constrained benzhydryl sulfonamides as anticancer and neuroprotective agents
WO2017044572A1 (en) * 2015-09-09 2017-03-16 Icahn School Of Medicine At Mount Sinai Ring constrained diarylamino sulfonamides as anti-cancer agents
CN111171006B (zh) * 2020-01-29 2023-05-12 成都睿智化学研究有限公司 一种3-取代亚氨基二苄氨基类化合物的工艺方法
US12398103B2 (en) * 2020-03-20 2025-08-26 Atux Iskay Llc 3-diarylmethylenes and uses thereof
GB2597446A (en) 2020-07-21 2022-02-02 Demuris Ltd Compounds and their uses
CN118119607A (zh) 2021-08-18 2024-05-31 阿图什伊斯卡伊有限责任公司 作为抗癌、抗炎、抗纤维和神经保护剂的2-二芳基甲基-4-氨基四氢吡喃衍生物及相关化合物
CN115554303B (zh) * 2021-09-18 2024-07-09 上海科技大学 一种三环类化合物、其制备方法及其应用
EP4673135A1 (en) * 2023-02-27 2026-01-07 Atux Iskay LLC N,n'-sulfonimidamides as anticancer, antiinflammatory, antifibrotic and neuroprotective agents
CN118026942B (zh) * 2024-04-11 2024-06-28 江西师范大学 11-碘-二苯并[b,e][1,4]二氮杂卓化合物及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK88606C (da) 1958-05-09 1960-02-29 Kefalas As Fremgangsmåde til fremstilling af i 9-stillingen substituerede thiaxantener eller deres syreadditionssalte.
GB8510680D0 (en) 1985-04-26 1985-06-05 Smith Kline French Lab Pyridine derivatives
US4882351A (en) 1987-10-14 1989-11-21 Roussel Uclaf Tricyclic compounds
WO1995003279A1 (en) 1993-07-26 1995-02-02 Eisai Co., Ltd. Sulfonamide and sulfonic ester derivatives each having tricyclic hetero ring
GB9703992D0 (en) 1997-02-26 1997-04-16 Rolabo Sl Process
TWI329108B (en) 2001-09-06 2010-08-21 Schering Corp 17-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
EP1481673A4 (en) * 2002-02-05 2008-09-24 Ajinomoto Kk MEDICAL COMPOSITIONS WITH GABAPENTIN OR PREGABALINE AND N-TYPE CALCIUM CHANNEL ANTAGONIST
TW200400816A (en) 2002-06-26 2004-01-16 Lilly Co Eli Tricyclic steroid hormone nuclear receptor modulators
CA2587664A1 (en) * 2004-12-21 2006-06-29 Devgen N.V. Compounds with kv4 ion channel activity
EP1888562B1 (en) 2005-04-22 2014-06-18 Alantos Pharmaceuticals Holding, Inc. Dipeptidyl peptidase-iv inhibitors
GB0508992D0 (en) * 2005-05-03 2005-06-08 Novartis Ag Organic compounds
WO2008121859A1 (en) * 2007-03-30 2008-10-09 Xenon Pharmaceuticals Inc. Methods of using tricyclic compounds in treating sodium channel-mediated diseases or conditions

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