CN103857406B - 趋化因子‑免疫球蛋白融合多肽、组合物及其制备和使用方法 - Google Patents
趋化因子‑免疫球蛋白融合多肽、组合物及其制备和使用方法 Download PDFInfo
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- 206010046766 uterine cancer Diseases 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
Abstract
Description
趋化因子/受体 | 蛋白登录号 | SEQ ID NO: |
CCL1 | NP_002972 | 1 |
CCL2 | NP_002973 | 2 |
CCL3 | NP_002974 | 3 |
CCL4 | NP_002975 | 4 |
CCL4L1 | NP_001001435 | 5 |
CCL5 | NP_002976 | 6 |
CCL7 | NP_006264 | 7 |
CCL8 | NP_005614 | 8 |
CCL11 | CAG33702 | 9 |
CCL13 | NP_005399 | 10 |
CCL14-1 | NP_116739 | 11 |
CCL14-2 | NP_116738 | 12 |
CCL15 | NP_116741 | 13 |
CCL16 | NP_004581 | 14 |
CCL17 | NP_002978 | 15 |
CCL18 | NP_002979 | 16 |
CCL19 | NP_006265 | 17 |
CCL20-1 | NP_004582 | 18 |
CCL20-2 | NP_001123518 | 19 |
CCL21 | NP_002980 | 20 |
CCL22 | NP_002981 | 21 |
CCL23-1 | NP_665905 | 22 |
CCL23-2 | NP_005055 | 23 |
CCL24 | NP_002982 | 24 |
CCL25-1 | NP_005615 | 25 |
CCL25-2 | NP_683686 | 26 |
CCL25-3 | EAW68951 | 27 |
CCL26 | NP_006063 | 28 |
CCL27 | NP_006655 | 29 |
CCL28 | NP_683513 | 30 |
趋化因子/受体 | 蛋白登录号 | SEQ ID NO: |
CXCL1 | NP_001502 | 31 |
CXCL2 | NP_002080 | 32 |
CXCL3 | NP_002081 | 33 |
CXCL4 | NP_002610 | 34 |
CXCL5 | NP_002985 | 35 |
CXCL6 | NP_002984 | 36 |
CXCL7 | NP_002695 | 37 |
CXCL8 | NP_000575 | 38 |
CXCL9 | NP_002407 | 39 |
CXCL10 | NP_001556 | 40 |
CXCL11 | NP_005400 | 41 |
CXCL12 | NP_000600 | 42 |
CXCL13 | NP_006410 | 43 |
CXCL16 | NP_071342 | 44 |
XCL1 | AAH69817 | 45 |
XCL2 | NP_003166 | 46 |
CX3CL1 | NP_002987 | 47 |
IgG1Fc | CBX54381.1 | 48 |
IgG2Fc | CBX54382.1 | 49 |
IgG3Fc | CBX54383.1 | 50 |
IgG4Fc | CBX54384.1 | 51 |
Claims (19)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810054247.XA CN108219001A (zh) | 2011-06-01 | 2012-05-25 | 趋化因子-免疫球蛋白融合多肽、组合物及其制备和使用方法 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161492260P | 2011-06-01 | 2011-06-01 | |
US61/492,260 | 2011-06-01 | ||
PCT/US2012/039550 WO2012166588A2 (en) | 2011-06-01 | 2012-05-25 | Chemokine-immunoglobulin fusion polypeptides, compositions, method of making and use thereof |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810054247.XA Division CN108219001A (zh) | 2011-06-01 | 2012-05-25 | 趋化因子-免疫球蛋白融合多肽、组合物及其制备和使用方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103857406A CN103857406A (zh) | 2014-06-11 |
CN103857406B true CN103857406B (zh) | 2018-02-23 |
Family
ID=47260212
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810054247.XA Pending CN108219001A (zh) | 2011-06-01 | 2012-05-25 | 趋化因子-免疫球蛋白融合多肽、组合物及其制备和使用方法 |
CN201280032847.7A Expired - Fee Related CN103857406B (zh) | 2011-06-01 | 2012-05-25 | 趋化因子‑免疫球蛋白融合多肽、组合物及其制备和使用方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810054247.XA Pending CN108219001A (zh) | 2011-06-01 | 2012-05-25 | 趋化因子-免疫球蛋白融合多肽、组合物及其制备和使用方法 |
Country Status (7)
Country | Link |
---|---|
US (2) | US8541564B2 (zh) |
EP (1) | EP2714065A4 (zh) |
JP (1) | JP2014518632A (zh) |
CN (2) | CN108219001A (zh) |
AU (1) | AU2012262491A1 (zh) |
HK (1) | HK1198126A1 (zh) |
WO (1) | WO2012166588A2 (zh) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9717777B2 (en) | 2010-05-05 | 2017-08-01 | Rappaport Family Institute For Research In The Medical Sciences | Use of CCL1 in therapy |
WO2011138785A2 (en) | 2010-05-05 | 2011-11-10 | Rappaport Family Institute For Research In The Medical Sciences | Use of ccl1 in therapy |
JP2014534807A (ja) * | 2011-09-23 | 2014-12-25 | ユニバーシティ オブ オスロUniversity of Oslo | クロスプレゼンテーションを行う樹状細胞を標的としたワクチボディ |
CA2870006A1 (en) * | 2012-04-10 | 2013-10-17 | Agency For Science, Technology And Research | Methods for bladder cancer therapy using baculoviral vectors |
WO2015034897A1 (en) | 2013-09-03 | 2015-03-12 | Mayo Foundation For Medical Education And Research | Reducing the risk of major adverse cardiac events |
WO2016126719A1 (en) * | 2015-02-03 | 2016-08-11 | Jyant Technologies, Inc. | Chemokine-immunoglobulin fusion polypeptides, compositions, method of making and use thereof |
GB201603631D0 (en) * | 2016-03-02 | 2016-04-13 | Isis Innovation | Therapy and diagnostics |
KR20170123849A (ko) * | 2016-04-29 | 2017-11-09 | 주식회사유한양행 | Ccl3 변이체를 포함하는 융합 단백질 및 이의 용도 |
SG10201606949QA (en) * | 2016-08-19 | 2018-03-28 | Singapore Health Serv Pte Ltd | Immunosuppressive composition for use in treating immunological disorders |
EP3580230A1 (en) | 2017-02-07 | 2019-12-18 | VIB vzw | Immune-cell targeted bispecific chimeric proteins and uses thereof |
BR112019019973A2 (pt) * | 2017-03-24 | 2020-04-28 | Orpheus Bioscience Inc | pantlds para tratamento de transtornos autoimunes |
CN110573529A (zh) * | 2017-04-05 | 2019-12-13 | 韩国生命工学研究院 | 激活nk细胞的融合蛋白、nk细胞和包含其的药物组合物 |
ES2905757T3 (es) * | 2017-08-03 | 2022-04-12 | Taiga Biotechnologies Inc | Métodos y composiciones para el tratamiento del melanoma |
CN109422816B (zh) * | 2017-08-25 | 2020-11-20 | 诺未科技(北京)有限公司 | 一种靶向次级淋巴组织的肝癌疫苗 |
US20190218285A1 (en) * | 2018-01-18 | 2019-07-18 | Molecular Cloning Laboratories (MCLAB) LLC | Long-Acting Therapeutic Fusion Proteins |
EA202190228A1 (ru) | 2018-07-10 | 2021-04-14 | Ридженерон Фармасьютикалз, Инк. | Модификация связывающих молекул для минимизации уже существующих взаимодействий |
US20220160753A1 (en) * | 2019-03-27 | 2022-05-26 | Immunophotonics, Inc. | Semi-synthetic biopolymers for use in stimulating the immune system |
CN114106207B (zh) * | 2022-01-24 | 2022-04-26 | 诺未科技(北京)有限公司 | Ccl5的用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5766897A (en) * | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
US6723520B2 (en) * | 1996-07-05 | 2004-04-20 | Schering Corporation | Antibodies that bind chemokine teck |
US20070116669A1 (en) * | 2002-09-13 | 2007-05-24 | Chemokine Therapeutics Corporation | Interferon-inducible protein-10 (IP-10 or CXCL10) chemokine analogs for the treatment of human diseases |
US20050053579A1 (en) | 2001-10-23 | 2005-03-10 | Jacques Galipeau | Novel synthetic chimeric fusion transgene with immuno-therapeutic uses |
AR046594A1 (es) * | 2003-10-16 | 2005-12-14 | Applied Research Systems | Usos terapeuticos de variantes de quemoquina |
MX2008002101A (es) * | 2005-08-12 | 2008-04-19 | Schering Corp | Fusiones de la proteina-1 quimiotactica de monocito. |
WO2007148317A1 (en) * | 2006-06-21 | 2007-12-27 | Compugen Ltd. | Mcp-1 splice variants and methods of using same |
ES2456963T3 (es) * | 2007-06-04 | 2014-04-24 | Rappaport Family Institute For Research In The Medical Sciences | Agentes para el tratamiento de enfermedades inflamatorias y métodos para usar los mismos |
EP2205271B1 (en) * | 2007-10-08 | 2014-05-21 | Quintessence Biosciences, Inc. | Compositions and methods for ribonuclease-based therapies |
-
2012
- 2012-05-25 JP JP2014513620A patent/JP2014518632A/ja active Pending
- 2012-05-25 US US13/480,526 patent/US8541564B2/en not_active Expired - Fee Related
- 2012-05-25 CN CN201810054247.XA patent/CN108219001A/zh active Pending
- 2012-05-25 CN CN201280032847.7A patent/CN103857406B/zh not_active Expired - Fee Related
- 2012-05-25 AU AU2012262491A patent/AU2012262491A1/en not_active Abandoned
- 2012-05-25 WO PCT/US2012/039550 patent/WO2012166588A2/en unknown
- 2012-05-25 EP EP12792144.3A patent/EP2714065A4/en not_active Ceased
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2013
- 2013-08-08 US US13/962,401 patent/US8987210B2/en not_active Expired - Fee Related
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2014
- 2014-11-18 HK HK14111652.0A patent/HK1198126A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN108219001A (zh) | 2018-06-29 |
US8541564B2 (en) | 2013-09-24 |
JP2014518632A (ja) | 2014-08-07 |
US20120308565A1 (en) | 2012-12-06 |
WO2012166588A2 (en) | 2012-12-06 |
EP2714065A4 (en) | 2015-04-08 |
HK1198126A1 (zh) | 2015-03-13 |
US20130315909A1 (en) | 2013-11-28 |
AU2012262491A1 (en) | 2014-01-16 |
CN103857406A (zh) | 2014-06-11 |
WO2012166588A3 (en) | 2013-02-14 |
EP2714065A2 (en) | 2014-04-09 |
US8987210B2 (en) | 2015-03-24 |
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