CN103827145A - 相对于亲和性复合物的抗体 - Google Patents

相对于亲和性复合物的抗体 Download PDF

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Publication number
CN103827145A
CN103827145A CN201280045570.1A CN201280045570A CN103827145A CN 103827145 A CN103827145 A CN 103827145A CN 201280045570 A CN201280045570 A CN 201280045570A CN 103827145 A CN103827145 A CN 103827145A
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CN
China
Prior art keywords
antibody
affinity
mixture
vitamin
respect
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CN201280045570.1A
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English (en)
Chinese (zh)
Inventor
小见和也
安藤豪
内田好昭
碁石胜利
冈麻子
白川贵志
佐久拓弥
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Fujirebio Inc
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Fujirebio Inc
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Publication of CN103827145A publication Critical patent/CN103827145A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201280045570.1A 2011-09-21 2012-07-04 相对于亲和性复合物的抗体 Pending CN103827145A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2011-206162 2011-09-21
JP2011206162 2011-09-21
JP2012006359 2012-01-16
JP2012-006359 2012-01-16
PCT/JP2012/067062 WO2013042426A1 (ja) 2011-09-21 2012-07-04 親和性複合体に対する抗体

Publications (1)

Publication Number Publication Date
CN103827145A true CN103827145A (zh) 2014-05-28

Family

ID=47914207

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280045570.1A Pending CN103827145A (zh) 2011-09-21 2012-07-04 相对于亲和性复合物的抗体

Country Status (13)

Country Link
US (1) US9599608B2 (de)
EP (1) EP2759551B1 (de)
JP (1) JP6156144B2 (de)
KR (1) KR101720394B1 (de)
CN (1) CN103827145A (de)
AU (1) AU2012310880B2 (de)
BR (1) BR112014006405A2 (de)
CA (1) CA2849274C (de)
IL (1) IL231404A0 (de)
IN (1) IN2014CN02113A (de)
RU (1) RU2014115676A (de)
TW (1) TW201313743A (de)
WO (1) WO2013042426A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10983136B2 (en) 2013-01-28 2021-04-20 Diasorin S.P.A. Use of 1,25-dihydroxyvitamin D values in ratio with PTH as a prognostic biomarker
EP2759550B1 (de) 2013-01-28 2018-08-15 DiaSorin S.p.A. Verfahren und Kit zur Detektion von 1,25-Dihydroxyvitamin D und zugehöriger Antikörper
US11261257B2 (en) 2013-01-28 2022-03-01 Diasorin S.P.A. Methods for detecting 1,25-dihydroxyvitamin D and related antibodies
CA2898712C (en) 2013-02-06 2017-09-05 Fujirebio Inc. Vitamin d measurement method and measurement kit
JP6512214B2 (ja) * 2014-02-25 2019-05-15 富士レビオ株式会社 改変単量体ＩｇＭ
US10808024B2 (en) 2015-12-21 2020-10-20 Turun Yliopisto Antibodies against immunocomplexes comprising cyanobacterial cyclic peptide hepatotoxins
EP3954376A1 (de) * 2016-01-22 2022-02-16 Affimedix, Inc. Verfahren zur quantifizierung von vitamin d-metaboliten
CN106244562B (zh) * 2016-05-20 2019-07-23 杭州奥泰生物技术股份有限公司 杂交瘤细胞株及其分泌的抗25羟基维生素d3单克隆抗体和应用
US11435367B2 (en) * 2016-07-29 2022-09-06 Diazyme Laboratories, Inc. Methods and kits for assaying a vitamin D moiety
JP2020522239A (ja) * 2017-05-19 2020-07-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 細胞療法を調節するための分子スイッチとしての抗体化学誘導二量体形成化合物（ＡｂＣＩＤ）
JP7325336B2 (ja) 2017-12-25 2023-08-14 富士レビオ株式会社 マクロライド系免疫抑制剤についての血液検査方法
JP7434824B2 (ja) * 2019-11-20 2024-02-21 東ソー株式会社 抗イムノコンプレックス抗体を用いた測定方法
CN114746754A (zh) * 2019-11-20 2022-07-12 东曹株式会社 使用抗免疫复合物抗体的测定方法
CN113125696B (zh) * 2019-12-31 2024-03-26 科美博阳诊断技术(上海)有限公司 一种雌二醇均相化学发光检测试剂盒及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001174460A (ja) * 1999-12-17 2001-06-29 Tosoh Corp 免疫測定方法および免疫測定試薬

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091760B1 (de) * 1982-04-09 1986-07-02 FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. Anti-Immunkomplex-Antikörper und Verfahren zur Herstellung desselben
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8408193D0 (en) * 1984-03-30 1984-05-10 Cambridge Patent Dev Antibodies
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5223441A (en) 1986-10-09 1993-06-29 Syntex (U.S.A.) Inc. Receptors for immune complexes
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5413923A (en) 1989-07-25 1995-05-09 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US5187065A (en) * 1989-12-22 1993-02-16 Schutzer Steven E Method and materials for detecting lyme disease
DE69133566T2 (de) 1990-01-12 2007-12-06 Amgen Fremont Inc. Bildung von xenogenen Antikörpern
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
EP0519596B1 (de) 1991-05-17 2005-02-23 Merck & Co. Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
ES2341666T3 (es) 1991-12-02 2010-06-24 Medimmune Limited Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
HU218069B (hu) 1992-06-09 2000-05-28 Hoppe Ag. Kilincses zárrendszer
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
KR20050085971A (ko) 1995-04-27 2005-08-29 아브게닉스, 인크. 면역화된 제노마우스 유래의 인간 항체
AU2466895A (en) 1995-04-28 1996-11-18 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
EP2314625B1 (de) 1996-12-03 2014-05-07 Amgen Fremont Inc. Transgene Säugetiere, die menschliche Ig-loci einschliesslich mehrere VH und Vkappa Regionen enthalten, und davon erhaltene Antikörper
DK0972445T3 (da) 1997-02-28 2006-10-23 Kirin Brewery Kimærisk mus som udtrykker et humant antistof
TWI255853B (en) 1998-08-21 2006-06-01 Kirin Brewery Method for modifying chromosomes
US7122339B2 (en) 1998-10-09 2006-10-17 Medical Research Council Method for generating diversity
CA2375441A1 (en) 1999-06-04 2000-12-14 Tranxenogen, Inc. Methods for manipulating the avian genome
JP2001231403A (ja) 2000-02-18 2001-08-28 Kirin Brewery Co Ltd 改変された外来染色体あるいはその断片を保持する非ヒト動物
KR100882030B1 (ko) 2000-11-17 2009-02-09 교와 핫꼬 기린 가부시키가이샤 클로닝된 트랜스제닉 유제류에서 이종 (사람)면역글로블린의 발현
WO2003047336A2 (en) 2001-11-30 2003-06-12 Abgenix, Inc. TRANSGENIC ANIMALS BEARING HUMAN Igμ LIGHT CHAIN GENES
BR0309145A (pt) 2002-04-09 2005-02-01 Kyowa Hakko Kogyo Kk Células das quais o genoma é modificado
CN100379862C (zh) 2002-07-30 2008-04-09 独立行政法人理化学研究所 增强体细胞同源重组的方法和构建特异抗体的方法
FI20022048A0 (fi) * 2002-11-18 2002-11-18 Valtion Teknillinen Ei-kompetetiivinen immunomääritys pienille analyyteille
JP5319863B2 (ja) 2002-12-26 2013-10-16 独立行政法人理化学研究所 体細胞相同組換えの誘発方法
NZ550106A (en) 2004-04-22 2009-06-26 Kyowa Hakko Kirin Co Ltd Transgenic animals and uses thereof
US20060117398A1 (en) 2004-10-22 2006-06-01 Roland Buelow Suppression of endogenous immunoglobulin expression
JP4892717B2 (ja) 2005-03-31 2012-03-07 国立大学法人広島大学 ニワトリキメラ抗体およびその利用
CN101273062A (zh) * 2005-09-29 2008-09-24 霍夫曼-拉罗奇有限公司 抗25-羟基维生素d的抗体
FI20075251A0 (fi) * 2007-04-13 2007-04-13 Hytest Oy Immunomääritys epästabiilien antigeenien määrittämiseksi
JP2009082033A (ja) 2007-09-28 2009-04-23 Kaneka Corp 完全ヒト型抗体生産法
FI20085579A0 (fi) * 2008-06-12 2008-06-12 Valtion Teknillinen Kannabiskäytön toteaminen
US20110097733A1 (en) * 2009-10-27 2011-04-28 Michel Anciaux Process for the production of a hybridoma and antibody obtained therefrom, able to recognize more than one vitamin d metabolite

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001174460A (ja) * 1999-12-17 2001-06-29 Tosoh Corp 免疫測定方法および免疫測定試薬

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
IHARA M等: "Open-sandwich enzyme immunoassay for one-step noncompetitive detection of corticosteroid 11-deoxycortisol", 《ANAL.CHEM》, vol. 81, no. 20, 31 December 2009 (2009-12-31), pages 8298 - 8304, XP055145692, DOI: 10.1021/ac900700a *
ROSSOTTI MA等: "Phage anti-immunocomplex assay for clomazone:two-site recognition increasing assay specificity and facilitating adaptation into an on-site format", 《ANAL.CHEM》, vol. 82, no. 21, 31 December 2010 (2010-12-31), pages 8838 - 8843, XP055145690, DOI: 10.1021/ac101476f *
张红等: "鸡免疫球蛋白基因结构与抗体多样性产生的分子机制", 《河南农业科学》, 15 February 2007 (2007-02-15), pages 102 - 105 *

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Publication number Publication date
AU2012310880A1 (en) 2014-04-10
US20150037813A1 (en) 2015-02-05
JP6156144B2 (ja) 2017-07-05
EP2759551A4 (de) 2015-03-04
IL231404A0 (en) 2014-04-30
IN2014CN02113A (de) 2015-05-29
RU2014115676A (ru) 2015-10-27
EP2759551A1 (de) 2014-07-30
TW201313743A (zh) 2013-04-01
EP2759551B1 (de) 2019-05-22
KR20140044940A (ko) 2014-04-15
BR112014006405A2 (pt) 2017-04-04
AU2012310880B2 (en) 2015-12-03
JPWO2013042426A1 (ja) 2015-03-26
CA2849274A1 (en) 2013-03-28
KR101720394B1 (ko) 2017-03-27
CA2849274C (en) 2018-12-04
WO2013042426A1 (ja) 2013-03-28
US9599608B2 (en) 2017-03-21

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