CN103768344A - External medicine for treating cervical carcinoma - Google Patents
External medicine for treating cervical carcinoma Download PDFInfo
- Publication number
- CN103768344A CN103768344A CN201410038348.XA CN201410038348A CN103768344A CN 103768344 A CN103768344 A CN 103768344A CN 201410038348 A CN201410038348 A CN 201410038348A CN 103768344 A CN103768344 A CN 103768344A
- Authority
- CN
- China
- Prior art keywords
- grams
- patients
- medicine
- acid
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides an external medicine for treating cervical carcinoma, which is prepared from the following active ingredients: 3-6g of Galla Chinensis, 3-6g of Brucea javanica fruit, 3-6g of aconitum carmichaeli rootlet, 13-17g of prunus mume charcoal, 7.5-10.5g of indigo naturalis, 2-4g of borneol, 4.5-7.5g of benzoin, 4.5-7.5g of bezoar, 11.5-12.5g of scolopendra subspinipes, 8.5-10.5g of scorpion, 5.8-10.5g of daemonorops draco, 4-8g of radix arnebiae and 5.5-6.5g of toad. The neck of uterus is exposed in the visual field by use of a vaginal dilator, and the medicinal powder is dipped with a cotton swab and smeared on the canceration part on the neck of uterus, and the Chinese medicine is applied once a day. After the external medicine is used for three days, the sizes of the tumors of some patients start shrinking; after continuous application of the medicine for 1-3 months, among all of 36 patients with cervical carcinoma, tumor disappearance is found in 22 patients (61.1%), tumor size shrinkage is found in 12 patients (33.3%), and no change of tumor size is found in 2 patients (5.6%), and the total effective rate is 94.4%.
Description
Technical field
The present invention relates to a kind of medicine for external use for the treatment of cervical cancer, belong to cervical cancer practical technique field.
Background technology
Cervical cancer (cervical cancer) is once find to be just second phase or three, the fourth phase, and patient and doctor advocate operative treatment conventionally.For the women who has given birth to, little to self and home influence by surgical removal uterus.And the women who did not also give birth to, extract in uterus is influential to her life, some impacts also may be very large.Some is because of not thoroughly also easily recurrence of operation.And use at present Drug therapy cervical cancer successful story also rarely found.
Summary of the invention
The object of the invention is the problem existing in order to solve above-mentioned prior art, the women who did not give birth to, extract in uterus is influential to her life, some impacts also may be very large.Some is because of not thoroughly also easily recurrence of operation.And use at present Drug therapy cervical cancer successful story also rarely found.And then provide a kind of medicine for external use for the treatment of cervical cancer.
Above-mentioned object realizes by following technical scheme:
Treat a medicine for external use for cervical cancer, calculate by weight its active component and formed by 5.5～6.5 grams of 3～6 grams of Galla Chinensiss, 3～6 grams of Fructus Bruceaes, 3～6 grams of Radix Aconiti Lateralis, 13～17 grams of carbonized Fructus Mume, 7.5～10.5 grams of Indigo Naturaliss, 2～4 grams of Borneolum Syntheticums, 4.5～7.5 grams of Benzoinumes, 4.5～7.5 grams of Calculus Boviss, Scolopendra 11.5～12.5,8.5～10.5 grams of Scorpios, 8.5～10.5 grams of Sanguis Draxonis, 4～8 grams of Radix Arnebiae (Radix Lithospermi)s and Bufo siccuss.
By above-mentioned various for medicine material clear water (room temperature) soak 48 hours, at the beginning of immersion, water was limited just to flood medicine material, after do not add again water, within every four hours, stir once, after 48 hours, water base is absorbed by medicine material, then dries, and grinds to form fineness at 300-1000 object micropowder, mix, be prepared into drug powder for subsequent use.
The screening of case and efficacy analysis:
Select at random and suffer from Patients with Cervical Cancer 36 people at hospital outpatient, wherein cervical cancer second phase patient 12 people, three phase of cervical cancer patient 13 people, cervical cancer fourth phase patient 11 people.47.6 years old mean age.There is treatment history.
Administrated method: cervix uteri is exposed under the visual field with vagina vaginal dilator, dips in drug powder and spread upon canceration (lump) position of cervix uteri with cotton swab, once a day.
The criterion of curative effect: lump disappear for cure, lump is reduced into effectively, lump do not dwindle or continue to be increased to invalid.
Observe: after 3 days (72 hours), some patient's lump starts to dwindle, continuous use one was to three months (a month the fastest lump disappeared, and majority needs trimestral treatment), and in whole 36 cervical cancer patients, lump disappearance person 22 people, account for 61.1%; The lump person of dwindling 12 people, account for 33.3%, and unchanged person 2 people of lump, account for 5.6%, and total effective rate is 94.4%.During treatment, do not find the untoward reaction of medicine.Patient's tracing observation that lump is disappeared 2 years, has no recurrence.
The above-mentioned 13 taste Chinese medicines that the present invention uses, wherein:
Galla Chinensis is the insect gall forming after the upper parasitic times Aphidiadae insecticide Chinese Nut-gall aphid of the trees such as Anacardiaceae plant Fructus rhois chinensis or melaphis peitan Tsai et Tang, main containing Gallotannin.These tannins comprise: 1, 2, 3, 4, 6-five-O-galloyl-beta-D-glucose, 3-O-bis-galloyl-1, 2, 4, 6-tetra--O-galloyl-beta-D-glucose, 2-O-bis-galloyl-1, 3, 4, 6-tetra--O-galloyl-beta-D-glucose, 4-O-bis-galloyl-1, 2, 3, 6-tetra--O-galloyl-beta-D-glucose, 2, 3-O-bis-galloyl-1, 4, 6-tri--O-galloyl-beta-D-glucose, 3-O-tri-galloyl-1, 2, 4, 6-tetra--O-galloyl-beta-D-glucose, 3, 4-pair-O-bis-galloyl-1, 2, 6-tri--O-galloyl-beta-D-glucose, 2, 4-pair-O-bis-galloyl-1, 3, 6-tri--O-galloyl-beta-D-glucose.
The main component of Fructus Bruceae is bruceine A, B, C, D, E, F, G, H, I, bruceolide, Brusatol; Also containing alkaloid, as brucamarine, yatanine; Glucoside, as brucealin, brucealin and brucenol, bruceolic acid and vanillic acid.The fatty oil of java brucea seed (Oleum Fructus Bruceae) 56.23%.In oil, non-saponifiable matter accounts for 1.36%, include volatile oil a little.Saponifiedly in oil account for 92.47%, include oleic acid, account for 81.87% of crude oil; Linoleic acid, accounts for 3.37% of crude oil; Stearic acid, accounts for 2.65% of crude oil; Palmic acid, accounts for 6.62% of crude oil.Fusing point is the spun silk shape crystalline solid 4.59% of 152 ℃ in addition.
Radix Aconiti Lateralis Preparata is the processed goods of Radix Aconiti daughter root, main containing the less monoesters Alkaloid of toxicity: benzoyl aconine, benzoyl mesaconitine, benzoyl hypo-aconine, be even hydrolyzed to the amine alcohols alkali that toxicity is less: aconine, mesaconitine, hypo-aconine.Radix Aconiti Lateralis Preparata is containing aconitine, mesaconitine, hypaconitine, talastisamine, higenamine is racemization demethyl coclaurine, coryneine chloride, different delphinine, benzoylmesaconitine, Xin Wuning alkali, the peaceful alkali of Radix Aconiti Lateralis Preparata, septentrionaline, karacoline, deoxyaconitine, Fuzitine alkali, songorine uracil, river oil aconitine, neojiangyouaconitine, Salsolinol etc.
The main component of carbonized Fructus Mume is: containing citric acid, solid black alcohol and oleanolic acid sample material.
Indigo Naturalis is named again and is floated black pigment used by women in ancient times to paint their eyebrows powder, speckled celadon black pigment used by women in ancient times to paint their eyebrows, and Indigo Naturalis has effect of heat clearing away, blood cooling and ecchymoses removing, removing toxic substances, purging liver-fire, arresting convulsion, and Indigo Naturalis has that treatment epidemic febrile disease intenseness of heat, macule, haematemesis, spitting of blood, pediatric epilepsy scared, skin ulcer are swollen, the effect of erysipelas, snake bite and insect sting.
Borneolum Syntheticum is mainly containing Borneolum Syntheticum 59.78%～58.93%, isoborneol 38.98%～37.52%, Camphora 2.70%～2.09%.The crystallization obtaining from the resin of Borneolum Syntheticum and volatile oil is almost pure dextro Borneolum Syntheticum.In the resin of Borneolum Syntheticum and volatile oil, contain multiple ter penoids.Except Borneolum Syntheticum, still contain the triterpenes components such as the sesquiterpenoids compositions such as Humuleno, beta-elemene, caryophyllene and oleanolic acid, alphitolic acid, asiatic acid, dipterocarpol, dryobalanone, erythrodiol.
Styrax tonkinensis master is resinous 70%～80%, and its composition has 3-benzoyl siaresinolic acid ester, 4-hydroxy-3-methoxycinnamic alcohol benzoate, and free benzoic acid 20%, vanillin 0.15%～2.3%, containing cinnamic acid.
The main component of Calculus Bovis is: containing cholic acid 5%～11%, and deoxycholic acid approximately 2%, chenodeoxycholic acid 0.6%～1.7% and its esters, bilirubin and calcium salt thereof; And shrink smooth muscle and reducing blood pressure effect containing cholesterol, ergosterol, lecithin, fatty acid, vitamin D, water-soluble peptide constituents SMC(tool), and copper, ferrum, magnesium, zinc etc. Australia produces Calculus Bovis and contains the several amino acids such as carotenoid, alanine, glycine, taurine, aspartic acid, arginine, leucine, methionine.
The main component of Scolopendra is: containing the toxic component of two kinds of similar Venenum apis, i.e. histamine sample material and hemolytic protein; Still fatty oil, cholesterol, formic acid etc.Also once isolated δ-oxylysine; Aminoacid has histidine, arginine, ornithine, lysine, glycine, alanine, valine, leucine, phenylalanine, serine, taurine, glutamic acid.
The main component of Scorpio is: containing scorpion venom.In scorpion venom, contain more complicated toxic protein and non-toxic protein, the Neurotoxic protein of a kind of similar snake venom. in thick poison, contain multiple charybdotoxin, comprise insects neurotoxin, shell-fish neurotoxin, mammalian nervous toxin, the polypeptide (AEP) of antiepileptic activity, analgesic activities polypeptide is as charybdotoxin.III, hyaluronidase.Scorpio hydrolyzed solution contains 17 kinds of essential amino acids.
And containing 29 kinds of inorganic elementss, there are sodium, phosphorus, potassium, calcium, magnesium, zinc, ferrum, aluminum, copper, manganese, chlorine etc.In addition, still containing trimethylamine, betanin, ammonium salt, picric acid azanol, cholesterol, lecithin, scorpion acid, taurine palmitic acid, linolenic acid ， behenic acid, positive 17 carbonic acid, vaccenic acid, 20 carbonic acid.
The main component of Sanguis Draxonis is: contain dracorhodin, dracorubin, (2s) 5-methoxyl group-6-methyl flavane-7-alcohol (being flavonol) and benzoic acid etc.
The main component of Radix Arnebiae (Radix Lithospermi) is: Radix Arnebiae (Radix Lithospermi) is containing pigment composition, fatty acid. pigment composition is naphthoquinone derivatives; there are shikonin (shikonin), acetylshikonin, deoxyshikonin, isobutyl group shikonin, IVS, β; beta-dimethyl-acryloyl shikonin, beta-hydroxy-IVS, alkannan, Radix Arnebiae (Radix Lithospermi) are red, Alpha-Methyl-n-butyryl shikonin, 3,4-dimethyl pentene-3-acyl group shikonin.The false Radix Arnebiae (Radix Lithospermi) in Xinjiang is containing β-Hydroxyisovalerylshikonin, 3,4-dimethyl pentene-3-acyl group shikonin. and fatty acid is mainly palmitic acid, oleic acid and linoleic acid etc.
Flower back of the body Bufo siccus ear rear gland secretions contains cholesterol, marinobufgin, Japanese bufotalien, cinobufacin far away, Arenobufagin.Volatile ingredient in ear glandular secretion thing contains n-nonanoic acid, capric acid, a small amount of n-octadecane, AI3-36122, positive melissane, heneicosane, octadecadienoic acid.
The present invention is by the synergism of above 13 taste Chinese medicines, and performance drug effect separately, for treatment cervical cancer, has brought into play good effect, has removed slight illness for most of Patients with Cervical Cancers, and evident in efficacy, toxic and side effects is little, is difficult for recurrence.
The specific embodiment
The present invention is described in further detail below: the present embodiment is implemented under take technical solution of the present invention as prerequisite, provided detailed embodiment, but protection scope of the present invention is not limited to following embodiment.
Embodiment 1:
The medicine for external use for the treatment of cervical cancer, calculates by weight its active component and is made up of 5.5～6.5 grams of 3～6 grams of Galla Chinensiss, 3～6 grams of Fructus Bruceaes, 3～6 grams of Radix Aconiti Lateralis, 13～17 grams of carbonized Fructus Mume, 7.5～10.5 grams of Indigo Naturaliss, 2～4 grams of Borneolum Syntheticums, 4.5～7.5 grams of Benzoinumes, 4.5～7.5 grams of Calculus Boviss, Scolopendra 11.5～12.5,8.5～10.5 grams of Scorpios, 8.5～10.5 grams of Sanguis Draxonis, 4～8 grams of Radix Arnebiae (Radix Lithospermi)s and Bufo siccuss.By above-mentioned various for medicine material clear water (room temperature) soak 48 hours, at the beginning of immersion, water was limited just to flood medicine material, after do not add again water, within every four hours, stir once, after 48 hours, water base is absorbed by medicine material, then dries, and grinds to form fineness at 300-1000 object micropowder, mix, be prepared into drug powder for subsequent use.
Embodiment 2:
The medicine for external use of described treatment cervical cancer, calculates by weight its active component and is made up of 5.8～6.2 grams of 3.5～5.5 grams of Galla Chinensiss, 3.5～5.5 grams of Fructus Bruceaes, 3.5～5.5 grams of Radix Aconiti Lateralis, 14～16 grams of carbonized Fructus Mume, 8～10 grams of Indigo Naturaliss, 2.5～3.5 grams of Borneolum Syntheticums, 5～7 grams of Benzoinumes, 5～7 grams of Calculus Boviss, Scolopendra 11.8～12.2,8～10 grams of Scorpios, 8～10 grams of Sanguis Draxonis, 5～7 grams of Radix Arnebiae (Radix Lithospermi)s and Bufo siccuss.Manufacture method is identical with embodiment 1.
Embodiment 3:
The medicine for external use of described treatment cervical cancer, calculates by weight its active component and is made up of 6 grams of 4.5 grams of Galla Chinensiss, 4.5 grams of Fructus Bruceaes, 4.5 grams of Radix Aconiti Lateralis, 15 grams of carbonized Fructus Mume, 9 grams of Indigo Naturaliss, 3 grams of Borneolum Syntheticums, 6 grams of Benzoinumes, 6 grams of Calculus Boviss, 12 grams of Scolopendras, 9 grams of Scorpios, 9 grams of Sanguis Draxonis, 6 grams of Radix Arnebiae (Radix Lithospermi)s and Bufo siccuss.Manufacture method is identical with embodiment 1.
Claims (3)
1. treat the medicine for external use of cervical cancer for one kind; it is characterized in that, calculate by weight its active component and formed by 5.5～6.5 grams of 3～6 grams of Galla Chinensiss, 3～6 grams of Fructus Bruceaes, 3～6 grams of Radix Aconiti Lateralis, 13～17 grams of carbonized Fructus Mume, 7.5～10.5 grams of Indigo Naturaliss, 2～4 grams of Borneolum Syntheticums, 4.5～7.5 grams of Benzoinumes, 4.5～7.5 grams of Calculus Boviss, Scolopendra 11.5～12.5,8.5～10.5 grams of Scorpios, 8.5～10.5 grams of Sanguis Draxonis, 4～8 grams of Radix Arnebiae (Radix Lithospermi)s and Bufo siccuss.
2. the medicine for external use for the treatment of cervical cancer according to claim 1; it is characterized in that, calculate by weight its active component and formed by 5.8～6.2 grams of 3.5～5.5 grams of Galla Chinensiss, 3.5～5.5 grams of Fructus Bruceaes, 3.5～5.5 grams of Radix Aconiti Lateralis, 14～16 grams of carbonized Fructus Mume, 8～10 grams of Indigo Naturaliss, 2.5～3.5 grams of Borneolum Syntheticums, 5～7 grams of Benzoinumes, 5～7 grams of Calculus Boviss, Scolopendra 11.8～12.2,8～10 grams of Scorpios, 8～10 grams of Sanguis Draxonis, 5～7 grams of Radix Arnebiae (Radix Lithospermi)s and Bufo siccuss.
3. the medicine for external use for the treatment of cervical cancer according to claim 1; it is characterized in that, calculate by weight its active component and formed by 6 grams of 4.5 grams of Galla Chinensiss, 4.5 grams of Fructus Bruceaes, 4.5 grams of Radix Aconiti Lateralis, 15 grams of carbonized Fructus Mume, 9 grams of Indigo Naturaliss, 3 grams of Borneolum Syntheticums, 6 grams of Benzoinumes, 6 grams of Calculus Boviss, 12 grams of Scolopendras, 9 grams of Scorpios, 9 grams of Sanguis Draxonis, 6 grams of Radix Arnebiae (Radix Lithospermi)s and Bufo siccuss.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410038348.XA CN103768344B (en) | 2014-01-27 | 2014-01-27 | The medicine for external use for the treatment of cervical cancer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410038348.XA CN103768344B (en) | 2014-01-27 | 2014-01-27 | The medicine for external use for the treatment of cervical cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103768344A true CN103768344A (en) | 2014-05-07 |
| CN103768344B CN103768344B (en) | 2016-06-08 |
Family
ID=50561404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410038348.XA Expired - Fee Related CN103768344B (en) | 2014-01-27 | 2014-01-27 | The medicine for external use for the treatment of cervical cancer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103768344B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104116772A (en) * | 2014-07-24 | 2014-10-29 | 彭小菊 | Ointment for removing stasis and preparation method thereof |
| CN105477554A (en) * | 2015-12-31 | 2016-04-13 | 蒲敬北 | Medicine for treating HPV infection and preventing cervical cancer and preparation method of medicine |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167820A (en) * | 2006-11-21 | 2008-04-30 | 张财 | External-applied traditional Chinese medicine for curing uterus cancer and its preparation method |
| CN103182063A (en) * | 2013-01-01 | 2013-07-03 | 夏义深 | Chinese patented drug pill for treating cancer |
-
2014
- 2014-01-27 CN CN201410038348.XA patent/CN103768344B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167820A (en) * | 2006-11-21 | 2008-04-30 | 张财 | External-applied traditional Chinese medicine for curing uterus cancer and its preparation method |
| CN103182063A (en) * | 2013-01-01 | 2013-07-03 | 夏义深 | Chinese patented drug pill for treating cancer |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104116772A (en) * | 2014-07-24 | 2014-10-29 | 彭小菊 | Ointment for removing stasis and preparation method thereof |
| CN105477554A (en) * | 2015-12-31 | 2016-04-13 | 蒲敬北 | Medicine for treating HPV infection and preventing cervical cancer and preparation method of medicine |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103768344B (en) | 2016-06-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2007262265B2 (en) | Skin external preparation containing triterpenic acid | |
| CN109157450A (en) | A kind of anti-acne essence cream | |
| CN109248105A (en) | A kind of makeup removing stick and preparation method thereof | |
| CN107184448A (en) | A kind of acne eliminating cream that there is prevention pockmark to generate | |
| CN111110619A (en) | Oil-control acne-removing composition and application thereof in cosmetics | |
| CN101653409B (en) | Whitening and spot eliminating cream and preparation method thereof | |
| CN105726720A (en) | Muscular soreness relieving and massaging cream and preparing method thereof | |
| CN103768344B (en) | The medicine for external use for the treatment of cervical cancer | |
| CN104095783A (en) | Traditional Chinese medicine antiphlogistic and acne-removing beauty cream and preparation method thereof | |
| CN102196813B (en) | Topical composition comprising extracts of A. indica and M. charantia or S. indicum | |
| CN106236650B (en) | A kind of removing acnes and controlling oil cream and preparation method thereof | |
| CN109966232A (en) | A kind of removing acne and freckle, Chinese medicine compound prescription facial mask of beauty face-whitening-nourishing and preparation method thereof | |
| CN102793640B (en) | Vitiligo covering composition and preparation method thereof | |
| CN104825519A (en) | Preparation method and application of vernonia anthelmintica phenolic acid part | |
| CN104958385B (en) | A kind of Chinese medicine composition, its preparation method and Chinese medicine preparation | |
| CN106727893A (en) | Pharmaceutical composition for radiation stomatitis and preparation method thereof | |
| CN105343244A (en) | External medicine composition for treating verruca plana and application of external medicine composition | |
| JP6386773B2 (en) | Hair restorer | |
| CN106667851A (en) | Traditional Chinese medicine acne removal cream and preparation method thereof | |
| CN106726972A (en) | A kind of hippophae rhamnoides compositions and application and the cold cream formed by its preparation and the preparation method of the cold cream | |
| CN105663605A (en) | Garlic emulsion gel preparation having health-caring and protective effects on skin and mucosa | |
| CN104173984A (en) | Orally taken traditional Chinese medicine capable of removing freckles and whitening | |
| Kumari et al. | Antileishmaniasis effects of monoherbal skin ointment made from bark and leaf of Holoptelea integrifolia (Roxb.) Planch. in patients of cutaneous leishmaniasis. | |
| CN109984973A (en) | A kind of acne-eliminating cosmetic and preparation method thereof containing compound plant extract | |
| JPH03112931A (en) | Remedy for psoriasis bulgaris |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160608 Termination date: 20210127 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |