CN104116772A - Ointment for removing stasis and preparation method thereof - Google Patents
Ointment for removing stasis and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of external-use compound traditional Chinese medicines, and relates to ointment for removing stasis and a preparation method of the ointment. The ointment is prepared from the following raw materials in parts by weight: 120-150 parts of tribulus terrestris, 30-40 parts of artemisia anomala, 20-30 parts of brucea javanica, 20-40 parts of asarum sieboldi, 50-70 parts of lithospermum, 9-15 parts of leech, 12-18 parts of venenum bufonis, 15-20 parts of indigo naturalis, 1000-1200 parts of sesame oil and 200-300 parts of medical vaseline. The ointment is prepared by boiling raw materials with sesame oil, and then filtering and adding vaseline to obtain a finished product, and the ointment for removing stasis can treat benign and malignant tumor and lump on body surfaces. The components are not prepared at high temperature, the original traditional Chinese medicine properties are maintained, high curative effects are achieved, the medicine properties of the raw materials are brought into play sufficiently; as the traditional Chinese medicines according to the formula are made into ointment, the ointment is convenient to use externally, effective components are easy to contact with affected regions sufficiently, then the curative effect is brought into play sufficiently, and a function of protecting and repairing skin is achieved. The ointment belongs to external-use cancer treatment methods, has no harm to intestines and stomachs, is small in side effect on human bodies and is high in security.
Description
Technical field
The present invention relates to a kind of external application Chinese medicine for the treatment of body surface innocent and malignant tumour and caking, belong to a kind of external treatment Chinese medicine compound, is a kind of external application Chinese medicine formula for the treatment of body surface innocent and malignant tumour and caking and preparation method thereof specifically.
Background technology
Malignant tumor threatens patient's life, causes people's the human body and the misery of spirit, and sickness rate, the case fatality rate of malignant tumor are sharply rising in recent years.Whole nation tumor Register issues " 2012 Chinese tumor registration annual report " data show: China is per minute just has 6 people to be diagnosed as cancer.China resident, because the probability of cancer mortality is 13%, has 1 people because of cancer death in every 7 to 8 people.Skin carcinoma, cancer body surface lymph metastasis and fester, malignant lymphoma sends out in body surface etc., all causes great misery to patient.Other dermatosiss, as slightly thick, tuberosity, diabrosis etc. of skin appear in condyloma acuminatum, variability eczema or neurodermatitis, are also puzzlement patient's refractory diseases.
At present, except the means such as operation, chemotherapy, radiotherapy, Biotherapeutics, Chinese medicine and Chinese medicine preparation have become an indispensable part in treating malignant tumor, and external application Chinese medicine effectively, directly, economy, safety, in the treatment of malignant tumor, occupy critical role.
From theory of Chinese medical science angle analysis, lumps in the chest and abdomen, all tuberositys of human body, enclosed mass (fester or without festering) are all stagnant relevant with expectorant, poison, the stasis of blood, at expectorant, poison, the stasis of blood is stagnant gather before, must have the healthy energy virtual loss of human body.Positive so-called " healthy energy deposit in, heresy can not be done ", " institute of heresy gathers, its gas must void ".Except application oral Chinese medicine strengthening vital QI to eliminate pathogenic factors, the eliminating evil counteracting toxic substances of application external application Chinese medicine is also in daily use.From ancient times to the present, there have been a lot of external treatment cmm of simple prescription, compound recipe or Chinese medicine extract to be used for treating description or the report of above-mentioned disease.As the Chen Chengqin report of the attached tumour hospital of Zhongshan Medical College, Arsenicum sablimatum, Caput Felis domestica satin ash medicine are successively outward for malignant tumour of skin surface, after January, tumor disappears, after half a year, follow up a case by regular visits to not recurrence (coming from: 1994-2014China Academia Journal Electronic Publishing House, P54).Handan City's the 3rd Zhang Shaoxi of hospital useization tumor (main component: arsenicum, Rhizoma Curcumae, Rhizoma Sparganii, Olibanum, Myrrha, Sanguis Draxonis) external curing Maxillofacial derma cancer ulcer of faling apart, obtain satisfactory effect (coming from: " special journal is cured in Handan " in JIUYUE, 1994, P239).Gu has the records such as " Five Tiger Pellet " external treatment body surface carbuncle skin ulcer furunculosis.
In clinical practice, run into some malignant tumor patients, their carcinoma is grown in skin surface, or be born in subcutaneous, hands can clearly touch, skin carcinoma, malignant lymphoma or the sarcoma that is equivalent to modern medicine scope send out carry down in skin or subcutaneous, various malignant tumor superficial lymph move, Subcutaneous metastasis tumor etc.Although had from ancient times to the present a lot of external treatment cmm of simple prescription, compound recipe or Chinese medicine extract to be used for treating description or the report of above-mentioned disease, but the repeatability of curative effect is undesirable, or toxic and side effects is too large and patient can not tolerate, or Therapeutic Method is loaded down with trivial details difficult universal, particularly to stubbornness, repeatedly recurrence grow in skin or subcutaneous carcinoma, clinical treatment is very thorny, and in a lot of situations, doctor feels simply helpless.Chinese patent CN101543585 discloses a kind of control and the Chinese medicine for the treatment of skin carcinoma, needs orally, has decoction inconvenience, takes effect slow, and large-scale production exists and is difficult for preserving, and medicine is the problem such as expired easily.
Summary of the invention
Through retrieval, existing body surface carcinoma external treatment Chinese medicine formula relatively limits to, arsenicum sablimatum application is more, better for its curative effect of skin carcinoma, but unclear to other body surface carcinoma curative effect, and corrosivity is strong, toxic and side effects large and the difficult tolerance of patient, or Therapeutic Method is loaded down with trivial details difficult universal, particularly, to the carcinoma that grows in skin diabrosis, stubbornness, that repeatedly recur, clinical treatment is very thorny, and in a lot of situations, doctor feels simply helpless.
The object of the invention is to solve the awkward situation in above-mentioned treating malignant tumor, provide that one can treat that body surface is good, malignant tumor and other dermatosiss be with caking, coarse, ulcer, obstinate difficult more person.The present invention is that the external application Chinese medicine formula ， Neng G for the treatment of body surface innocent and malignant tumour and caking cuts down, eliminates carcinoma, caking, and the pain of alleviate carcinoma, luming and causing, makes patient's local skin repair gradually, heal.The present invention designs for solving the Superficial Malignant Tumours person of festering (magic flower), and curative effect is rather good, in clinical practice, finds, the present invention is for optimum furuncle, wart, the enclosed mass effect of body surface, so expanded the range of application of this formula.
The invention provides the one furuncle eliminate indigestion ointment that disappears, preparation of raw material by following parts by weight forms: 120～150 parts of Fructus Tribulis, 30～40 parts of Herba Artemisiae Anomalaes, 20～30 parts of Fructus Bruceaes, 20～40 parts of Herba Asaris, 50～70 parts of Radix Arnebiae (Radix Lithospermi)s, 9～15 parts of Hirudos, 12～18 parts of Venenum Bufoniss, 15～20 parts of Indigo Naturaliss, 1000～1200 parts of Oleum sesami, 200～300 parts of medical ventolins.
More preferably formed by the preparation of raw material of following parts by weight: 150 parts of Fructus Tribulis, 40 parts of Herba Artemisiae Anomalaes, 20 parts of Fructus Bruceaes, 20 parts of Herba Asaris, 50 parts of Radix Arnebiae (Radix Lithospermi)s, 9 parts of Hirudos, 12 parts of Venenum Bufoniss, 15 parts of Indigo Naturaliss, 1000 parts of Oleum sesami, 200 parts of medical ventolins.
The method of external application Chinese medicine of preparing treatment body surface tumor of the present invention is as follows:
(1) Fructus Tribuli, Herba Artemisiae Anomalae, Fructus Bruceae, Herba Asari, Radix Arnebiae (Radix Lithospermi) are broken into respectively to coarse powder; Hirudo, Venenum Bufonis are broken into fine powder;
(2) Oleum sesami is placed in stainless-steel pan, pot is placed in big fire and is heated to 80～90 degree, put into Fructus Tribuli, Herba Artemisiae Anomalae, the Fructus Bruceae pulverized, endure 5～10 minutes, change little fire, treat temperature be down to 40～45 degree, put into again Herba Asari, the Radix Arnebiae (Radix Lithospermi) of pulverizing, endure 5～10 minutes;
(3) remove fire, leave standstill 18～30 hours;
(4) elimination medicinal residues;
(5) medical ventolin is put into stainless-steel pan, be placed in fire upper, molten opening.Subtract fire, in the time that vaseline to 40～45 are spent, put into the medicine oil of filtering residue, stir;
(6) remove fire, add immediately Hirudo, Venenum Bufonis and the Indigo Naturalis powder pulverized, stir;
(7) bottling, cooling.
Further be optimized for:
(1) Fructus Tribuli, Herba Artemisiae Anomalae, Fructus Bruceae, Herba Asari, Radix Arnebiae (Radix Lithospermi) are broken into respectively to coarse powder; Hirudo, Venenum Bufonis are broken into fine powder;
(2) Oleum sesami is placed in stainless-steel pan, pot is placed in big fire and is heated to 80 degree, put into Fructus Tribuli, Herba Artemisiae Anomalae, the Fructus Bruceae pulverized, endure 5 minutes, change little fire, treat that temperature is down to 40～45 degree, then put into Herba Asari, the Radix Arnebiae (Radix Lithospermi) of pulverizing, endure 5 minutes;
(3) remove fire, leave standstill 24 hours;
(4) elimination medicinal residues;
(5) medical ventolin is put into stainless-steel pan, be placed in fire upper, molten opening.Subtract fire, in the time that vaseline to 45 is spent, put into the medicine oil of filtering residue, stir;
(6) remove fire, add immediately Hirudo, Venenum Bufonis and the Indigo Naturalis powder pulverized, stir;
(7) bottling, cooling.
Pharmacology analysis:
Fructus Tribuli: property is flat, and bitter in the mouth, pungent, returns Liver Channel.Function dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, removing dampness to relieve itching, dispelling pathogenic wind for improving eyesight.Cure mainly syndrome of stagnation of liver qi, the headache of excessive rising of liver-YANG, the many tear of wind heat conjunctival congestion, the pruritus of rubella, eczema etc.Ancient books " herbal classic " is stated: " main stagnant blood ， Po Disorder knot gathers, sore throat, dystocia, improving eyesight." modern pharmacological research report, Fructus Tribuli is improved the effects such as blood supply of cardiac muscle, heart tonifying, atherosclerosis, antiplatelet aggregation, defying age, raising sexual function.Nearly have Fructus Tribuli to treat the reports such as wart, furuncle carbuncle, hand desquamation pruritus, eczema, vitiligo more 40 years.Because of invigorate blood circulation the brokenly property of knot of its heat clearing away suppressing the hyperactive liver dampness, blood stasis dispelling, non-evident effect (except anemia of pregnant woman), in addition economical and practical again, is convenient to a large amount of uses, therefore be chosen as the monarch drug of Chinese medicine formula of the present invention.
Herba Artemisiae Anomalae: warm in nature, bitter in the mouth, GUIXIN, liver, spleen channel.Function removing blood stasis stimulates the menstrual flow, eliminating stasis to stop pain, promoting digestion and removing stagnation.Zhu Zhi mass in the abdomen, stomachache, amenorrhea, traumatic injury, wound hemorrhage, abdominal pain due to retention of food etc.Ancient books " Newly Revised Canon of Materia Medica " is stated: " main removing blood stasis, lower swollen." " book on Chinese herbal medicine cover mirror " state: “ Xiao burning swelling carbuncle poison, the burning hot pain of the soup that goes out." modern pharmacological research shows, Herba Artemisiae Anomalae has antioxidation, strengthen bone-marrow-derived lymphocyte transforms, expands the effects such as blood vessel, antibacterial, antiviral.Because temperature leading to scattered silt, promoting blood circulation and stopping pain, economical and practical again, can strengthen the effect of Fructus Tribuli removing toxic substances eliminate indigestion, selecting Herba Artemisiae Anomalae is the ministerial drug of Chinese medicine formula of the present invention.
Fructus Bruceae: bitter in the mouth, cold in nature, slightly poisonous, return large intestine, Liver Channel.There are the effects such as heat-clearing and toxic substances removing, corrosion wart, dysentery relieving preventing the attack (or recurrence) of malaria.Cure mainly wart wart, tumor, clavus, malaria, dysentery etc." Records of Tradition Chinese and Western Medicine in Combination Fructus Bruceae solution " stated: " mash vinegar and dress furunculosis.The kind wart of controlling." modern pharmacological research demonstration, Fructus Bruceae has the effects such as antitumor, malaria, parasiticide.Because of its counteracting toxic substances gram heavily fortified point, be chosen as the ministerial drug of Chinese medicine formula of the present invention.
Hirudo: salty in the mouth, hardship, property is flat, slightly poisonous, returns Liver Channel.There is the merit of removing blood stasis." herbal classic " stated: " main by stagnant blood, blood stasis, the moon closes, and removing blood stasis abdominal mass is gathered." modern pharmacological research demonstration, Hirudo has antitumor, promotes absorption of hematoma, improves the effects such as renal ischemic, is chosen as the ministerial drug of Chinese medicine formula of the present invention.
Venenum Bufonis: acrid in the mouth, sweet, warm in nature, poisonous, GUIXIN warp.There are removing toxic substances and promoting subsidence of swelling, pain relieving removing food stagnancy, have one's ideas straightened out and ward off dirty effect, cure mainly cancerous protuberance, scrofula, various pain, furuncle swelling toxin etc.The effects such as modern pharmacological research shows, Venenum Bufonis has antitumor, analgesia, antiinflammatory, antiallergic, enhancing immunity, heart tonifying, boost, are chosen as the ministerial drug of Chinese medicine formula of the present invention.
Indigo Naturalis: nature and flavor are salty-cold, returns liver, lung, stomach warp.There are the effects such as loose swollen, the purging liver-fire of heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion.Cure mainly epidemic febrile disease intenseness of heat, macule, spits blood, spitting of blood, and pharyngalgia, aphtha, pediatric epilepsy scared, skin ulcer is swollen, erysipelas, eczema, Cuo carbuncle, mumps, snake bite and insect sting etc.The effects such as modern pharmacological research shows, Indigo Naturalis has antitumor, antibacterium and dermatophytes, enhancing immunity, treatment ulcer, protect the liver, are chosen as the ministerial drug of Chinese medicine formula of the present invention.
Although Herba Artemisiae Anomalae, Fructus Bruceae, Hirudo, Venenum Bufonis, Indigo Naturalis nature and flavor are respectively inclined to one side to some extent, but the common ground Shi G of effect cuts down, eliminates carcinoma, caking, Cheng is lumps in the chest and abdomen traditionally, the pain of alleviate carcinoma, luming and causing, make patient's local skin repair gradually, heal, all medicines share, and strengthen the effect of monarch drug, are ministerial drug altogether.
Herba Asari: property is pungent, taste temperature, slightly poisonous, return lung, the heart, kidney channel.Function is dispeled the wind, cold expelling, and row water, has one's ideas straightened out.Cure mainly air-cooled headache, rheumatic arthralgia, toothache, nasal sinusitis, phlegm retention cough with dyspnea.Modern pharmacological research shows that Herba Asari analgesic activity is obvious, and skin surface carcinoma furuncle, often with pain, is the adjuvant drug of Chinese medicine formula of the present invention therefore select Herba Asari.
Radix Arnebiae (Radix Lithospermi): sweet in the mouth, salty, cold in nature, GUIXIN, Liver Channel.Function removing heat from blood and promoting blood circulation, removing toxic substances rash.Cure mainly heat in blood poison and contain, macule purple is black, measles without adequate eruption, and skin infection, eczema, burn due to hot liquid or fire, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, burn, constipation with heat retention, dislikes insect bite wound etc.Modern pharmacological research shows that Radix Arnebiae (Radix Lithospermi) has the effects such as analgesia, calmness, antipyretic, hepatoprotective, antiinflammatory, antibacterial, antiviral, and has certain antitumaous effect.With Radix Arnebiae (Radix Lithospermi) be the reaction of red and swollen heat pain in order to reduce skin surface, also in order to reduce the zest of the medicines such as Hirudo, Venenum Bufonis, Fructus Bruceae, therefore elect the adjuvant drug of Chinese medicine formula of the present invention as.
Oleum sesami: claim again Oleum Sesami, i.e. edible, does again medicinally, is lubricant and excipient.Be applicable to skin injured, withered rough, physical weakness, early whitening of hair, anemia is sallow, deficiency of body fluid, constipation due to dry stool, dizziness and tinnitus etc.The for oral administration skin and hair of can moistening, enrich blood, intestine moistening, the lung moistening and production of body fluid promoting, lactogenesis, be used as ointment machin plaster substrate outward, can make other drug fully contact performance drug effect with affected part, itself can promote again skin self reparation, make medicine therefore be Chinese medicine formula of the present invention with Oleum sesami.
Medical ventolin: excipient and lubricant, often do the substrate of plaster.Spread upon on skin and can keep skin wet, make the skin histology of wound site keep optimum state, can make other drug fully contact performance drug effect with affected part, itself can promote again skin self reparation, can also stop from airborne antibacterial and contact skin, thereby reduce the possibility infecting, therefore elect the medicine that makes of Chinese medicine formula of the present invention as together with Oleum sesami.
Malignant tumor (cancer) threatens people's life.Although have the means such as operation, chemotherapy, radiotherapy, Chinese medicine to treat it now, have limitation.Especially to stubbornness, the malignant tumor of recurrence repeatedly, clinical treatment is very thorny, is exactly at a loss what to do sometimes.Body surface tumour and other dermatosiss are with caking, coarse, ulcer, obstinate difficult more person, also a difficult problem that is puzzlement doctor, suffer from, such as variability eczema or neurodermatitis, prolonged more not or outbreak repeatedly, and occur that slightly thick, red and swollen, diabrosis of skin, pruritus are unbearably etc.Therefore, in conjunction with traditional Chinese medical science traditional treatment stone furuncle, wart, magic flower (body surface innocent and malignant tumour and other dermatosiss bes's with slightly thick, caking, diabrosis person of skin) experience, and on the basis of my clinical practice of Chinese medicine, formulate Chinese medicine formula involved in the present invention and preparation method thereof etc.
The present invention is based on Chinese medical theory knowledge and clinical practice and a kind of external Chinese medicine ointment of founding, be used for eliminating and be raisedly born in the subcutaneous and raised malignant tumor enclosed mass in skin (furuncle, wart) in skin or root, or with the malignant tumor of festering (magic flower), or benign tumor and other dermatosiss are with slightly thick, tuberosity, ulcer person's (furuncle, wart, magic flower) of skin, play Xiao Ding G long-pending, cooling blood and relieving pain, the effect of removing the rotten and letting fresh grow.The present invention has formed a new Chinese medicine formula, through clinical use, proves effectively; This Chinese medicine formula is concocted without high temperature, preserves original herbal nature, and curative effect is strong, makes the crude drug property of medicine obtain fully playing utilization; This Chinese medicine formula is made ointment, is convenient to external, easily allows effective ingredient fully contact with affected part, better brings into play curative effect; This Chinese medicine formula is made ointment, and skin is had to protection and repair; The invention belongs to external tumor method for cancer, do not hinder the intestines and stomach, little to human body side effect, safe.
Curative effect judgement:
Effect: Xiao Ding G is long-pending, and cooling blood and relieving pain, removes the rotten and lets fresh grow.
Cure mainly: pyretic toxicity gather or excessive noxious heat due to stone furuncle, wart, magic flower, long-pending etc.Ulcerations such as Superficial Malignant Tumours, skin carcinoma, malignant lymphoma, the various malignant tumor superficial lymph that is equivalent to modern medicine carried down and moved, Subcutaneous metastasis cancer, benign tumor and the optimum furuncle of body surface, wart, enclosed mass or without ulceration person.
Points for attention: organ failure, shock, high heat, apoplexy and myocardial infarction acute stage, those who are allergic to this drug's forbidding.Anemia of pregnant woman's forbidding.The person of having a delicate constitution is cautious use of.This medicine should be applied under doctor of traditional Chinese medicine instructs, according to patient's concrete condition, with mediator's yin-yang, the same use of strengthening vital QI to eliminate pathogenic factors Chinese medicine for oral administration.
Curative effect judgement:
Recovery from illness: the disappearance such as tumor or tuberosity of skin surface, wound healing, skin surface recovers normal morphology, without recurrence.
Take a turn for the better: the tumor of skin surface or tuberosity homalographic or volume-diminished, wound dwindles or heals.
Invalid: all diseases are not improved.
Result of use: treatment 99 cases, use external used medicine of the present invention, be 1 course for the treatment of January, during this time can further consultation, use 2-5 the course for the treatment of according to the state of an illness.After 5 courses for the treatment of, recovery from illness 38 examples, account for 38.4%; 42 examples that take a turn for the better, account for 42.4%; Invalid 19 examples, account for 19.2%.Total effective rate 80.8%.
Attached several routine case is described further:
Case 1:
Patient king so-and-so, male, on August 13rd, 1948 birth, because left arm has 3 tumors and hurt like hell in Affiliated Hospital of Lai University Of Qingdao department of Chinese medicine outpatient clinic Augusts 9 in 2012.Before 3 years 3 months, be diagnosed as non-Hodgkin′s malignant lymphoma.
Medical history: in October, 2008, mother patient died, and he is oversad, feels tired, loss of appetite, extremity progressive pain, finding subsequently has tag in its axillary fossa, groin, and with obvious pain.Patient goes to Qingdao Municipal Hospital medical in April, 2009, the surgeon of this institute gives the left groin Tumor resection of patient and does pathology, show: (left groin) lymph node Fei Huoqijinshi Diffuse Large B-Cell Lymphoma, tumor tissue involves skin, does not involve each side surgical resection margins and substrate incisxal edge.SABC: LCA (+), CD3 (-), CD20 (+), EMA (-), Vim (+), CK (-).B ultrasonic shows: double inguinal groove, right axillary fossa, right Enlarged Cervical Lymph Nodes.Abdominal CT is shown: splenomegaly, and multiple little low-density shadow in liver, liver multiple cyst, ascending colon intestinal wall is slightly thick.Consider to be the III B phase by stages.This institute's oncology gives 6 cycle R-CHOP scheme chemotherapies (specifically not quite clear), and in December, 2009 finishes.Side reaction is with the bone marrow depression of III degree, and the gastrointestinal reactions such as nausea and vomiting are main, after symptomatic treatment, take a turn for the better.In treatment, there is whole skin erythema, pruritus.In 6 cycle chemotherapy, focus has repeatedly, and multiple nodules appears in rear whole skin, and CT shows: the several small lymph nodes of double inguinal groove, again capable right thoracic wall eminectomy.In December, 2009 Fudan University in Shanghai hospital attached to a medical college Pathology Consultation: (right breast) skin primary cutaneous type.Between (left skin of groin, lymph node) primary cutaneous, become maxicell lymphoma probability large.It is rear swollen that thing is cumulative increases greatly, on February 9th, 2010 in 1 cycle of Qingdao City Tumour Hospital's row chemotherapy: ifosfamide 1.5d1-4, beautiful this sodium 0.4 in IFO start 0,4,8h, DDP40mg d1-4, VP-16:0.1d1-5.Fail to respond to any medical treatment.After take voluntarily treatment by Chinese herbs effect not good enough (specifically not quite clear).In in JIUYUE, 2010 to the Chinese People's Liberation Army's 307 hospital admissions, consider to meet west and reach the II clinical trial phase of aniline treatment recurrent and refractory lymphoma peripheral T cell, entered group, within 20th, begin to take medicine in JIUYUE in 2010, tumour progression after 3 courses for the treatment of, is gone out group.After repeatedly there is skin nodules, on January 16,23 days to 2012 March in 2011 is in repeatedly row left upper arm, left buttocks, left side thoracic wall, two forearm, left axillary fossa radiotherapy of Qingdao City Tumour Hospital, radiotherapy rear section focus disappears, but the control time is short, still have multiple skin noduless residual, and have indivedual focus progress.Then on February 24th, 2012 at Affiliated Hospital of University Of Qingdao row 1 cycle GDL scheme chemotherapy, medication: gemcitabine 1.6d1,8, dexamethasone 10mgd1-5, asparaginase 10000ud2-8.Chemotherapy side effect is with the bone marrow depression of III degree, and the gastrointestinal reactions such as nausea and vomiting are main, after symptomatic treatment, take a turn for the better.After chemotherapy, indivedual tuberositys dwindle, and swelling alleviates, but patient's lumbago, weight loss is obvious, and left upper extremity is swelling pain still, and tuberosity increases again gradually, and indivedual ulcerations are hemorrhage.
On August 9th, 2012 patient to carry out my department of Chinese medicine medical, on skin, have 3 obvious tumors, wherein 2 diabrosis, 6 × 5 maximum × 4.5cm, hurt like hell outside its left arm.Patient's skin of upper extremity color is dark, coarse and hardening is thought of as caused by radiation.
Other symptoms of patient, sign have: anxious, weak, insomnia, and body of the tongue purple, yellow fur is thick, slippery and rapid pulse.Because surgeon considers that the difficult healing of skin refuse to patient's row operative treatment after its radiotherapy, oncologist advises that patient carrys out department of Chinese medicine row symptomatic treatment (health invigorating eases the pain and anxiety), prepares against follow-up chemotherapy or radiotherapy.After indagation patient, I give tcm diagnosis and dialectical, first allow patient oral containing Chinese patent medicines such as Hirudo, Pheretima, Rhizoma Corydalis one week, only want the auxiliary treatment as pain relieving, blood stasis-eliminating and stagnation-dissipating.Because patient is still taking etoposide in this week, I do not give other treatments by Chinese herbs.
But the limbs pain through this week treatment patient does not subtract, left upper extremity tumor shape size is without changing, and other symptoms are without improvement.So it is medical that patient initiatively carrys out again my department of Chinese medicine on August 16th, 2012, and withdrawn etoposide.Now, the tumor of patient's left arm maximum is festered as cauliflower form, and with hemorrhage, left upper extremity is pain extremely, and with dizziness, rapid breathing, vexed, insomnia, soft stool, body of the tongue is dark reddish purple, and yellow fur is thick, thready and rapid pulse.According to theory of Chinese medical science, I am dialectical thinks that this patient is that expectorant heat, blood stasis are tied mutually, excessive noxious heat, and gas, cloudy two wounds, and with giving supplementing QI and nourishing YIN, blood stasis dispelling removing heat from blood, heat-clearing and toxic substances removing, the Chinese medicine decoction of pain relieving dampness, advises it to serve on ten days, improves its body constitution.Meanwhile, I output external application Chinese medicine to this patient, i.e. the related formula of patent application of the present invention, advises it that this medicine is coated onto to tumor surface uniformly, and be coated with 2--3 every day, connects and be coated with 10 days.After 10 days, patient's General Symptoms is alleviated to some extent, and tumor size is unchanged, bleed only, and pain relief but still obviously.
Patient repeatedly carrys out here further consultation on August 27th, 2012, JIUYUE 5 days, JIUYUE 10 days, JIUYUE 17 days, JIUYUE 28 days and October 10, I give oral Chinese medicine according to conditions of patients, nurse one's health its negative and positive of qi and blood, and advise it to adhere to applying above-mentioned external application Chinese medicine ointment.Patient compliance is good, and during to October in 2012 further consultation on the 10th, its left arm tumor has come off most.
After this, this patient adheres to applying above-mentioned external application Chinese medicine ointment and oral traditional Chinese medicine decoction, and when within 2012, November 4,11,16 examined, its left arm tumor all comes off, and wound heals gradually.On April 27th, 2013 is paid a return visit patient, and its left arm tumor does not recur again, and left arm skin color is front ruddy.
Case 2:
Patient Zhang, male, the birth on the 17th of nineteen fifty-five JIUYUE.Because of the cervical region enclosed mass of repeatedly growing, with uncomfortable in chest, chest pain, weak, nervous 3 years, increase the weight of 20 days, and in March 16 in 2014 Affiliated Hospital of the Lai University Of Qingdao department of Chinese medicine see a doctor.Before 3 years, this patient is diagnosed as malignant lymphoma, through once controlling by the chemotherapy state of an illness, but since in February, 2014, Diagnosis of Cervical Masses obviously increases again, and in February, 2014, CT showed: on two hilus pulumonis, two oxter, clavicle, cervical region, the multiple lymphadenectasis of double inguinal groove, and hydrothorax.Local hospital oncology gives 2 cycle chemotherapy, on two oxters, clavicle, cervical region, double inguinal groove lymph node disappear.But nearly 20 days left necks raw lump again, and ramp.When within 2014, March 16 examined, the left neck root of patient touches enclosed mass, and matter is hard, uneven, and highest point is higher than the about 3cm of skin, and approximately 3.5 × 5cm of chassis area, without diabrosis.Simultaneously patient is uncomfortable in chest, and cough is nervous, weak, and two lower limb are aching and limp and be afraid of cold, chest pain sometimes, and light purplish tongue, tongue fur is thick in vain, and pulse condition is counted accurately and is slided, two CHI-pulse being weak.
When head examines, give the strengthening vital QI to eliminate pathogenic factors Chinese medicine decoction such as Radix Rehmanniae Preparata, the Radix Astragali, Rhizoma Curcumae, Herba Hedyotidis Diffusae oral, give present patent application related ointment external simultaneously, advise it to smear affected part 2-3 times/day, be used in conjunction 30 days.
15 days two April in 2014 examines, the deliquescing of the left neck root of patient tuberosity, dwindles obviously, and approximately 2 × 3 × 4cm, patient is uncomfortable in chest, cough, chest pain, nervous, weak, two lower limb are aching and limp and be afraid of cold etc., and symptom is clearly better, gastral cavilty is slightly uncomfortable, loose stool, pale tongue, tongue fur is thick in vain, and pulse condition is heavy thin, two CHI-pulse being weak.Still give the strengthening vital QI to eliminate pathogenic factors Chinese medicine decoction conditionings such as Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Curcumae, Herba Hedyotidis Diffusae, give present patent application related ointment external simultaneously, advise it to smear affected part 2-3 times/day, be used in conjunction 30 days.
15 days three May in 2014 examines, and the left neck root of patient tuberosity obviously dwindles, approximately 1.0 × 1.5 × 2.5cm, and patient, without uncomfortable in chest, chest pain, coughs once in a while, has palpitation, weak, and two lower limb are strong before, but still are afraid of cold, pale tongue, tongue fur is white, and pulse condition is heavy thin, two CHI-pulse being weak.Give the strengthening vital QI to eliminate pathogenic factors Chinese medicine decoction conditionings such as Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria, Ramulus Cinnamomi, Rhizoma Amorphophalli, Rhizoma Curcumae, Herba Hedyotidis Diffusae, give present patent application related ointment external simultaneously, advise it to smear affected part 3-4 times/day, be used in conjunction 30 days.
The four diagnostic methods on June 16 in 2014, the left neck root of patient tuberosity obviously dwindles once again, and skin surface is not seen, but touch can and, approximately 0.5 × 0.6 × 0.8cm, patient is afraid of cold etc. without nervous, weak, two lower limb, and appetite is good, activity increases, dry cough once in a while, body of the tongue is light red, thin white fur of tongue, pulse condition stringy and thready pulse, CHI-pulse being weak.Give present patent application related formula external, smear 3 times/day, affected part, then use 30 days.Patient's further consultation on July 14 in 2014, cervical region tuberosity size during as on June 16th, 2014, does not disappear and does not also increase, and subjective symptoms is not obvious, and the exercise of climbing the mountain every day, can orthobiosis.
Case 3:
Lee, male, 28 years old, because of in glans penis and foreskin repeatedly raw little wart within 2 years, carry out the department of Chinese medicine on February 13rd, 2014 and see a doctor.
Patient marries the year before, and half a year after marriage, its glans penis is found the hard little wart of multiple taupe matter around and in foreskin, and the maximum diameter 2.5cm, with pain and pruritus, is diagnosed as at local hospital " condyloma acuminatum ", and row laser therapy is removed it.When within 2014, February 13 examined, its glans penis and foreskin place bear again multiple little warts, the maximum diameter 0.8cm, scratchy discomfort, and lather, body void is weak, xerostomia halitosis, constipation with dry stool, frequent micturition and color depth, insomnia forgetfulness, deep red tongue, yellow fur is thick greasy, and deep pulse is counted accurately and two CHI-pulse being weak.Patient is in the past healthy, and states: its wife conceived 6.5 months, also suffers from " condyloma acuminatum ".
It is dialectical that I give traditional Chinese medical science differential diagnosis of diseases: the shy wart of sick genus, and card belongs to impairment of both QI and YIN, and disarmony between the heart and kidney, accumulates in damp and hot malicious heresy.Give the formula that present patent application relates to, advise patient that this medicine is coated onto to surface, affected part uniformly, be coated with 3-5 every day, within 30 days, is a course for the treatment of.Patient repeatedly carrys out here further consultation on February 23rd, 2014, March 5, March 15, March 25, April 5, simultaneously, I give according to conditions of patients that boosting qi and nourishing yin is calmed the nerves and dampness heat-clearing and toxic substances removing among medicine decoction oral, and advise it to adhere to applying above-mentioned external application Chinese medicine ointment.
Patient compliance is better, and during to April in 2014 further consultation on the 15th, the multiple little warts in its glans penis and foreskin place come off, and its lather, body void are weak, xerostomia halitosis, constipation with dry stool, frequent micturition and the symptoms such as color depth, insomnia forgetfulness also disappear, and then advise its drug withdrawal.Two, after March, on June 15th, 2014, return visit further consultation on July 15, patient's glans penis and foreskin place condyloma acuminatum do not recur.
Detailed description of the invention
Embodiment 1:
The invention provides the one furuncle eliminate indigestion ointment that disappears, formed by the preparation of raw material of following parts by weight: 150 parts of Fructus Tribulis, 40 parts of Herba Artemisiae Anomalaes, 20 parts of Fructus Bruceaes, 20 parts of Herba Asaris, 50 parts of Radix Arnebiae (Radix Lithospermi)s, 9 parts of Hirudos, 12 parts of Venenum Bufoniss, 15 parts of Indigo Naturaliss, 1000 parts of Oleum sesami, 200 parts of medical ventolins.
Prepare according to following steps:
(1) Fructus Tribuli, Herba Artemisiae Anomalae, Fructus Bruceae, Herba Asari, Radix Arnebiae (Radix Lithospermi) are broken into respectively to coarse powder; Hirudo, Venenum Bufonis are broken into fine powder;
(2) Oleum sesami is placed in stainless-steel pan, pot is placed in big fire and is heated to 80 degree, put into Fructus Tribuli, Herba Artemisiae Anomalae, the Fructus Bruceae pulverized, endure 5 minutes, change little fire, treat that temperature is down to 40 degree, then put into Herba Asari, the Radix Arnebiae (Radix Lithospermi) of pulverizing, endure 5 minutes;
(3) remove fire, leave standstill 24 hours;
(4) elimination medicinal residues;
(5) medical ventolin is put into stainless-steel pan, be placed in fire upper, molten opening.Subtract fire, in the time that vaseline to 40 is spent, put into the medicine oil of filtering residue, stir;
(6) remove fire, add immediately Hirudo, Venenum Bufonis and the Indigo Naturalis powder pulverized, stir;
(7) bottling, cooling.
Embodiment 2:
The invention provides the one furuncle eliminate indigestion ointment that disappears, formed by the preparation of raw material of following parts by weight: 120 parts of Fructus Tribulis, 30 parts of Herba Artemisiae Anomalaes, 30 parts of Fructus Bruceaes, 40 parts of Herba Asaris, 70 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts of Hirudos, 18 parts of Venenum Bufoniss, 20 parts of Indigo Naturaliss, 1200 parts of Oleum sesami, 300 parts of medical ventolins.
Prepare according to following steps:
(1) Fructus Tribuli, Herba Artemisiae Anomalae, Fructus Bruceae, Herba Asari, Radix Arnebiae (Radix Lithospermi) are broken into respectively to coarse powder; Hirudo, Venenum Bufonis are broken into fine powder;
(2) Oleum sesami is placed in stainless-steel pan, pot is placed in big fire and is heated to 90 degree, put into Fructus Tribuli, Herba Artemisiae Anomalae, the Fructus Bruceae pulverized, endure 10 minutes, change little fire, treat that temperature is down to 45 degree, then put into Herba Asari, the Radix Arnebiae (Radix Lithospermi) of pulverizing, endure 10 minutes;
(3) remove fire, leave standstill 18 hours;
(4) elimination medicinal residues;
(5) medical ventolin is put into stainless-steel pan, be placed in fire upper, molten opening.Subtract fire, in the time that vaseline to 45 is spent, put into the medicine oil of filtering residue, stir;
(6) remove fire, add immediately Hirudo, Venenum Bufonis and the Indigo Naturalis powder pulverized, stir;
(7) bottling, cooling.
Embodiment 3:
The invention provides the one furuncle eliminate indigestion ointment that disappears, formed by the preparation of raw material of following parts by weight: 135 parts of Fructus Tribulis, 35 parts of Herba Artemisiae Anomalaes, 25 parts of Fructus Bruceaes, 30 parts of Herba Asaris, 60 parts of Radix Arnebiae (Radix Lithospermi)s, 12 parts of Hirudos, 15 parts of Venenum Bufoniss, 18 parts of Indigo Naturaliss, 1100 parts of Oleum sesami, 260 parts of medical ventolins.
Prepare according to following steps:
(1) Fructus Tribuli, Herba Artemisiae Anomalae, Fructus Bruceae, Herba Asari, Radix Arnebiae (Radix Lithospermi) are broken into respectively to coarse powder; Hirudo, Venenum Bufonis are broken into fine powder;
(2) Oleum sesami is placed in stainless-steel pan, pot is placed in big fire and is heated to 85 degree, put into Fructus Tribuli, Herba Artemisiae Anomalae, the Fructus Bruceae pulverized, endure 8 minutes, change little fire, treat that temperature is down to 43 degree, then put into Herba Asari, the Radix Arnebiae (Radix Lithospermi) of pulverizing, endure 7 minutes;
(3) remove fire, leave standstill 30 hours;
(4) elimination medicinal residues;
(5) medical ventolin is put into stainless-steel pan, be placed in fire upper, molten opening.Subtract fire, in the time that vaseline to 43 is spent, put into the medicine oil of filtering residue, stir;
(6) remove fire, add immediately Hirudo, Venenum Bufonis and the Indigo Naturalis powder pulverized, stir;
(7) bottling, cooling.
Claims (4)
1. the furuncle eliminate indigestion ointment that disappears, it is characterized in that, formed by the preparation of raw material of following parts by weight: 120～150 parts of Fructus Tribulis, 30～40 parts of Herba Artemisiae Anomalaes, 20～30 parts of Fructus Bruceaes, 20～40 parts of Herba Asaris, 50～70 parts of Radix Arnebiae (Radix Lithospermi)s, 9～15 parts of Hirudos, 12～18 parts of Venenum Bufoniss, 15～20 parts of Indigo Naturaliss, 1000～1200 parts of Oleum sesami, 200～300 parts of medical ventolins.
2. the furuncle eliminate indigestion ointment that disappears as claimed in claim 1, is characterized in that, is formed by the preparation of raw material of following parts by weight: 150 parts of Fructus Tribulis, 40 parts of Herba Artemisiae Anomalaes, 20 parts of Fructus Bruceaes, 20 parts of Herba Asaris, 50 parts of Radix Arnebiae (Radix Lithospermi)s, 9 parts of Hirudos, 12 parts of Venenum Bufoniss, 15 parts of Indigo Naturaliss, 1000 parts of Oleum sesami, 200 parts of medical ventolins.
3. the method for preparation external application Chinese medicine as claimed in claim 1 or 2, is characterized in that, comprises the following steps:
(1) Fructus Tribuli, Herba Artemisiae Anomalae, Fructus Bruceae, Herba Asari, Radix Arnebiae (Radix Lithospermi) are broken into respectively to coarse powder; Hirudo, Venenum Bufonis are broken into fine powder;
(2) Oleum sesami is placed in stainless-steel pan, pot is placed in big fire and is heated to 80～90 degree, put into Fructus Tribuli, Herba Artemisiae Anomalae, the Fructus Bruceae pulverized, endure 5～10 minutes, change little fire, treat temperature be down to 40～45 degree, put into again Herba Asari, the Radix Arnebiae (Radix Lithospermi) of pulverizing, endure 5～10 minutes;
(3) remove fire, leave standstill 18～30 hours;
(4) elimination medicinal residues;
(5) medical ventolin is put into stainless-steel pan, be placed in fire upper, molten opening.Subtract fire, in the time that vaseline to 40～45 are spent, put into the medicine oil of filtering residue, stir;
(6) remove fire, add immediately Hirudo, Venenum Bufonis and the Indigo Naturalis powder pulverized, stir;
(7) bottling, cooling.
4. the external application Chinese medicine preparation method for the treatment of body surface tumor as claimed in claim 3, is characterized in that, comprises the following steps:
(1) Fructus Tribuli, Herba Artemisiae Anomalae, Fructus Bruceae, Herba Asari, Radix Arnebiae (Radix Lithospermi) are broken into respectively to coarse powder; Hirudo, Venenum Bufonis are broken into fine powder;
(2) Oleum sesami is placed in stainless-steel pan, pot is placed in big fire and is heated to 80 degree, put into Fructus Tribuli, Herba Artemisiae Anomalae, the Fructus Bruceae pulverized, endure 5 minutes, change little fire, treat that temperature is down to 40～45 degree, then put into Herba Asari, the Radix Arnebiae (Radix Lithospermi) of pulverizing, endure 5 minutes;
(3) remove fire, leave standstill 24 hours;
(4) elimination medicinal residues;
(5) medical ventolin is put into stainless-steel pan, be placed in fire upper, molten opening.Subtract fire, in the time that vaseline to 40～45 are spent, put into the medicine oil of filtering residue, stir;
(6) remove fire, add immediately Hirudo, Venenum Bufonis and the Indigo Naturalis powder pulverized, stir;
(7) bottling, cooling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410356256.6A CN104116772B (en) | 2014-07-24 | 2014-07-24 | Ointment for removing stasis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012121828A (en) * | 2010-12-08 | 2012-06-28 | Nippon Menaade Keshohin Kk | Phototoxicity inhibitor |
| CN103768344A (en) * | 2014-01-27 | 2014-05-07 | 杨德发 | External medicine for treating cervical carcinoma |
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2014
- 2014-07-24 CN CN201410356256.6A patent/CN104116772B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012121828A (en) * | 2010-12-08 | 2012-06-28 | Nippon Menaade Keshohin Kk | Phototoxicity inhibitor |
| CN103768344A (en) * | 2014-01-27 | 2014-05-07 | 杨德发 | External medicine for treating cervical carcinoma |
Non-Patent Citations (4)
| Title |
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| 殷子斐等: "外用蟾酥在肿瘤治疗中的应用", 《中医药导报》 * |
| 董永良: "去疣灵治疗病毒疣的临床观察", 《皮肤病与性病》 * |
| 赵瑞芝等: "疣毒净霜剂的薄层鉴别方法", 《中国药业》 * |
| 陈正堂: "《临床肿瘤学概论》", 31 October 2000, 中国协和医科大学出版社 * |
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