CN103100047B - Traditional Chinese medicine composition for treating gastric cancer and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating gastric cancer and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating gastric cancer, in particular to a traditional Chinese medicine composition for treating gastric cancer and a preparation method thereof. The traditional Chinese medicine composition comprises pseudo-ginseng, bittersweet herb, hairyvein agrimonia herb and bud, Indian iphigenia bulb, pinellia tuber, spreading hedyotis herb, barbed skullcap herb, cochinchnese asparagus root, dwarf lilyturf tuber, flos sophorae, vietnamese sophora root, rhizoma corydalis, largehead atractylodes rhizome, turmeric and onions. The traditional Chinese medicine composition is effective in treatment of gastric cancer, and not only has the effects of relieving pain and stopping bleeding, but also is anticancer and antitumor. The traditional Chinese medicine composition for treating gastric cancer usually employs local common medicinal materials, so that the cost is low, and the economical burden of a patient is reduced.
Description
Technical field
The invention discloses a kind of gastric cancer Chinese medicine composition for the treatment of, especially treat Chinese medicine composition of gastric cancer and preparation method thereof.Belong to Chinese medicine field.
Background technology
Gastric cancer is one of cancer that in worldwide, sickness rate is the highest.Annual newly-increased 900,000 patients with gastric cancer in the whole world, have 700,000 people to die from gastric cancer every year.The sickness rate of gastric cancer significantly raises along with the increase at age, and the peak age of morbidity was at 50 years old～80 years old.Wherein, male's sickness rate is 1.5～2.5 times of women, and mortality rate is only second to pulmonary carcinoma, occupies second.Meanwhile, the trend that women's incidence gastric cancer rate and mortality rate have rising.China is the district occurred frequently of gastric cancer, gastric cancer year prevalence and mortality rate are all more than 2 times of world average level.According to the Second National coroner's inquest result of sanitation Ministry tissue, show, the mortality rate of Chinese gastric cancer accounts for all because of 23.2% of cancer mortality number, approaches 1/4th.
The symptom of gastric cancer:
1. the above non-evident sympton of early gastric cancer 70%, development along with the state of an illness, can engender nonspecific, to exactly like gastritis or gastric ulcer symptom, comprise the glutted discomfort of epigastrium or dull pain, pantothenic acid, belch, feel sick, occasionally have vomiting, loss of appetite, melena etc.
2. advanced gastric carcinoma symptom is shown in gastric area pain, is often gnawing property, without obvious relation, also has similar peptic ulcer pain with feed, after feed, can alleviate.
Epigastrium feeling of repletion, sense of heaviness, anorexia, stomachache, nausea,vomiting,diarrhea, become thin, anemia, edema, heating etc.Carcinoma of gastric cardia main manifestations is uncomfortable under xiphoid-process, pain or retrosternal pain, companion's dysphagia sense or dysphagia; At the bottom of stomach and the normal non-evident sympton of cardia inferior segment cancer, when the diabrosis that necroses causes upper gastrointestinal hemorrhage until tumor is huge, just arouse attention, or cause the attention of beginning to give after dysphagia because of the tumor-infiltrated cardia that extends to; Body of stomach cancer is more common with intumescent, and the uncomfortable appearance of pain is more late; Gastric antrum lesser curvature side is the most common with ulcer type cancer, thus the symptom of epigastrium pain occur early, when tumor prolong and during pyloric ostium, can cause nausea, the pyloric obstruction symptom such as vomiting.Cancerous protuberance diffusion transfer can cause the transfer of ascites, hepatomegaly, jaundice and lung, brain, the heart, prostate, ovary, bone marrow etc. and occur corresponding symptom.
For the treatment of gastric cancer, doctor trained in Western medicine adopts operative treatment, radiotherapy or chemotherapy three one conventionally now, or the method for together treating.Operative treatment: generally include radical surgery, palliative operation, the operation of detecting property.The operation of take is means complete removal of lesions was or cut-out focus, reaches the method for curing or controlling cancer.Radiotherapy: being called for short radiotherapy, is to utilize high-energy electromagnetic radiation line to act on life entity, changes biomolecular structure, reaches a kind of Therapeutic Method of destruction of cancer cells object.It is because cancerous cell is responsive to lonizing radiation that radiation can be treated cancer.The lonizing radiation of application have x-ray treatment and r line to treat two kinds clinically at present.Chemotherapy: chemotherapy is to take medicine intravascular to whole body, and health all cells is had to impact.This therapy is sometimes also referred to as " born of the same parents poison therapy ", because medicine used is all harmful to, or even with toxicity, and cells in vivo, whether no matter malignant cell, is all damaged.
No matter be adopt operative treatment, radiotherapy or adopt chemotherapy, all patient's health caused to great burden, and costly, sufferer is born painful large.
Summary of the invention
Development along with Chinese Chinese medicine, in treatment and control gastric cancer, people have recognized that treatment by Chinese herbs stomach cancer treatment procedure has no side effect gradually, patient bears painful little, and the advantage that cost is saved relatively, for the present situation of existing western medical treatment cancer, one of object of the present invention is to provide a kind of Chinese medicine composition for the treatment of cancer, there is feature easy to operate, evident in efficacy, and its adopts comparatively common in the localities Chinese crude drug as raw material, with low cost.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for gastric cancer, take off the primary raw material of stating weight proportion and be prepared from: Radix Notoginseng 3-9 part, Herba Solani Lyrati 15-30 part, Herba Agrimoniae 10-30 part, Pseudobulbus Cremastrae Seu Pleiones 3-9 part, Rhizoma Pinelliae 3-10 part, Herba Hedyotidis Diffusae 15-30 part (preferred, Herba Hedyotidis Diffusae 15.5-29.5 part), Herba Scutellariae Barbatae 15-30 part, Radix Asparagi 10-20 part, Radix Ophiopogonis 10-20 part, Flos Sophorae 5-9 part, Radix Sophorae Tonkinensis 3-6 part, Rhizoma Corydalis 3-15 part, Rhizoma Atractylodis Macrocephalae 15-40 part, Rhizoma Curcumae Longae 10-30 part, Bulbus Allii Cepae 10-30 part.
Treat a Chinese medicine composition for gastric cancer, preferred scheme, takes off the primary raw material of stating weight proportion and is prepared from: Radix Notoginseng 5-9 part, Herba Solani Lyrati 16-25 part, Herba Agrimoniae 15-25 part, Pseudobulbus Cremastrae Seu Pleiones 4-8 part, Rhizoma Pinelliae 4-8 part, Herba Hedyotidis Diffusae 18-28 part, Herba Scutellariae Barbatae 18-25 part, Radix Asparagi 12-18 part, Radix Ophiopogonis 14-18 part, Flos Sophorae 6-8 part, Radix Sophorae Tonkinensis 3.5-5 part, Rhizoma Corydalis 6-14 part, Rhizoma Atractylodis Macrocephalae 20-38 part, Rhizoma Curcumae Longae 15-28 part, Bulbus Allii Cepae 12-28 part.
Treat a Chinese medicine composition for gastric cancer, best scheme, takes off the primary raw material of stating weight proportion and is prepared from: 8 parts of Radix Notoginseng, 20 parts of Herba Solani Lyratis, 20 parts of Herba Agrimoniaes, 6 parts of Pseudobulbus Cremastrae Seu Pleioness, 5 parts of the Rhizoma Pinelliaes, 20 parts of Herba Hedyotidis Diffusaes, 20 parts of Herba Scutellariae Barbataes, 15 parts of Radix Asparagis, 15 parts of Radix Ophiopogonis, 7 parts, Flos Sophorae, 4 parts of Radix Sophorae Tonkinensiss, 12 parts of Rhizoma Corydalis, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts, Rhizoma Curcumae Longae, 15 parts of Bulbus Allii Cepaes.
Another object of the present invention is just to provide the preparation method of above-mentioned treatment gastric cancer.
Treat a preparation method for the Chinese medicine composition of gastric cancer, mainly by following step, be prepared from:
1. the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae Longae, Bulbus Allii Cepae are smashed to the 20-60 minute that is soaked in water, boiled with high heat, change slow fire and add thermal distillation or pass into vapor distillation 30-120 minute, volatile oil and water are together distilled, collect distillate, standing 20-50 minute, distillate is cooled to 20-30 ℃, after get upper strata fluid, fluid is heated to 100 ℃-200 ℃, keep sterilization in 2-8 minute, be cooled to room temperature, after to be distributed into air-tight bottle standby.
2. Herba Solani Lyrati, Pseudobulbus Cremastrae Seu Pleiones and Rhizoma Pinelliae intense fire are fried open, turn 10-20 minute at a simmer, then putting into Radix Notoginseng, Herba Agrimoniae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Radix Asparagi, Radix Ophiopogonis, Flos Sophorae, Radix Sophorae Tonkinensis and Rhizoma Corydalis changes intense fire and is fried open, the continuous 20-40 minute that decocts of rear slow fire, leach medicinal liquid, be a pair, once a day.
Treat a preparation method for the Chinese medicine composition of gastric cancer, preferred, mainly by following step, be prepared from:
1. the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae Longae, Bulbus Allii Cepae are smashed to the 30-50 minute that is soaked in water, boiled with high heat, change slow fire and add thermal distillation or pass into vapor distillation 40-80 minute, volatile oil and water are together distilled, collect distillate, standing 25-40 minute, distillate is cooled to 25-28 ℃, after get upper strata fluid, fluid is heated to 120-180 ℃, keep sterilization in 3-6 minute, be cooled to room temperature, after to be distributed into air-tight bottle standby.
2. Herba Solani Lyrati, Pseudobulbus Cremastrae Seu Pleiones and Rhizoma Pinelliae intense fire are fried open, turn 12-18 minute at a simmer, then putting into Radix Notoginseng, Herba Agrimoniae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Radix Asparagi, Radix Ophiopogonis, Flos Sophorae, Radix Sophorae Tonkinensis and Rhizoma Corydalis changes intense fire and is fried open, the continuous 25-35 minute that decocts of rear slow fire, leach medicinal liquid, be a pair, once a day.
Treat a preparation method for the Chinese medicine composition of gastric cancer, best, mainly by following step, be prepared from:
1. the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae Longae, Bulbus Allii Cepae are smashed and be soaked in water 35 minutes, boiled with high heat, change slow fire and add thermal distillation or pass into vapor distillation 45 minutes, volatile oil and water are together distilled, collect distillate, standing 30 minutes, distillate was cooled to 26 ℃, after get upper strata fluid, fluid is heated to 150 ℃, keep sterilization in 4 minutes, be cooled to room temperature, after to be distributed into air-tight bottle standby.
2. Herba Solani Lyrati, Pseudobulbus Cremastrae Seu Pleiones and Rhizoma Pinelliae intense fire are fried open, turn 15 minutes at a simmer, then put into Radix Notoginseng, Herba Agrimoniae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Radix Asparagi, Radix Ophiopogonis, Flos Sophorae, Radix Sophorae Tonkinensis and Rhizoma Corydalis and change intense fire and be fried open, rear slow fire is continuous to be decocted 30 minutes, leaching medicinal liquid, is a pair, once a day.
This Chinese medicine composition is remarkable to gastric cancer effect, not only has the effect of pain relieving, hemostasis, also has anticancer antineoplastic action.Local common medical material for multiselect of the present invention, cheap, alleviated patient's financial burden.
The pharmacological effect of each crude drug is respectively:
Radix Notoginseng: sweet in the mouth, micro-hardship, warm in nature.Have styptic powder blood, antiinflammatory, protects the liver, antitumor, and the effect of analgesic therapy, for having a delicate constitution and all kinds of mass formed by blood stasis patient.
Herba Solani Lyrati: another name Herba Solani Lyrati, Pennisetum centrasiaticum Tzvel, hair Herba Senecionis Scandentis, hair Radix seu Caulis fici Martinii, Solanum lyratum Thunb., hair Xiucai, calabash grass, gold thread mossback.Bitter in the mouth, property is flat, slightly poisonous.There is removing toxic substances and promoting subsidence of swelling, anticancer effect, for cancer, icterohepatitis.
Herba Agrimoniae: cry again Western Agrimony.Bitter in the mouth, warm in nature.Astringing to arrest bleeding, dysentery relieving, parasite killing.Be widely used in various hemorrhage cards, for example: haematemesis, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, impairment caused by overstrain takes off power, carbuncle, traumatic injury, the cards such as wound hemorrhage, have inhibitory action to cancerous cell, for cancer and various hemorrhage disease.
Pseudobulbus Cremastrae Seu Pleiones: sweet in the mouth, cool in nature.There is heat-clearing and toxic substances removing, eliminating stagnation, antineoplastic effect.
The Rhizoma Pinelliae: acrid in the mouth, warm in nature, slightly poisonous.Have antitussive, tell in town, anticancer, the effect of blood pressure lowering, and for cancer, nausea and vomiting.
Herba Hedyotidis Diffusae: bitter in the mouth, cold nature.Another name: Herba Hedyotidis Diffusae, Herba Turczaninowiae Fastigiatae, Radix Picriae felterrae are the dry herb of Maguireothamnus speciosus Herba Hedyotidis Diffusae.There is heat reliving and toxin-eliminating, resolving carbuncle and expulsing boil, detumescence, antitumor, the effect of antiinflammatory, for tumors such as acute lymphoblastic type, granulocyte types.
Herba Scutellariae Barbatae: acrid in the mouth, hardship, cold in nature.There is heat-clearing and toxic substances removing, dissipating blood stasis hemostasis, anticancer effect, for leukemia, gastric cancer, esophageal carcinoma.
Radix Asparagi: sweet in the mouth, cold in nature, be tonic.Have nourshing Yin and drynsessmoistening prescription, antibacterial, antineoplastic effect, for leukemia, the disease of the deficiency of YIN.
Radix Ophiopogonis: sweet in the mouth, cold nature.There is reinforcing stomach reg fluid, hemostasis, hypoglycemic effect, for diabetes, spitting of blood, the disease of haematemesis.
Flos Sophorae: bitter in the mouth, cold nature.There is hemostasis, pain relieving, antiinflammatory, antiulcer effect, for spitting blood, gastroenteritic ulcer etc.
Radix Sophorae Tonkinensis: bitter in the mouth, cold in nature.There is removing toxic substances, detumescence, pain relieving, antineoplastic effect is remarkable for malignant tumor effect.
Rhizoma Corydalis: acrid in the mouth, warm in nature.There is promoting blood circulation to remove blood stasis, promoting the circulation of QI pain relieving, the breast side of body, epigastric pain. amenorrhea dysmenorrhea, postpartum stagnation, the effect of tumbling and swelling.
The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, warm in nature.There is invigorating the spleen and benefiting QI, improve resistance against diseases, antineoplastic effect, for esophageal carcinoma, deficiency of the spleen causing weakness of QI.
Rhizoma Curcumae Longae: acrid in the mouth, warm in nature.There is circulation of qi promoting, inducing menstruation to relieve menalgia, antitumor, antiinflammatory, the effect of blood fat reducing, for lymphatic cancer, the twinge of the breast side of body.
Bulbus Allii Cepae: acrid in the mouth, warm in nature.Another name: ball Herba Alii fistulosi, onion, Onion, onion, Dutch Herba Alii fistulosi.There is stomach-invigorating intestine-moisturizing, cold expelling blood pressure lowering, the effect of prophylaxis of cancer, for inappetence, three-hypers.
Chinese medicine composition of the present invention is debated the principle of disease treatment based on Chinese medicine.The medical material of selecting is divided into Orally-administered decoction medicine and external is applied ointment or plaster, and inside and outsidely treats simultaneously, treats more comprehensively, and affected area administration is rapider, and lasting medicine is taken into account inside and outside belonging to, the gastric cancer prescription for the treatment of both the principal and secondary aspects of a disease.Gastric cancer is had to fabulous therapeutical effect, for having fabulous opsonic action because of the long-term thin and weak health of chemicotherapy.
The specific embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not by this restriction.
embodiment 1treat a Chinese medicine composition for gastric cancer, take off the primary raw material of stating weight proportion and be prepared from 3 grams of Radix Notoginseng, 15 grams of Herba Solani Lyratis, 10 grams of Herba Agrimoniaes, 3 grams of Pseudobulbus Cremastrae Seu Pleioness, 3 grams of the Rhizoma Pinelliaes, 15 grams of Herba Hedyotidis Diffusaes, 15 grams of Herba Scutellariae Barbataes, 10 grams of Radix Asparagis, 10 grams of Radix Ophiopogonis, 5 grams, Flos Sophorae, 3 grams of Radix Sophorae Tonkinensiss, 3 grams of Rhizoma Corydalis, 15 grams of the Rhizoma Atractylodis Macrocephalaes, 10 grams, Rhizoma Curcumae Longae, 10 grams of Bulbus Allii Cepaes.
1. the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae Longae, Bulbus Allii Cepae are smashed and be soaked in water 20 minutes, boiled with high heat, change slow fire and add thermal distillation or pass into vapor distillation 30 minutes, volatile oil and water are together distilled, collect distillate, standing 20 minutes, distillate was cooled to 20 ℃, after get upper strata fluid, fluid is heated to 100 ℃, keep sterilization in 2 minutes, be cooled to room temperature, after to be distributed into air-tight bottle standby.
2. Herba Solani Lyrati, Pseudobulbus Cremastrae Seu Pleiones and Rhizoma Pinelliae intense fire are fried open, turn 10 minutes at a simmer, then put into Radix Notoginseng, Herba Agrimoniae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Radix Asparagi, Radix Ophiopogonis, Flos Sophorae, Radix Sophorae Tonkinensis and Rhizoma Corydalis and change intense fire and be fried open, rear slow fire is continuous to be decocted 20 minutes, leaching medicinal liquid, is a pair, once a day.
embodiment 2treat a Chinese medicine composition for gastric cancer, take off the primary raw material of stating weight proportion and be prepared from 5 grams of Radix Notoginseng, 16 grams of Herba Solani Lyratis, 15 grams of Herba Agrimoniaes, 4 grams of Pseudobulbus Cremastrae Seu Pleioness, 4 grams of the Rhizoma Pinelliaes, 18 grams of Herba Hedyotidis Diffusaes, 18 grams of Herba Scutellariae Barbataes, 12 grams of Radix Asparagis, 14 grams of Radix Ophiopogonis, 6 grams, Flos Sophorae, 3.5 grams of Radix Sophorae Tonkinensiss, 6 grams of Rhizoma Corydalis, 20 grams of the Rhizoma Atractylodis Macrocephalaes, 15 grams, Rhizoma Curcumae Longae, 12 grams of Bulbus Allii Cepaes.
1. the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae Longae, Bulbus Allii Cepae are smashed and be soaked in water 30 minutes, boiled with high heat, change slow fire and add thermal distillation or pass into vapor distillation 40 minutes, volatile oil and water are together distilled, collect distillate, standing 25 minutes, distillate was cooled to 25 ℃, after get upper strata fluid, fluid is heated to 120 ℃, keep sterilization in 3 minutes, be cooled to room temperature, after to be distributed into air-tight bottle standby.
2. Herba Solani Lyrati, Pseudobulbus Cremastrae Seu Pleiones and Rhizoma Pinelliae intense fire are fried open, turn 12 minutes at a simmer, then put into Radix Notoginseng, Herba Agrimoniae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Radix Asparagi, Radix Ophiopogonis, Flos Sophorae, Radix Sophorae Tonkinensis and Rhizoma Corydalis and change intense fire and be fried open, rear slow fire is continuous to be decocted 25 minutes, leaching medicinal liquid, is a pair, once a day.
embodiment 3treat a Chinese medicine composition for gastric cancer, take off the primary raw material of stating weight proportion and be prepared from 9 grams of Radix Notoginseng, 25 grams of Herba Solani Lyratis, 25 grams of Herba Agrimoniaes, 8 grams of Pseudobulbus Cremastrae Seu Pleioness, 8 grams of the Rhizoma Pinelliaes, 28 grams of Herba Hedyotidis Diffusaes, 25 grams of Herba Scutellariae Barbataes, 18 grams of Radix Asparagis, 18 grams of Radix Ophiopogonis, 8 grams, Flos Sophorae, 5 grams of Radix Sophorae Tonkinensiss, 14 grams of Rhizoma Corydalis, 38 grams of the Rhizoma Atractylodis Macrocephalaes, 28 grams, Rhizoma Curcumae Longae, 28 grams of Bulbus Allii Cepaes.
1. the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae Longae, Bulbus Allii Cepae are smashed and be soaked in water 50 minutes, boiled with high heat, change slow fire and add thermal distillation or pass into vapor distillation 80 minutes, volatile oil and water are together distilled, collect distillate, standing 40 minutes, distillate was cooled to 28 ℃, after get upper strata fluid, fluid is heated to 180 ℃, keep sterilization in 6 minutes, be cooled to room temperature, after to be distributed into air-tight bottle standby.
2. Herba Solani Lyrati, Pseudobulbus Cremastrae Seu Pleiones and Rhizoma Pinelliae intense fire are fried open, turn 18 minutes at a simmer, then put into Radix Notoginseng, Herba Agrimoniae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Radix Asparagi, Radix Ophiopogonis, Flos Sophorae, Radix Sophorae Tonkinensis and Rhizoma Corydalis and change intense fire and be fried open, rear slow fire is continuous to be decocted 35 minutes, leaching medicinal liquid, is a pair, once a day.
embodiment 4treat a Chinese medicine composition for gastric cancer, take off the primary raw material of stating weight proportion and be prepared from 9 grams of Radix Notoginseng, 30 grams of Herba Solani Lyratis, 30 grams of Herba Agrimoniaes, 9 grams of Pseudobulbus Cremastrae Seu Pleioness, 10 grams of the Rhizoma Pinelliaes, 30 grams of Herba Hedyotidis Diffusaes, 30 grams of Herba Scutellariae Barbataes, 20 grams of Radix Asparagis, 20 grams of Radix Ophiopogonis, 9 grams, Flos Sophorae, 6 grams of Radix Sophorae Tonkinensiss, 15 grams of Rhizoma Corydalis, 40 grams of the Rhizoma Atractylodis Macrocephalaes, 30 grams, Rhizoma Curcumae Longae, 30 grams of Bulbus Allii Cepaes.
1. the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae Longae, Bulbus Allii Cepae are smashed and be soaked in water 60 minutes, boiled with high heat, change slow fire and add thermal distillation or pass into vapor distillation 120 minutes, volatile oil and water are together distilled, collect distillate, standing 50 minutes, distillate was cooled to 30 ℃, after get upper strata fluid, fluid is heated to 200 ℃, keep sterilization in 8 minutes, be cooled to room temperature, after to be distributed into air-tight bottle standby.
2. Herba Solani Lyrati, Pseudobulbus Cremastrae Seu Pleiones and Rhizoma Pinelliae intense fire are fried open, turn 20 minutes at a simmer, then put into Radix Notoginseng, Herba Agrimoniae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Radix Asparagi, Radix Ophiopogonis, Flos Sophorae, Radix Sophorae Tonkinensis and Rhizoma Corydalis and change intense fire and be fried open, rear slow fire is continuous to be decocted 40 minutes, leaching medicinal liquid, is a pair, once a day.
embodiment 5treat a Chinese medicine composition for gastric cancer, take off the primary raw material of stating weight proportion and be prepared from 8 grams of Radix Notoginseng, 20 grams of Herba Solani Lyratis, 20 grams of Herba Agrimoniaes, 6 grams of Pseudobulbus Cremastrae Seu Pleioness, 5 grams of the Rhizoma Pinelliaes, 20 grams of Herba Hedyotidis Diffusaes, 20 grams of Herba Scutellariae Barbataes, 15 grams of Radix Asparagis, 15 grams of Radix Ophiopogonis, 7 grams, Flos Sophorae, 4 grams of Radix Sophorae Tonkinensiss, 12 grams of Rhizoma Corydalis, 30 grams of the Rhizoma Atractylodis Macrocephalaes, 25 grams, Rhizoma Curcumae Longae, 15 grams of Bulbus Allii Cepaes.
1. the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae Longae, Bulbus Allii Cepae are smashed and be soaked in water 35 minutes, boiled with high heat, change slow fire and add thermal distillation or pass into vapor distillation 45 minutes, volatile oil and water are together distilled, collect distillate, standing 30 minutes, distillate was cooled to 26 ℃, after get upper strata fluid, fluid is heated to 150 ℃, keep sterilization in 4 minutes, be cooled to room temperature, after to be distributed into air-tight bottle standby.
2. Herba Solani Lyrati, Pseudobulbus Cremastrae Seu Pleiones and Rhizoma Pinelliae intense fire are fried open, turn 15 minutes at a simmer, then put into Radix Notoginseng, Herba Agrimoniae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Radix Asparagi, Radix Ophiopogonis, Flos Sophorae, Radix Sophorae Tonkinensis and Rhizoma Corydalis and change intense fire and be fried open, rear slow fire is continuous to be decocted 30 minutes, leaching medicinal liquid, is a pair, once a day.
For making the present invention reach optimum therapeuticing effect, Chinese medicine decoction of the present invention, once a day, each pair, volatile oil is applied in the body surface at Ashi point (generally all determine with sick at acupuncture point, and multidigit is around pathological changes), the tsusanli acupoint (two) and position, tumor place, twice of every day.
model case one
Liu xx, female, 47 years old, Shenxian County, Liaocheng of Shandong Province Zhang Lou.Symptom: the regular dull pain of stomach, belch, vomiting, do not have appetite, and health is become thin weak.Go to hospital to make a definite diagnosis and be gastric cancer mid-term, do chemotherapy 2 months, because standing and holding, can't stand that the untoward reaction of chemotherapy and high expense stop treatment.Sick age: 1 year.Examine the time: on March 23rd, 2011; Take Chinese medicine decoction of the present invention, once a day, and smear volatile oil in the tsusanli acupoint (two), WEIYU acupoint, Shangwan point, every day twice, use traditional Chinese medicine composition for treating of the present invention 5 days, pain symptom alleviates, and appetite is recovered to some extent; Use traditional Chinese medicine composition for treating of the present invention 4 months, go the not diffusion of hospital's check cancerous cell; Use traditional Chinese medicine composition for treating of the present invention 7 months, tumor cell diminishes, at present rehabilitation.
model case two
Liu xx, man, 39 years old, Meng Jia village, Jin Zhuan town, Sishui County, Jining City in Shandong Province.Symptom: the difficulty of swallowing of eating, weight loss, intermittent stomach pain is with serious vomiting, and removing hospital diagnosis is early gastric cancer.Sick age: 5 months.Examine the time: on July 3rd, 2010; Take Chinese medicine decoction of the present invention, once a day, and smear volatile oil in the tsusanli acupoint (two), diaphragm shu cave, every day twice, use traditional Chinese medicine composition for treating of the present invention 10 days, symptoms of emesis alleviates, and pain has very large alleviation; Use traditional Chinese medicine composition for treating of the present invention 3 months, function of deglutition recovers completely, through examination in hospital tumor, obviously diminishes.Use traditional Chinese medicine composition for treating of the present invention 10 months, tumor disappears; Use separately volatile oil to consolidate one month, so far without recurrence.
model case three
Open xx, female, 48 years old, the Su Han village, Pingdu City Lan Di town, Shandong Province.Symptom: just started to swallow pain obstinate, after with the symptom of serious cough, spitting of blood, the obvious enlargement of throat.Through examination in hospital, be diagnosed as intermediate gastric carcinoma.Sick age: 6 months.Examine the time: on July 22nd, 2011; Take Chinese medicine decoction of the present invention, once a day, and in (in forearm palmar band 2 cun of Neiguan acupoints, article two, between muscle), (below knee joint approximately 3 cun of the tsusanli acupoints, the distance of approximately 4 horizontal fingers), ZHONGWAN acupoint (central authorities of xiphoid-process and umbilicus line) massage administration, every day twice, use traditional Chinese medicine composition for treating of the present invention 10 days, spitting of blood symptom alleviates, and pharyngeal pain is alleviated to some extent; Use traditional Chinese medicine composition for treating of the present invention 2 months, laryngeal neoplasm dwindles; Use traditional Chinese medicine composition for treating of the present invention 5 months, after hospital's check, find atrophy of tumor, in continuing at present to take.
model case four
Liu xx, man, 55 years old, the Tang Cun of Zoucheng City, Jining City in Shandong Province.Symptom: on November 29th, 2010 is medical because of hepatic region severe pain, checks and finds that liver has a tumor llx10cm.December CT check tumor on the 31st increases to 13xl3cm, and various symptoms increase the weight of day by day, are unable to leave the bed, and are diagnosed as late gastric cancer, lose operation and chemicotherapy chance.Sick age: 1 year.Examine the time: on March 12nd, 2011; Take Chinese medicine decoction of the present invention, once a day, and in (in forearm palmar band 2 cun of Neiguan acupoints, article two, between muscle), (below knee joint approximately 3 cun of the tsusanli acupoints, the distance of approximately 4 horizontal fingers) with medicine for external use, massage, every day twice, use traditional Chinese medicine composition for treating of the present invention 20 days, self-induction gastric area pain symptom alleviates; Use traditional Chinese medicine composition for treating of the present invention 1 month, muscle power obviously increases, and oneself can get up and arrive outdoor stroll; Continue medication to 2011 year August, complexion, than originally there being very large change, is checked through hospital, cancerous cell is without diffusing phenomenon, and body weight increases, and quality of life has very large change during than western medical treatment, mood is more optimistic than originally, life has been had to new hope, in continuing at present to take.
In order to verify the effect of Chinese medicine composition of the present invention, we have carried out the experiment (embodiment 5) of medicine, and accurately data have been carried out to statistics and mathematical analysis.
Specific experiment result is as following table:
Table 1:
Table 2:
Through clinical trial, prove, use Chinese medicine composition of the present invention to compare with the means of western medical treatment cancer, control recurrence rate after healing low, treatment means is more comprehensive thoroughly, between the operating period, have no side effect, in treatment gastric cancer, can alleviate the symptoms such as the pain brought by gastric cancer, inappetence.Through clinical trial, prove, Chinese drugs agentia effective percentage of the present invention is 98%, for early stage and late gastric cancer, all has good therapeutical effect, and most of patients with gastric cancer are in medication about 5 days, and pain symptom has obviously and alleviates.For early gastric cancer patient, adhere to using Chinese medicine composition of the present invention, about 4 months, can thoroughly remove focus, advanced gastric carcinoma patient is using Chinese medicine composition of the present invention about 6 months, can reach the object of controlling or curing cancer, and for late gastric cancer patient, use Chinese medicine composition of the present invention, when effectively controlling cancerous cell high speed diffusion, can make the quality of life that remains life improve, increase the confidence for future life.Therefore Chinese medicine composition of the present invention is a kind of medicine for the treatment of safely and effectively gastric cancer.
Claims (7)
1. a preparation method for the treatment of the Chinese medicine composition of gastric cancer, is characterized in that, takes off the raw material of stating weight proportion: Radix Notoginseng 3-9 part, Herba Solani Lyrati 15-30 part, Herba Agrimoniae 10-30 part, Pseudobulbus Cremastrae Seu Pleiones 3-9 part, Rhizoma Pinelliae 3-10 part, Herba Hedyotidis Diffusae 15-30 part, Herba Scutellariae Barbatae 15-30 part, Radix Asparagi 10-20 part, Radix Ophiopogonis 10-20 part, Flos Sophorae 5-9 part, Radix Sophorae Tonkinensis 3-6 part, Rhizoma Corydalis 3-15 part, Rhizoma Atractylodis Macrocephalae 15-40 part, Rhizoma Curcumae Longae 10-30 part, Bulbus Allii Cepae 10-30 part, step is as follows;
1. the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae Longae, Bulbus Allii Cepae are smashed to the 20-60 minute that is soaked in water, boiled with high heat, change slow fire heating and collect distillate or pass into vapor distillation 30-120 minute with distillation equipment, volatile oil and water are together distilled, collect distillate, standing 20-50 minute, distillate is cooled to 20-30 ℃, after get upper strata fluid, fluid is heated to 100 ℃-200 ℃, keep sterilization in 2-8 minute, be cooled to room temperature, after to be distributed into air-tight bottle standby;
2. Herba Solani Lyrati, Pseudobulbus Cremastrae Seu Pleiones and Rhizoma Pinelliae intense fire are fried open, turn 10-20 minute at a simmer, then put into Radix Notoginseng, Herba Agrimoniae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Radix Asparagi, Radix Ophiopogonis, Flos Sophorae, Radix Sophorae Tonkinensis and Rhizoma Corydalis and change intense fire and be fried open, rear slow fire is continuous decocts 20-40 minute, leaches medicinal liquid standby.
2. according to the preparation method described in claim 1, it is characterized in that, each crude drug is as follows: Radix Notoginseng 5-9 part, Herba Solani Lyrati 16-25 part, Herba Agrimoniae 15-25 part, Pseudobulbus Cremastrae Seu Pleiones 4-8 part, Rhizoma Pinelliae 4-8 part, Herba Hedyotidis Diffusae 18-28 part, Herba Scutellariae Barbatae 18-25 part, Radix Asparagi 12-18 part, Radix Ophiopogonis 14-18 part, Flos Sophorae 6-8 part, Radix Sophorae Tonkinensis 3.5-5 part, Rhizoma Corydalis 6-14 part, Rhizoma Atractylodis Macrocephalae 20-38 part, Rhizoma Curcumae Longae 15-28 part, Bulbus Allii Cepae 12-28 part.
3. according to the preparation method described in claim 1, it is characterized in that, each crude drug is as follows: 8 parts of Radix Notoginseng, 20 parts of Herba Solani Lyratis, 20 parts of Herba Agrimoniaes, 6 parts of Pseudobulbus Cremastrae Seu Pleioness, 5 parts of the Rhizoma Pinelliaes, 20 parts of Herba Hedyotidis Diffusaes, 20 parts of Herba Scutellariae Barbataes, 15 parts of Radix Asparagis, 15 parts of Radix Ophiopogonis, 7 parts, Flos Sophorae, 4 parts of Radix Sophorae Tonkinensiss, 12 parts of Rhizoma Corydalis, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts, Rhizoma Curcumae Longae, 15 parts of Bulbus Allii Cepaes.
4. preparation method according to claim 1, is characterized in that, 1. step smashes by the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae Longae, Bulbus Allii Cepae the 30-50 minute that is soaked in water, boiled with high heat, change slow fire and add thermal distillation or pass into vapor distillation 40-80 minute, volatile oil and water are together distilled, collect distillate, standing 25-40 minute, distillate is cooled to 25-28 ℃, after get upper strata fluid, fluid is heated to 120-180 ℃, keep sterilization in 3-6 minute, be cooled to room temperature, after to be distributed into air-tight bottle standby.
5. according to the preparation method described in claim 4, it is characterized in that, 1. step is smashed the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae Longae, Bulbus Allii Cepae to be soaked in water 35 minutes, boiled with high heat, change slow fire and add thermal distillation or pass into vapor distillation 45 minutes, volatile oil and water are together distilled, collect distillate, standing 30 minutes, distillate was cooled to 26 ℃, after get upper strata fluid, fluid is heated to 150 ℃, keep sterilization in 4 minutes, be cooled to room temperature, after to be distributed into air-tight bottle standby.
6. preparation method according to claim 1, it is characterized in that, 2. step is fried open Herba Solani Lyrati, Pseudobulbus Cremastrae Seu Pleiones and Rhizoma Pinelliae intense fire, turn 12-18 minute at a simmer, then putting into Radix Notoginseng, Herba Agrimoniae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Radix Asparagi, Radix Ophiopogonis, Flos Sophorae, Radix Sophorae Tonkinensis and Rhizoma Corydalis changes intense fire and is fried open, rear slow fire is continuous decocts 25-35 minute, leaches medicinal liquid standby.
7. preparation method according to claim 6, it is characterized in that, 2. step is fried open Herba Solani Lyrati, Pseudobulbus Cremastrae Seu Pleiones and Rhizoma Pinelliae intense fire, turn 15 minutes at a simmer, then putting into Radix Notoginseng, Herba Agrimoniae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Radix Asparagi, Radix Ophiopogonis, Flos Sophorae, Radix Sophorae Tonkinensis and Rhizoma Corydalis changes intense fire and is fried open, rear slow fire is continuous to be decocted 30 minutes, leaches medicinal liquid standby.
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