CN103768344B - The medicine for external use for the treatment of cervical cancer - Google Patents
The medicine for external use for the treatment of cervical cancer Download PDFInfo
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- CN103768344B CN103768344B CN201410038348.XA CN201410038348A CN103768344B CN 103768344 B CN103768344 B CN 103768344B CN 201410038348 A CN201410038348 A CN 201410038348A CN 103768344 B CN103768344 B CN 103768344B
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Abstract
The invention provides a kind of medicine for external use treating cervical cancer, calculate by weight its active component and be made up of Galla Chinensis 3��6 grams, Fructus Bruceae 3��6 grams, Radix Aconiti Lateralis 3��6 grams, carbonized Fructus Mume 13��17 grams, Indigo Naturalis 7.5��10.5 grams, Borneolum Syntheticum 2��4 grams, Benzoinum 4.5��7.5 grams, Calculus Bovis 4.5��7.5 grams, Scolopendra 11.5��12.5, Scorpio 8.5��10.5 grams, Sanguis Draxonis 8.5��10.5 grams, Radix Arnebiae (Radix Lithospermi) 4��8 grams and Bufo siccus 5.5��6.5 grams. With vagina vaginal dilator, cervix uteri is exposed under the visual field, dips in drug powder with cotton swab and spread upon the cancer site of cervix uteri, once a day. Observe: after 3 days, the lump of some patient starts zooming out, continuous use one to three month, in whole 36 cervical cancer patients, lump disappearance person 22 people, account for 61.1%; Mass reduction person 12 people, accounts for 33.3%, lump unchanged person 2 people, accounts for 5.6%, and total effective rate is 94.4%.
Description
Technical field
The present invention relates to a kind of medicine for external use treating cervical cancer, belong to cervical cancer practical technique field.
Background technology
Cervical cancer (cervical cancer) once find be just second phase or three, the fourth phase, usual patient and doctor advocate operative treatment. For the women given birth to, by surgical removal uterus, self and home influence is little. Without the women given birth to, it is influential that the life on her is extractd in uterus, and some impacts are also possible to very big. Some is not thoroughly also easy to recurrence because of operation. And it is also rarely found by Drug therapy cervical cancer successful story at present.
Summary of the invention
The invention aims to solve above-mentioned prior art Problems existing, the women namely not given birth to, it is influential that the life on her is extractd in uterus, and some impacts are also possible to very big. Some is not thoroughly also easy to recurrence because of operation. And it is also rarely found by Drug therapy cervical cancer successful story at present. And then a kind of medicine for external use treating cervical cancer is provided.
Above-mentioned purpose is realized by following technical scheme:
A kind of medicine for external use treating cervical cancer, calculates by weight its active component and is made up of Galla Chinensis 3��6 grams, Fructus Bruceae 3��6 grams, Radix Aconiti Lateralis 3��6 grams, carbonized Fructus Mume 13��17 grams, Indigo Naturalis 7.5��10.5 grams, Borneolum Syntheticum 2��4 grams, Benzoinum 4.5��7.5 grams, Calculus Bovis 4.5��7.5 grams, Scolopendra 11.5��12.5, Scorpio 8.5��10.5 grams, Sanguis Draxonis 8.5��10.5 grams, Radix Arnebiae (Radix Lithospermi) 4��8 grams and Bufo siccus 5.5��6.5 grams.
Above-mentioned various medicine material clear water (room temperature) are soaked 48 hours, at the beginning of immersion, water is limited just flooding medicine material, after add water again, within every four hours, stir once, after 48 hours, water base is absorbed by medicine material, then dries, and grinds to form the fineness micropowder at 300-1000 order, mixing, prepares into drug powder standby.
The screening of case and efficacy analysis:
Select at random at hospital outpatient and suffer from Patients with Cervical Cancer 36 people, wherein cervical cancer second phase patient 12 people, cervical cancer three phase patient 13 people, cervical cancer fourth phase patient 11 people. 47.6 years old mean age. There is treatment history.
Administrated method: be exposed under the visual field by cervix uteri with vagina vaginal dilator, dips in drug powder with cotton swab and spreads upon canceration (lump) position of cervix uteri, once a day.
The criterion of curative effect: lump disappears for curing, and mass reduction be effective, lump do not reduce or continue to be increased to invalid.
Observe: within 3 days, (72 hours) lump of some patient afterwards starts zooming out, continuous use one to three month (namely a month the fastest lump disappears, the trimestral treatment of most needs), in whole 36 cervical cancer patients, lump disappearance person 22 people, account for 61.1%; Mass reduction person 12 people, accounts for 33.3%, lump unchanged person 2 people, accounts for 5.6%, and total effective rate is 94.4%. The untoward reaction of medicine is not found during treatment. The patient that lump is disappeared follows the tracks of observation 2 years, has no recurrence.
The above-mentioned 13 taste Chinese medicines that the present invention uses, wherein:
Galla Chinensis is the insect gall formed after the upper parasitic times Aphidiadae insecticide horned gall aphid of the trees such as Anacardiaceae plant Fructus rhois chinensis or melaphis peitan Tsai et Tang, main containing Gallotannin. these tannins include: 1, 2, 3, 4, 6-five-O-galloyl-beta-D-glucose, 3-O-bis-galloyl-1, 2, 4, 6-tetra--O-galloyl-beta-D-glucose, 2-O-bis-galloyl-1, 3, 4, 6-tetra--O-galloyl-beta-D-glucose, 4-O-bis-galloyl-1, 2, 3, 6-tetra--O-galloyl-beta-D-glucose, 2, 3-O-bis-galloyl-1, 4, 6-tri--O-galloyl-beta-D-glucose, 3-O-tri-galloyl-1, 2, 4, 6-tetra--O-galloyl-beta-D-glucose, 3, double, two-O-two galloyl-1 of 4-, 2, 6-tri--O-galloyl-beta-D-glucose, 2, double, two-O-two galloyl-1 of 4-, 3, 6-tri--O-galloyl-beta-D-glucose.
The main component of Fructus Bruceae is bruceine A, B, C, D, E, F, G, H, I, bruceolide, Brusatol; Also containing alkaloid, such as brucamarine, yatanine; Glucoside, such as brucealin, brucealin and brucenol, bruceolic acid and vanillic acid. The fatty oil of java brucea seed (Oleum Fructus Bruceae) 56.23%. In oil, non-saponifiable matter accounts for 1.36%, includes volatile oil a little. Saponified in oil account for 92.47%, include oleic acid, account for the 81.87% of crude oil; Linoleic acid, accounts for the 3.37% of crude oil; Stearic acid, accounts for the 2.65% of crude oil; Palmic acid, accounts for the 6.62% of crude oil. The spun silk shape crystalline solid 4.59% also having fusing point to be 152 DEG C.
Radix Aconiti Lateralis Preparata is the processed goods of Radix Aconiti daughter root, the main monoesters Alkaloid less containing toxicity: benzoyl aconine, benzoyl mesaconitine, benzoyl hypo-aconine, is even hydrolyzed to the amine alcohols alkali that toxicity is less: aconine, mesaconitine, hypo-aconine. Radix Aconiti Lateralis Preparata is containing aconitine, mesaconitine, hypaconitine, talastisamine, namely higenamine is racemization demethyl coclaurine, coryneine chloride, different delphinine, benzoylmesaconitine, Xin Wuning alkali, the peaceful alkali of Radix Aconiti Lateralis Preparata, septentrionaline, karacoline, deoxyaconitine, Fuzitine alkali, songorine uracil, river oil aconitine, neojiangyouaconitine, Salsolinol etc.
Being mainly composed of of carbonized Fructus Mume: containing citric acid, solid black alcohol and oleanolic acid sample material.
Indigo Naturalis is again drift black pigment used by women in ancient times to paint their eyebrows powder, speckled celadon black pigment used by women in ancient times to paint their eyebrows, and Indigo Naturalis has effect of heat clearing away, blood cooling and ecchymoses removing, removing toxic substances, purging liver-fire, arresting convulsion, and Indigo Naturalis has that treatment epidemic febrile disease intenseness of heat, macule, haematemesis, spitting of blood, pediatric epilepsy scared, skin ulcer be swollen, the effect of erysipelas, snake bite and insect sting.
Borneolum Syntheticum is mainly containing Borneolum Syntheticum 59.78%��58.93%, isoborneol 38.98%��37.52%, Camphora 2.70%��2.09%.The crystallization obtained from the resin of Borneolum Syntheticum and volatile oil, is almost pure dextro Borneolum Syntheticum. Containing multiple ter penoids in the resin of Borneolum Syntheticum and volatile oil. Except Borneolum Syntheticum, still contain the triterpenes components such as sesquiterpene constituents and oleanolic acid, alphitolic acid, asiatic acid, dipterocarpol, dryobalanone, erythrodiol such as oxalene, beta-elemene, caryophyllene.
Styrax tonkinensis master resinous 70%��80%, and its composition has 3-benzoyl siaresinolic acid ester, 4-hydroxy-3-methoxycinnamic alcohol benzoate, and free benzoic acid 20%, vanillin 0.15%��2.3%, without cinnamic acid.
Being mainly composed of of Calculus Bovis: containing cholic acid 5%��11%, deoxycholic acid about 2%, chenodeoxycholic acid 0.6%��1.7% and its esters, bilirubin and calcium salt thereof; And shrink smooth muscle and the effect of reducing blood pressure containing cholesterol, ergosterol, lecithin, fatty acid, vitamin D, water-soluble peptide constituents SMC(tool), Yi Jitong, ferrum, magnesium, zinc etc. Australia produces Calculus Bovis containing several amino acids such as carotenoid, alanine, glycine, taurine, aspartic acid, arginine, leucine, methionine.
Being mainly composed of of Scolopendra: containing the toxic component of two kinds of similar Venenum apis, i.e. histamine sample material and hemolytic protein; Still fatty oil, cholesterol, formic acid etc. Also ��-oxylysine was once isolated; Aminoacid has histidine, arginine, ornithine, lysine, glycine, alanine, valine, leucine, phenylalanine, serine, taurine, glutamic acid.
Being mainly composed of of Scorpio: containing scorpion venom. Containing more complicated toxic protein and non-toxic albumen in scorpion venom, it is a kind of Neurotoxic protein of similar snake venom. containing multiple charybdotoxin in thick poison, including insects neurotoxin, shell-fish neurotoxin, mammalian nervous toxin, the polypeptide (AEP) of antiepileptic activity, analgesic activities polypeptide such as charybdotoxin. III, hyaluronidase. Scorpio hydrolyzed solution contains 17 kinds of essential amino acids.
And containing 29 kinds of inorganic elementss, have sodium, phosphorus, potassium, calcium, magnesium, zinc, ferrum, aluminum, copper, manganese, chlorine etc. Additionally, still containing trimethylamine, glycine betaine, ammonium salt, picric acid azanol, cholesterol, lecithin, scorpion acid, taurine palmitic acid, linolenic acid, mountain acid, positive 17 carbonic acid, vaccenic acid, 20 carbonic acid.
Being mainly composed of of Sanguis Draxonis: containing dracorhodin, dracorubin, (2s) 5-methoxyl group-6-methyl flavane-7-alcohol (i.e. flavonol) and benzoic acid etc.
Being mainly composed of of Radix Arnebiae (Radix Lithospermi): Radix Arnebiae (Radix Lithospermi) is containing pigment composition, fatty acid. pigment composition is naphthoquinone derivatives; there are shikonin (shikonin), acetylshikonin, deoxyshikonin, isobutyl group shikonin, IVS, ��; beta-dimethyl acryloyl shikonin, beta-hydroxy-IVS, alkannan, Radix Arnebiae (Radix Lithospermi) are red, Alpha-Methyl-n-butyryl shikonin, 3,4-dimethyl pentene-3-acyl group shikonins. Vacation Radix Arnebiae (Radix Lithospermi) in Xinjiang is containing ��-Hydroxyisovalerylshikonin, 3,4-dimethyl pentene-3-acyl group shikonin. and fatty acid is mainly palmitic acid, oleic acid and linoleic acid etc.
Bufo raddie strauch ear rear gland secretions is containing cholesterol, marinobufgin, Japan's bufotalien, remote cinobufacin, Arenobufagin. Volatile ingredient in ear glandular secretion thing is containing n-nonanoic acid, capric acid, a small amount of n-octadecane, AI3-36122, positive melissane, heneicosane, octadecadienoic acid.
The present invention synergism by above 13 taste Chinese medicines, plays respective drug effect, for treatment cervical cancer, has played good effect, has relieved slight illness for most of Patients with Cervical Cancers, and evident in efficacy, toxic and side effects is little, not easily recurs.
Detailed description of the invention
The present invention is described in further detail below: the present embodiment is carried out under premised on technical solution of the present invention, gives detailed embodiment, but protection scope of the present invention is not limited to following embodiment.
Embodiment 1:
The medicine for external use for the treatment of cervical cancer, calculates by weight its active component and is made up of Galla Chinensis 3��6 grams, Fructus Bruceae 3��6 grams, Radix Aconiti Lateralis 3��6 grams, carbonized Fructus Mume 13��17 grams, Indigo Naturalis 7.5��10.5 grams, Borneolum Syntheticum 2��4 grams, Benzoinum 4.5��7.5 grams, Calculus Bovis 4.5��7.5 grams, Scolopendra 11.5��12.5, Scorpio 8.5��10.5 grams, Sanguis Draxonis 8.5��10.5 grams, Radix Arnebiae (Radix Lithospermi) 4��8 grams and Bufo siccus 5.5��6.5 grams. Above-mentioned various medicine material clear water (room temperature) are soaked 48 hours, at the beginning of immersion, water is limited just flooding medicine material, after add water again, within every four hours, stir once, after 48 hours, water base is absorbed by medicine material, then dries, and grinds to form the fineness micropowder at 300-1000 order, mixing, prepares into drug powder standby.
Embodiment 2:
The medicine for external use of described treatment cervical cancer, calculates by weight its active component and is made up of Galla Chinensis 3.5��5.5 grams, Fructus Bruceae 3.5��5.5 grams, Radix Aconiti Lateralis 3.5��5.5 grams, carbonized Fructus Mume 14��16 grams, Indigo Naturalis 8��10 grams, Borneolum Syntheticum 2.5��3.5 grams, Benzoinum 5��7 grams, Calculus Bovis 5��7 grams, Scolopendra 11.8��12.2, Scorpio 8��10 grams, Sanguis Draxonis 8��10 grams, Radix Arnebiae (Radix Lithospermi) 5��7 grams and Bufo siccus 5.8��6.2 grams. Manufacture method is identical with embodiment 1.
Embodiment 3:
The medicine for external use of described treatment cervical cancer, calculates by weight its active component and is made up of Galla Chinensis 4.5 grams, Fructus Bruceae 4.5 grams, Radix Aconiti Lateralis 4.5 grams, carbonized Fructus Mume 15 grams, Indigo Naturalis 9 grams, Borneolum Syntheticum 3 grams, Benzoinum 6 grams, Calculus Bovis 6 grams, Scolopendra 12 grams, Scorpio 9 grams, Sanguis Draxonis 9 grams, Radix Arnebiae (Radix Lithospermi) 6 grams and Bufo siccus 6 grams. Manufacture method is identical with embodiment 1.
Claims (3)
1. the medicine for external use treating cervical cancer, it is characterized in that, calculate by weight its active component and be made up of Galla Chinensis 3��6 grams, Fructus Bruceae 3��6 grams, Radix Aconiti Lateralis 3��6 grams, carbonized Fructus Mume 13��17 grams, Indigo Naturalis 7.5��10.5 grams, Borneolum Syntheticum 2��4 grams, Benzoinum 4.5��7.5 grams, Calculus Bovis 4.5��7.5 grams, Scolopendra 11.5��12.5, Scorpio 8.5��10.5 grams, Sanguis Draxonis 8.5��10.5 grams, Radix Arnebiae (Radix Lithospermi) 4��8 grams and Bufo siccus 5.5��6.5 grams; Above-mentioned various medicine material clear water are soaked 48 hours at ambient temperature, at the beginning of immersion, water is limited just flooding medicine material, after add water again, within every four hours, stir once, after 48 hours, water base is absorbed by medicine material, then dries, and grinds to form the fineness micropowder at 300-1000 order, mixing, prepares into drug powder standby.
2. the medicine for external use for the treatment of cervical cancer according to claim 1; it is characterized in that, calculate by weight its active component and be made up of Galla Chinensis 3.5��5.5 grams, Fructus Bruceae 3.5��5.5 grams, Radix Aconiti Lateralis 3.5��5.5 grams, carbonized Fructus Mume 14��16 grams, Indigo Naturalis 8��10 grams, Borneolum Syntheticum 2.5��3.5 grams, Benzoinum 5��7 grams, Calculus Bovis 5��7 grams, Scolopendra 11.8��12.2, Scorpio 8��10 grams, Sanguis Draxonis 8��10 grams, Radix Arnebiae (Radix Lithospermi) 5��7 grams and Bufo siccus 5.8��6.2 grams.
3. the medicine for external use for the treatment of cervical cancer according to claim 1; it is characterized in that, calculate by weight its active component and be made up of Galla Chinensis 4.5 grams, Fructus Bruceae 4.5 grams, Radix Aconiti Lateralis 4.5 grams, carbonized Fructus Mume 15 grams, Indigo Naturalis 9 grams, Borneolum Syntheticum 3 grams, Benzoinum 6 grams, Calculus Bovis 6 grams, Scolopendra 12 grams, Scorpio 9 grams, Sanguis Draxonis 9 grams, Radix Arnebiae (Radix Lithospermi) 6 grams and Bufo siccus 6 grams.
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| CN201410038348.XA CN103768344B (en) | 2014-01-27 | 2014-01-27 | The medicine for external use for the treatment of cervical cancer |
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| CN104116772B (en) * | 2014-07-24 | 2017-05-10 | 彭小菊 | Ointment for removing stasis and preparation method thereof |
| CN105477554A (en) * | 2015-12-31 | 2016-04-13 | 蒲敬北 | Medicine for treating HPV infection and preventing cervical cancer and preparation method of medicine |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167820A (en) * | 2006-11-21 | 2008-04-30 | 张财 | External-applied traditional Chinese medicine for curing uterus cancer and its preparation method |
| CN103182063A (en) * | 2013-01-01 | 2013-07-03 | 夏义深 | Chinese patented drug pill for treating cancer |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167820A (en) * | 2006-11-21 | 2008-04-30 | 张财 | External-applied traditional Chinese medicine for curing uterus cancer and its preparation method |
| CN103182063A (en) * | 2013-01-01 | 2013-07-03 | 夏义深 | Chinese patented drug pill for treating cancer |
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Granted publication date: 20160608 Termination date: 20210127 |