CN103766905B - 一种石斛滁菊保健颗粒剂 - Google Patents
一种石斛滁菊保健颗粒剂 Download PDFInfo
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Abstract
本发明公开了一种石斛滁菊保健颗粒剂，由下述重量份数的原料制成：铁皮石斛粉0.5-1.5份，滁菊全浸膏冻干粉0.5-2份，辅料2-5份。本发明结合药食两用的铁皮石斛和滁菊的优点，将两种中药材合用，制备成颗粒剂，石斛与滁菊配伍，调和阴阳，标本兼顾，协同发挥保健功效，长期服用，保护心血管系统、肝组织，增强免疫力，耐疲劳，抗衰老，对高血压、高血糖、高血脂有预防和辅助治疗作用，而且有明目功效，对近视和老年白内障有保护和防治作用。同时，采用铁皮石斛粉和滁菊全浸膏粉的形式制备成颗粒剂，充分利用药效，易于吸收，剂量小而效果显著，使用方便，保留了滁菊花多类活性成分，提高了利用率。
Description
技术领域
本发明涉及中药保健领域，尤其涉及一种石斛滁菊保健颗粒剂及其制备方法。
背景技术
肝之阴阳失调，常因肝阴不足，不能制约肝阳，以致肝阳上亢，早期表现为眩晕耳鸣，头目胀痛，面红目赤，急躁易怒，心悸健忘，失眠多梦，腰膝酸软，口苦咽干，舌红，脉细数等；久之，血管硬化，血压升高，心率失常等，继而出现心脑血管的脆性增加，血流不畅，极易出现脑出血或心脑的梗塞，即肝阳上亢，亢极引动肝风，出现肝阳化风证。
铁皮石斛自古被称为“滋阴圣品”，具有滋养肝阴，明目功效，适用于肝阴不足的眼目干涩、内障不明，现已大量人工培育，但是仍然价格昂贵，而且药效利用率低；滁菊花为诸药用菊花之首，具有很高的药用价值，滁菊花以平肝明目见长，适用于风热上扰，肝火上炎之目赤红肿、视物模糊症状，常用于治疗肝阳上亢、高血压等所致的头晕目眩等症。
发明内容
本发明的目的是克服现有技术的不足，提供一种石斛与滁菊配伍，制备成颗粒剂，可以调和阴阳，标本兼顾，起到抗衰老、延年益寿功效的石斛滁菊保健颗粒剂，对高血压、高血糖、高血脂有预防和辅助治疗作用，药味少而效果显著，利用率提高。
为了实现上述目的本发明采用如下技术方案：
一种石斛滁菊保健颗粒剂，由下述重量份数的原料制成：
铁皮石斛粉0.5-1.5份
滁菊全浸膏冻干粉0.5-2份。
优选地，铁皮石斛1份，滁菊花全浸膏冻干粉1.5份。
石斛滁菊保健颗粒剂的制备方法，包括以下制备步骤：
（1）铁皮石斛粉制备：将铁皮石斛洗净，50℃烘干，粉碎至100-200目细粉，备用；
（2）滁菊全浸膏冻干粉制备：将滁菊花采用双提法制得挥发油和水提取物，得到的药渣再经乙醇提取得到醇提取物，合并水提物和醇提物，浓缩，冷冻干燥得到冻干粉，将制得的挥发油用β-环糊精包裹后，形成包裹物，最后将得到的冻干粉和包裹物混合，制备成滁菊全浸膏冻干粉，备用；
（3）按上述重量份数称取步骤（1）和步骤（2）中制得的铁皮石斛粉和滁菊全浸膏冻干粉，加入辅料2-5份，混合后湿法制粒，过筛整粒，制备成颗粒剂。
所述步骤（3）中的辅料为蔗糖粉、糊精、羧甲基淀粉钠、微晶纤维素中的一种或多种。
使用方法：分装成6g/袋，1-2袋/次，1-3次/日，开水冲服或嚼服，也可作为生产保健品的原料。
铁皮石斛，味甘，性微寒，具有滋养肝阴，明目功效。药理研究表明：铁皮石斛能提高应激能力，具有良好的抗疲劳、耐缺氧作用；可促进循环、降低血糖、扩张血管、降低血胆固醇和甘油三脂。含有丰富的多糖类物质，具有增强免疫功能的作用。现代药理研究证实：石斛对防治老年白内障和保护少儿视力有明显效果。
滁菊为诸药用菊花之首，具有很高的药用价值，试验研究发现，滁菊花中含有大量的黄酮、挥发油、多酚、多糖、人体必需氨基酸及矿物元素等，其中黄酮、挥发油、锌、硒等含量均超过其它菊花。滁菊花以平肝明目见长，常用于治疗肝阳上亢、高血压等所致的头晕目眩等症。滁菊花所含的挥发油具有广谱抗菌作用；菊花中黄酮类化合物具有显著的清除人体内自由基、抗老化、抗突变、调血脂、降血压等药理保健功能，能扩张冠状动脉，增加血流量，改善糖和脂类代谢，保护心血管系统、肝组织等；所含的锌、硒，可促进细胞分裂、延缓肌体衰老。滁菊花有明目的功效，可缓解眼睛疲劳、视力模糊，对恢复视力也有帮助。
与已有技术相比，本发明的有益效果如下：
本发明结合药食两用的铁皮石斛和滁菊的优点，滁菊具有改善糖和脂类代谢作用，石斛能够降低血糖、降低血胆固醇和甘油三脂，将两种中药材合用，制备成颗粒剂，石斛与滁菊配伍，调和阴阳，标本兼顾，协同发挥保健功效，长期服用，保护心血管系统、肝组织等，增强免疫力，耐疲劳，抗衰老，对高血压、高血糖、高血脂有预防和辅助治疗作用，两药均有明目功效，对常用电脑的上班族、近视、老年白内障等，有保护和防治作用。
同时，采用铁皮石斛细粉和滁菊全浸膏粉的形式制备成颗粒剂，充分利用药效，易于吸收，剂量小而效果显著，使用方便，保留了滁菊花多类活性成分，提高了利用率。
具体实施方式
下面结合实施例对本发明作进一步的描述。
实施例1：
首先将铁皮石斛洗净，50℃烘干，粉碎至100目细粉，制成铁皮石斛粉备用；
再将滁菊花采用双提法制得挥发油和水提取物，得到的药渣再经乙醇提取得到醇提取物，合并水提物和醇提物，浓缩，冷冻干燥得到冻干粉，将制得的挥发油用β-环糊精包裹后，形成包裹物，最后将得到的冻干粉和包裹物混合，制备成滁菊全浸膏冻干粉，备用；然后称取10g铁皮石斛粉、15g滁菊全浸膏冻干粉，加入羧甲基淀粉钠25g、糊精20g，混合后湿法制粒，过筛整粒，制备成颗粒剂。
实施例2：
首先将铁皮石斛洗净，50℃烘干，粉碎至100目细粉，制成铁皮石斛粉备用；
再将滁菊花采用双提法制得挥发油和水提取物，得到的药渣再经乙醇提取得到醇提取物，合并水提物和醇提物，浓缩，冷冻干燥得到冻干粉，将制得的挥发油用β-环糊精包裹后，形成包裹物，最后将得到的冻干粉和包裹物混合，制备成滁菊全浸膏冻干粉，备用；然后称取5g铁皮石斛粉、20g滁菊全浸膏冻干粉，加入蔗糖粉40g、糊精10g，混合后湿法制粒，过筛整粒，制备成颗粒剂。
实施例3：
首先将铁皮石斛洗净，50℃烘干，粉碎至100目细粉，制成铁皮石斛粉备用；
再将滁菊花采用双提法制得挥发油和水提取物，得到的药渣再经乙醇提取得到醇提取物，合并水提物和醇提物，浓缩，冷冻干燥得到冻干粉，将制得的挥发油用β-环糊精包裹后，形成包裹物，最后将得到的冻干粉和包裹物混合，制备成滁菊全浸膏冻干粉，备用；然后称取15g铁皮石斛粉、10g滁菊全浸膏冻干粉，加入微晶纤维素50g、蔗糖粉20g，混合后湿法制粒，过筛整粒，制备成颗粒剂。
试验例
本发明的石斛滁菊保健颗粒剂的使用效果如下：
| 使用对象 | 人数 | 使用天数 | 有效率 | 使用后效果 |
| 肝阳化风证患者 | 30 | 90 | 70% | 头目胀痛、腰膝酸软、口苦咽干等症状消失，血压恢复正常 |
| 疲劳精神不振者 | 100 | 90 | 90% | 疲劳感减弱，精力明显提高 |
| 血糖偏高 | 100 | 60 | 82% | 高血糖症状得到缓解 |
| 70-90岁老年人 | 200 | 120 | 95% | 老年白内障患者明显减少 |
Claims (3)
1.一种石斛滁菊保健颗粒剂，其特征在于：由下述重量份数的原料制成：
铁皮石斛粉0.5-1.5份
滁菊全浸膏冻干粉0.5-2份；
所述的石斛滁菊保健颗粒剂的制备方法，包括以下制备步骤：
(1)铁皮石斛粉制备：将铁皮石斛洗净，50℃烘干，粉碎至100-200目细粉，备用；
(2)滁菊全浸膏冻干粉制备：将滁菊花采用双提法制得挥发油和水提取物，得到的药渣再经乙醇提取得到醇提取物，合并水提物和醇提物，浓缩，冷冻干燥得到冻干粉，将制得的挥发油用β-环糊精包裹后，形成包裹物，最后将得到的冻干粉和包裹物混合，制备成滁菊全浸膏冻干粉，备用；
(3)按上述重量份数称取步骤(1)和步骤(2)中制得的铁皮石斛粉和滁菊全浸膏冻干粉，加入辅料2-5份，混合后湿法制粒，过筛整粒，制备成颗粒剂。
2.根据权利要求1所述的石斛滁菊保健颗粒剂，其特征在于：由下述重量份数的原料制成：铁皮石斛1份，滁菊花全浸膏冻干粉1.5份。
3.根据权利要求1所述的石斛滁菊保健颗粒剂，其特征在于：所述步骤(3)中的辅料为蔗糖粉、糊精、羧甲基淀粉钠、微晶纤维素中的一种或多种。
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