CN103766497A - Formula milk powder for enhancing immunity of human body - Google Patents
Formula milk powder for enhancing immunity of human body Download PDFInfo
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Abstract
The invention relates to formula milk powder for enhancing the immunity of a human body. The main ingredient of the formula milk powder is one of whole milk powder, whole milk powder or demineralized whey powder. The formula milk powder is characterized in that each 100g of the formula milk powder contains 100mg to 3000mg of Beta-glucan and 100mg to 3000mg of lactoferrin, wherein the Beta-glucan is optimally extracted from pure natural materials. A preparation method is simple and convenient; the formula milk powder is high in purity and is suitable for being taken as an added nutrient of milk powder. The formula milk powder can be used for enhancing the immunity of the human body well during the long-term and targeted supplementation process of nutrient substances.
Description
Technical field
The present invention relates to a kind of formula milk that strengthens body immunity, with and the preparation method of main component beta glucan, belong to dairy products processing and manufacturing field.
Background technology
Beta glucan is the polysaccharide that D-Glucose monomer forms by the bond of glycosidic bond, the polysaccharide that the biologically active structure of beta glucan is made up of glucose monomer, it can activated macrophage, neutrophils etc., thereby improve the content of human leukocytes element, the basic element of cell division and distinct antibodies, comprehensively the immune system in stimulation and activating human body.Beta glucan can be used as the inhereditary material playing the role of a nucleus in vital movement, can control cell division and differentiation, regulates Growth of Cells, aspect treatment tumour, hepatitis, cardiovascular, diabetes and reducing blood lipid, anti-ageing waiting for a long time, is having unique biologically active.Great many of experiments shows, beta glucan can promote the generation of IgM antibody in body, immunity supervision and recognition mechanism that can quick active body self, thereby strengthen their fighting capacity, make autoimmunity system reach good poised state, improve rapidly at short notice human body resistance against diseases, keep the health of human body.The effects such as in addition, beta glucan is removed free radical, radioresistance, dissolving cholesterol in addition, the infection that prevention hyperlipidemia and opposing filterable virus, fungi, bacterium etc. cause.Beta glucan is widely used in to the industry such as health care of food, beauty and skin care in multiple countries such as Japan, the U.S., Russia.China has also listed beta glucan in new resources type food catalogue, can be widely used in the product of food and relevant category.
Lactoferrin is that in milk, a kind of important nonheme iron, in conjunction with glycoprotein, has the monomer glycoprotein of bactericidal activity in neutrophil leucocyte particle, and its molecular weight is 80 kDa, mainly by galactophore epithelial cell expression and secretion.Research shows, lactoferrin is the native protein in animal foremilk, is a kind of multifunctional protein, has broad-spectrum antiseptic, viral infection resisting function, can control agent in the balance of iron; Regulate the generation of bone marrow cell, promote the growth of cell; Regulate body's immunity, strengthen body resistance against diseases; Suppress the effect of human body tumour cell; Can, with Multiple Classes of Antibiotics and antifungal preparation synergy, more effectively treat disease.Lactoferrin is in the breast milk composition of generally acknowledging in the world, to help baby to strengthen the high-quality nutrient of immunity, has a large amount of documents and experimental results show that lactoferrin has the effect that strengthens body immunity.
In prior art, the health food that a kind of people of formula milk Chang Zuowei supplement the nutrients, has various formula milks on the market, but at present, has not still added the formula milk product of β-glucan and lactoferrin.
China Patent No. 201110450192.2 discloses the patent that name is called " a kind of liquid milk and preparation method thereof ", this patent is added arachidonic acid, yeast beta glucan in milk, both enriched the nutrition of milk, and made again the liquid milk of preparing possess the function that regulates immunity; But this patent is not added lactoferrin, and be a kind of liquid milk, strengthen the effect of immunity good not, edible and preserve conveniently not, do not overcome well the defect of prior art; In addition, what this patent was added is yeast beta glucan, and and the method for preparing yeast beta glucan that provides useless.
China Patent No. 201210201269.7 discloses the patent that name is called " a kind of functional milk and production method thereof ", this patent has been added yeast β-glucan and two kinds of prebioticses in milk product, optimize environment in human body intestinal canal, strengthened body immunity simultaneously, there is reducing blood lipid, hypoglycemic, to promote mineral element absorption effect; But this patent is not added lactoferrin, and be a kind of liquid milk, strengthen the effect of immunity good not, edible and preserve conveniently not, do not overcome well the defect of prior art; In addition, what this patent was added is yeast beta-dextran, and and the method for preparing yeast beta glucan that provides useless.
China Patent No. 201210041279.9 discloses the patent that name is called " containing baby formula milk powder and the preparation method of ALA and lactoferrin ", this patent has been added the composition of α-lactoalbumin and lactoferrin in milk powder, effectively improve infant's resistance and immunity, and there is the effect of the sleep of regulating; But this milk powder for be infant, and do not add beta glucan, the effect that strengthens immunity is good not, does not overcome well the defect of prior art.
China Patent No. 200810140214.3 discloses the patent that name is called " water-soluble yeast beta-dextran and preparation method thereof ", this patent system for beta glucan take yeast as raw material, process comprises hot water treatment, alkali treatment, technique is simple, the control of technological parameter easy operating, yield, the purity of product water-soluble yeast beta-glucan are all higher.
China Patent No. 201110093678.5 discloses the patent that name is called " highland barley Beta-dextran preparation method ", and this patent system take highland barley as raw material, adopts water-bath extraction method to obtain for beta glucan, and reagent is nontoxic, and technique is simple, extracts flow process pollution-free.
Summary of the invention
The object of the invention is in order to help the crowd that need to strengthen immunity from the angle supplementing the nutrients, crowd that such as autoimmunity is low, the crowd after convalescent crowd, cancer chemotherapy, postpartum women, children etc. after being ill, and a kind of formula milk that strengthens immunity is provided.
The present invention addresses the above problem adopted technical scheme: a kind of formula milk that strengthens body immunity, the main component of described formula milk comprises at least one in whole milk powder, skimmed milk power and desalted whey powder, it is characterized in that: in the every 100g of described formula milk, also contain beta glucan 100mg-3000mg and lactoferrin 100mg-3000mg.In milk powder, whole milk powder and/or skimmed milk power and/or desalted whey powder be as matrix, and preferably whole milk powder and/or skimmed milk power and/or desalted whey powder quality percentage composition are more than or equal to 60% and be less than 100%; Adopt beta glucan and these two kinds of material compatibilities of lactoferrin, can obtain the humidification using than single material, add in ordinary powdered milk, can supplement in process at long-term, effective nutriment, improve better, strengthen body immunity.
As preferably, in the every 100g of formula milk of the present invention, also have one or both compositions of following content:
Maltodextrin 0.1g-20g, FOS 0.1g-20g.
Above composition can increase the nutrition of milk powder, and makes mouthfeel better.
As preferably, in the every 100g of formula milk of the present invention, also have one or more compositions of following content:
Vitamin A 30-900ug, vitamin D 1-5ug, vitamin E 1-30mg, vitamin B6 0.1-16mg; vitamin C 10-300mg, folic acid 20-800ug, calcium 480-1000mg, iron 1-50mg; zinc 1-10mg, taurine 3-80mg, beta carotene 10-300ug, l-cn 3-80mg.
Above composition can supplement vitamin and the trace element that needed by human body is wanted, and makes healthyly, coordinates beta glucan and lactoferrin to strengthen body immunity.
Beta glucan of the present invention and lactoferrin can be mixed together with the form of powder with all the other milk formula compositions, are suitable for the method for preparing milk of various routines, and application is convenient, does not need special operational.
The preparation method of beta glucan of the present invention comprises the following steps:
(1), feed pretreatment step: take the material that is rich in beta glucan as raw material, clean, pulverize;
(2), alkali treatment and ultrasonic wave treatment step: raw material after pretreatment is dropped in alkaline aqueous solution, the ratio of described alkaline aqueous solution volume ml number and material quality g number is 5:1 to 20:1, first mix and be heated to afterwards 80-150 ℃, stir 1-8 hour, obtain reactant A; Then open the ultrasonic unit of installing in reactor, allow reactant A stir process 1-4 hour in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: reactant B is cooled to after room temperature centrifugal, is precipitated thing C; Sediment C is sent into reactor, adds sediment C weight 5-30 water doubly, be heated to 25-50 ℃, then add the neutral proteinase of the 0.001%-1% of sediment C weight, under 50-70 ℃ of condition, process 10 hours centrifugal again, be precipitated thing D; At room temperature, sediment D is processed 2 hours with the acetic acid solution of mass concentration 1-8 %, more centrifugal, obtains sediment E, and sediment E is through washing, alcohol wash, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: sediment F is dried to 12 hours under-80 ℃ to-40 ℃ cryogenic conditions, can makes beta glucan finished product.
In preparation process, can allow raw material, reactant or sediment fully contact with solvent by stirring, thereby reaction more fully, completely, the setting of each parameter is also the optimization reaction condition that long term test draws.
In the preparation method's of beta glucan of the present invention step (1), described in be rich in beta glucan material be preferably marine alga, sea-tangle, highland barley wheat and brewer's yeast etc.These materials that are rich in beta glucan are pure natural substance, not only environmental protection but also can ensure food safety.
In the preparation method's of beta glucan of the present invention step (2), described alkaline aqueous solution is preferably the NaOH aqueous solution of mass concentration 2-8%.
In the preparation method's of beta glucan of the present invention step (3), described alcohol is methyl alcohol or ethanol etc.Methyl alcohol, ethanol etc. are the conventional alcohols of chemical industry.
The preparation method of beta glucan of the present invention adopts enzymatic isolation method to combine with supercritical ultrasonics technology, compared with conventional single technology, can improve yield.Device therefor (standard device and non-standard equipment) is the chemical industry equipment that China can be produced, and equipment investment is low; Operating pressure can adopt normal pressure, and temperature, below 150 ℃, operates and device easy maintenance; Can produce the product that purity is suitable with international like product, and product yield is higher more than 10% than other method, the indices of product meets Unite States Standard and the requirement of client to appearance luster etc. completely.
The present invention compared with prior art, have the following advantages and effect: the beta glucan in formula milk is preferably in pure natural substance and extracts, preparation method is easier, product purity is high, be more suitable for the interpolation nutrient as milk powder, can be for a long time, targetedly in the supplementary process of nutriment, strengthen better body immunity.
Accompanying drawing explanation
Fig. 1 is milk powder preparation flow block diagram of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing and by specific embodiment, the invention will be further described.
Embodiment 1.
Referring to Fig. 1; the every 100g of formula milk that strengthens body immunity in the present embodiment comprises following composition: maltodextrin 10g, FOS 10g, vitamin A 500ug, vitamin D 3ug, vitamin E 15mg, vitamin B6 8mg, vitamin C 150mg, folic acid 400ug, calcium 800mg, iron 20mg, zinc 5mg, taurine 40mg, 15'-dioxygenase 0ug, l-cn 40mg, beta glucan 1500mg, lactoferrin 1500mg, whole milk powder 30g, skimmed milk power 30g, surplus is desalted whey powder (preparation process has physics loss).
Wherein, the preparation method of beta glucan used comprises the following steps:
(1), feed pretreatment step: take the material marine alga of being rich in beta glucan as raw material, clean, pulverize;
(2), alkali treatment and ultrasonic wave treatment step: raw material after pretreatment is dropped in the NaOH aqueous solution of mass concentration 5%, the ratio of described NaOH aqueous solution volume ml number and material quality g number is 10:1, first mix and be heated to afterwards 100 ℃, stir 8 hours, obtain reactant A; Then open the ultrasonic unit of installing in reactor, allow reactant A stir process 4 hours in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: reactant B is cooled to after room temperature centrifugal, is precipitated thing C; Sediment C is sent into reactor, adds the water of 10 times of weight of sediment C weight, be heated to 35 ℃, then add the neutral proteinase of 0.1% weight of sediment C weight, under 60 ℃ of conditions, process 10 hours centrifugal again, be precipitated thing D; At room temperature, sediment D is processed 2 hours with the acetic acid solution of mass concentration 5%, more centrifugal, obtains sediment E, and sediment E washes through washing, ethanol, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: sediment F is dried to 12 hours under-60 ℃ of cryogenic conditions, can makes beta glucan finished product.
The preparation method of formula milk is as follows: in 500g milk powder, by above-mentioned recipe calculation and weigh each component, first add whole milk powder, skimmed milk power, desalted whey powder, maltodextrin, FOS, add again vitamin A, vitamin D, vitamin E, vitamin B6, vitamin C, folic acid, calcium, iron, zinc, taurine, beta carotene, l-cn, beta glucan and lactoferrin, in 50 ℃ of mixed dissolutions, then at temperature 45 C, with homogeneous under pressure 15Mpa condition, 85 ℃ of pasteurization 30s, concentrated, the dry formula milk 500g (comprising physics loss) that makes of finally spraying.
Embodiment 2.
Referring to Fig. 1; the every 100g of formula milk that strengthens body immunity in the present embodiment comprises following composition: maltodextrin 10g, FOS 10g, vitamin A 500ug, vitamin D 3ug, vitamin E 15mg, vitamin B6 8mg, vitamin C 150mg, folic acid 400ug, calcium 800mg, iron 20mg, zinc 5mg, taurine 40mg, 15'-dioxygenase 0ug, l-cn 40mg, beta glucan 1500mg, lactoferrin 1500mg, whole milk powder 30g, skimmed milk power 30g, surplus is desalted whey powder (preparation process has physics loss).
Wherein, the preparation method of beta glucan used comprises the following steps:
(1), feed pretreatment step: take the material brewer's yeast that is rich in beta glucan as raw material, clean, pulverize;
(2), alkali treatment and ultrasonic wave treatment step: raw material after pretreatment is dropped in the NaOH aqueous solution of mass concentration 5%, the ratio of described NaOH aqueous solution volume ml number and material quality g number is 10:1, first mix and be heated to afterwards 100 ℃, stir 8 hours, obtain reactant A; Then open the ultrasonic unit of installing in reactor, allow reactant A stir process 4 hours in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: reactant B is cooled to after room temperature centrifugal, is precipitated thing C; Sediment C is sent into reactor, adds the water of 10 times of weight of sediment C weight, be heated to 35 ℃, then add the neutral proteinase of 0.1% weight of sediment C weight, under 60 ℃ of conditions, process 10 hours centrifugal again, be precipitated thing D; At room temperature, sediment D is processed 2 hours with the acetic acid solution of mass concentration 5%, more centrifugal, obtains sediment E, and sediment E washes through washing, methyl alcohol, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: sediment F is dried to 12 hours under-60 ℃ of cryogenic conditions, can makes beta glucan finished product.
The preparation method of formula milk is as follows: in 500g milk powder, by above-mentioned recipe calculation and weigh each component, first add whole milk powder, skimmed milk power, desalted whey powder, maltodextrin, FOS, add again vitamin A, vitamin D, vitamin E, vitamin B6, vitamin C, folic acid, calcium, iron, zinc, taurine, beta carotene, l-cn, beta glucan and lactoferrin, in 50 ℃ of mixed dissolutions, then at temperature 45 C, with homogeneous under pressure 15Mpa condition, 85 ℃ of pasteurization 30s, concentrated, the dry formula milk 500g (comprising physics loss) that makes of finally spraying.
Embodiment 3.
Referring to Fig. 1; the every 100g of formula milk that strengthens body immunity in the present embodiment comprises following composition: maltodextrin 0.1g, FOS 0.1g, vitamin A 30ug, vitamin D 1ug, vitamin E 1mg, vitamin B6 0.1mg, vitamin C 10mg, folic acid 20ug, calcium 480mg, iron 1mg, zinc 1mg, taurine 3mg, beta carotene 10ug, l-cn 3mg, beta glucan 100mg, lactoferrin 100mg, whole milk powder 30g, skimmed milk power 30g, surplus is desalted whey powder (preparation process has physics loss).
Wherein, the preparation method of beta glucan used comprises the following steps:
(1), feed pretreatment step: take the material highland barley wheat of being rich in beta glucan as raw material, clean, pulverize;
(2), alkali treatment and ultrasonic wave treatment step: raw material after pretreatment is dropped in the NaOH aqueous solution of mass concentration 2%, the ratio of described NaOH aqueous solution volume ml number and material quality g number is 20:1, first mix and be heated to afterwards 150 ℃, stir 1 hour, obtain reactant A; Then open the ultrasonic unit of installing in reactor, allow reactant A stir process 1 hour in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: reactant B is cooled to after room temperature centrifugal, is precipitated thing C; Sediment C is sent into reactor, adds the water of 30 times of weight of sediment C weight, be heated to 25 ℃, then add the neutral proteinase of 1% weight of sediment C weight, under 50 ℃ of conditions, process 10 hours centrifugal again, be precipitated thing D; At room temperature, sediment D is processed 2 hours with the acetic acid solution of mass concentration 1%, more centrifugal, obtains sediment E, and sediment E washes through washing, ethanol, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: sediment F is dried to 12 hours under-40 ℃ of cryogenic conditions, can makes beta glucan finished product.
The preparation method of formula milk is as follows: in 500g milk powder, by above-mentioned recipe calculation and weigh each component, first add whole milk powder, skimmed milk power, desalted whey powder, maltodextrin, FOS, add again vitamin A, vitamin D, vitamin E, vitamin B6, vitamin C, folic acid, calcium, iron, zinc, taurine, beta carotene, l-cn, beta glucan and lactoferrin, in 50 ℃ of mixed dissolutions, then at temperature 45 C, with homogeneous under pressure 15Mpa condition, 85 ℃ of pasteurization 30s, concentrated, the dry formula milk 500g (comprising physics loss) that makes of finally spraying.
Embodiment 4.
Referring to Fig. 1; the every 100g of formula milk that strengthens body immunity in the present embodiment comprises following composition: maltodextrin 20g, FOS 20g, vitamin A 900ug, vitamin D 5ug, vitamin E 30mg, vitamin B6 16mg, vitamin C 300mg, folic acid 800ug, calcium 1000mg, iron 50mg, zinc 10mg, taurine 80mg, beta carotene 300ug, l-cn 80mg, beta glucan 3000mg, lactoferrin 3000mg, surplus is skimmed milk power (preparation process has physics loss).
Wherein, the preparation method of beta glucan used comprises the following steps:
(1), feed pretreatment step: take the material sea-tangle of being rich in beta glucan as raw material, clean, pulverize;
(2), alkali treatment and ultrasonic wave treatment step: raw material after pretreatment is dropped in the NaOH aqueous solution of mass concentration 8%, the ratio of described NaOH aqueous solution volume ml number and material quality g number is 5:1, first mix and be heated to afterwards 80 ℃, stir 5 hours, obtain reactant A; Then open the ultrasonic unit of installing in reactor, allow reactant A stir process 3 hours in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: reactant B is cooled to after room temperature centrifugal, is precipitated thing C; Sediment C is sent into reactor, adds the water of 5 times of weight of sediment C weight, be heated to 50 ℃, then add the neutral proteinase of 0.001% weight of sediment C weight, under 70 ℃ of conditions, process 10 hours centrifugal again, be precipitated thing D; At room temperature, sediment D is processed 2 hours with the acetic acid solution of mass concentration 8%, more centrifugal, obtains sediment E, and sediment E washes through washing, ethanol, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: sediment F is dried to 12 hours under-80 ℃ of cryogenic conditions, can makes beta glucan finished product.
The preparation method of formula milk is as follows: in 500g milk powder, by above-mentioned recipe calculation and weigh each component, first add skimmed milk power, maltodextrin, FOS, add again vitamin A, vitamin D, vitamin E, vitamin B6, vitamin C, folic acid, calcium, iron, zinc, taurine, beta carotene, l-cn, beta glucan and lactoferrin, in 50 ℃ of mixed dissolutions, then at temperature 45 C, with homogeneous under pressure 15Mpa condition, 85 ℃ of pasteurization 30s, concentrated, the dry formula milk 500g (comprising physics loss) that makes of finally spraying.
Embodiment 5.
Referring to Fig. 1, the every 100g of formula milk that strengthens body immunity in the present embodiment comprises following composition: maltodextrin 10g, vitamin A 500ug, vitamin D 3ug, vitamin E 15mg, vitamin B6 8mg, vitamin C 150mg, folic acid 400ug, beta glucan 1500mg, lactoferrin 1500mg, surplus is whole milk powder (preparation process has physics loss).
Wherein, the preparation method of beta glucan used comprises the following steps:
(1), feed pretreatment step: take the material brewer's yeast that is rich in beta glucan as raw material, clean, pulverize;
(2), alkali treatment and ultrasonic wave treatment step: raw material after pretreatment is dropped in the NaOH aqueous solution of mass concentration 5%, the ratio of described NaOH aqueous solution volume ml number and material quality g number is 15:1, first mix and be heated to afterwards 120 ℃, stir 6 hours, obtain reactant A; Then open the ultrasonic unit of installing in reactor, allow reactant A stir process 2 hours in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: reactant B is cooled to after room temperature centrifugal, is precipitated thing C; Sediment C is sent into reactor, adds the water of 20 times of weight of sediment C weight, be heated to 40 ℃, then add the neutral proteinase of 0.01% weight of sediment C weight, under 55 ℃ of conditions, process 10 hours centrifugal again, be precipitated thing D; At room temperature, sediment D is processed 2 hours with the acetic acid solution of mass concentration 3%, more centrifugal, obtains sediment E, and sediment E washes through washing, ethanol, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: sediment F is dried to 12 hours under-60 ℃ of cryogenic conditions, can makes beta glucan finished product.
The preparation method of formula milk is as follows: in 500g milk powder, by above-mentioned recipe calculation and weigh each component, first add whole milk powder, maltodextrin, add again vitamin A, vitamin D, vitamin E, vitamin B6, vitamin C, folic acid, beta glucan and lactoferrin, in 50 ℃ of mixed dissolutions, then homogeneous under temperature 45 C and pressure 15Mpa condition, 85 ℃ of pasteurization 30s, concentrated, the dry formula milk 500g (comprising physics loss) that makes of finally spraying.
Embodiment 6.
Referring to Fig. 1; the every 100g of formula milk that strengthens body immunity in the present embodiment comprises following composition: vitamin A 500ug, vitamin D 3ug, vitamin E 15mg, vitamin B6 8mg, vitamin C 150mg, folic acid 400ug, calcium 800mg, iron 20mg, zinc 5mg, taurine 40mg, 15'-dioxygenase 0ug, l-cn 40mg, beta glucan 1500mg, lactoferrin 1500mg, whole milk powder 30g, skimmed milk power 30g, surplus is desalted whey powder (preparation process has physics loss).
Wherein, the preparation method of beta glucan used comprises the following steps:
(1), feed pretreatment step: take the material marine alga of being rich in beta glucan as raw material, clean, pulverize;
(2), alkali treatment and ultrasonic wave treatment step: raw material after pretreatment is dropped in the NaOH aqueous solution of mass concentration 3%, the ratio of described NaOH aqueous solution volume ml number and material quality g number is 20:1, first mix and be heated to afterwards 120 ℃, stir 6 hours, obtain reactant A; Then open the ultrasonic unit of installing in reactor, allow reactant A stir process 4 hours in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: reactant B is cooled to after room temperature centrifugal, is precipitated thing C; Sediment C is sent into reactor, adds the water of 10 times of weight of sediment C weight, be heated to 35 ℃, then add the neutral proteinase of 0.1% weight of sediment C weight, under 60 ℃ of conditions, process 10 hours centrifugal again, be precipitated thing D; At room temperature, sediment D is processed 2 hours with the acetic acid solution of mass concentration 5%, more centrifugal, obtains sediment E, and sediment E washes through washing, methyl alcohol, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: sediment F is dried to 12 hours under-60 ℃ of cryogenic conditions, can makes beta glucan finished product.
The preparation method of formula milk is as follows: in 500g milk powder, by above-mentioned recipe calculation and weigh each component, first add whole milk powder, skimmed milk power, desalted whey powder, add again vitamin A, vitamin D, vitamin E, vitamin B6, vitamin C, folic acid, calcium, iron, zinc, taurine, beta carotene, l-cn, beta glucan and lactoferrin, in 50 ℃ of mixed dissolutions, then at temperature 45 C, with homogeneous under pressure 15Mpa condition, 85 ℃ of pasteurization 30s, concentrated, the dry formula milk 500g (comprising physics loss) that makes of finally spraying.
Embodiment 7.
Referring to Fig. 1; the every 100g of formula milk that strengthens body immunity in the present embodiment comprises following composition: maltodextrin 10g, FOS 10g, calcium 800mg, iron 20mg, zinc 5mg, taurine 40mg, 15'-dioxygenase 0ug, l-cn 40mg, beta glucan 1500mg, lactoferrin 1500mg, whole milk powder 30g, surplus is skimmed milk power (preparation process has physics loss).
Wherein, the preparation method of beta glucan used comprises the following steps:
(1), feed pretreatment step: take the material highland barley wheat of being rich in beta glucan as raw material, clean, pulverize;
(2), alkali treatment and ultrasonic wave treatment step: raw material after pretreatment is dropped in the NaOH aqueous solution of mass concentration 5%, the ratio of described NaOH aqueous solution volume ml number and material quality g number is 10:1, first mix and be heated to afterwards 100 ℃, stir 8 hours, obtain reactant A; Then open the ultrasonic unit of installing in reactor, allow reactant A stir process 4 hours in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: reactant B is cooled to after room temperature centrifugal, is precipitated thing C; Sediment C is sent into reactor, adds the water of 10 times of weight of sediment C weight, be heated to 35 ℃, then add the neutral proteinase of 0.1% weight of sediment C weight, under 60 ℃ of conditions, process 10 hours centrifugal again, be precipitated thing D; At room temperature, sediment D is processed 2 hours with the acetic acid solution of mass concentration 5%, more centrifugal, obtains sediment E, and sediment E washes through washing, ethanol, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: sediment F is dried to 12 hours under-80 ℃ of cryogenic conditions, can makes beta glucan finished product.
The preparation method of formula milk is as follows: in 500g milk powder; by above-mentioned recipe calculation and weigh each component; first add whole milk powder, skimmed milk power, maltodextrin, FOS; add again calcium, iron, zinc, taurine, beta carotene, l-cn, beta glucan and lactoferrin; in 50 ℃ of mixed dissolutions; then homogeneous under temperature 45 C and pressure 15Mpa condition; 85 ℃ of pasteurization 30s; concentrated, the dry formula milk 500g (comprising physics loss) that makes of finally spraying.
Embodiment 8.
Referring to Fig. 1, the every 100g of formula milk that strengthens body immunity in the present embodiment comprises following composition: maltodextrin 10g, FOS 10g, beta glucan 1500mg, lactoferrin 1500mg, skimmed milk power 50g, surplus is desalted whey powder (preparation process has physics loss).
Wherein, the preparation method of beta glucan used comprises the following steps:
(1), feed pretreatment step: take the material brewer's yeast that is rich in beta glucan as raw material, clean, pulverize;
(2), alkali treatment and ultrasonic wave treatment step: raw material after pretreatment is dropped in the NaOH aqueous solution of mass concentration 6%, the ratio of described NaOH aqueous solution volume ml number and material quality g number is 10:1, first mix and be heated to afterwards 100 ℃, stir 8 hours, obtain reactant A; Then open the ultrasonic unit of installing in reactor, allow reactant A stir process 3 hours in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: reactant B is cooled to after room temperature centrifugal, is precipitated thing C; Sediment C is sent into reactor, adds the water of 10 times of weight of sediment C weight, be heated to 35 ℃, then add the neutral proteinase of 0.1% weight of sediment C weight, under 60 ℃ of conditions, process 10 hours centrifugal again, be precipitated thing D; At room temperature, sediment D is processed 2 hours with the acetic acid solution of mass concentration 6%, more centrifugal, obtains sediment E, and sediment E washes through washing, ethanol, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: sediment F is dried to 12 hours under-60 ℃ of cryogenic conditions, can makes beta glucan finished product.
The preparation method of formula milk is as follows: in 500g milk powder, by above-mentioned recipe calculation and weigh each component, first add skimmed milk power, desalted whey powder, maltodextrin, FOS, add again beta glucan and lactoferrin, in 50 ℃ of mixed dissolutions, then homogeneous under temperature 45 C and pressure 15Mpa condition, 85 ℃ of pasteurization 30s, concentrated, the dry formula milk 500g (comprising physics loss) that makes of finally spraying.
Embodiment 9.
Referring to Fig. 1; the every 100g of formula milk that strengthens body immunity in the present embodiment comprises following composition: maltodextrin 10g, FOS 10g, vitamin A 500ug, vitamin D 3ug, vitamin E 15mg, vitamin B6 8mg, vitamin C 150mg, folic acid 400ug, calcium 800mg, iron 20mg, zinc 5mg, taurine 40mg, 15'-dioxygenase 0ug, l-cn 40mg, beta glucan 1500mg, lactoferrin 1500mg, whole milk powder 30g, skimmed milk power 30g, surplus is desalted whey powder (preparation process has physics loss).
Wherein, beta glucan used is what buy on the market.
The preparation method of formula milk is as follows: in 500g milk powder, by above-mentioned recipe calculation and weigh each component, first add whole milk powder, skimmed milk power, desalted whey powder, maltodextrin, FOS, add again vitamin A, vitamin D, vitamin E, vitamin B6, vitamin C, folic acid, calcium, iron, zinc, taurine, beta carotene, l-cn, beta glucan and lactoferrin, in 50 ℃ of mixed dissolutions, then at temperature 45 C, with homogeneous under pressure 15Mpa condition, 85 ℃ of pasteurization 30s, concentrated, the dry formula milk 500g (comprising physics loss) that makes of finally spraying.
By foregoing description, those skilled in the art can implement.
Above-described embodiment has only comprised several common prescription of the present invention, and main component of the present invention can be one or more in whole milk powder, skimmed milk power and desalted whey powder, can comprise one or both compositions of following content in every 100g formula milk:
Maltodextrin 0.1g-20g, FOS 0.1g-20g; Also can not contain;
In every 100g formula milk, can also comprise one or more compositions of following content:
Vitamin A 30-900ug, vitamin D 1-5ug, vitamin E 1-30mg, vitamin B6 0.1-16mg, vitamin C 10-300mg, folic acid 20-800ug, calcium 480-1000mg, iron 1-50mg, zinc 1-10mg, taurine 3-80mg, beta carotene 10-300ug, l-cn 3-80mg; Also can not contain.
Although the present invention with embodiment openly as above, it is not in order to limit protection scope of the present invention, and all equivalence or simple change of doing according to principle of the present invention, Method and process, all belong in the protection domain of patent of the present invention.
Claims (8)
1. one kind strengthens the formula milk of body immunity, the main component of described formula milk comprises at least one in whole milk powder, skimmed milk power and desalted whey powder, it is characterized in that: in the every 100g of described formula milk, also contain beta glucan 100mg-3000mg and lactoferrin 100mg-3000mg.
2. the formula milk of enhancing body immunity according to claim 1, is characterized in that: one or both compositions that also have following content in the every 100g of described formula milk:
Maltodextrin 0.1g-20g, FOS 0.1g-20g.
3. the formula milk of enhancing body immunity according to claim 1, is characterized in that: one or more compositions that also have following content in the every 100g of described formula milk:
Vitamin A 30-900ug, vitamin D 1-5ug, vitamin E 1-30mg, vitamin B6 0.1-16mg; vitamin C 10-300mg, folic acid 20-800ug, calcium 480-1000mg, iron 1-50mg; zinc 1-10mg, taurine 3-80mg, beta carotene 10-300ug, l-cn 3-80mg.
4. according to the formula milk of the enhancing body immunity described in claim 1 or 2 or 3, it is characterized in that: described beta glucan and lactoferrin and all the other milk formula compositions are mixed together with the form of powder.
5. the formula milk of enhancing body immunity according to claim 1, is characterized in that: the preparation method of described beta glucan comprises the following steps:
(1), feed pretreatment step: take the material that is rich in beta glucan as raw material, clean, pulverize;
(2), alkali treatment and ultrasonic wave treatment step: raw material after pretreatment is dropped in alkaline aqueous solution, the ratio of described alkaline aqueous solution volume ml number and material quality g number is 5:1 to 20:1, first mix and be heated to afterwards 80-150 ℃, stir 1-8 hour, obtain reactant A; Then open the ultrasonic unit of installing in reactor, allow reactant A stir process 1-4 hour in ultrasonic environment, obtain reactant B;
(3), enzymolysis processing step: reactant B is cooled to after room temperature centrifugal, is precipitated thing C; Sediment C is sent into reactor, adds sediment C weight 5-30 water doubly, be heated to 25-50 ℃, then add the neutral proteinase of the 0.001%-1% of sediment C weight, under 50-70 ℃ of condition, process 10 hours centrifugal again, be precipitated thing D; At room temperature, sediment D is processed 2 hours with the acetic acid solution of mass concentration 1-8 %, more centrifugal, obtains sediment E, and sediment E is through washing, alcohol wash, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: sediment F is dried to 12 hours under-80 ℃ to-40 ℃ cryogenic conditions, makes beta glucan.
6. the formula milk of enhancing body immunity according to claim 5, is characterized in that: in the preparation method's of described beta glucan step (1), described in be rich in beta glucan material be the one in marine alga, sea-tangle, highland barley wheat and brewer's yeast.
7. the formula milk of enhancing body immunity according to claim 5, is characterized in that: in the preparation method's of described beta glucan step (2), described alkaline aqueous solution is the NaOH aqueous solution of mass concentration 2-8%.
8. the formula milk of enhancing body immunity according to claim 5, is characterized in that: in the preparation method's of described beta glucan step (3), described alcohol is methyl alcohol or ethanol.
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| CN111670951A (en) * | 2020-04-30 | 2020-09-18 | 上海紫丁进出口有限公司 | Modified milk powder and preparation method thereof |
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