CN103766497B - A kind of formula milk strengthening body immunity - Google Patents
A kind of formula milk strengthening body immunity Download PDFInfo
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- CN103766497B CN103766497B CN201410039658.3A CN201410039658A CN103766497B CN 103766497 B CN103766497 B CN 103766497B CN 201410039658 A CN201410039658 A CN 201410039658A CN 103766497 B CN103766497 B CN 103766497B
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Abstract
The present invention relates to a kind of formula milk strengthening body immunity, main component is at least one in whole milk powder, skimmed milk power and desalted whey powder, it is characterized in that: also containing beta glucan 100mg-3000mg and lactoferrin 100mg-3000mg in the every 100g of described formula milk.Beta glucan in formula milk of the present invention is preferably in pure natural substance and extracts, preparation method is easier, and product purity is high, is more suitable for the interpolation nutrient as milk powder, for a long time, in the supplementary process of nutriment targetedly, body immunity can be strengthened better.
Description
Technical field
The present invention relates to a kind of formula milk strengthening body immunity, and the preparation method of its main component beta glucan, belong to dairy products processing and manufacturing field.
Background technology
The beta glucan polysaccharide that to be D-Glucose monomer formed by the bond of glycosidic bond, the polysaccharide that the biologically active structure of beta glucan is made up of glucose monomer, it can activated macrophage, neutrophils etc., thus improve the content of human leukocytes element, the basic element of cell division and distinct antibodies, stimulate and immune system in activating human body comprehensively.Beta glucan as the inhereditary material played the role of a nucleus in vital movement, can control cell division and differentiation, regulates Growth of Cells, treatment tumour, hepatitis, cardiovascular, diabetes and reducing blood lipid, anti-ageing wait for a long time in have unique biologically active.Great many of experiments shows, beta glucan can promote the generation of IgM antibody in body, can the immunity supervision of quick active body self and recognition mechanism, thus strengthen their fighting capacity, self immune system is made to reach good poised state, improve human disease resistance rapidly at short notice, keep the health of human body.The effects such as in addition, beta glucan removes free radical, radioresistance, dissolving cholesterol in addition, the infection that prevention hyperlipidemia and opposing filterable virus, fungi, bacterium etc. cause.Beta glucan is widely used in the industry such as health care of food, beauty and skin care in multiple countries such as Japan, the U.S., Russia.Beta glucan is also listed in new resources type food items by China, can be widely used in the product of food and relevant category.
Lactoferrin is that in milk, a kind of important nonheme iron, in conjunction with glycoprotein, has the monomeric glycoprotein of bactericidal activity in neutrophil leucocyte particle, and its molecular weight is 80kDa, primarily of galactophore epithelial cell expression and secretion.Research shows, lactoferrin is the native protein in animal foremilk, is a kind of multifunctional protein, has broad-spectrum antiseptic, viral infection resisting function, the balance of iron in energy control agent; Regulate the generation of bone marrow cell, promote the growth of cell; Conditioner body immunity function, strengthens body resistance against diseases; Suppress the effect of human body tumour cell; Can with Multiple Classes of Antibiotics and antifungal preparation synergy, more effectively disease therapy.Lactoferrin is the high-quality nutrient helping baby's develop immunitypty in the breast milk composition of generally acknowledging in the world, has a large amount of documents and experiment to demonstrate lactoferrin and has the effect strengthening body immunity.
In prior art, the health food that a kind of people of formula milk Chang Zuowei supplement the nutrients, has various formula milk on the market, but at present, still not with the addition of the formula milk product of beta glucan and lactoferrin.
China Patent No. 201110450192.2 discloses the patent that name is called " a kind of liquid milk and preparation method thereof ", this patent adds arachidonic acid, yeast beta glucan in milk, both enriched the nutrition of milk, and made again the liquid milk prepared possess the function of immunity moderation power; But this patent does not add lactoferrin, and be a kind of liquid milk, the effect of develop immunitypty is good not, edible and preservation is convenient not, does not overcome the defect of prior art well; In addition, what this patent was added is yeast beta glucan, and and uselessly provides the method preparing yeast beta glucan.
China Patent No. 201210201269.7 discloses the patent that name is called " a kind of functional milk and production method thereof ", this patent with the addition of yeast beta-dextran and two kinds of prebioticses in milk product, optimize human body intestinal canal environment, enhance body immunity simultaneously, there is reducing blood lipid, hypoglycemic, to promote mineral element absorption effect; But this patent does not add lactoferrin, and be a kind of liquid milk, the effect of develop immunitypty is good not, edible and preservation is convenient not, does not overcome the defect of prior art well; In addition, what this patent was added is yeast beta-dextran, and and uselessly provides the method preparing yeast beta glucan.
China Patent No. 201210041279.9 discloses the patent that name is called " baby formula milk powder and preparation method containing ALA and lactoferrin ", this patent with the addition of the composition of ALA and lactoferrin in milk powder, effective raising infant's resistance and immunity, and there is the effect regulating sleep; But this milk powder for be infant, and do not add beta glucan, the effect of develop immunitypty is good not, does not overcome the defect of prior art well.
China Patent No. 200810140214.3 discloses the patent that name is called " water-soluble yeast beta-dextran and preparation method thereof ", this patent system is raw material for beta glucan with yeast, process comprises hot water treatment, alkali treatment, technique is simple, technological parameter is easy to operation and controls, and yield, the purity of product water-soluble yeast beta-dextran are all higher.
China Patent No. 201110093678.5 discloses the patent that name is called " highland barley Beta-dextran preparation method ", and this patent system is raw material for beta glucan with highland barley, and adopt water-bath extraction method to obtain, reagent is nontoxic, and technique is simple, extracts flow process pollution-free.
Summary of the invention
The object of the invention is the crowd in order to help to need develop immunitypty from the angle supplemented the nutrients, such as, crowd, postpartum women, children etc. after the crowd that autoimmunity is low, after being ill convalescent crowd, cancer chemotherapy, and a kind of formula milk of develop immunitypty is provided.
The present invention's adopted technical scheme that solves the problem is: a kind of formula milk strengthening body immunity, the main component of described formula milk comprises at least one in whole milk powder, skimmed milk power and desalted whey powder, it is characterized in that: also containing beta glucan 100mg-3000mg and lactoferrin 100mg-3000mg in the every 100g of described formula milk.In milk powder, whole milk powder and/or skimmed milk power and/or desalted whey powder are as matrix, and preferred whole milk powder and/or skimmed milk power and/or desalted whey powder mass percentage are more than or equal to 60% and are less than 100%; Adopt beta glucan and these two kinds of material compatibilities of lactoferrin, the humidification than single substance migration can be obtained, add in ordinary powdered milk, can supplement in process at long-term, effective nutriment, improve better, strengthen body immunity.
As preferably, in the every 100g of formula milk of the present invention, also have one or both compositions of following content:
Maltodextrin 0.1g-20g, FOS 0.1g-20g.
Above composition can increase the nutrition of milk powder, and makes mouthfeel better.
As preferably, in the every 100g of formula milk of the present invention, also have one or more compositions of following content:
3-Hydroxyretinol 0-900ug, vitamine D1-5ug, vitamin e1-30mg, vitamin B6 0.1-16mg; vitamin C 10-300mg, folic acid 20-800ug, calcium 480-1000mg, iron 1-50mg; zinc 1-10mg, taurine 3-80mg, beta carotene 10-300ug, l-cn 3-80mg.
Above composition can supplement the vitamin and trace element that needed by human body wants, and makes healthy, coordinates beta glucan and lactoferrin to strengthen body immunity.
Beta glucan of the present invention and lactoferrin can be mixed together in the form of a powder with all the other milk formula compositions, are suitable for the method for preparing milk of various routine, and application is convenient, does not need special operational.
The preparation method of beta glucan of the present invention comprises the following steps:
(1), feed pretreatment step: to be rich in the material of beta glucan for raw material, clean, pulverize;
(2), alkali treatment and sonicating step: raw material after pretreatment is dropped in alkaline aqueous solution, the ratio of described alkaline aqueous solution volume ml number and material quality g number is 5:1 to 20:1, first mix and be heated to 80-150 DEG C afterwards, stir 1-8 hour, obtain reactant A; Then open in reactor the ultrasonic unit installed, allow reactant A stir process 1-4 hour in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: centrifugal after reactant B being cooled to room temperature, be precipitated thing C; Sediment C is sent into reactor, adds sediment C weight 5-30 water doubly, be heated to 25-50 DEG C, then add the neutral proteinase of 0.001%-1% of sediment C weight, process under 50-70 DEG C of condition 10 hours centrifugal again, be precipitated thing D; At room temperature, the sediment D acetic acid solution process 2 hours of mass concentration 1-8%, more centrifugal, obtain sediment E, sediment E through washing, alcohol wash, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: by sediment F under-80 DEG C to-40 DEG C cryogenic conditions dry 12 hours, beta glucan finished product can be obtained.
In preparation process, raw material, reactant or sediment can be allowed fully to contact with solvent by stirring, thus reaction is more abundant, completely, the setting of each parameter is also the Optimal reaction conditions that long term test draws.
In the step (1) of the preparation method of beta glucan of the present invention, described in be rich in beta glucan material be preferably marine alga, sea-tangle, highland barley wheat and brewer's yeast etc.These materials being rich in beta glucan are pure natural substance, not only environmental protection but also can ensure food safety.
In the step (2) of the preparation method of beta glucan of the present invention, described alkaline aqueous solution is preferably the NaOH aqueous solution of mass concentration 2-8%.
In the step (3) of the preparation method of beta glucan of the present invention, described alcohol is methyl alcohol or ethanol etc.Methyl alcohol, ethanol etc. are chemical industry and commonly use alcohols.
The preparation method of beta glucan of the present invention adopts enzymatic isolation method to combine with supercritical ultrasonics technology, compared with the single technology of routine, can improve yield.Device therefor (standard device and non-standard equipment) is the chemical industry equipment that China can be produced, and equipment investment is low; Operating pressure can adopt normal pressure, and temperature, below 150 DEG C, operates and device easy maintenance; Can produce the product that purity is suitable with international like product, and product yield is higher than other method by more than 10%, the indices of product meets Unite States Standard and client completely to the requirement of appearance luster etc.
The present invention compared with prior art, have the following advantages and effect: the beta glucan in formula milk is preferably in pure natural substance and extracts, preparation method is easier, product purity is high, be more suitable for the interpolation nutrient as milk powder, for a long time, in the supplementary process of nutriment targetedly, body immunity can be strengthened better.
Accompanying drawing explanation
Fig. 1 is milk powder preparation flow block diagram of the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing, also by specific embodiment, the invention will be further described.
Embodiment 1.
See Fig. 1; the every 100g of formula milk strengthening body immunity in the present embodiment comprises following composition: maltodextrin 10g, FOS 10g, vitamin A 500ug, vitamine D3 ug, vitamin e1 5mg, vitamin B6 8mg, vitamin C 150mg, folic acid 400ug, calcium 800mg, iron 20mg, zinc 5mg, taurine 40mg, 15'-dioxygenase 0ug, l-cn 40mg, beta glucan 1500mg, lactoferrin 1500mg, whole milk powder 30g, skimmed milk power 30g, and surplus is desalted whey powder (preparation process has physical deterioration).
Wherein, the preparation method of beta glucan used comprises the following steps:
(1), feed pretreatment step: to be rich in the material marine alga of beta glucan for raw material, clean, pulverize;
(2), alkali treatment and sonicating step: raw material after pretreatment is dropped in the NaOH aqueous solution of mass concentration 5%, the ratio of described NaOH aqueous solution volume ml number and material quality g number is 10:1, first mix and be heated to 100 DEG C afterwards, stir 8 hours, obtain reactant A; Then open in reactor the ultrasonic unit installed, allow reactant A stir process 4 hours in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: centrifugal after reactant B being cooled to room temperature, be precipitated thing C; Sediment C is sent into reactor, adds the water of sediment C weight 10 times of weight, be heated to 35 DEG C, then add the neutral proteinase of 0.1% weight of sediment C weight, process under 60 DEG C of conditions 10 hours centrifugal again, be precipitated thing D; At room temperature, the sediment D acetic acid solution process 2 hours of mass concentration 5%, more centrifugal, obtain sediment E, sediment E washes through washing, ethanol, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: by sediment F under-60 DEG C of cryogenic conditions dry 12 hours, beta glucan finished product can be obtained.
The preparation method of formula milk is as follows: in 500g milk powder, each component is weighed by above-mentioned recipe calculation, first add whole milk powder, skimmed milk power, desalted whey powder, maltodextrin, FOS, add vitamin A again, vitamin D, vitamin E, vitamin B6, vitamin C, folic acid, calcium, iron, zinc, taurine, beta carotene, l-cn, beta glucan and lactoferrin, in 50 DEG C of mixed dissolutions, then at temperature 45 C, with homogeneous under pressure 15Mpa condition, 85 DEG C of pasteurization 30s, concentrated, last spraying dry makes formula milk 500g (comprising physical deterioration).
Embodiment 2.
See Fig. 1; the every 100g of formula milk strengthening body immunity in the present embodiment comprises following composition: maltodextrin 10g, FOS 10g, vitamin A 500ug, vitamine D3 ug, vitamin e1 5mg, vitamin B6 8mg, vitamin C 150mg, folic acid 400ug, calcium 800mg, iron 20mg, zinc 5mg, taurine 40mg, 15'-dioxygenase 0ug, l-cn 40mg, beta glucan 1500mg, lactoferrin 1500mg, whole milk powder 30g, skimmed milk power 30g, and surplus is desalted whey powder (preparation process has physical deterioration).
Wherein, the preparation method of beta glucan used comprises the following steps:
(1), feed pretreatment step: to be rich in the material brewer's yeast of beta glucan for raw material, clean, pulverize;
(2), alkali treatment and sonicating step: raw material after pretreatment is dropped in the NaOH aqueous solution of mass concentration 5%, the ratio of described NaOH aqueous solution volume ml number and material quality g number is 10:1, first mix and be heated to 100 DEG C afterwards, stir 8 hours, obtain reactant A; Then open in reactor the ultrasonic unit installed, allow reactant A stir process 4 hours in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: centrifugal after reactant B being cooled to room temperature, be precipitated thing C; Sediment C is sent into reactor, adds the water of sediment C weight 10 times of weight, be heated to 35 DEG C, then add the neutral proteinase of 0.1% weight of sediment C weight, process under 60 DEG C of conditions 10 hours centrifugal again, be precipitated thing D; At room temperature, the sediment D acetic acid solution process 2 hours of mass concentration 5%, more centrifugal, obtain sediment E, sediment E through washing, methanol wash column, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: by sediment F under-60 DEG C of cryogenic conditions dry 12 hours, beta glucan finished product can be obtained.
The preparation method of formula milk is as follows: in 500g milk powder, each component is weighed by above-mentioned recipe calculation, first add whole milk powder, skimmed milk power, desalted whey powder, maltodextrin, FOS, add vitamin A again, vitamin D, vitamin E, vitamin B6, vitamin C, folic acid, calcium, iron, zinc, taurine, beta carotene, l-cn, beta glucan and lactoferrin, in 50 DEG C of mixed dissolutions, then at temperature 45 C, with homogeneous under pressure 15Mpa condition, 85 DEG C of pasteurization 30s, concentrated, last spraying dry makes formula milk 500g (comprising physical deterioration).
Embodiment 3.
See Fig. 1; the every 100g of formula milk strengthening body immunity in the present embodiment comprises following composition: maltodextrin 0.1g, FOS 0.1g, 3-Hydroxyretinol 0ug, vitamine D1 ug, vitamin e1 mg, vitamin B6 0.1mg, vitamin C 10mg, folic acid 20ug, calcium 480mg, iron 1mg, zinc 1mg, taurine 3mg, beta carotene 10ug, l-cn 3mg, beta glucan 100mg, lactoferrin 100mg, whole milk powder 30g, skimmed milk power 30g, and surplus is desalted whey powder (preparation process has physical deterioration).
Wherein, the preparation method of beta glucan used comprises the following steps:
(1), feed pretreatment step: to be rich in the material highland barley wheat of beta glucan for raw material, clean, pulverize;
(2), alkali treatment and sonicating step: raw material after pretreatment is dropped in the NaOH aqueous solution of mass concentration 2%, the ratio of described NaOH aqueous solution volume ml number and material quality g number is 20:1, first mix and be heated to 150 DEG C afterwards, stir 1 hour, obtain reactant A; Then open in reactor the ultrasonic unit installed, allow reactant A stir process 1 hour in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: centrifugal after reactant B being cooled to room temperature, be precipitated thing C; Sediment C is sent into reactor, adds the water of sediment C weight 30 times of weight, be heated to 25 DEG C, then add the neutral proteinase of 1% weight of sediment C weight, process under 50 DEG C of conditions 10 hours centrifugal again, be precipitated thing D; At room temperature, the sediment D acetic acid solution process 2 hours of mass concentration 1%, more centrifugal, obtain sediment E, sediment E washes through washing, ethanol, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: by sediment F under-40 DEG C of cryogenic conditions dry 12 hours, beta glucan finished product can be obtained.
The preparation method of formula milk is as follows: in 500g milk powder, each component is weighed by above-mentioned recipe calculation, first add whole milk powder, skimmed milk power, desalted whey powder, maltodextrin, FOS, add vitamin A again, vitamin D, vitamin E, vitamin B6, vitamin C, folic acid, calcium, iron, zinc, taurine, beta carotene, l-cn, beta glucan and lactoferrin, in 50 DEG C of mixed dissolutions, then at temperature 45 C, with homogeneous under pressure 15Mpa condition, 85 DEG C of pasteurization 30s, concentrated, last spraying dry makes formula milk 500g (comprising physical deterioration).
Embodiment 4.
See Fig. 1; the every 100g of formula milk strengthening body immunity in the present embodiment comprises following composition: maltodextrin 20g, FOS 20g, vitamin A 900ug, Vitamin D5 ug, vitamin E 30mg, vitamin B6 16mg, vitamin C 300mg, folic acid 800ug, calcium 1000mg, iron 50mg, zinc 10mg, taurine 80mg, beta carotene 300ug, l-cn 80mg, beta glucan 3000mg, lactoferrin 3000mg, and surplus is skimmed milk power (preparation process has physical deterioration).
Wherein, the preparation method of beta glucan used comprises the following steps:
(1), feed pretreatment step: to be rich in the material sea-tangle of beta glucan for raw material, clean, pulverize;
(2), alkali treatment and sonicating step: raw material after pretreatment is dropped in the NaOH aqueous solution of mass concentration 8%, the ratio of described NaOH aqueous solution volume ml number and material quality g number is 5:1, first mix and be heated to 80 DEG C afterwards, stir 5 hours, obtain reactant A; Then open in reactor the ultrasonic unit installed, allow reactant A stir process 3 hours in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: centrifugal after reactant B being cooled to room temperature, be precipitated thing C; Sediment C is sent into reactor, adds the water of sediment C weight 5 times of weight, be heated to 50 DEG C, then add the neutral proteinase of 0.001% weight of sediment C weight, process under 70 DEG C of conditions 10 hours centrifugal again, be precipitated thing D; At room temperature, the sediment D acetic acid solution process 2 hours of mass concentration 8%, more centrifugal, obtain sediment E, sediment E washes through washing, ethanol, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: by sediment F under-80 DEG C of cryogenic conditions dry 12 hours, beta glucan finished product can be obtained.
The preparation method of formula milk is as follows: in 500g milk powder, each component is weighed by above-mentioned recipe calculation, first add skimmed milk power, maltodextrin, FOS, add vitamin A again, vitamin D, vitamin E, vitamin B6, vitamin C, folic acid, calcium, iron, zinc, taurine, beta carotene, l-cn, beta glucan and lactoferrin, in 50 DEG C of mixed dissolutions, then at temperature 45 C, with homogeneous under pressure 15Mpa condition, 85 DEG C of pasteurization 30s, concentrated, last spraying dry makes formula milk 500g (comprising physical deterioration).
Embodiment 5.
See Fig. 1, the every 100g of formula milk strengthening body immunity in the present embodiment comprises following composition: maltodextrin 10g, vitamin A 500ug, vitamine D3 ug, vitamin e1 5mg, vitamin B6 8mg, vitamin C 150mg, folic acid 400ug, beta glucan 1500mg, lactoferrin 1500mg, and surplus is whole milk powder (preparation process has physical deterioration).
Wherein, the preparation method of beta glucan used comprises the following steps:
(1), feed pretreatment step: to be rich in the material brewer's yeast of beta glucan for raw material, clean, pulverize;
(2), alkali treatment and sonicating step: raw material after pretreatment is dropped in the NaOH aqueous solution of mass concentration 5%, the ratio of described NaOH aqueous solution volume ml number and material quality g number is 15:1, first mix and be heated to 120 DEG C afterwards, stir 6 hours, obtain reactant A; Then open in reactor the ultrasonic unit installed, allow reactant A stir process 2 hours in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: centrifugal after reactant B being cooled to room temperature, be precipitated thing C; Sediment C is sent into reactor, adds the water of sediment C weight 20 times of weight, be heated to 40 DEG C, then add the neutral proteinase of 0.01% weight of sediment C weight, process under 55 DEG C of conditions 10 hours centrifugal again, be precipitated thing D; At room temperature, the sediment D acetic acid solution process 2 hours of mass concentration 3%, more centrifugal, obtain sediment E, sediment E washes through washing, ethanol, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: by sediment F under-60 DEG C of cryogenic conditions dry 12 hours, beta glucan finished product can be obtained.
The preparation method of formula milk is as follows: in 500g milk powder, each component is weighed by above-mentioned recipe calculation, first add whole milk powder, maltodextrin, add vitamin A, vitamin D, vitamin E, vitamin B6, vitamin C, folic acid, beta glucan and lactoferrin again, in 50 DEG C of mixed dissolutions, then homogeneous under temperature 45 C and pressure 15Mpa condition, 85 DEG C of pasteurization 30s, concentrated, last spraying dry makes formula milk 500g (comprising physical deterioration).
Embodiment 6.
See Fig. 1; the every 100g of formula milk strengthening body immunity in the present embodiment comprises following composition: vitamin A 500ug, vitamine D3 ug, vitamin e1 5mg, vitamin B6 8mg, vitamin C 150mg, folic acid 400ug, calcium 800mg, iron 20mg, zinc 5mg, taurine 40mg, 15'-dioxygenase 0ug, l-cn 40mg, beta glucan 1500mg, lactoferrin 1500mg, whole milk powder 30g, skimmed milk power 30g, and surplus is desalted whey powder (preparation process has physical deterioration).
Wherein, the preparation method of beta glucan used comprises the following steps:
(1), feed pretreatment step: to be rich in the material marine alga of beta glucan for raw material, clean, pulverize;
(2), alkali treatment and sonicating step: raw material after pretreatment is dropped in the NaOH aqueous solution of mass concentration 3%, the ratio of described NaOH aqueous solution volume ml number and material quality g number is 20:1, first mix and be heated to 120 DEG C afterwards, stir 6 hours, obtain reactant A; Then open in reactor the ultrasonic unit installed, allow reactant A stir process 4 hours in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: centrifugal after reactant B being cooled to room temperature, be precipitated thing C; Sediment C is sent into reactor, adds the water of sediment C weight 10 times of weight, be heated to 35 DEG C, then add the neutral proteinase of 0.1% weight of sediment C weight, process under 60 DEG C of conditions 10 hours centrifugal again, be precipitated thing D; At room temperature, the sediment D acetic acid solution process 2 hours of mass concentration 5%, more centrifugal, obtain sediment E, sediment E through washing, methanol wash column, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: by sediment F under-60 DEG C of cryogenic conditions dry 12 hours, beta glucan finished product can be obtained.
The preparation method of formula milk is as follows: in 500g milk powder, each component is weighed by above-mentioned recipe calculation, first add whole milk powder, skimmed milk power, desalted whey powder, add vitamin A again, vitamin D, vitamin E, vitamin B6, vitamin C, folic acid, calcium, iron, zinc, taurine, beta carotene, l-cn, beta glucan and lactoferrin, in 50 DEG C of mixed dissolutions, then at temperature 45 C, with homogeneous under pressure 15Mpa condition, 85 DEG C of pasteurization 30s, concentrated, last spraying dry makes formula milk 500g (comprising physical deterioration).
Embodiment 7.
See Fig. 1; the every 100g of formula milk strengthening body immunity in the present embodiment comprises following composition: maltodextrin 10g, FOS 10g, calcium 800mg, iron 20mg, zinc 5mg, taurine 40mg, 15'-dioxygenase 0ug, l-cn 40mg, beta glucan 1500mg, lactoferrin 1500mg, whole milk powder 30g, and surplus is skimmed milk power (preparation process has physical deterioration).
Wherein, the preparation method of beta glucan used comprises the following steps:
(1), feed pretreatment step: to be rich in the material highland barley wheat of beta glucan for raw material, clean, pulverize;
(2), alkali treatment and sonicating step: raw material after pretreatment is dropped in the NaOH aqueous solution of mass concentration 5%, the ratio of described NaOH aqueous solution volume ml number and material quality g number is 10:1, first mix and be heated to 100 DEG C afterwards, stir 8 hours, obtain reactant A; Then open in reactor the ultrasonic unit installed, allow reactant A stir process 4 hours in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: centrifugal after reactant B being cooled to room temperature, be precipitated thing C; Sediment C is sent into reactor, adds the water of sediment C weight 10 times of weight, be heated to 35 DEG C, then add the neutral proteinase of 0.1% weight of sediment C weight, process under 60 DEG C of conditions 10 hours centrifugal again, be precipitated thing D; At room temperature, the sediment D acetic acid solution process 2 hours of mass concentration 5%, more centrifugal, obtain sediment E, sediment E washes through washing, ethanol, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: by sediment F under-80 DEG C of cryogenic conditions dry 12 hours, beta glucan finished product can be obtained.
The preparation method of formula milk is as follows: in 500g milk powder; each component is weighed by above-mentioned recipe calculation; first add whole milk powder, skimmed milk power, maltodextrin, FOS; add calcium, iron, zinc, taurine, beta carotene, l-cn, beta glucan and lactoferrin again; in 50 DEG C of mixed dissolutions; then homogeneous under temperature 45 C and pressure 15Mpa condition; 85 DEG C of pasteurization 30s; concentrated, last spraying dry makes formula milk 500g (comprising physical deterioration).
Embodiment 8.
See Fig. 1, the every 100g of formula milk strengthening body immunity in the present embodiment comprises following composition: maltodextrin 10g, FOS 10g, beta glucan 1500mg, lactoferrin 1500mg, skimmed milk power 50g, and surplus is desalted whey powder (preparation process has physical deterioration).
Wherein, the preparation method of beta glucan used comprises the following steps:
(1), feed pretreatment step: to be rich in the material brewer's yeast of beta glucan for raw material, clean, pulverize;
(2), alkali treatment and sonicating step: raw material after pretreatment is dropped in the NaOH aqueous solution of mass concentration 6%, the ratio of described NaOH aqueous solution volume ml number and material quality g number is 10:1, first mix and be heated to 100 DEG C afterwards, stir 8 hours, obtain reactant A; Then open in reactor the ultrasonic unit installed, allow reactant A stir process 3 hours in ultrasonic environment, obtain reactant B and close ultrasonic unit;
(3), enzymolysis processing step: centrifugal after reactant B being cooled to room temperature, be precipitated thing C; Sediment C is sent into reactor, adds the water of sediment C weight 10 times of weight, be heated to 35 DEG C, then add the neutral proteinase of 0.1% weight of sediment C weight, process under 60 DEG C of conditions 10 hours centrifugal again, be precipitated thing D; At room temperature, the sediment D acetic acid solution process 2 hours of mass concentration 6%, more centrifugal, obtain sediment E, sediment E washes through washing, ethanol, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: by sediment F under-60 DEG C of cryogenic conditions dry 12 hours, beta glucan finished product can be obtained.
The preparation method of formula milk is as follows: in 500g milk powder, each component is weighed by above-mentioned recipe calculation, first add skimmed milk power, desalted whey powder, maltodextrin, FOS, add beta glucan and lactoferrin again, in 50 DEG C of mixed dissolutions, then homogeneous under temperature 45 C and pressure 15Mpa condition, 85 DEG C of pasteurization 30s, concentrated, last spraying dry makes formula milk 500g (comprising physical deterioration).
Embodiment 9.
See Fig. 1; the every 100g of formula milk strengthening body immunity in the present embodiment comprises following composition: maltodextrin 10g, FOS 10g, vitamin A 500ug, vitamine D3 ug, vitamin e1 5mg, vitamin B6 8mg, vitamin C 150mg, folic acid 400ug, calcium 800mg, iron 20mg, zinc 5mg, taurine 40mg, 15'-dioxygenase 0ug, l-cn 40mg, beta glucan 1500mg, lactoferrin 1500mg, whole milk powder 30g, skimmed milk power 30g, and surplus is desalted whey powder (preparation process has physical deterioration).
Wherein, beta glucan used is what buy on the market.
The preparation method of formula milk is as follows: in 500g milk powder, each component is weighed by above-mentioned recipe calculation, first add whole milk powder, skimmed milk power, desalted whey powder, maltodextrin, FOS, add vitamin A again, vitamin D, vitamin E, vitamin B6, vitamin C, folic acid, calcium, iron, zinc, taurine, beta carotene, l-cn, beta glucan and lactoferrin, in 50 DEG C of mixed dissolutions, then at temperature 45 C, with homogeneous under pressure 15Mpa condition, 85 DEG C of pasteurization 30s, concentrated, last spraying dry makes formula milk 500g (comprising physical deterioration).
By foregoing description, those skilled in the art can implement.
Above-described embodiment contains only several common prescription of the present invention, and main component of the present invention can be one or more in whole milk powder, skimmed milk power and desalted whey powder, can comprise one or both compositions of following content in every 100g formula milk:
Maltodextrin 0.1g-20g, FOS 0.1g-20g; Also can not contain;
One or more compositions of following content can also be comprised in every 100g formula milk:
3-Hydroxyretinol 0-900ug, vitamine D1-5ug, vitamin e1-30mg, vitamin B6 0.1-16mg, vitamin C 10-300mg, folic acid 20-800ug, calcium 480-1000mg, iron 1-50mg, zinc 1-10mg, taurine 3-80mg, beta carotene 10-300ug, l-cn 3-80mg; Also can not contain.
Although the present invention with embodiment openly as above, it is also not used to limit protection scope of the present invention, and all equivalences of doing according to principle of the present invention, Method and process or simple change, all belong in the protection domain of patent of the present invention.
Claims (7)
1. one kind strengthens the formula milk of body immunity, the main component of described formula milk comprises at least one in whole milk powder, skimmed milk power and desalted whey powder, it is characterized in that: also containing beta glucan 100mg-3000mg and lactoferrin 100mg-3000mg in the every 100g of described formula milk;
The preparation method of described beta glucan comprises the following steps:
(1), feed pretreatment step: to be rich in the material of beta glucan for raw material, clean, pulverize;
(2), alkali treatment and sonicating step: raw material after pretreatment is dropped in alkaline aqueous solution, the ratio of described alkaline aqueous solution volume ml number and material quality g number is 5:1 to 20:1, first mix and be heated to 80-150 DEG C afterwards, stir 1-8 hour, obtain reactant A; Then open in reactor the ultrasonic unit installed, allow reactant A stir process 1-4 hour in ultrasonic environment, obtain reactant B;
(3), enzymolysis processing step: centrifugal after reactant B being cooled to room temperature, be precipitated thing C; Sediment C is sent into reactor, adds sediment C weight 5-30 water doubly, be heated to 25-50 DEG C, then add the neutral proteinase of 0.001%-1% of sediment C weight, process under 50-70 DEG C of condition 10 hours centrifugal again, be precipitated thing D; At room temperature, the sediment D acetic acid solution process 2 hours of mass concentration 1-8%, more centrifugal, obtain sediment E, sediment E through washing, alcohol wash, then washes twice with absolute ether, then washes, finally centrifugal, obtains sediment F;
(4), purification step: by sediment F under-80 DEG C to-40 DEG C cryogenic conditions dry 12 hours, i.e. obtained beta glucan.
2. the formula milk of enhancing body immunity according to claim 1, is characterized in that: one or both compositions also having following content in the every 100g of described formula milk:
Maltodextrin 0.1g-20g, FOS 0.1g-20g.
3. the formula milk of enhancing body immunity according to claim 1, is characterized in that: one or more compositions also having following content in the every 100g of described formula milk:
3-Hydroxyretinol 0-900ug, vitamine D1-5ug, vitamin e1-30mg, vitamin B6 0.1-16mg; vitamin C 10-300mg, folic acid 20-800ug, calcium 480-1000mg, iron 1-50mg; zinc 1-10mg, taurine 3-80mg, beta carotene 10-300ug, l-cn 3-80mg.
4. the formula milk of the enhancing body immunity according to claim 1 or 2 or 3, is characterized in that: described beta glucan and lactoferrin and all the other milk formula compositions are mixed together in the form of a powder.
5. the formula milk of enhancing body immunity according to claim 1, is characterized in that: in the step (1) of the preparation method of described beta glucan, described in be rich in beta glucan material be one in marine alga, sea-tangle, highland barley wheat and brewer's yeast.
6. the formula milk of enhancing body immunity according to claim 1, is characterized in that: in the step (2) of the preparation method of described beta glucan, and described alkaline aqueous solution is the NaOH aqueous solution of mass concentration 2-8%.
7. the formula milk of enhancing body immunity according to claim 1, is characterized in that: in the step (3) of the preparation method of described beta glucan, described alcohol is methyl alcohol or ethanol.
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| CN105192072A (en) * | 2015-09-10 | 2015-12-30 | 浙江康诺邦健康产品有限公司 | Nutrient and formula milk powder for pregnant woman |
| CN105123948B (en) * | 2015-09-14 | 2018-07-17 | 齐鲁工业大学 | A kind of U.S. face skin care Goat milk powder improving immunity and anti-aging |
| CN105166905A (en) * | 2015-10-09 | 2015-12-23 | 广州市炜鑫生物科技有限公司 | Compound weight-reducing powder and preparation method thereof |
| CN109430413A (en) * | 2018-09-26 | 2019-03-08 | 北京斯利安药业有限公司 | A kind of composition of strengthen immunity, functional food and preparation method thereof |
| CN109452370A (en) * | 2018-11-16 | 2019-03-12 | 上海晨冠乳业有限公司 | A kind of student's formula milk and its preparation process |
| CN113545399A (en) * | 2020-04-26 | 2021-10-26 | 黑龙江飞鹤乳业有限公司 | Dairy product and method for producing the same |
| CN111670951A (en) * | 2020-04-30 | 2020-09-18 | 上海紫丁进出口有限公司 | Modified milk powder and preparation method thereof |
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