CN105029408A - Dendrobium officinale and gynostemma pentaphylla capsule and preparation method thereof - Google Patents
Dendrobium officinale and gynostemma pentaphylla capsule and preparation method thereof Download PDFInfo
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- CN105029408A CN105029408A CN201510323793.5A CN201510323793A CN105029408A CN 105029408 A CN105029408 A CN 105029408A CN 201510323793 A CN201510323793 A CN 201510323793A CN 105029408 A CN105029408 A CN 105029408A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 11
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- 241001065361 Gynostemma Species 0.000 claims abstract description 56
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a dendrobium officinale and gynostemma pentaphylla capsule. The capsule is prepared from the following raw materials in parts by weight: 50-60 parts of dendrobium officinale and 10-20 parts of gynostemma pentaphylla. The capsule is prepared by using dendrobium officinale as a main material and gynostemma pentaphylla as an auxiliary, has health effects of reinforcing immunity, relieving physical fatigue, reducing hyperlipidemia, hypertension and hyperglycemia and the like by means of synergy of the raw materials. The capsule is convenient to take, can be used for meeting health requirement of people at all levels, and has huge market potential. The invention further discloses a method for preparing the dendrobium officinale and gynostemma pentaphylla capsule. The method comprises the following steps: preparing dendrobium officinale extract powder from dendrobium officinale by means of ultrasonic enzymolysis, alcohol extraction, concentration and drying; grinding gynostemma pentaphylla, extracting with water, concentrating and drying to obtain gynostemma pentaphylla extract powder; and mixing the dendrobium officinale extract powder and the gynostemma pentaphylla extract powder to prepare the capsule. The preparation method has the advantages of simple steps, low equipment requirement, stable process, strong operability and high efficiency, and is suitable for industrial production.
Description
Technical field
The present invention relates to health products preparing technical field, especially relate to a kind of dendrobium candidum gynostemma pentaphylla capsule and preparation method thereof.
Background technology
Dendrobium candidum (Dendrobiumofficinale), belongs to the orchid family, Dendrobium, dendrobium candidum kind, the perennial herbaceous plant that grows nonparasitically upon another plant.Dendrobium candidum is mainly containing dendrobium polysaccharide, alkaloid, amino acid, the plurality of active ingredients such as trace element and phenolic compound, have nourishing Yin and moistening lung, nourishing the stomach to improve the production of body fluid, brain nourishing and eyesight improving, the Proheparin heart, heat-clearing and fire-reducing, the consumptive disease of tonifying five zang organs, to make light of one's life by commiting suicide the magical effect of prolonging life, to chronic fatigue syndrome, tuberculosis, coronary heart disease, ephrosis, chronic liver disease, hypertension, high fat of blood, hyperglycaemia, diabetes, chronic gastropathy, dry syndrome, the diseases such as cancer have definite curative effect and conditioning rehabilitative action, and can body immunity be strengthened, anti-oxidant, anti-ageing, excessive to tobacco and wine, overwork, night life is excessive, overstrain one's nerves with eye, hoarseness, mouth parched and tongue scorched, the rehabilitations such as the deficiency of Yin that decline of old gonosome low force have special efficacy.
It is gynosaponin, gynostemma pentaphylla glucoside (polysaccharide), water-soluble amino acids, flavonoids, multivitamin, trace element, mineral matter etc. that gynostemma pentaphylla mainly contains effective constituent, hypertension, high fat of blood, hyperglycaemia can be treated, the diseases such as fatty liver, have effect of protecting liver and detoxication, hypotensive, reducing blood lipid blood sugar.
But current dendrobium candidum, gynostemma pentaphylla also exist inconvenient eating, active ingredient is low by the absorption rate of human body, the problems such as effect is not remarkable, if the medicinal efficacy of dendrobium candidum, gynostemma pentaphylla therefore can be made full use of, developing a kind of is major ingredient with dendrobium candidum, gynostemma pentaphylla is auxiliary material, and the more significant health product of taking convenience, result of use, exists huge market value undoubtedly.
Summary of the invention
It is reasonable to the object of the invention is to provide a kind of compatibility, and taking convenience, absorption of human body is good, and utilization rate is high, has develop immunitypty, alleviating physical fatigue, falls the dendrobium candidum gynostemma pentaphylla capsule of three high various health care functions.
Present invention also offers a kind of dendrobium candidum gynostemma pentaphylla capsule preparation method thereof, processing step is simple, low for equipment requirements, process stabilizing, and workable, production efficiency is high, is applicable to suitability for industrialized production.
To achieve these goals, the present invention is by the following technical solutions:
A kind of dendrobium candidum gynostemma pentaphylla capsule, is made up of the raw material of following weight portion: 50 ~ 60 parts of dendrobium candidums, 10 ~ 20 portions of gynostemma pentaphylla.Dendrobium candidum gynostemma pentaphylla capsule of the present invention makes full use of the medicinal efficacy of dendrobium candidum, gynostemma pentaphylla, take dendrobium candidum as major ingredient, gynostemma pentaphylla is that auxiliary material is made, by the Synergistic of each raw material, there is develop immunitypty, alleviating physical fatigue, fall three high health-care efficacies, taking convenience, can meet the health care demand of each aspect personage, have huge market potential.
A kind of dendrobium candidum gynostemma pentaphylla capsule preparation method thereof, comprises the following steps:
(1) prepare burden
Dendrobium candidum, gynostemma pentaphylla is taken by above-mentioned weight, stand-by.
(2) dendrobium candidum extract powder is prepared
(1) dendrobium candidum weighed up is cleaned, dries, pulverized, cross 60 ~ 80 mesh sieves and obtain dendrobium officinale powder.
(2) add water be incorporated as the complex enzyme of dendrobium candidum quality 0.3 ~ 0.5% in dendrobium officinale powder after, the addition of water is as the criterion with just submergence dendrobium officinale powder, regulates pH to be 5 ~ 6, be warming up to 50 ~ 60 DEG C after stirring, 90 ~ 95 DEG C of enzymes that go out are warming up to, cooling after ultrasonic enzymolysis 1 ~ 2h.Active ingredient in dendrobium candidum is wrapped in cell membrane usually, and cell membrane increase active ingredient from cell to Extraction medium diffusion resistance to mass tranfer, the recovery rate of active ingredient can be affected, therefore the present invention assists alcohol extracting method to improve the recovery rate of active ingredient and the extracting efficiency of alcohol extracting method in dendrobium candidum by conbined enzymolysis, can be made the ingredient degradation such as cellulose, pectin in cell membrane and cytoplasm by enzymolysis, in reduction dendrobium candidum, active ingredient is from the resistance to mass tranfer of the diffusion that is situated between to extraction in cell; The present invention adopts intensified by ultrasonic wave enzymolysis means in addition, accelerates enzymolysis process, greatly improves hydrolysis result, be conducive to the extraction efficiency improving follow-up alcohol extracting.
(3) regulate pH be 8 ~ 9, then be incorporated as dendrobium officinale powder quality 8 ~ 12 times 75 ~ 80% ethanolic solution, be warming up to 75 ~ 80 DEG C of refluxing extraction 2 times, each 0.5 ~ 1 hour, merge alcohol extract, filter, reclaim ethanol, obtain extract.The present invention adopts alcohol extracting to ensure that the active ingredient in dendrobium candidum can fully leach, and ethanol can reclaim, and is conducive to reducing costs.
(4) be 1.08 ~ 1.12 (20 DEG C) by extract Vacuum Concentration to relative density, obtain dendrobium candidum medicinal extract;
(5) by dendrobium candidum medicinal extract spraying dry, dendrobium candidum extract powder is obtained.
(3) gynostemma pentaphyllum extract powder is prepared
A () is incorporated as the water of gynostemma pentaphylla quality 10 ~ 12 times after being pulverized by gynostemma pentaphylla, be heated to 100 DEG C of lixiviates 2 times, each lixiviate 1 ~ 2h, filters and collect filtrate, obtaining leaching liquor.
B leaching liquor Vacuum Concentration to relative density is 1.08 ~ 1.12 (20 DEG C) by (), obtain gynostemma pentaphyllum extract;
C (), by gynostemma pentaphyllum extract spraying dry, obtains gynostemma pentaphyllum extract powder.
(4) capsule is prepared
Obtained dendrobium candidum extract powder is mixed rear pulverizing with gynostemma pentaphyllum extract powder, crosses 30 ~ 40 mesh sieves, particulate processed, whole grain, finally carry out that namely capsule is filling obtains dendrobium candidum gynostemma pentaphylla capsule.
As preferably, in step (2), described complex enzyme is made up of cellulase, pectase and papain, and wherein the mass percentage of each enzyme is: 20 ~ 25% pectases, 5 ~ 10% papains, and surplus is cellulase.Main component dendrobium polysaccharide in dendrobium candidum is often together with protein bound, exist with the form of proteoglycan, and the cell membrane of dendrobium candidum cell increase active ingredient from cell to Extraction medium diffusion resistance to mass tranfer, above-mentioned two kinds of factors make the extraction time of dendrobium candidum longer, the recovery rate of extracting efficiency and active ingredient is low, based on this, the present invention is by strict screening, select by cellulase, the complex enzyme of pectase and papain composition carries out enzymolysis to dendrobium candidum, wherein papain can the effective protein that combines of enzymolysis and polysaccharide, polysaccharide is discharged and improves the yield of polysaccharide, reduce the content of protein in polysaccharide simultaneously, cellulase can abundant swelling cell membrane, impels intracellular polysaccharide in abundant stripping, pectic substance between pectase energy degradation of cell, cell separation out, thus is conducive to cellulase and acts on dendrobium candidum cell, improves recovery rate, by the synergy of 3 kinds of enzymes, can by the hydrolysis of the constituent of cell membrane or degraded, destroy the structure of cell membrane, the active ingredient of dendrobium candidum is fully come out, dissolve, be suspended in solvent, thus reach the object improving extraction efficiency (alcohol extracting time shorten is 0.5 ~ 1h) and recovery rate.
As preferably, in step (2), supersonic frequency is 40 ~ 50kHz.Hyperacoustic frequency is key point of the present invention, underfrequency, although comparatively strong for active forces such as the cavitation of single and shearings, within a certain period of time due to underfrequency, corresponding useful effect number of times is less, not obvious for the effect improving hydrolysis result; Otherwise amplitude is less, at every turn more weak to the active force of material, also not obvious for the effect improving hydrolysis result, therefore adopt the supersonic frequency of 40 ~ 50kHz to carry out ultrasonic enzymolysis in the present invention, its action effect is best.
As preferably, step (4) is with step (b), and the technological parameter of Vacuum Concentration is: thickening temperature 60 ~ 70 DEG C, and vacuum is-0.08 ~-0.09MPa.
As preferably, step (5) is with step (c), and spray-dired technological parameter is: EAT: 170 ~ 180 DEG C; Outlet temperature: 60 ~ 70 DEG C; Feed liquor speed: 40 ~ 45ml/min.
Therefore, the present invention has following beneficial effect:
(1) dendrobium candidum gynostemma pentaphylla capsule of the present invention makes full use of the medicinal efficacy of dendrobium candidum, gynostemma pentaphylla, take dendrobium candidum as major ingredient, gynostemma pentaphylla is that auxiliary material is made, by the Synergistic of each raw material, there is develop immunitypty, alleviating physical fatigue, fall three high health-care efficacies, taking convenience, can meet the health care demand of each aspect personage, have huge market potential;
(2) complex enzyme be made up of cellulase, pectase and papain is selected to carry out ultrasonic enzymolysis to dendrobium candidum in advance at alcohol, alcohol extracting method is assisted by ULTRASONIC COMPLEX enzymatic isolation method, thus improve the object of extraction efficiency and recovery rate to reach active ingredient in dendrobium candidum, processing step is simple, low for equipment requirements, process stabilizing, workable, production efficiency is high, is applicable to suitability for industrialized production.
Detailed description of the invention
Below by detailed description of the invention, the present invention will be further described.
Embodiment 1
(1) prepare burden
By 550Kg dendrobium candidum, the proportioning of 150Kg gynostemma pentaphylla takes dendrobium candidum, gynostemma pentaphylla, stand-by.
(2) dendrobium candidum extract powder is prepared
(1) dendrobium candidum weighed up is cleaned, dries, pulverized, cross 70 mesh sieves and obtain dendrobium officinale powder.
(2) add water be incorporated as the complex enzyme of dendrobium candidum quality 0.4% in dendrobium officinale powder after, the addition of water is as the criterion with just submergence dendrobium officinale powder, regulates pH to be 5.5, be warming up to 55 DEG C after stirring, 92 DEG C of enzymes that go out are warming up to after ultrasonic enzymolysis 1.2h, cooling, wherein, complex enzyme is made up of cellulase, pectase and papain, wherein the mass percentage of each enzyme is: 22% pectase, 8% papain, surplus is cellulase, and frequency is 42kHz.
(3) regulate pH be 8.5, then be incorporated as dendrobium officinale powder quality 10 times 78% ethanolic solution, be warming up to 78 DEG C of refluxing extraction 2 times, each 0.6 hour, merge alcohol extract, filter, reclaim ethanol, obtain extract.
(4) be 1.1 (20 DEG C) by extract Vacuum Concentration to relative density, obtain dendrobium candidum medicinal extract, the technological parameter of Vacuum Concentration is: thickening temperature 65 DEG C, and vacuum is-0.085MPa.
(5) by dendrobium candidum medicinal extract spraying dry, obtain dendrobium candidum extract powder, spray-dired technological parameter is: EAT: 172 DEG C; Outlet temperature: 65 DEG C; Feed liquor speed: 43ml/min.
(3) gynostemma pentaphyllum extract powder is prepared
A () is incorporated as the water of gynostemma pentaphylla quality 10 ~ 12 times after being pulverized by gynostemma pentaphylla, be heated to 100 DEG C of lixiviates 2 times, each lixiviate 1.5h, filters and collect filtrate, obtaining leaching liquor.
B leaching liquor Vacuum Concentration to relative density is 1.1 (20 DEG C) by (), obtain gynostemma pentaphyllum extract, the technological parameter of Vacuum Concentration is: thickening temperature 65 DEG C, and vacuum is-0.085MPa.
C (), by gynostemma pentaphyllum extract spraying dry, obtains gynostemma pentaphyllum extract powder, spray-dired technological parameter is: EAT: 172 DEG C; Outlet temperature: 65 DEG C; Feed liquor speed: 43ml/min.
(4) capsule is prepared
Obtained dendrobium candidum extract powder is mixed rear pulverizing with gynostemma pentaphyllum extract powder, crosses 35 mesh sieves, particulate processed, whole grain, finally carry out that namely capsule is filling obtains dendrobium candidum gynostemma pentaphylla capsule.
Embodiment 2
(1) prepare burden
By 600Kg dendrobium candidum, the proportioning of 200Kg gynostemma pentaphylla takes dendrobium candidum, gynostemma pentaphylla, stand-by.
(2) dendrobium candidum extract powder is prepared
(1) dendrobium candidum weighed up is cleaned, dries, pulverized, cross 80 mesh sieves and obtain dendrobium officinale powder.
(2) add water be incorporated as the complex enzyme of dendrobium candidum quality 0.5% in dendrobium officinale powder after, the addition of water is as the criterion with just submergence dendrobium officinale powder, regulates pH to be 6, be warming up to 60 DEG C after stirring, 95 DEG C of enzymes that go out are warming up to after ultrasonic enzymolysis 2h, cooling, wherein, complex enzyme is made up of cellulase, pectase and papain, wherein the mass percentage of each enzyme is: 25% pectase, 10% papain, surplus is cellulase, and frequency is 50kHz.
(3) regulate pH be 9, then be incorporated as dendrobium officinale powder quality 12 times 80% ethanolic solution, be warming up to 80 DEG C of refluxing extraction 2 times, each 1 hour, merge alcohol extract, filter, reclaim ethanol, obtain extract.
(4) be 1.12 (20 DEG C) by extract Vacuum Concentration to relative density, obtain dendrobium candidum medicinal extract, the technological parameter of Vacuum Concentration is: thickening temperature 70 DEG C, and vacuum is-0.09MPa.
(5) by dendrobium candidum medicinal extract spraying dry, obtain dendrobium candidum extract powder, spray-dired technological parameter is: EAT: 180 DEG C; Outlet temperature: 70 DEG C; Feed liquor speed: 45ml/min.
(3) gynostemma pentaphyllum extract powder is prepared
A () is incorporated as the water of gynostemma pentaphylla quality 12 times after being pulverized by gynostemma pentaphylla, be heated to 100 DEG C of lixiviates 2 times, each lixiviate 2h, filters and collect filtrate, obtaining leaching liquor.
B leaching liquor Vacuum Concentration to relative density is 1.12 (20 DEG C) by (), obtain gynostemma pentaphyllum extract, the technological parameter of Vacuum Concentration is: thickening temperature 70 DEG C, and vacuum is-0.09MPa.
C (), by gynostemma pentaphyllum extract spraying dry, obtains gynostemma pentaphyllum extract powder, spray-dired technological parameter is: EAT: 180 DEG C; Outlet temperature: 70 DEG C; Feed liquor speed: 45ml/min.
(4) capsule is prepared
Obtained dendrobium candidum extract powder is mixed rear pulverizing with gynostemma pentaphyllum extract powder, crosses 40 mesh sieves, particulate processed, whole grain, finally carry out that namely capsule is filling obtains dendrobium candidum gynostemma pentaphylla capsule.
Embodiment 3
(1) prepare burden
By 500Kg dendrobium candidum, the proportioning of 100Kg gynostemma pentaphylla takes dendrobium candidum, gynostemma pentaphylla, stand-by.
(2) dendrobium candidum extract powder is prepared
(1) dendrobium candidum weighed up is cleaned, dries, pulverized, cross 60 mesh sieves and obtain dendrobium officinale powder.
(2) add water be incorporated as the complex enzyme of dendrobium candidum quality 0.3% in dendrobium officinale powder after, the addition of water is as the criterion with just submergence dendrobium officinale powder, regulates pH to be 5, be warming up to 50 DEG C after stirring, 90 DEG C of enzymes that go out are warming up to after ultrasonic enzymolysis 1h, cooling, wherein, complex enzyme is made up of cellulase, pectase and papain, wherein the mass percentage of each enzyme is: 20% pectase, 5% papain, surplus is cellulase, and frequency is 40kHz.
(3) regulate pH be 8, then be incorporated as dendrobium officinale powder quality 8 times 75% ethanolic solution, be warming up to 75 DEG C of refluxing extraction 2 times, each 0.5 hour, merge alcohol extract, filter, reclaim ethanol, obtain extract.
(4) be 1.08 (20 DEG C) by extract Vacuum Concentration to relative density, obtain dendrobium candidum medicinal extract, the technological parameter of Vacuum Concentration is: thickening temperature 60 DEG C, and vacuum is-0.08MPa.
(5) by dendrobium candidum medicinal extract spraying dry, obtain dendrobium candidum extract powder, spray-dired technological parameter is: EAT: 170 DEG C; Outlet temperature: 60 DEG C; Feed liquor speed: 40ml/min.
(3) gynostemma pentaphyllum extract powder is prepared
A () is incorporated as the water of gynostemma pentaphylla quality 10 times after being pulverized by gynostemma pentaphylla, be heated to 100 DEG C of lixiviates 2 times, each lixiviate 1h, filters and collect filtrate, obtaining leaching liquor.
B leaching liquor Vacuum Concentration to relative density is 1.08 (20 DEG C) by (), obtain gynostemma pentaphyllum extract, the technological parameter of Vacuum Concentration is: thickening temperature 60 DEG C, and vacuum is-0.08MPa.
C (), by gynostemma pentaphyllum extract spraying dry, obtains gynostemma pentaphyllum extract powder, spray-dired technological parameter is: EAT: 170 DEG C; Outlet temperature: 60 DEG C; Feed liquor speed: 40ml/min.
(4) capsule is prepared
Obtained dendrobium candidum extract powder is mixed rear pulverizing with gynostemma pentaphyllum extract powder, crosses 30 mesh sieves, particulate processed, whole grain, finally carry out that namely capsule is filling obtains dendrobium candidum gynostemma pentaphylla capsule.
The quality index of the dendrobium candidum gynostemma pentaphylla capsule that the present invention obtains is:
One. organoleptic indicator
| Project | Index |
| Color and luster | Pale brown or yellow |
| Tissue morphology | Fine particulate |
| Taste, smell | There is the distinctive fragranced of dendrobium candidum |
| Impurity | Free from admixture |
Two. physical and chemical index
| Project | Index |
| Moisture/(%) | ≤6.0 |
| Ash content/(%) | ≤6.0 |
| Disintegration time limited/(min) | ≤30 |
| Arsenic (in As), (mg/kg) | ≤1.0 |
| Plumbous (in Pa), (mg/kg) | ≤1.5 |
| Tribute (in Hg), (mg/kg) | ≤0.3 |
| BHC/(mg/kg) | ≤0.2 |
| (DDT/(mg/kg) | ≤0.2 |
Three. microbiological indicator
Four. effective component index
| Project | Index |
| Thick many candies (in glucan)/(g/100g) | ≥7.74 |
Above-described embodiment is one of the present invention preferably scheme, not does any pro forma restriction to the present invention, also has other variant and remodeling under the prerequisite not exceeding the technical scheme described in claim.
Claims (6)
1. a dendrobium candidum gynostemma pentaphylla capsule, is characterized in that, is made up of the raw material of following weight portion: 50 ~ 60 parts of dendrobium candidums, 10 ~ 20 portions of gynostemma pentaphylla.
2. a dendrobium candidum gynostemma pentaphylla capsule preparation method thereof as claimed in claim 1, is characterized in that, comprise the following steps:
(1) prepare burden
Dendrobium candidum, gynostemma pentaphylla is taken by above-mentioned weight, stand-by;
(2) dendrobium candidum extract powder is prepared
(1) dendrobium candidum weighed up is cleaned, dries, pulverized, cross 60 ~ 80 mesh sieves and obtain dendrobium officinale powder;
(2) add water be incorporated as the complex enzyme of dendrobium candidum quality 0.3 ~ 0.5% in dendrobium officinale powder after, the addition of water is as the criterion with just submergence dendrobium officinale powder, regulates pH to be 5 ~ 6, be warming up to 50 ~ 60 DEG C after stirring, 90 ~ 95 DEG C of enzymes that go out are warming up to, cooling after ultrasonic enzymolysis 1 ~ 2h;
(3) regulate pH be 8 ~ 9, then be incorporated as dendrobium officinale powder quality 8 ~ 12 times 75 ~ 80% ethanolic solution, be warming up to 75 ~ 80 DEG C of refluxing extraction 2 times, each 0.5 ~ 1 hour, merge alcohol extract, filter, reclaim ethanol, obtain extract;
(4) be 1.08 ~ 1.12 (20 DEG C) by extract Vacuum Concentration to relative density, obtain dendrobium candidum medicinal extract;
(5) by dendrobium candidum medicinal extract spraying dry, dendrobium candidum extract powder is obtained;
(3) gynostemma pentaphyllum extract powder is prepared
A () is incorporated as the water of gynostemma pentaphylla quality 10 ~ 12 times after being pulverized by gynostemma pentaphylla, be heated to 100 DEG C of lixiviates 2 times, each lixiviate 1 ~ 2h, filters and collect filtrate, obtaining leaching liquor;
B leaching liquor Vacuum Concentration to relative density is 1.08 ~ 1.12 (20 DEG C) by (), obtain gynostemma pentaphyllum extract;
C (), by gynostemma pentaphyllum extract spraying dry, obtains gynostemma pentaphyllum extract powder;
(4) capsule is prepared
Obtained dendrobium candidum extract powder is mixed rear pulverizing with gynostemma pentaphyllum extract powder, crosses 30 ~ 40 mesh sieves, particulate processed, whole grain, finally carry out that namely capsule is filling obtains dendrobium candidum gynostemma pentaphylla capsule.
3. dendrobium candidum gynostemma pentaphylla capsule preparation method thereof according to claim 2, it is characterized in that, in step (2), described complex enzyme is made up of cellulase, pectase and papain, wherein the mass percentage of each enzyme is: 20 ~ 25% pectases, 5 ~ 10% papains, surplus is cellulase.
4. dendrobium candidum gynostemma pentaphylla capsule preparation method thereof according to claim 2, is characterized in that, in step (2), supersonic frequency is 40 ~ 50kHz.
5. dendrobium candidum gynostemma pentaphylla capsule preparation method thereof according to claim 2, it is characterized in that, step (4) is with step (b), and the technological parameter of Vacuum Concentration is: thickening temperature 60 ~ 70 DEG C, and vacuum is-0.08 ~-0.09MPa.
6. dendrobium candidum gynostemma pentaphylla capsule preparation method thereof according to claim 2, is characterized in that, step (5) is with step (c), and spray-dired technological parameter is: EAT: 170 ~ 180 DEG C; Outlet temperature: 60 ~ 70 DEG C; Feed liquor speed: 40 ~ 45ml/min.
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