CN1586507A - Officinal Dendrobium stem capsule and preparing method - Google Patents
Officinal Dendrobium stem capsule and preparing method Download PDFInfo
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- CN1586507A CN1586507A CN 200410052850 CN200410052850A CN1586507A CN 1586507 A CN1586507 A CN 1586507A CN 200410052850 CN200410052850 CN 200410052850 CN 200410052850 A CN200410052850 A CN 200410052850A CN 1586507 A CN1586507 A CN 1586507A
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- 240000006509 Gynostemma pentaphyllum Species 0.000 claims abstract description 9
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- 239000000843 powder Substances 0.000 claims description 22
- 239000000284 extract Substances 0.000 claims description 20
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- 238000002360 preparation method Methods 0.000 claims description 9
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- 239000005017 polysaccharide Substances 0.000 claims description 3
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
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Abstract
The present invention discloses one kind of Officinal Dendrobium stem capsule. The capsule consists of Officinal Dendrobium extractum in 42-56 wt% and gynostemma pentaphylla extractum in 44-58 wt%. The capsule has the functions of strengthening immunity and resisting fatigue.
Description
Technical field
The present invention relates to the Chinese medicine health care product field, especially, relate to a kind of Herba Dendrobii capsule and preparation method.
Background technology
Along with being showing improvement or progress day by day and developing of society, people's work pressure is also along with increasing the weight of, and research antifatigue food is extremely rising; People very pay attention to the immunomodulating of self simultaneously.
Herba Dendrobii is the fresh or dry stem of orchid Herba Dendrobii (Dendrobium candidum Wall.ex Lindl.), there are some researches show: Herba Dendrobii is a kind of of great value immunostimulant, clinical trial shows: Herba Dendrobii has dual regulation to immunologic function, and has antioxidation.
Herb Gynostemmae Pentaphylli is the herb of cucurbitaceae genus gynostemma Herb Gynostemmae Pentaphylli, and experiment shows that Herb Gynostemmae Pentaphylli extract has the effect that increases mouse movement endurance; Have resisting fatigue, anoxia enduring, high temperature resistance effect.A large amount of experiments show its energy raise immunity simultaneously, and the energy physical strength reinforcing, allaying tiredness.
At present few to the research of Herba Dendrobii and Herb Gynostemmae Pentaphylli, at present based on they health product seldom.The present invention uses Chinese medical theory exactly, and fully in conjunction with modern medicine means and advanced pharmaceutical technology, the great potential of performance motherland medicine and pharmacology is made the health food that people take like a shot, and reached the purpose of alleviating physical fatigue and enhancing immunity.
Summary of the invention
The object of the present invention is to provide a kind of Herba Dendrobii capsule and preparation method, alleviating physical fatigue, enhancing immunity.
The objective of the invention is to be achieved through the following technical solutions: a kind of Herba Dendrobii capsule is characterized in that this capsule is that 42%～56% Herba Dendrobii and 44～58% gynostemma pentaphyllum extract powder are formed by percentage by weight substantially.
The capsular preparation method of the described Herba Dendrobii of a kind of claim 1 is characterized in that this method comprises:
(1) Herba Dendrobii is cleaned, and is ground into the Herba Dendrobii fine powder after the oven dry;
(2) get Herb Gynostemmae Pentaphylli, be cut into segment after cleaning, soak, be heated to and boil, extract, filter time extracting solution of winning;
(3) residue adds water, is heated to boil, and extracts, filter extracting solution for the second time;
(4) merge extracted twice liquid, the extracting solution after merging is carried out concentrating under reduced pressure;
(5) concentrated solution is carried out spray drying, get extract powder;
(6) with Herba Dendrobii fine powder and the abundant mix homogeneously of gynostemma pentaphyllum extract powder;
(7) filled capsules.
The present invention has following technique effect: regulate immunologic function, resisting fatigue, boosting qi and nourishing yin, be applicable to and have a delicate constitution and the fatiguability person, especially to rehabilitation after being ill, overwork, the lung-stomach yin deficiency shower has good effect, eliminate people by the spiritlessness and weakness due to the busy working and learning, can improve working and learning efficient effectively.
Carry out the toxicological safety experiment with Herba Dendrobii capsule of the present invention:
1, acute toxicity testing conclusion:, belong to nontoxic level goods and materials according to the classification of acute toxicity half lethal dose.
2, micronucleus test conclusion: the result is negative for bone marrow polychromatic erythrocyte micronucleus test.
3, sperm deformity experiment conclusion: the sperm deformity experimental result is negative.
4, Ames experiment conclusion: feminine gender.
5, fed experiment in 30 days: sample rat growing state is good substantially.The check result of hematochrome, erythrocyte, numeration of leukocyte and classification thereof is all in normal range.The histological examination result of main organs such as liver,kidney,spleen, gastrointestinal, sexual organ does not find and tests relevant pathological changes.
Carry out relevant enhancing immunity function and anti-fatigue effect experiment with Herba Dendrobii capsule of the present invention.
One. the enhancing immunity function:
1. sample character: sample is the yellowish-brown powder.
2. animal origin: ICR kind white mice, body weight 18～22 grams, female, the cleaning level animal that provides by Chinese Academy of Sciences's Shanghai Experimental Animal Center.
3. dosage design: this sample human body recommended dose is 2.4g/60kg every day, and basic, normal, high three dosage groups are set up in this experiment, is respectively 0.2,0.4,1.2g/kg, is equivalent to 5,10,30 times of human body recommended amounts respectively, and matched group is irritated stomach with distilled water.
4. experimental technique and result:
Body weight: animal is weighed, and by the body weight random stratified, is divided into 16 groups, and 10 every group, per 4 groups is an experimental group.Design was according to dosage fed 30 days continuously, weighed once respectively in experiment mid-term and experiment end.
Table 1 sample is to the influence of the weight of animals
The final weight gain of the initial body weight body weight in mid-term of group number of animals (only)
Contrast 40 19 ± 1.1 27 ± 0.7 34 ± 1.1 15 ± 0.6
0.2g/kg 40 20±1.1 27±0.6 34±1.0 14±0.2
0.4g/kg 40 20±1.1 27±0.6 35±1.1 15±0.5
1.2g/kg 40 19±1.1 27±0.7 34±1.1 15±0.6
By table 1 as seen, each dosage group of sample is compared with matched group, does not all have significant difference.
5. serum hemolysin experiment: animal gives sample after 30 days continuously, and after 5 days, eye socket is taken a blood sample with the 2%SRBC immune animal, and separation of serum is put to death in the cervical vertebra dislocation.Add the 25ul normal saline on 96 hole Microhemagglutination plates, add 25ul serum first row respectively again, each row opposes and doubly dilutes later on, and every hole adds 1%SRBCI drips, and vibrates back 37 ℃ to place observed result after sinking appears in the blood cell contrast 3 hours.
Table 2
Group number of animals (only) time (my god) the antibody product
Contrast 10 30 69.4 ± 28.2
0.2g/kg 10 30 70.5±18.8
0.4g/kg 10 30 106.8±22.3
1.2g/kg 10 30 140.6±23.1
By table 2 as seen, sample 0.4g/kg, 1.2g/kg dosage group are compared with matched group, and significant difference is all arranged.
6.NK cytoactive is measured: animal gives sample after 30 days continuously, and the cervical vertebra dislocation is put to death, and gets spleen, makes splenocyte suspension (effector lymphocyte), gets the back 24h YAC-1 cell that goes down to posterity and adds 1640 complete culture solutions, and adjusting cell concentration is 1 * 10
5Individual/ml (target cell) gets each 100ul of target cell and effector lymphocyte and imitates target than 50: 1, adds U type 96 each 100ul of hole culture fluid, and maximum release aperture adds target cell and each 100ul of 1%NP40, and above-mentioned every three multiple holes of all establishing are in 37 ℃, 5%CO
2Cultivation is 4 hours in the incubator, in 96 well culture plates, adds HDH substrate industry 100ul simultaneously at the bottom of every hole absorption supernatant 100ul horizontalization, reacts 3 minutes, and every hole adds 1mol/L ground HCL30ul and stops, and uses microplate reader in 490mm place mensuration optical density value (OD).
Table 3
Group number of animals (only) time (my god) the NK cytoactive
Contrast 10 30 30.46 ± 2.84
0.2g/kg 10 30 31.55±4.36
0.4g/kg 10 30 35.67±2.88
1.2g/kg 10 30 50.04±6.17
By table 3 as seen, sample 0.4g/kg, 1.2g/kg dosage group are compared with matched group, and significant difference is all arranged.
7. animal gives sample after 30 days continuously, every Mus lumbar injection 20% chicken erythrocyte suspension 1ml, 30 minutes at interval, the cervical vertebra dislocation is put to death, and is fixed on the Mus plate, cuts off abdominal skin, injecting normal saline 2ml, rotated the Mus plate 1 minute, sucking-off abdominal cavity washing liquid 1ml divides and drips on 2 wave plates, 37 ℃ of wet incubating 30 minutes of incubator, use the normal saline rinsing, dry, fix with 1: 1 acetone methanol solution, 4%Giemsa-phosphate buffer dyeing 3 minutes, the rinsing of reuse distilled water is dried, and with oily mirror microscopy, calculates and engulfs % and phagocytic index.
Table 4
Group number of animals (only) is engulfed the % phagocytic index
Contrast 10 11 ± 1.5 0.16 ± 0.02
0.2g/kg 10 11±1.2 0.16±0.02
0.4g/kg 10 16±1.5 0.25±0.03
1.2g/kg 10 17±2.2 0.30±0.04
By table 4 as seen, sample 0.4g/kg, 1.2g/kg dosage group are engulfed % and are compared with matched group, and significant difference is all arranged.
8. sum up: per os gave mice various dose Herba Dendrobii capsule sample after 30 days, had the enhancing immunity function.
Two. anti-fatigue effect:
1. sample character: sample is the yellowish-brown powder.
2. animal origin: Kunming kind white mice, body weight 18～22 grams, female, the cleaning level animal that provides by Chinese Academy of Sciences's Shanghai Experimental Animal Center.
3. dosage design: this sample human body recommended dose is 2.4g/60kg every day, and basic, normal, high three dosage groups are set up in this experiment, is respectively 0.2,0.4,1.2g/kg, and other establishes distilled water blank group.
3. experimental technique and result:
Body weight: get 150 of Kunming kind white mice, by only weighing, by the body weight random stratified, be divided into 15 groups, 10 every group, per 5 groups is an experimental group.Design was according to dosage fed 30 days continuously, weighed once respectively in experiment mid-term and experiment end.
Table 5 sample is to the influence of the weight of animals
The final body weight of the initial body weight body weight in mid-term of group number of animals (only)
Contrast 30 21 ± 0.9 28 ± 1.7 38 ± 2.1
0.2g/kg 30 21±1.0 28±1.7 38±2.2
0.4g/kg 30 21±0.8 28±1.5 38±2.0
1.2g/kg 30 21±0.9 28±1.5 39±1.8
By table 5 as seen, sample does not have obvious influence to the weight of animals.
4. swimming with a load attached to the body experiment: get above-mentioned design according to dosage and feed each one group of three dosage groups after 30 days and each control animals continuously, after last is irritated stomach 30 minutes, mice is put into water swim, depth of water 30cm, 25 ± 0.5 ℃ of water temperatures, the load sheet lead of 5% body weight of Mus root of the tail portion writes down little
5. Mus is from the extremely dead time of swimming beginning.
Table 6 sample is to the influence of mice swimming with a load attached to the body time
Group number of animals (only) swimming with a load attached to the body time (second)
Contrast 10 692 ± 160
0.2g/kg 10 711±168
0.4g/kg 10 760±190
1.2g/kg 10 962±315
By table 6 as seen, sample 1.2g/kg dosage group is compared with matched group, and significant difference is arranged.
6. plain nitrogen determination: three dosage groups and each control animals after 30 days are fed continuously in above-mentioned design according to dosage, after last is irritated stomach 30 minutes, mice is put into 30 ℃ of water swimming 90 minutes, take out, hot-air seasoning makes peace and quiet, and is centrifugal, gets serum and surveys blood urea nitrogen.
Table 7 sample to mouse movement after the influence of serum urea nitrogen
Group number of animals (only) blood urea nitrogen (mmol/l)
Contrast 10 9.45 ± 0.35
0.2g/kg 10 8.74±0.31
0.4g/kg 10 8.70±0.50
1.2g/kg 10 7.38±0.45
By table 7 as seen, sample 0.2g/kg, 0.4g/kg, 1.2g/kg dosage group are compared with matched group, and significant difference is all arranged.
7. hepatic glycogen is measured: get 40 of white mice, be divided into 5 groups at random, 10 every group, according to dosage establish
8. meter was fed 30 days continuously, and after last is irritated stomach 30 minutes, mice is put into 30 ℃ of water swimming 90 minutes, take out, it is dirty to get Hepar Mus at once, surveys hepatic glycogen.
Table 8 sample to mouse movement after the influence of hepatic glycogen
Group number of animals (only) hepatic glycogen (mg/100g)
Contrast 10 500 ± 37
0.2g/kg 10 511±26
0.4g/kg 10 550±24
1.2g/kg 10 552±19
By table 8 as seen, sample 0.4g/kg, 1.2g/kg dosage group are compared with matched group, and significant difference is all arranged.
Sum up: per os gave mice various dose Herba Dendrobii capsule sample after 30 days, had anti-fatigue effect.
The specific embodiment
Describe specific embodiments of the invention below in detail.
Get Herba Dendrobii 5000 grams, clean, oven dry is put ultrafine crusher with it and is ground into the Herba Dendrobii fine powder, and powder is all by 120 mesh sieves, and is standby.Get Herb Gynostemmae Pentaphylli 30000 grams, be cut into segment after cleaning, drop in the multi-function extractor, add the water of 10 times of amounts, soaked 0.5 hour, be heated to and boil, extracted 1.5 hours, filter time extracting solution of winning.Residue adds 8 times of water gagings again, is heated to and boils, and extracts 1 hour, filter extracting solution for the second time.Merge extracted twice liquid, extraction ratio is 13～23%.The relative density that extracting solution after merging is evaporated to concentrated solution is 1.10～1.15, and promptly the density of concentrated solution is 1.10～1.15g/ml.Thickening temperature is less than 70 ℃.Concentrated solution is carried out spray drying, get 3900～6900 gram extract powders, wherein the shower nozzle rotating speed is 18000 rev/mins, and inlet temperature is 195 ℃, and leaving air temp is 90 ℃, the moisture of gained extract powder≤3.5%.Herba Dendrobii fine powder and gynostemma pentaphyllum extract powder are put in the mixer, fully mix homogeneously.Carrying out capsule by 0.3g/ grain loading amount fills.Every capsules contains 0.126～0.168 gram Herba Dendrobii and 0.132～0.174 gram gynostemma pentaphyllum extract powder, be that to contain percentage by weight in every capsules be 42%～56% Herba Dendrobii and 44～58% gynostemma pentaphyllum extract powder, its effective ingredient is: crude polysaccharides 36～50mg, Herb Gynostemmae Pentaphylli total glycosides 1～2mg.
Herba Dendrobii capsule oral of the present invention, each 4, every day 2 times.
The foregoing description is used for the present invention that explains, rather than limits the invention, and in the protection domain of spirit of the present invention and claim, any modification and change to the present invention makes all fall into protection scope of the present invention.
Claims (10)
1. a Herba Dendrobii capsule is characterized in that, this capsule is that 42%～56% Herba Dendrobii and 44～58% gynostemma pentaphyllum extract powder are formed by percentage by weight substantially.
2. Herba Dendrobii capsule according to claim 1 is characterized in that, the percentage by weight that described capsular best proportioning is Herba Dendrobii and gynostemma pentaphyllum extract powder is 50%.
3. Herba Dendrobii capsule according to claim 1 is characterized in that, described capsular effective ingredient is crude polysaccharides and Herb Gynostemmae Pentaphylli total glycosides; Every heavy 0.3g of described capsule contains crude polysaccharides 36～50mg, Herb Gynostemmae Pentaphylli total glycosides 1～2mg.
4. Herba Dendrobii capsule according to claim 1 is characterized in that, described Herba Dendrobii extremely passes through 120 mesh sieves through superfine grinding.
5. Herba Dendrobii capsule according to claim 1 is characterized in that, described Herba Dendrobii capsule has enhancing immunity, antifatigue function.
6. the capsular preparation method of the described Herba Dendrobii of claim 1 is characterized in that, comprising:
(1) Herba Dendrobii is cleaned, and is ground into the Herba Dendrobii fine powder after the oven dry;
(2) get Herb Gynostemmae Pentaphylli, be cut into segment after cleaning, soak, be heated to and boil, extract, filter time extracting solution of winning;
(3) residue adds water, is heated to boil, and extracts, filter extracting solution for the second time;
(4) merge extracted twice liquid, the extracting solution after merging is carried out concentrating under reduced pressure;
(5) concentrated solution is carried out spray drying, get extract powder;
(6) with Herba Dendrobii fine powder and the abundant mix homogeneously of gynostemma pentaphyllum extract powder;
(7) filled capsules.
7. preparation method according to claim 6 is characterized in that, in the described step (1), the Herba Dendrobii fine powder is all by 120 mesh sieves.
8. preparation method according to claim 6 is characterized in that, in the described step (2), adds the water of 10 times of amounts, soaks 0.5 hour, is heated to and boils, and extracts 1.5 hours, filters time extracting solution of winning; In the described step (3), residue adds 8 times of water gagings, is heated to and boils, and extracts 1 hour, filter extracting solution for the second time.
9. preparation method according to claim 6 is characterized in that, in the described step (4), the relative density that is evaporated to concentrated solution is 1.10～1.15, and thickening temperature is less than 70 ℃.
10. preparation method according to claim 6 is characterized in that, spray-dired shower nozzle rotating speed is 18000 rev/mins in the described step (5), and inlet temperature is 195 ℃, and leaving air temp is 90 ℃.
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| CNB2004100528502A CN1311855C (en) | 2004-07-12 | 2004-07-12 | Officinal Dendrobium stem capsule and preparing method |
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| CN101695328B (en) * | 2009-10-27 | 2012-11-14 | 白汉玉 | Dendrobium tea |
| CN102987022A (en) * | 2012-12-03 | 2013-03-27 | 湖北民族学院 | Method for processing dendrobium candidum gynostemma pentaphyllum zhulan scented tea |
| CN104522674A (en) * | 2015-01-29 | 2015-04-22 | 广西浙商投资有限公司 | Method for preparing dendrobium officinale-musa balbisiana capsules |
| CN105012707A (en) * | 2015-06-12 | 2015-11-04 | 浙江仙人草保健品有限公司 | Dendrobium officinale capsules and preparation method thereof |
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