CN1283269C - Compound preparation of forest frog, and preparation method - Google Patents
Compound preparation of forest frog, and preparation method Download PDFInfo
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- CN1283269C CN1283269C CNB2004100416723A CN200410041672A CN1283269C CN 1283269 C CN1283269 C CN 1283269C CN B2004100416723 A CNB2004100416723 A CN B2004100416723A CN 200410041672 A CN200410041672 A CN 200410041672A CN 1283269 C CN1283269 C CN 1283269C
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- oviductus ranae
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Abstract
The present invention relates to a compound forest frog preparation of and a preparation method thereof. The basic formula of the present invention comprises the following raw materials of forest frog's oviduct miropowder, polypeptide miropowder of forest frog's meat, epimedium extract, ginkgo biloba extract and aweto mycelium; raw materials of soybean peptide collagen polypeptide, xanthophyll, powdered milk, etc. are added on the basis of the basic formula; the preparation method of the compound forest frog preparation comprises that after the forest frog's meat is enzymolyzed, dried by zymolyte and finely pulverized to obtain the polypeptide miropowder of the forest frog's meat and the forest frog's oviduct miropowder, the polypeptide miropowder of the forest frog's meat and the forest frog's oviduct miropowder are proportionally mixed and manufactured into capsules or tablets or powder. The present invention has the advantage that the formula is matched with the epimedium with warm nature, the aweto mycelium and the ginkgo biloba extract with neutral nature according to the cold tending nature of the forest frog's oviduct to make the compound forest frog preparation balance between yin and yang, nourish blood and promote blood circulation; the compound forest frog preparation has the health care functions of fatigue resistance, immunological regulation, etc. The biotechnology of enzymes is used for making the forest frog's oviduct and the forest frog's meat enzymolyzed into the polypeptide with small molecules; a fine pulverization technique is used for finely pulverizing the polypeptide with the small molecules to make the compound forest frog preparation easily absorbed and used by organisms, so the pharmacodynamic action is exerted.
Description
Technical field
The present invention relates to a kind of health product, especially a kind of compound recipe clam scholar toad preparation that contains Oviductus Ranae micropowder, Oviductus Ranae polypeptide micropowder and preparation method thereof.
Background technology
One of important famous and precious tonic Chinese medicine that Oviductus Ranae records at Chinese Pharmacopoeia has the kidney invigorating and essence nourishing, the effect of nourishing YIN and moistening the lung.Past people had further investigation for the applied research of Oviductus Ranae, put down in writing according to Chinese patent literature: on April 19th, 1994 applied for to State Patent Office that name was called the application for a patent for invention of " China's snow is breathed out smart (getting Oviductus Ranae alive (Rana temporaria chensinensis David) and ovum) preparation " by high civilian material, application number is 94103512.3, and publication number is CN1117352A; Zhang Hongchao applies for that to State Patent Office name is called the application for a patent for invention of " a kind of forest frog's egg fat nourishing healthy capsule and method for making thereof with effect for reducing blood fat " on February calendar year 2001 27, and application number is 01106212.6, and publication number is CN1370544A; Liu Li applied for to State Patent Office that name was called the application for a patent for invention of " a kind of defying age, foster preserve moisture health food and the compound method thereof held " on May 27th, 2002, and application number is 02117964.6, and publication number is CN1461604A; Center Hospital's December in 2002 31 days has applied for that to State Patent Office name is called the application for a patent for invention of " forest frog ovum oil soft capsule and production method thereof ", and application number is 02158888.0, and publication number is CN1432368A etc.But the foregoing invention technology generally all only relates to Oviductus Ranae, and adopts common process to make, and in this series products, Oviductus Ranae protein might cause losing of effective ingredient in the degraded of digestive tract endogenous cause of ill, and the degree of utilizing of Oviductus Ranae is affected.
Contain high protein in the Oviductus Ranae meat, among the people to cook, the research and development report of Related product is comparatively rare.
Summary of the invention
The objective of the invention is to: by to Oviductus Ranae meat enzymolysis, and carry out micronizing, provide a kind of compound recipe clam scholar toad preparation its preparation method that contains Oviductus Ranae micropowder, Oviductus Ranae polypeptide micropowder to people.
The object of the present invention is achieved like this: a kind of compound recipe clam scholar toad preparation, it is characterized in that it comprises that following raw materials according prepares by weight: Oviductus Ranae micropowder 1-16 part, Oviductus Ranae polypeptide micropowder 1-60 part, Herba Epimedii extract 0.5-12 part, Folium Ginkgo extract 0.5-6 part, Cordyceps mycelium 5-80 part.
Its preparation method is: Oviductus Ranae meat enzymolysis: broken the soaking of dry product Oviductus Ranae meat powder carried out homogenate after rubbing in 24 hours, add protease and stir, enzymolysis was carried out in 37 ℃ of insulations in 12 hours; Zymolyte drying: zymolyte is carried out behind the concentrating under reduced pressure spray drying or vacuum drying again; Micronizing: dry thing is carried out the low-temperature airflow micronizing, obtain the Oviductus Ranae polypeptide micropowder, Oviductus Ranae is carried out the low-temperature airflow micronizing, obtain the Oviductus Ranae micropowder; Proportioning is mixed: get Oviductus Ranae micropowder 1-16 part, Oviductus Ranae polypeptide micropowder 1-60 part, Herba Epimedii extract 0.5-12 part, Folium Ginkgo extract 0.5-6 part, Cordyceps mycelium 5-80 part uniform mixing; Granulate and dry: the dried cream powder of mix homogeneously is granulated according to a conventional method, and 60 ℃ of dryings 2 hours; Fill capsule: the granule filling for preparing is formed capsule.
The raw material that also comprises following weight portion in the compound recipe clam scholar toad preparation: soyabean polypeptide powder 20-60 part, collagen protein polypeptide 3-6 part, 10 parts of hydroxyl isomaltuloses, phylloxanthin 3-10 part, dextrin 9-39 part.
Its preparation method is: after Oviductus Ranae meat enzymolysis, zymolyte drying, micronizing obtain Oviductus Ranae polypeptide micropowder and Oviductus Ranae micropowder, mix by following proportioning: get Oviductus Ranae micropowder 1-16 part, Oviductus Ranae polypeptide micropowder 1-60 part, Herba Epimedii extract 0.5-12 part, Folium Ginkgo extract 0.5-6 part, Cordyceps mycelium 5-80 part, soyabean polypeptide powder 20-30 part, collagen protein polypeptide 3-6 part, 10 parts of hydroxyl isomaltuloses, phylloxanthin 3-10 part, dextrin 9-39 part uniform mixing; The dry powder of mix homogeneously is granulated according to a conventional method 60 ℃ of dryings 2 hours; The granule of making is pressed into chewable tablet.
The raw material that also comprises following weight portion in the compound recipe clam scholar toad preparation: 6 parts of collagen protein polypeptide, milk powder 50-60 part.
Its preparation method is: after Oviductus Ranae meat enzymolysis, zymolyte drying, micronizing obtain Oviductus Ranae polypeptide micropowder and Oviductus Ranae micropowder, mix by proportioning: get Oviductus Ranae micropowder 1-16 part, Oviductus Ranae polypeptide micropowder 1-60 part, Herba Epimedii extract 0.5-12 part, Folium Ginkgo extract 0.5-6 part, Cordyceps mycelium 5-80 part, 6 parts of collagen protein polypeptide, milk powder 50-60 part and be uniformly mixed to form.
Oviductus Ranae has the kidney invigorating and essence nourishing, nourishing lung-YIN, strengthening by means of tonics, and resisting fatigue, anti-stress effect can improve some symptom of suffering from a deficiency of the kidney, and improves hypoxia-bearing capability, can promote the synthetic of protein, particularly immunoglobulin, enhance immunity ability and resistance against diseases.
Cordyceps is as the good merchantable brand of nourishing and fit keeping function, and supplementary Amplifications of the Compendium of Materia Medica carries it " controls empty old damage that disappear, suitable old man ".Record in " Bencao Congxin ", its sweet in the mouth, warm in nature, return lung, kidney channel, have the effect of invigorating the lung and the kidney.And the Cordyceps mycelium of artificial fermentation, composition is similar to natural cordyceps.Modern study report, Cordyceps mycelium have the phagocytic activity that improves macrophage, the cytophagous ability of cleaning up, promote lymphocyte transformation, improve serum hemolysin and cell immunity of spleen hemolytic activity, have the effect of very strong enhancing human body immunity.Have antioxidation simultaneously, can suppress the pyrogallol autoxidation and produce super oxide anion system, significantly reduce the content of cardiac muscle and liver homogenate lipid peroxide.
Herba Epimedii acrid in the mouth, sweet, warm in nature.Return liver, kidney channel, have the effect of kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Herba Epimedii can strengthen collective's non-specific immunity and cellular immune function, regulates humoral immune function, and effective ingredient is mainly icariin and epimedium brevicornum polysaccharide (3).In addition, can also strengthen specific immune function and can significantly promote lymphocyte transformation, strengthen cellular immune function, improve hypoxia-bearing capability, have the obvious anti-fatigue effect.
Folium Ginkgo extract has significant antiplatelet aggregation, antioxidation, is widely used in the health care and the treatment of cardiovascular and cerebrovascular diseases such as coronary heart disease, cerebral thrombosis, alzheimer disease.
The invention has the advantages that: the property of medicine that prescription is cold partially according to Oviductus Ranae, being aided with the flat Folium Ginkgo extract of Herba Epimedii warm in nature, Cordyceps mycelium and property is basic prescription, make we embody the characteristics of YIN and YANG in a relative equilibrium, nourshing blood and promoting blood circulation, have health cares such as resisting fatigue, immunomodulating.On technology, at first adopt biotechnology of enzymes that Oviductus Ranae and Oviductus Ranae meat are carried out enzymolysis and become micromolecule polypeptide, secondly formula material is carried out micronizing, it is easilier absorbed by body with superfine communication technique, and the performance effect.On the basis of basic recipe, add raw materials such as soybean polypeptide, collagen protein polypeptide, phylloxanthin, milk powder, utilize the conventional formulation Technology to be prepared into capsule or dosage forms such as tablet, powder.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment 1
Compound recipe clam scholar toad capsule (snow is breathed out aweto capsule) and preparation method thereof.
Compound recipe clam scholar toad capsule adopts following raw materials according to prepare by weight:
13 parts of Oviductus Ranae micropowders
55 parts of Oviductus Ranae polypeptide micropowders
10 parts of Herba Epimedii extracts
4 parts of Folium Ginkgo extract
68 parts of Cordyceps myceliums.
Preparation method is:
A) Oviductus Ranae meat enzymolysis: broken the soaking of dry product Oviductus Ranae meat powder carried out homogenate after rubbing in 24 hours, add protease and stir, enzymolysis was carried out in 37 ℃ of insulations in 12 hours;
B) zymolyte drying: zymolyte is carried out behind the concentrating under reduced pressure spray drying or vacuum drying again;
C) micronizing: dry thing is carried out the low-temperature airflow micronizing, obtain the Oviductus Ranae polypeptide micropowder, Oviductus Ranae is carried out the low-temperature airflow micronizing, obtain the Oviductus Ranae micropowder;
D) proportioning is mixed: take by weighing 13 parts of Oviductus Ranae micropowders, 55 parts of Oviductus Ranae polypeptide micropowders, 10 parts of Herba Epimedii extracts, 4 parts of Folium Ginkgo extract, 68 parts of uniform mixing of Cordyceps mycelium;
E) granulate and dry: the dried cream powder of mix homogeneously is granulated according to a conventional method, and 60 ℃ of dryings 2 hours;
F) fill capsule: the granule filling for preparing is formed capsule.
Be an embodiment more than, in the specific implementation, each raw material can be selected in following scope:
Oviductus Ranae micropowder 1-16 part
Oviductus Ranae polypeptide micropowder 1-60 part
Herba Epimedii extract 0.5-12 part
Folium Ginkgo extract 0.5-6 part
Cordyceps mycelium 5-80 part.
Embodiment 2
Compound recipe clam scholar toad tablet (snow is breathed out chewable tablet) and preparation method thereof.
Compound recipe clam scholar toad tablet adopts following raw materials according to prepare by weight:
1 part of Oviductus Ranae micropowder
20 parts of Oviductus Ranae polypeptide micropowders
0.5 part of Herba Epimedii extract
0.5 part of Folium Ginkgo extract
5 parts of Cordyceps myceliums
25 parts of soyabean polypeptide powders
3 parts of collagen protein polypeptide
10 parts of hydroxyl isomaltuloses
5 parts of phylloxanthins
30 parts in dextrin.
Preparation method is:
A) Oviductus Ranae meat enzymolysis: broken the soaking of dry product Oviductus Ranae meat powder carried out homogenate after rubbing in 24 hours, add protease and stir, enzymolysis was carried out in 37 ℃ of insulations in 12 hours;
B) zymolyte drying: zymolyte is carried out behind the concentrating under reduced pressure spray drying or vacuum drying again;
C) micronizing: dry thing is carried out the low-temperature airflow micronizing, obtain the Oviductus Ranae polypeptide micropowder, Oviductus Ranae is carried out the low-temperature airflow micronizing, obtain the Oviductus Ranae micropowder;
D) proportioning is mixed: get 1 part of Oviductus Ranae micropowder, 20 parts of Oviductus Ranae polypeptide micropowders, 0.5 part of Herba Epimedii extract, 0.5 part of Folium Ginkgo extract, 5 parts of Cordyceps myceliums, 25 parts of soyabean polypeptide powders, 3 parts of collagen protein polypeptide, 10 parts of hydroxyl isomaltuloses, 5 parts of phylloxanthins, 30 parts of uniform mixing of dextrin;
E) granulate and dry: the dry powder of mix homogeneously is granulated according to a conventional method 60 ℃ of dryings 2 hours;
F) tabletting: the granule of making is pressed into chewable tablet.
Be an embodiment more than, in the specific implementation, each raw material can be selected in following scope:
Oviductus Ranae micropowder 1-16 part
Oviductus Ranae polypeptide micropowder 1-60 part
Herba Epimedii extract 0.5-12 part
Folium Ginkgo extract 0.5-6 part
Cordyceps mycelium 5-80 part
Soyabean polypeptide powder 20-60 part
Collagen protein polypeptide 3-6 part
10 parts of hydroxyl isomaltuloses
Phylloxanthin 3-10 part
Dextrin 9-39 part.
Embodiment 3
Compound recipe clam scholar toad powder (snow is breathed out egg albumen powder) and preparation method thereof.
Compound recipe clam scholar toad powder adopts following raw materials according to prepare by weight:
3 parts of Oviductus Ranae micropowders
46 parts of Oviductus Ranae polypeptide micropowders
0.5 part of Herba Epimedii extract
0.5 part of Folium Ginkgo extract
40 parts of Cordyceps myceliums
6 parts of collagen protein polypeptide
60 parts of milk powder.
Preparation method is:
A) Oviductus Ranae meat enzymolysis: broken the soaking of dry product Oviductus Ranae meat powder carried out homogenate after rubbing in 24 hours, add protease and stir, enzymolysis was carried out in 37 ℃ of insulations in 12 hours;
B) zymolyte drying: zymolyte is carried out behind the concentrating under reduced pressure spray drying or vacuum drying again;
C) micronizing: dry thing is carried out the low-temperature airflow micronizing, obtain the Oviductus Ranae polypeptide micropowder, Oviductus Ranae is carried out the low-temperature airflow micronizing, obtain the Oviductus Ranae micropowder;
D) proportioning is mixed: get 3 parts of Oviductus Ranae micropowders, 46 parts of Oviductus Ranae polypeptide micropowders, 0.5 part of Herba Epimedii extract, 0.5 part of Folium Ginkgo extract, 40 parts of Cordyceps myceliums, 6 parts of collagen protein polypeptide, milk powder and be uniformly mixed to form for 60 parts.
Be an embodiment more than, in the specific implementation, each raw material can be selected in following scope:
Oviductus Ranae micropowder 1-16 part
Oviductus Ranae polypeptide micropowder 1-60 part
Herba Epimedii extract 0.5-12 part
Folium Ginkgo extract 0.5-6 part
Cordyceps mycelium 5-80 part
6 parts of collagen protein polypeptide
Milk powder 50-60 part.
Claims (6)
1, a kind of compound recipe clam scholar toad preparation is characterized in that, it comprises that following raw materials according prepares by weight:
Oviductus Ranae micropowder 1-16 part
Oviductus Ranae polypeptide micropowder 1-60 part
Herba Epimedii extract 0.5-12 part
Folium Ginkgo extract 0.5-6 part
Cordyceps mycelium 5-80 part.
2, the preparation method of compound recipe clam scholar toad preparation according to claim 1 is characterized in that:
A) Oviductus Ranae meat enzymolysis: broken the soaking of dry product Oviductus Ranae meat powder carried out homogenate after rubbing in 24 hours, add protease and stir, enzymolysis was carried out in 37 ℃ of insulations in 12 hours;
B) zymolyte drying: zymolyte is carried out behind the concentrating under reduced pressure spray drying or vacuum drying again;
C) micronizing: dry thing is carried out the low-temperature airflow micronizing, obtain the Oviductus Ranae polypeptide micropowder, Oviductus Ranae is carried out the low-temperature airflow micronizing, obtain the Oviductus Ranae micropowder;
D) proportioning is mixed: get Oviductus Ranae micropowder 1-16 part, Oviductus Ranae polypeptide micropowder 1-60 part, Herba Epimedii extract 0.5-12 part, Folium Ginkgo extract 0.5-6 part, Cordyceps mycelium 5-80 part uniform mixing;
E) granulate and dry: the dried cream powder of mix homogeneously is granulated according to a conventional method, and 60 ℃ of dryings 2 hours;
F) fill capsule: the granule filling for preparing is become capsule.
3, compound recipe clam scholar toad preparation according to claim 1 is characterized in that, also comprises the raw material of following weight portion:
Soyabean polypeptide powder 20-60 part
Collagen protein polypeptide 3-6 part
10 parts of hydroxyl isomaltuloses
Phylloxanthin 3-10 part
Dextrin 9-39 part.
4, the preparation method of compound recipe clam scholar toad preparation according to claim 3 is characterized in that:
A) Oviductus Ranae meat enzymolysis: broken the soaking of dry product Oviductus Ranae meat powder carried out homogenate after rubbing in 24 hours, add protease and stir, enzymolysis was carried out in 37 ℃ of insulations in 12 hours;
B) zymolyte drying: zymolyte is carried out behind the concentrating under reduced pressure spray drying or vacuum drying again;
C) micronizing: dry thing is carried out the low-temperature airflow micronizing, obtain the Oviductus Ranae polypeptide micropowder, Oviductus Ranae is carried out the low-temperature airflow micronizing, obtain the Oviductus Ranae micropowder;
D) proportioning is mixed: get Oviductus Ranae micropowder 1-16 part, Oviductus Ranae polypeptide micropowder 1-60 part, Herba Epimedii extract 0.5-12 part, Folium Ginkgo extract 0.5-6 part, Cordyceps mycelium 5-80 part, soyabean polypeptide powder 20-60 part, collagen protein polypeptide 3-6 part, 10 parts of hydroxyl isomaltuloses, phylloxanthin 3-10 part, dextrin 9-39 part uniform mixing;
E) granulate and dry: the dry powder of mix homogeneously is granulated according to a conventional method 60 ℃ of dryings 2 hours;
F) tabletting: the granule of making is pressed into chewable tablet.
5, compound recipe Oviductus Ranae preparation according to claim 1 is characterized in that, also comprises the raw material of following weight portion:
6 parts of collagen protein polypeptide
Milk powder 50-60 part.
6, the preparation method of compound recipe clam scholar toad preparation according to claim 5 is characterized in that:
A) Oviductus Ranae meat enzymolysis: broken the soaking of dry product Oviductus Ranae meat powder carried out homogenate after rubbing in 24 hours, add protease and stir, enzymolysis was carried out in 37 ℃ of insulations in 12 hours;
B) zymolyte drying: zymolyte is carried out behind the concentrating under reduced pressure spray drying or vacuum drying again;
C) micronizing: dry thing is carried out the low-temperature airflow micronizing, obtain the Oviductus Ranae polypeptide micropowder, Oviductus Ranae is carried out the low-temperature airflow micronizing, obtain the Oviductus Ranae micropowder;
D) proportioning is mixed: get Oviductus Ranae micropowder 1-16 part, Oviductus Ranae polypeptide micropowder 1-60 part, Herba Epimedii extract 0.5-12 part, Folium Ginkgo extract 0.5-6 part, Cordyceps mycelium 5-80 part, 6 parts of collagen protein polypeptide, milk powder 50-60 part and be uniformly mixed to form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100416723A CN1283269C (en) | 2004-08-12 | 2004-08-12 | Compound preparation of forest frog, and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100416723A CN1283269C (en) | 2004-08-12 | 2004-08-12 | Compound preparation of forest frog, and preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1626235A CN1626235A (en) | 2005-06-15 |
| CN1283269C true CN1283269C (en) | 2006-11-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CNB2004100416723A Expired - Fee Related CN1283269C (en) | 2004-08-12 | 2004-08-12 | Compound preparation of forest frog, and preparation method |
Country Status (1)
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| CN (1) | CN1283269C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102860498A (en) * | 2011-07-04 | 2013-01-09 | 吉林博大农林生物科技有限公司 | Method for processing Chinese forest frog radiation resistant oral liquid |
| CN102885296B (en) * | 2011-07-21 | 2013-12-25 | 成都永康制药有限公司 | Formula of dietary supplement for female health care |
| CN103271334A (en) * | 2013-06-06 | 2013-09-04 | 吉林省起泰科技有限公司 | Cordyceps militaris-rana japonica nutrient liquid and preparation method thereof |
| CN103876163A (en) * | 2014-04-01 | 2014-06-25 | 吉林大学 | Rana japonica meat composite protein powder and preparation method thereof |
| CN104522668A (en) * | 2015-01-12 | 2015-04-22 | 康美（北京）药物研究院有限公司 | Chinese forest frog particle and preparing method thereof |
| CN112569264A (en) * | 2020-12-14 | 2021-03-30 | 佛山手心制药有限公司 | Preparation method of Xueha cordyceps sinensis soft capsule |
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2004
- 2004-08-12 CN CNB2004100416723A patent/CN1283269C/en not_active Expired - Fee Related
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| CN1626235A (en) | 2005-06-15 |
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