CN1194742C - Chinese medicinal composition with delaying senility and improving sleep functions, and preparing method thereof - Google Patents
Chinese medicinal composition with delaying senility and improving sleep functions, and preparing method thereof Download PDFInfo
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- CN1194742C CN1194742C CNB021573840A CN02157384A CN1194742C CN 1194742 C CN1194742 C CN 1194742C CN B021573840 A CNB021573840 A CN B021573840A CN 02157384 A CN02157384 A CN 02157384A CN 1194742 C CN1194742 C CN 1194742C
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- pharmaceutical composition
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- concentrated solution
- angelicae sinensis
- ethanol
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Abstract
The present invention discloses a Chinese medicinal composition having the functions of delaying senescence and improving sleep, and a preparing method thereof. The Chinese medicine composition comprises astragalus root, arillus longan, jujube seed and angelica. When the composition is prepared, processes of ethanol extraction, decoction, etc. are carried out to different components so as to give full play of the effective components. The composition has good effects of delaying senescence and improving sleep without toxicity or side effects.
Description
Invention field
The present invention relates to a kind of Chinese medicine composition, particularly a kind of have slow down aging and improve the Chinese medicine composition of sleep function, relates to the preparation method of said composition simultaneously.
Background technology
Along with the raising day by day of living standards of the people, healthyly also come into one's own day by day.People are because work strain, often work and rest is immoderate, irregular diet, in addition the comparatively serious air quality of environmental pollution is poor again, people often are among the atmospheric environment of nervous working environment of fatigue and exhaust emission, cause immunity to descend, shallow complexion, with a haggard face, lassitude, fatigue and asthenia, insomnia and dreamful sleep, appetite is not good enough, poor memory, geromorphism symptom such as weak and sickly.More with the Chinese medicine of drinks form appearance at present, as with Formica fusca Fructus Mori, the Radix Astragali, Cordyceps, etc. the medicine bubble formed of multiple components in wine, drink, these medicated wine are that the master is good as nourishing healthy, but work is remarkable inadequately because of the powerful inadequately effect of the efficacy of a drug, and take medicine by drinking, to some people that can not drink, particularly the people of weather hot area, China south are not suitable for especially.
Task of the present invention provides a kind of medicine that can obviously improve the intravital resistivity of people (immune function of human body), and it is made up of Chinese medicine fully, with drinks coexistence, adapts to widely, and clinical application effect is obvious, can not have side effects after taking.
Summary of the invention
One object of the present invention is to disclose a kind of new Chinese medicine composition that has slow down aging and improve sleep function; Another object of the present invention is a kind of new method that has slow down aging and improve the Chinese medicine composition of sleep function of open preparation.
The raw material of Chinese medicine composition of the present invention is formed and proportioning following (by weight):
Radix Astragali 100-400 weight portion Arillus Longan 100-400 weight portion
Semen Ziziphi Spinosae 100-400 weight portion Radix Angelicae Sinensis 100-400 weight portion
Medicine of the present invention also can add conventional drug excipient, as solvent, disintegrating agent, correctives, antiseptic, coloring agent etc.
This preparation of drug combination method:
Radix Angelicae Sinensis adds 1.5-3 and doubly measures soak with ethanol 10-14 hour of 40-60%, and reuse 8-12 doubly measures the ethanol of 40-60%, carries out percolation, percolate and residue, the percolate decompression recycling ethanol, reconcentration to 70-85 ℃ of following proportion p be 1.20-1.30, concentrated solution a; The residue of the Radix Astragali, Arillus Longan, Semen Ziziphi Spinosae and percolation decocts 1-3 time with 7-9 times of water gaging respectively together, each 1-2.5 hour, merges decoction liquor, filter, filtrate is concentrated in right amount, and is centrifugal, get centrifugal liquid, it is 1.25-1.35 that centrifugal liquid is concentrated into 70-85 ℃ of following proportion p, gets concentrated solution b; Merge concentrated solution a, b, add an amount of corn starch and maltodextrin, mix thoroughly, at 70-85 ℃ of following drying under reduced pressure, at last directly or add pharmaceutically acceptable excipient and make capsule, oral liquid, tablet, granule through conventional operation.
This Chinese medicine composition has qi and blood tonifying, and the characteristics that heart spleen is ruled together are given birth to the prosperous blood of gas, hemapodium and the heart is foster to some extent, and can repose and sleep peacefully, thus reach slow down aging and improve the health care of sleep, and free of toxic effects.
Experimental example
1. materials and methods
1.1 given the test agent:
Present composition preparation, content are brown granular.Provide by Lianyun Harbour Kang Sheng pharmaceutical Co. Ltd.
1.2 experimental animal:
The SD female rats at 20 monthly ages, must be provided by triumphant laboratory animal company limited by west, Shanghai pul one.
The quality certification number: Shanghai is moving closes the card word No. 154.
1.3 main agents and instrument:
SOD, MDA, GSH-Px, lipofuscin try neat box and build up biotechnology research by Nanjing and provided.722 type spectrophotometers (Shanghai the 3rd analytical tool factory), RF-5000 type spectrofluorophotometer (day island proper Tianjin).
1.4 dosage grouping:
According to human body recommended intake (3150mg/ people/sky is equivalent to 52.5mg/kgbw), respectively by three dosage groups of its 5 times, 10 times, 30 times designs promptly 263,525,1575mg/kgbw, and establish matched group, per os is irritated the stomach mode and is given experimental animal.
1.5 test method: undertaken by the delaying senility function method of inspection in the Ministry of Public Health promulgation " the health food function assessment assessment process and the method for inspection ".
1.5.1 grouping reaches to sample:
Select 32 of 20 monthly age SD female rats for use, be divided into four groups at random, 8 every group, gavage respectively the basic, normal, high dosage of this composite preparation (Kang Yuan board YSY capsule) promptly 263,525,1575mg/kgbw (label 1,2,3) and distilled water matched group.Matched group removes not add and is tried beyond the region of objective existence, and all the other are consistent with test group.Per os is tried thing, continuous 30 days.
1.5.2 experimental procedure:
Each treated animal gives this composite preparation (Kang Yuan board YSY capsule) (promptly 263,525,1575rng/kgbw) and the matched group of corresponding dosage every day respectively, after continuous 30 days, gets rat heart blood, measures its SOD, MDA, GSH-Px respectively; Put to death animal then, get liver and carry out homogenate, measure lipofuscin in the liver organization.
1.5.3 raising condition
Animal feeding is in the environment of 20-24 ℃ of room temperature and 50-70% relative temperature.
1.5.4 date processing:
Adopt SPSS10.0 for windows software that data are carried out variance analysis.
2, result of the test
2.1 this composite preparation (Kang Yuan board YSY capsule) is to the influence of rat body weight
As seen table 1 respectively organizes body weight event no significant difference p＞0.05 between rat, so this composite preparation (Kang Yuan board YSY capsule) does not have obvious influence to rat body weight before and after test.
This composite preparation of table 1 (Kang Yuan board YSY capsule) is to the influence of rat body weight
The initial body weight of group body weight in mid-term finishes body weight
Number of animals (only) body weight (g) number of animals (only) body weight (g) number of animals (only) body weight (g)
Matched group 8 338 ± 23 8 352 ± 24 8 363 ± 20
1 8 340±26 8 356±30 8 368±25
2 8 342±23 8 359±25 8 377±34
3 8 341±22 8 354±39 8 367±26
2.2 the mensuration of MDA
By table 2 as seen, high dose group rat blood serum MDA is starkly lower than matched group (P＜0.01).
This composite preparation of table 2 (Kang Yuan board YSY capsule) is to the influence of rat blood serum MDA level
Group dosage (mg/kg) number of animals serum MDA (nmol/ml)
Matched group 08 4.98 ± 0.45
1 263 8 4.90±0.44
2 525 8 4.83±0.57
3 1575 8 4.31±0.43
**
Annotate: " * * " expression is compared P＜0.01 with matched group.
2.3 the liver lipofuscin is measured
As can be seen from Table 3, lipofuscin content and matched group compare in each dosage group rat liver, there was no significant difference (P＞0.05).
This composite preparation of table 3 (Kang Yuan board YSY capsule) is to the influence of liver tissues of rats lipofuscin level
Group dosage (mg/kg) number of animals lipofuscin (μ g/g tissue)
Matched group 08 2.14 ± 0.48
1 263 8 1.91±0.33
2 525 8 1.78±0.47
3 1575 8 1.75±0.48
2.4 superoxide dismutase (SOD) vitality test
As can be seen from Table 4, high, middle dosage group rat blood serum SOD vigor is apparently higher than matched group (P＜0.01).Illustrate that this composite preparation (Kang Yuan board YSY capsule) has the effect of rising rat blood serum SOD vigor.
This composite preparation of table 4 (Kang Yuan board YSY capsule) is to the influence of rat blood serum SOD vigor
Group dosage (mg/kg) number of animals SOD in serum (NU/ml)
Matched group 08 338 ± 36
1 263 8 398±108
2 525 8 441±57
**
3 1575 8 478±46
**
Annotate: " * * " expression is compared P＜0.01 with matched group.
2.5 glutathion peroxidase (GSH-Px) determination of activity
Can be got by table 5, high dose group rat blood serum GSH-Px vigor is apparently higher than matched group (P＜0.01).Illustrate that this composite preparation (Kang Yuan board YSY capsule) has the effect of rising rat blood serum GSH-Px vigor.
This composite preparation of table 5 (Kang Yuan board YSY capsule) is to the influence of rat blood serum GSH-Px vigor
Group dosage (mg/kg) number of animals GSH-Px (unit of activity)
Matched group 08 272 ± 39
1 263 8 295±35
2 525 8 303±23
3 1575 8 316±16
**
Annotate: " * * " expression is compared P＜0.01 with the contrast knob.
3. conclusion
Estimated this composite preparation (Kang Yuan board YSY capsule) to the rat function in delaying senility with lipid peroxide (MDA, lipofuscin) content, antioxidase activity (SOD, GSH-Px).This composite preparation (Kang Yuan board YSY capsule) with 263,525,1575rog/kg gives SD senile rat, irritated stomaches in continuous 30 days after, measure lipofuscin content in rat blood serum SOD, MDA, GSH-Px and the liver organization.The result shows that this composite preparation (Kang Yuan board YSY capsule) can obviously improve rat blood serum SOD and GSH-Px vigor and can reduce the content of rat blood serum MDA.Therefore think that this composite preparation (Kang Yuan board YSY capsule) has antioxidation, and point out it to have delaying senility function.The following example all can be realized the effect of above-mentioned experimental example.
Embodiment 1:
Radix Astragali 355g Arillus Longan 355g Semen Ziziphi Spinosae 177.5g Radix Angelicae Sinensis 177.5g
Radix Angelicae Sinensis adds 2 times of amount soak with ethanol of 50% 12 hours, the ethanol of 10 times of amounts 50% of reuse, with the speed percolation of 3ml/kg.min, percolate and residue, the percolate decompression recycling ethanol, reconcentration to 80 a ℃ following proportion p is 1.25, concentrated solution a; The residue of the Radix Astragali, Arillus Longan, Semen Ziziphi Spinosae and percolation together, decoct 2 times with 8 times of water gagings respectively, each 1.5 hours, merge decoction liquor, filter, filtrate is concentrated in right amount, wherein every milliliter of concentrated solution is equivalent to raw medicinal herbs 2g, and is centrifugal, gets centrifugal liquid, it is 1.30 that centrifugal liquid is concentrated into 80 ℃ of following proportion p, gets concentrated solution b; Merge concentrated solution a, b, add each 15g of an amount of corn starch and maltodextrin, mix thoroughly,, get dry extract at 80 ℃ of following drying under reduced pressure, pulverize, granulate, granulate is made .1000 grain hard capsule, ethylene oxide sterilizing, that is, every hard capsule loading amount 0.35g is equivalent to former compositions 1.09g.Oral, three times on the one, one time 3～4.
Embodiment 2:
Radix Astragali 170g Arillus Longan 170g Semen Ziziphi Spinosae 160.5g Radix Angelicae Sinensis 160.5g
Radix Angelicae Sinensis adds 2 times of amount soak with ethanol of 50% 12 hours, the ethanol of 10 times of amounts 50% of reuse, with the speed percolation of 3ml/kg.min, percolate and residue, the percolate decompression recycling ethanol, reconcentration to 80 a ℃ following proportion p is 1.25, concentrated solution a; The residue of the Radix Astragali, Arillus Longan, Semen Ziziphi Spinosae and percolation together, decoct 2 times with 8 times of water gagings respectively, each 1.5 hours, merge decoction liquor, filter, filtrate is concentrated in right amount, wherein every milliliter of concentrated solution is equivalent to raw medicinal herbs 2g, and is centrifugal, gets centrifugal liquid, it is 1.30 that centrifugal liquid is concentrated into 80 ℃ of following proportion p, gets concentrated solution b; Merge concentrated solution a, b, add each 17g of an amount of corn starch and maltodextrin, mix thoroughly, at 80 ℃ of following drying under reduced pressure, get dry extract, pulverize, granulate, granulate is pressed into 1000, and promptly every heavy 0.35g is equivalent to former compositions 1.09g.Oral, three times on the one, one time 3～4.
Embodiment 3:
Radix Astragali 120g Arillus Longan 120g Semen Ziziphi Spinosae 360.5g Radix Angelicae Sinensis 360.5g
Radix Angelicae Sinensis adds 2 times of amount soak with ethanol of 50% 12 hours, the ethanol of 10 times of amounts 50% of reuse, with the speed percolation of 3ml/kg.min, percolate and residue, the percolate decompression recycling ethanol, reconcentration to 80 a ℃ following proportion p is 1.25, concentrated solution a; The residue of the Radix Astragali, Arillus Longan, Semen Ziziphi Spinosae and percolation together, decoct 2 times with 8 times of water gagings respectively, each 1.5 hours, merge decoction liquor, filter, filtrate is concentrated in right amount, wherein every milliliter of concentrated solution is equivalent to raw medicinal herbs 2g, and is centrifugal, gets centrifugal liquid, it is 1.30 that centrifugal liquid is concentrated into 80 ℃ of following proportion p, gets concentrated solution b; Merge concentrated solution a, b, add each 17g of an amount of corn starch and maltodextrin, mix thoroughly, at 80 ℃ of following drying under reduced pressure, get dry extract, pulverize, granulate, granulate is pressed into 1000, i.e. every heavy 0.35g.Oral, three times on the one, one time 3～4.
Claims (10)
1. one kind has slow down aging and improves the Chinese medicine composition of sleep function, it is characterized in that this pharmaceutical composition made by following raw material medicaments:
Radix Astragali 100-400 weight portion Arillus Longan 100-400 weight portion
Semen Ziziphi Spinosae 100-400 weight portion Radix Angelicae Sinensis 100-400 weight portion.
2, pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition also can add corn starch 10-20 weight portion, maltodextrin 10-20 weight portion.
3. pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition made by following raw material medicaments:
The Radix Astragali 355 weight portion Arillus Longans 355 weight portions
Semen Ziziphi Spinosae 177.5 weight portion Radix Angelicae Sinensis 177.5 weight portions.
4, pharmaceutical composition as claimed in claim 3 is characterized in that this pharmaceutical composition also can add corn starch 15 weight portions, maltodextrin 17 weight portions.
5, pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition made by following raw material medicaments:
The Radix Astragali 170 weight portion Arillus Longans 170 weight portions
Semen Ziziphi Spinosae 160.5 weight portion Radix Angelicae Sinensis 160.5 weight portions.
6, pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition made by following raw material medicaments:
Radix Astragali 120g Arillus Longan 120g Semen Ziziphi Spinosae 360.5g Radix Angelicae Sinensis 360.5g.
7,, it is characterized in that this pharmaceutical composition also can add excipient and make clinical acceptable forms as claim 1,2,3,4,5 or 6 described pharmaceutical compositions.
8, as claim 1,2,3,4,5 or 6 described preparation of drug combination methods, it is characterized in that this method is: Radix Angelicae Sinensis adds 1.5-3 and doubly measures soak with ethanol 10-14 hour of 40-60%, reuse 8-12 doubly measures the ethanol of 40-60%, carry out percolation, get percolate and residue, the percolate decompression recycling ethanol, reconcentration to 70-85 ℃ of following proportion p be 1.20-1.30, concentrated solution a; The residue of the Radix Astragali, Arillus Longan, Semen Ziziphi Spinosae and percolation decocts 1-3 time with 7-9 times of water gaging respectively together, each 1-2.5 hour, merges decoction liquor, filter, filtrate is concentrated in right amount, and is centrifugal, get centrifugal liquid, it is 1.25-1.35 that centrifugal liquid is concentrated into 70-85 ℃ of following proportion p, gets concentrated solution b; Merge concentrated solution a, b, add an amount of corn starch and maltodextrin, mix thoroughly, at 70-85 ℃ of following drying under reduced pressure, at last directly or add pharmaceutically acceptable excipient and make capsule, oral liquid, tablet, granule through conventional operation.
9, preparation of drug combination method as claimed in claim 8, it is characterized in that the method for making hard capsule is: Radix Angelicae Sinensis adds 2 times of amount soak with ethanol of 50% 12 hours, the ethanol of 10 times of amounts 50% of reuse, speed percolation with 3ml/kg.min, get percolate and residue, the percolate decompression recycling ethanol, reconcentration to 80 a ℃ following proportion p is 1.25, gets concentrated solution a; The residue of the Radix Astragali, Arillus Longan, Semen Ziziphi Spinosae and percolation together, decoct 2 times with 8 times of water gagings respectively, each 1.5 hours, merge decoction liquor, filter, filtrate is concentrated in right amount, wherein every milliliter of concentrated solution is equivalent to raw medicinal herbs 2g, and is centrifugal, gets centrifugal liquid, it is 1.30 that centrifugal liquid is concentrated into 80 ℃ of following proportion p, gets concentrated solution b; Merge concentrated solution a, b, add each 15g of an amount of corn starch and maltodextrin, mix thoroughly, at 80 ℃ of following drying under reduced pressure, get dry extract, pulverize, granulate, granulate is made hard capsule.
10, as claim 1,2,3,4,5 or 6 described pharmaceutical compositions preparation have slow down aging and improve sleep function health product in application.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021573840A CN1194742C (en) | 2002-12-23 | 2002-12-23 | Chinese medicinal composition with delaying senility and improving sleep functions, and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021573840A CN1194742C (en) | 2002-12-23 | 2002-12-23 | Chinese medicinal composition with delaying senility and improving sleep functions, and preparing method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1509737A CN1509737A (en) | 2004-07-07 |
| CN1194742C true CN1194742C (en) | 2005-03-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021573840A Expired - Lifetime CN1194742C (en) | 2002-12-23 | 2002-12-23 | Chinese medicinal composition with delaying senility and improving sleep functions, and preparing method thereof |
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| CN (1) | CN1194742C (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393782B (en) * | 2013-07-12 | 2015-11-11 | 中国人民解放军总医院 | There is the Chinese medicine composition of resolving stagnation for tranquilization effect, preparation and preparation method thereof |
| CN103535734B (en) * | 2013-11-05 | 2016-03-30 | 广东生命一号药业有限公司 | Bagged instant preparation of a kind of improving water flood and preparation method thereof |
| CN103536860A (en) * | 2013-11-05 | 2014-01-29 | 广东生命一号药业有限公司 | Health care product capable of improving sleep |
| CN104056052B (en) * | 2014-07-08 | 2015-06-03 | 福建金山生物制药股份有限公司 | Preparation process of powerful anti-aging Chinese patent medicine with anti-aging effect |
| CN105250419A (en) * | 2015-11-11 | 2016-01-20 | 北京市祖国红医疗科技中心（有限合伙） | Foot bath medicine used for moderating physique and preparation method and application thereof |
| CN107334142A (en) * | 2017-06-23 | 2017-11-10 | 天津金匮堂生物科技有限公司 | A kind of deficiency of heart-blood that improves causes health products of insomnia and preparation method thereof |
| CN108721480A (en) * | 2018-07-03 | 2018-11-02 | 晨光生物科技集团邯郸有限公司 | A kind of compound Chinese medicinal preparation for treating a variety of insomnias |
-
2002
- 2002-12-23 CN CNB021573840A patent/CN1194742C/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| CN1509737A (en) | 2004-07-07 |
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