CN1067270C - Nutritious health care medicine - Google Patents
Nutritious health care medicine Download PDFInfo
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- CN1067270C CN1067270C CN98119902A CN98119902A CN1067270C CN 1067270 C CN1067270 C CN 1067270C CN 98119902 A CN98119902 A CN 98119902A CN 98119902 A CN98119902 A CN 98119902A CN 1067270 C CN1067270 C CN 1067270C
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Abstract
The present invention discloses a nourishing health care medicine which comprises the following components: raw coloured malt, mung bean sprout, raw hawthorn fruit, sheep placenta, deer placenta and fructus alpiniae oxyphyllae. The present invention has the functions of invigorating the spleen, tonifying the kidney, nourishing blood, benefiting qi, nourishing lives and delaying senescence.
Description
The present invention is a kind of nutrient and healthcare products, is a kind of strengthening spleen, tonifying kidney that has specifically, and nourishing blood and invigorating qi nourishes life, the Chinese medicine health care product of delaying senility function.
Nutrient and healthcare products are various in style at current medical market, and function is extensive, relate to the various aspects of field of medicaments, are broadly divided in this series products: defying age class health product; Male Yang tonifying class health product; Women's cosmetic slimming class health product; Child nutrition sex-health products or the like.Although wherein be no lack of effective product, the effect of most of products do not resemble propagated mystery so that health care medicine and functional food market are caused confusion, consumer is had no way of doing it when selecting nutrient and healthcare products.It is too much particularly to add pharmaceutical compositions in some health foods, is not suitable for the selection of the consumer of most of demand nourishing healthies, even takes too much and can bring many side effect to consumer.Do not have major disease and only need concerning health nourishes consumer with nutrition, to invent a kind of effect balancing and the respond well health product of nourishing the human Body for general physical condition, promptly satisfied this class crowd's needs.
The object of the invention provides a kind of strengthening spleen, tonifying kidney, nourishing blood and invigorating qi, nourishing life, the nourishing health product of slow down aging.
The composition of raw materials of medicine of the present invention is as follows:
Fructus Hordei Germinatus 10-20 weight portion Fructus Hordei Germinatus (parched) 10-20 weight portion
Semen Phaseoli radiati Germinatus 3-10 weight portion Fructus Crataegi 3-10 weight portion
Placenta caprae seu ovis 0.1-2 weight portion Embryo cervi 0.1-2 weight portion
Fructus Alpiniae Oxyphyllae 1-3 weight portion
The preferred weight proportioning of above-mentioned each component is as follows:
15 parts of 15 parts of Fructus Hordei Germinatus (parched)s of Fructus Hordei Germinatus
4.5 parts of 5 portions of Fructus Crataegis of Semen Phaseoli radiati Germinatus
0.5 part of 0.5 part of Embryo cervi of Placenta caprae seu ovis
1.5 parts of Fructus Alpiniae Oxyphyllae
In the above-mentioned component, Fructus Crataegi is preferably used Fructus Crataegi.
Component with above-mentioned prescription is a raw material, can adopt conventional extraction process to extract its active ingredient, be prepared into conventional dosage form, as tablet, capsule, powder, oral liquid, pill, unguentum etc., join in the middle of the food after also above-mentioned component can being pulverized or extracted, make functional food, also can be encapsulated with pulverizing behind the above-mentioned component convection drying.
Medicine of the present invention is formed preparation rationally, effect balancing, wherein:
Fructus Hordei Germinatus is monarch drug, and nature and flavor are sweet flat, return spleen, stomach, Liver Channel.Have help digestion and in, galactopoiesis, soothing liver and strengthening spleen effect; Placenta Hominis is a ministerial drug, and nature and flavor are sweet, hot, warm, returns lung, liver, kidney channel, the smart kidney yang of the kidney invigorating, nourishing blood and invigorating qi, health invigorating; Fructus Crataegi is a ministerial drug, and the sweet tepor of nature and flavor acid is returned the taste Liver Channel; Semen Phaseoli radiati Germinatus is an adjuvant drug, and stomach, heart channel are returned in the sweet cold of nature and flavor, detoxifcation, dampness removing.Compendium of Material Medica day: " alcoholic intoxication, pyretic toxicity, sharp three warmers "; Fructus Alpiniae Oxyphyllae is a messenger drug, and property and flavor of peppery and warm is returned spleen, kidney channel.
Fructus Hordei Germinatus and Placenta Hominis, a monarch one minister, one for containing the life active substance of sprouting, and one is the in love product of flesh and blood.One tonifying the spleen and stomach nourishes the foundation of acquired constitution, and the smart kidney yang of a kidney invigorating is filled congenital root, plays moist life, slow down aging, the effect of adjusting human body state balance altogether.Fructus Hordei Germinatus and Fructus Crataegi are the good merchantable brand of digestion-promoting spleen-invigorating altogether, have been total to promote the human consumption Absorption.The Fructus Crataegi regulating qi to disperse stagnation, the tonic of both having gone is stagnant, promotes absorbing of Placenta Hominis again.Semen Phaseoli radiati Germinatus assistant Fructus Hordei Germinatus, the special efficacy of enhancing plumule material, two plumules are brought into play the function of bioactive substance effect jointly, play moist life, delaying senility function altogether.Semen Phaseoli radiati Germinatus has the effect of detoxifcation again, can resist noxious substance in the environment.Fructus Alpiniae Oxyphyllae is a messenger drug, its warming and recuperating the spleen and kidney not only, and can carry all medicines and go into to return spleen kidney two warps, strengthened the effect of reinforcing spleen and kidney in the prescription.The number medicine cooperates, and monarch is clear and definite, and effect is outstanding, plays strengthening spleen, tonifying kidney altogether, and nourishing blood and invigorating qi nourishes life, delaying senility function.
The method for making of health product preferred dosage form capsule of the present invention is as follows:
Give birth to Fructus Hordei Germinatus (parched), Semen Phaseoli radiati Germinatus, Fructus Crataegi mixing.Add 75% soak with ethanol and cross powder.Reflux, extract, three times.Each 1.5-2.0 hour.Extracting solution merges, and concentrating under reduced pressure gets extractum (25 ℃ of proportion 1.30-1.40).The extractum vacuum drying.
Placenta caprae seu ovis, Embryo cervi, Fructus Alpiniae Oxyphyllae are ground into fine powder, in proportion with the extract powder mix homogeneously, cross sieve No. 4.During medicated powder incapsulated.
Health product of the present invention are reasonable recipe not only, the effect equilibrium, and have good functions of strengthening stomach and promoting digestion and the effect of regulating immunologic mechanism, be a kind of nourishing health product that most people takes that are suitable for.
Experimental example 1
The evaluation of effect of medicine of the present invention (commodity plumule by name nourishes capsule in this experiment, down together) functions of strengthening stomach and promoting digestion.
1, to the influence of mouse small intestine wriggling
Materials and methods
Experimental animal: KM mice, male and female half and half.Non-inbred line closed colony.Body weight: 25.34 ± 2.23.Available from zooscopy institute of the Chinese Academy of Medical Sciences.Card number: moving word (95) 01-3001 of doctor.
Be subjected to the reagent thing: plumule nourishes capsule.This institute new drug research center provides.Lot number: 980625.0.45g/ grain.
Test method: get mice and be divided into four groups at random.Every group 10.Give the medicine that contains the 0.5g/ml active carbon of various dose respectively.30 fens execution mices after 1 administration.Separate small intestinal, divide survey the small intestinal total length and and charcoal not the forward position to the length of small intestinal terminal.Calculate charcoal off-duty length and charcoal off-duty length percentage rate [=charcoal off-duty length/small intestinal total length %].The administration volume, 0.2ml/10g.
The test grouping:
Grouping drug dose (g/kg)
1 distilled water
2 JIANWEI XIAOSHI PIAN 3.36
3 plumules nourish capsule 0.2
4 plumules nourish capsule 1.2
Positive control drug: JIANWEI XIAOSHI PIAN.Pharmaceutical factory produces in the river.0.8g/ sheet.Lot number: 9712023.Function with cure mainly:
Invigorating the stomach and promoting digestion.Be used for weakness of the spleen and stomach, dyspepsia.
The result
The influence of table 1 plumule nourishing capsule energy mouse small intestine motion (x ± s)
| Grouping | Medicine | Dosage mg | Charcoal off-duty length cm | Charcoal off-duty length percent % |
| 1 2 3 4 | Distilled water JIANWEI XIAOSHI PIAN plumule nourishes the capsule plumule and nourishes capsule | 3.36 0.2 1.2 | 27.88±1.72 32.46±2.5* 28.04±5.61 25.97±3.69 | 75.31±5.66 86.69±6.41* 73.7±6.74 66.63±11.53 |
Compare with the 1st group,, * P＜0.05.n=10。
Conclusion
Plumule nourishes capsule to the obviously effect of mouse small intestine motion nothing.
2, to the influence of mice food-intake
Materials and methods
Experimental animal: KM mice, male and female half and half.Non-inbred line closed colony.Body weight: 16.9+2.93.Available from zooscopy institute of the Chinese Academy of Medical Sciences.Card number: moving word (95) 01-3001 of doctor.
Be subjected to the reagent thing: plumule nourishes capsule.This institute new drug research center provides.Lot number: 980625.0.45g/ grain.
Test method: get mice and be divided into four groups at random.Every group 20 (every group is divided four boxes to raise again.5/box).Give the medicine of various dose respectively.Be administered once every day.Successive administration 10 days.Respectively at the 1st, 3,5,7 before the administration and after the administration, 24 hours food-intakes of 10 days mensuration mices.
Test grouping: the same.
Positive control drug: JIANWEI XIAOSHI PIAN.Pharmaceutical factory produces in the river.0.8g/ sheet.Lot number: 9712023.Function with cure mainly: invigorating the stomach and promoting digestion.Be used for weakness of the spleen and stomach, dyspepsia.
The result
Table 2 plumule nourishes capsule to the influence of mice food-intake (x ± s)
| Grouping | Medicine | Dosage mg | Food-intake (g/24 hour/only) | |||||
| 0 | 1 | 3 | 5 | 7 | 10 days | |||
| 1 2 3 4 | Distilled water JIANWEI XIAOSHI PIAN plumule nourishes the capsule plumule and nourishes capsule | 3.36 0.2 1.2 | 3.44 ±0.12 3.41 ±0.13 3.45 ±0.14 3.41 ±0.09 | 3.67 ±0.09 3.91 ±0.06 3.81 ±0.12 4.01* ±0.08 | 4.19 ±0.11 3.64 ±0.09 4.24 ±0.09 4.14 ±0.11 | 4.31 ±0.08 3.09 ±0.11 3.85 ±0.09 4.30 ±0.08 | 4.65 ±0.09 3.28 ±0.08 4.25 0.11 4.75 ±0.08 | 4.45 ±0.07 4.33 ±0.11 4.31 ±0.09 4.76* ±0.09 |
Compare * p＜0.05 with the 1st group.n=20。
Conclusion
Plumule nourishes the effect that capsule has certain promotion mice feed.Positive control drug does not have obvious effect.
3, to the influence of small intestinal Absorption
Materials and methods
Experimental animal: KM mice, male and female half and half.Non-inbred line closed colony.Body weight: 16.9 ± 2.93.Available from zooscopy institute of Sinology academy of science.Card number: moving word (95) 01-3001 of doctor.
Be subjected to the reagent thing: plumule nourishes capsule.This institute new drug research center provides.Lot number: 980625.0.45g/ grain.
Test method: Deng mice is divided into 5 groups at random.Every group 10 (the 5th group 4).Give the medicine of various dose respectively.Be administered once every day.Successive administration 10 days.The mice fasting is 12 hours after administration in the 10th day.Tested in second day.Every mouse stomach includes the GC liquid (giving the equal-volume distilled water for the 5th group) of 10% glucose and 5% cholesterol during test.0.2ml/10g。Irritate behind the stomach and to pluck eyeball in 20 minutes and get blood, separation of serum is surveyed blood glucose and cholesterol level.Used kit all available from living biochemical reagents company.Lot number: 980407,980405.Test instrunment is the ZS-1A semi-automatic biochemical analyzer.
The test grouping:
Grouping modeling drug dose (g/kg)
1 GC liquid distilled water
2 GC liquid JIANWEI XIAOSHI PIAN 3.36
3 GC liquid plumules nourish capsule 0.2
4 GC liquid plumules nourish capsule 1.2
5 distilled water distilled water
Positive control drug: JIANWEI XIAOSHI PIAN.Pharmaceutical factory produces in the river.0.8g/ sheet.Lot number: 9712023.Function with cure mainly: invigorating the stomach and promoting digestion.Be used for weakness of the spleen and stomach, dyspepsia.
The result
The influence that table 3 plumule nourishing capsule absorbs mouse small intestine (x ± s)
| Grouping | Medicine | n | Dosage mg | Blood glucose mmol/L | Cholesterol u/L |
| 1 2 3 4 5 | Distilled water JIANWEI XIAOSHI PIAN plumule nourishes the capsule plumule and nourishes the capsule distilled water | 10 10 10 10 4 | 3.36 0.2 1.2 | 2.5603△ ±0.3112 2.7808 ±0.3748 2.8255 ±0.2509 2.409 ±0.2959 2.3558△△ ±0.1979 | 988.5** ±15.05 945.8* ±53.21 1004.6** ±43.97 912.4 ±41.3 881.3 ±38.81 |
Compare △ △ △ P＜0.05, P＜0.01 with the 3rd group.
Compare * * * P＜0.05, P＜0.01 with the 5th group.n=10。
Conclusion
Plumule nourishes the effect that capsule has certain little intestinal absorption of promotion.But dose-effect relationship is not obvious.
Experimental example 2 medicines of the present invention are to the regulating action evaluation of immunologic function
1, to the effect of mice carbon clearance
Materials and methods
Experimental animal: KM mice, male and female half and half.Non-inbred line closed colony.Body weight: 21.12 ± 1.89.Available from zooscopy institute of the Chinese Academy of Medical Sciences.Card number: moving word (95) 01-3001 of doctor.
Be subjected to the reagent thing: plumule nourishes capsule.This institute new drug research center provides.Lot number: 980625.0.45g/ grain.
Test method: get mice and be divided into 4 groups at random.Every group 10.Give the medicine of various dose respectively.Be administered once every day.Successive administration 10 days.After administration in the 10th day 1 hour, the india ink of mouse tail vein injection dilution (with 4 times of normal saline dilutions).0.1ml/10g。Get blood 20ul respectively at 2,10 minutes mice angular vein clumps behind the injection india ink, and it is dissolved in 2ml 0.1%Na
2CO
3In the liquid, with 752 spectrophotometers at 600nm place photometry density value.And with Na
2CO
3Make blank.
After mice execution, get liver, spleen is weighed, and calculates phagocytic index (a) fully.
Index is expressed: the K value=(logOD1-logOD2)/(t2-t1)
A=body weight/(liver weight+spleen is heavy) 3K
The test grouping:
| Grouping | Modeling | Medicine | Dosage (g/kg) |
| 1 2 3 4 | GC liquid GC liquid GC liquid GC liquid | Distilled water JIANWEI XIAOSHI PIAN plumule nourishes the capsule plumule and nourishes capsule | 3.36 0.2 1.2 |
Positive control drug: JIANWEI XIAOSHI PIAN.Pharmaceutical factory produces in the river: the 0.8g/ sheet.Lot number: 9712023.Function with cure mainly: invigorating the stomach and promoting digestion.Be used for weakness of the spleen and stomach, dyspepsia.
The result
Table 4 plumule nourishes capsule to the influence of mice carbon clearance and spleen weight (x ± s)
| Grouping | Medicine | Dosage mg | Ka | Spleen Coefficient m g/g | |
| 1 2 3 4 | Distilled water JIANWEI XIAOSHI PIAN plumule nourishes the capsule plumule and nourishes capsule | 3.36 0.2 1.2 | 0.0281±0.0096 0.0345±0.01 0.0377±0.0076* 0.0351±0.0151 | 5.3234±1.1265 5.7207±0.6582 6.2835±0.6892* 5.872±0.7528 | 5.06±1.25 5.84±1.71 5.21±1.22 4.83±0.92 |
Compare * P＜0.05 with the 1st group.n=10。
Conclusion
Plumule nourishes the effect that capsule has certain promotion mouse monokaryon macrophage phagocytic.Low dose promptly has tangible effect.
2, to the influence of mouse spleen lymphocyte transformation
Materials and methods
Experimental animal: the KM mice, female.Non-inbred line closed colony.Body weight: 20.83 ± 1.02g.Available from zooscopy institute of the Chinese Academy of Medical Sciences.Card number: moving word (95) 01-3001 of doctor.
Be subjected to the reagent thing: plumule nourishes capsule.This institute new drug research center provides.Lot number: 980625.0.45g/ grain.
Reagent: RPMI1640 culture fluid (Sigma).Acid isopropyl alcohol liquid (adding 4ml1mol/LHCl in the 96ml isopropyl alcohol liquid).MTT(sigma)。ConA(Sigma)。
Test method: get mice and be divided into 4 groups at random.Every group 3.Give the medicine of various dose respectively.Be administered once every day.Successive administration 7 days.Put to death mice in 1 hour after administration in the 7th day, the aseptic spleen of getting extracts the T cell.Adjusting cell concentration is 2 * 10
6Cell/ml.Divide 2 holes to add in 24 well culture plates 1ml/ hole Cell sap.And do not add ConA liquid control wells.Add ConA concentration 100 μ g/ml 50 μ l.Place 5%CO2, cultivated 72 hours for 37 ℃.Cultivate and finish preceding 4 hours, every hole adds 5mg/ml MTT50ul/ hole.Continue to cultivate 4 hours.After cultivating end, every hole adds 1ml acid isopropyl alcohol, and the piping and druming mixing dissolves purple crystal fully.Divide then and be filled in 96 orifice plates every hole packing 3 holes.Detect wavelength 570nm with the 318MC microplate reader.Calculate T ability of cell proliferation (=OD adds conA-OD and do not add conA).T cell proliferation percentage rate [=(OD adds conA-OD and do not add conA)/OD does not add conA].
The test grouping:
| Grouping | Modeling | Medicine | Dosage (g/kg) |
| 1 2 3 4 | GC liquid GC liquid GC liquid GC liquid | Distilled water JIANWEI XIAOSHI PIAN plumule nourishes the capsule plumule and nourishes capsule | 3.36 0.2 1.2g |
Positive control drug: JIANWEI XIAOSHI PIAN.Pharmaceutical factory produces in the river.0.8g/ sheet.Lot number: 9712023.Function with cure mainly: invigorating the stomach and promoting digestion.Be used for weakness of the spleen and stomach, dyspepsia.
The result
Table 5 plumule nourishes capsule to the influence of mouse spleen T cell proliferation function (x ± s)
Grouping drug dose OD does not add ConA OD and adds ConA propagation percentage rate
mg
1 distilled water 0.107 0.182 69.45
±0.001 ±0.023 ±19.45
2 JIANWEI XIAOSHI PIAN 3.36 0.162 0.231 41.95
±0.016 ±0.033 ±6.35
3 plumules nourish capsule 0.2 0.149 0.257 71.64
±0.004 ±0.003 ±2.3
4 plumules nourish capsule 1.2 0.114 0.250** 118.55*
± 0.015 ± 0.007+30.95 compare * * * * P＜0.05, P＜0.01 with the 1st group.n=3。
Conclusion
Plumule nourishes capsule and has the ability that promotes that spleen lymphocyte transforms.Obvious with heavy dose of effect.
Embodiment 1
Prescription:
Give birth to each 15 gram Semen Phaseoli radiati Germinatuss, 5 gram Fructus Crataegi, 4.5 gram of Fructus Hordei Germinatus (parched)
Placenta caprae seu ovis 0.5 gram Embryo cervi 0.5 gram Fructus Alpiniae Oxyphyllae 1.5 grams
Method for making:
Give birth to Fructus Hordei Germinatus (parched), Semen Phaseoli radiati Germinatus, Fructus Crataegi mixing, add 75% soak with ethanol and cross powder, reflux, extract, three times, each 1.5-2.0 hour, extracting solution merged, and concentrating under reduced pressure gets extractum (25 ℃ of proportion 1.30-1.40), extractum vacuum drying.
Placenta caprae seu ovis, Embryo cervi, Fructus Alpiniae Oxyphyllae are ground into fine powder, in proportion with the extract powder mix homogeneously, cross sieve No. 4, and with the medicated powder capsule of packing into No. 0, average every capsules is adorned 0.3 gram raw material.
Claims (5)
1, a kind of nutrient and healthcare products is characterized in that these health product are made by following raw material:
Fructus Hordei Germinatus 10-20 weight portion Fructus Hordei Germinatus (parched) 10-20 weight portion
Semen Phaseoli radiati Germinatus 3-10 weight portion Fructus Crataegi 3-10 weight portion
Placenta caprae seu ovis 0.1-2 weight portion Embryo cervi 0.1-2 weight portion
Fructus Alpiniae Oxyphyllae 1-3 weight portion
2,, it is characterized in that the weight proportion of this raw material is according to the nutrient and healthcare products of claim 1:
15 parts of 15 parts of Fructus Hordei Germinatus (parched)s of Fructus Hordei Germinatus
4.5 parts of 5 portions of Fructus Crataegis of Semen Phaseoli radiati Germinatus
0.5 part of 0.5 part of Embryo cervi of Placenta caprae seu ovis
1.5 parts of Fructus Alpiniae Oxyphyllae
3,, it is characterized in that Fructus Crataegi is a Fructus Crataegi according to the nutrient and healthcare products of claim 1 or 2.
4,, it is characterized in that these nutrient and healthcare products are capsules of making after each raw material is extracted according to the nutrient and healthcare products of claim 1 or 2.
5,, it is characterized in that these nutrient and healthcare products are capsules made from following method: will give birth to Fructus Hordei Germinatus (parched), Semen Phaseoli radiati Germinatus, Fructus Crataegi mixing, and add 75% soak with ethanol and cross powder according to the nutrient and healthcare products of claim 4, reflux, extract, three times, each 1.5-2.0 hour, extracting solution merged, and 25 ℃ of concentrating under reduced pressure get proportion 1.30-1.40 extractum, the extractum vacuum drying, Placenta caprae seu ovis, Embryo cervi, Fructus Alpiniae Oxyphyllae are ground into fine powder, in proportion with the extract powder mix homogeneously, cross sieve No. 4, medicated powder is incapsulated, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98119902A CN1067270C (en) | 1998-09-15 | 1998-09-15 | Nutritious health care medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98119902A CN1067270C (en) | 1998-09-15 | 1998-09-15 | Nutritious health care medicine |
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| Publication Number | Publication Date |
|---|---|
| CN1214260A CN1214260A (en) | 1999-04-21 |
| CN1067270C true CN1067270C (en) | 2001-06-20 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98119902A Expired - Fee Related CN1067270C (en) | 1998-09-15 | 1998-09-15 | Nutritious health care medicine |
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|---|---|
| CN (1) | CN1067270C (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103468503B (en) * | 2013-09-06 | 2014-08-20 | 铁岭市西丰御林鹿业集团有限公司 | Fetus cervi healthcare wine |
| CN104187264B (en) * | 2014-07-08 | 2016-05-25 | 许伯宗 | A kind of alimentation composition that improves body immunity and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078395A (en) * | 1993-02-22 | 1993-11-17 | 东莞市燕东保健食品实业公司 | A kind of nutrition oral administration and production technology thereof |
| CN1138464A (en) * | 1995-06-16 | 1996-12-25 | 吉林省东盟保健品有限责任公司 | Female moth foetus deer oral liquor and its prodn. process |
-
1998
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078395A (en) * | 1993-02-22 | 1993-11-17 | 东莞市燕东保健食品实业公司 | A kind of nutrition oral administration and production technology thereof |
| CN1138464A (en) * | 1995-06-16 | 1996-12-25 | 吉林省东盟保健品有限责任公司 | Female moth foetus deer oral liquor and its prodn. process |
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|---|---|
| CN1214260A (en) | 1999-04-21 |
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