CN103765289B - 具有先进的成像性质的显微镜成像设备 - Google Patents

具有先进的成像性质的显微镜成像设备 Download PDF

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Publication number
CN103765289B
CN103765289B CN201180051943.1A CN201180051943A CN103765289B CN 103765289 B CN103765289 B CN 103765289B CN 201180051943 A CN201180051943 A CN 201180051943A CN 103765289 B CN103765289 B CN 103765289B
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imaging
microscope
image
microscopes
light
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CN103765289A (zh
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K·高希
L·伯恩斯
A·埃尔加默
M·J·施尼策尔
E·科克尔
T·W·何
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/20—Surgical microscopes characterised by non-optical aspects
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
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    • A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research
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    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
    • A61B2576/026—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part for the brain
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    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
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    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
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    • A61B5/48—Other medical applications
    • A61B5/4887—Locating particular structures in or on the body
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    • G06T2207/00—Indexing scheme for image analysis or image enhancement
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    • G06T2207/30004—Biomedical image processing
    • G06T2207/30016—Brain
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
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  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Multimedia (AREA)
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  • Molecular Biology (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Signal Processing (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Theoretical Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Quality & Reliability (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Lenses (AREA)
  • Studio Devices (AREA)
CN201180051943.1A 2010-08-27 2011-08-25 具有先进的成像性质的显微镜成像设备 Active CN103765289B (zh)

Applications Claiming Priority (3)

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US37759110P 2010-08-27 2010-08-27
US61/377,591 2010-08-27
PCT/US2011/049180 WO2012027586A2 (en) 2010-08-27 2011-08-25 Microscopy imaging device with advanced imaging properties

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CN103765289A CN103765289A (zh) 2014-04-30
CN103765289B true CN103765289B (zh) 2017-05-17

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US (7) US9195043B2 (enExample)
EP (2) EP2609742A4 (enExample)
JP (1) JP2013545116A (enExample)
CN (1) CN103765289B (enExample)
AU (2) AU2011293269B2 (enExample)
CA (3) CA3030720A1 (enExample)
GB (1) GB2483963B (enExample)
WO (1) WO2012027586A2 (enExample)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2609742A4 (en) 2010-08-27 2015-07-08 Univ Leland Stanford Junior MICROSCOPIC IMAGING DEVICE WITH ADVANCED IMAGING FEATURES
US20120105949A1 (en) * 2010-11-02 2012-05-03 Eric B Cummings Additive Manufacturing-Based Compact Epifluorescence Microscope
WO2013033954A1 (zh) 2011-09-09 2013-03-14 深圳市大疆创新科技有限公司 陀螺式动态自平衡云台
US20140043462A1 (en) 2012-02-10 2014-02-13 Inscopix, Inc. Systems and methods for distributed video microscopy
US9723990B2 (en) * 2012-03-21 2017-08-08 Korea Electro Technology Research Institute Transmitted light detection type measurement apparatus for skin autofluorescence
US9955871B2 (en) * 2012-03-21 2018-05-01 Korea Electrotechnology Research Institute Transmitted light detection type measurement apparatus for skin autofluorescence
JP6159391B2 (ja) 2012-04-03 2017-07-05 イラミーナ インコーポレーテッド 核酸シークエンシングに有用な統合化した読取りヘッド及び流体カートリッジ
EP2660639B1 (en) * 2012-05-02 2016-04-13 Centre National De La Recherche Scientifique Method and apparatus for single-particle localization using wavelet analysis
US20150297755A1 (en) * 2012-11-02 2015-10-22 Cesacar Participacions, S.L. Fluorescence coloring for eye surgery
US20150309295A1 (en) * 2012-11-05 2015-10-29 Inscopix, Inac. Miniaturized imaging devices, systems and methods
GB2511483B (en) * 2013-01-15 2016-11-23 Coolled Ltd LED Illumination
JP6166049B2 (ja) * 2013-01-25 2017-07-19 浜松ホトニクス株式会社 光検出装置および光検出方法
CN103676122A (zh) * 2013-06-24 2014-03-26 张晨 小型荧光/明场光学成像系统、光学成像方法及其用途
CN104251811A (zh) * 2013-06-28 2014-12-31 西门子医疗保健诊断公司 一种数字显微镜及其图像识别方法
JP6239881B2 (ja) * 2013-07-10 2017-11-29 浜松ホトニクス株式会社 画像取得装置及び画像取得方法
US8903568B1 (en) 2013-07-31 2014-12-02 SZ DJI Technology Co., Ltd Remote control method and terminal
CN104459098B (zh) * 2013-09-23 2016-11-23 西门子医疗保健诊断公司 一种采集医学样本图像的诊断装置
WO2015051501A1 (en) * 2013-10-08 2015-04-16 SZ DJI Technology Co., Ltd Apparatus and methods for stabilization and vibration reduction
WO2015171611A1 (en) * 2014-05-05 2015-11-12 Health Research, Inc. Clinical intravital microscope
US10016136B2 (en) 2014-06-20 2018-07-10 Optomak, Inc. Image relaying cannula with detachable self-aligning connector
US10520792B2 (en) * 2014-11-03 2019-12-31 Sintai Optical (Shenzhen) Co., Ltd. Range finder
CN105629255B (zh) * 2014-11-03 2019-02-12 信泰光学(深圳)有限公司 测距仪
US10292592B2 (en) 2014-11-13 2019-05-21 The Board Of Trustees Of The Leland Stanford Junior University Method and apparatus for optical recording of biological parameters in freely moving animals
CN107111013B (zh) * 2014-12-08 2020-11-06 Trw汽车美国有限责任公司 紧凑调制传递函数评估系统
US11112592B2 (en) * 2015-04-24 2021-09-07 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Fine focus microscope control
JP2018529125A (ja) * 2015-09-02 2018-10-04 インスコピックス， インコーポレイテッド カラー撮像のためのシステムおよび方法
DE102015116488A1 (de) 2015-09-29 2017-03-30 Carl Zeiss Microscopy Gmbh Mikroskop sowie Beleuchtungsvorrichtung und Beleuchtungssatz für ein Mikroskop
WO2020206362A1 (en) 2019-04-04 2020-10-08 Inscopix, Inc. Multi-modal microscopic imaging
US12251272B2 (en) 2015-11-05 2025-03-18 Inscopix, Inc. Systems and methods for optogenetic imaging using semi-kinematic coupling
US12514670B2 (en) 2015-11-05 2026-01-06 Inscopix, Inc. Multi-modal microscopic imaging
JP2018533768A (ja) 2015-11-05 2018-11-15 インスコピックス， インコーポレイテッド 光遺伝学撮像のためのシステムおよび方法
US12527642B2 (en) 2015-11-05 2026-01-20 Inscopix, Inc. Multi-modal microscopic imaging
US9846300B2 (en) 2016-01-08 2017-12-19 Optomak, Inc. Microscope with multiple image sensors for fluorescence imaging of multiple locations and/or wavelengths
US10274712B2 (en) 2016-01-08 2019-04-30 Optomak, Inc. Microscope for fluorescence imaging with variable focus
US9791683B2 (en) 2016-01-08 2017-10-17 Optomak, Inc. Microscope with multiple illumination channels for optogenetic stimulation and fluorescence imaging
JP6242447B2 (ja) * 2016-08-04 2017-12-06 オリンパス株式会社 顕微鏡システム
US10386623B2 (en) 2016-09-13 2019-08-20 Inscopix, Inc. Adapter for microscopic imaging
US10568695B2 (en) * 2016-09-26 2020-02-25 International Business Machines Corporation Surgical skin lesion removal
JP7332483B2 (ja) * 2017-05-16 2023-08-23 リサーチ ディベロップメント ファウンデーション 子宮内膜組織識別のための装置および方法
CA3064073A1 (en) * 2017-05-19 2018-11-22 The Rockefeller University Imaging signal extraction apparatus and methods of using same
WO2019010348A1 (en) * 2017-07-06 2019-01-10 The Johns Hopkins University MINIATURE MICROSCOPE FOR OPTICAL IMAGING WITH MULTIPLE CONTRASTS IN ANIMALS
DE102017127931A1 (de) 2017-11-27 2019-05-29 Henke-Sass, Wolf Gmbh Optikanordnung für ein Endoskop und Endoskop mit einer solchen Optikanordnung
US10827164B2 (en) * 2018-03-01 2020-11-03 Google Llc Active LCD shutters for virtual and augmented reality low persistence
JP6969459B2 (ja) * 2018-03-15 2021-11-24 オムロン株式会社 センサヘッド
CN108982444A (zh) * 2018-07-04 2018-12-11 浙江大学 一种led激发的短波红外荧光显微成像系统
US12038525B2 (en) * 2018-07-16 2024-07-16 Or-Ment Llc Electromagnetic wave medical imaging system, device and methods
CN109342369A (zh) * 2018-10-26 2019-02-15 中国科学院苏州生物医学工程技术研究所 用于循环肿瘤细胞快速检测的大视场生物成像、扫描、分析装置
DE102018127339A1 (de) * 2018-11-01 2020-05-07 Leibniz-Institut für Neurobiologie Magdeburg Bilderfassungseinrichtung, System und Verfahren zur Bilderfassung
CN110018558A (zh) * 2019-05-24 2019-07-16 福州大学 一种便携式荧光显微镜及其工作方法
JP7700040B2 (ja) * 2019-08-27 2025-06-30 株式会社島津製作所 イメージング装置、治療装置およびイメージング方法
KR102252113B1 (ko) 2019-09-19 2021-05-17 한국과학기술연구원 다중 형광 신호 측정을 위한 신경 탐침 구조체 및 그 제조방법
EP3805838B1 (en) * 2019-10-10 2023-12-06 Leica Instruments (Singapore) Pte. Ltd. Microscope and related apparatuses, methods and computer programs
US20230160806A1 (en) * 2020-04-24 2023-05-25 The Regents Of The University Of California Devices and methods for two-dimension (2d)-based protein and particle detection
NL2027950B1 (en) * 2021-04-12 2022-10-21 Nearfield Instr B V Compact optical microscope, metrology device comprising the optical microscope and a wafer positioning metrology apparatus comprising the metrology device
US20230218173A1 (en) * 2021-12-14 2023-07-13 Duke University Endoscopic imaging and patterned stimulation at cellular resolution
US20250352050A1 (en) * 2022-05-23 2025-11-20 The General Hospital Corporation System for stabilized noninvasive imaging of microvasculature in the oral mucosa
US12467939B2 (en) 2022-07-15 2025-11-11 The George Washington University Optical probe for measuring wall-shear stress
EP4602638A1 (en) * 2022-10-14 2025-08-20 Alpenglow Biosciences, Inc. Apparatuses, systems, and methods for processing of three dimensional optical microscopy image data
CN116338930B (zh) * 2023-03-06 2026-08-04 华中科技大学 一种模块化光场成像光路镜头组
US12480839B2 (en) * 2024-01-03 2025-11-25 Viavi Solutions Inc. Köhler illumination system for inspection of radiused end connectors

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040080750A1 (en) * 2002-08-01 2004-04-29 Wolf David E. Fluorescence correlation spectroscopy instrument and method of using the same
US20050051723A1 (en) * 2003-07-23 2005-03-10 Neagle Bradley D. Examination systems for biological samples
CN1623110A (zh) * 2002-03-18 2005-06-01 独立行政法人科学技术振兴机构 高稳定性光学显微镜
US20090161103A1 (en) * 2001-08-23 2009-06-25 D.N.R. Imaging Systems Ltd. Optical system and method for inspecting fluorescently labeled biological specimens
US20090201577A1 (en) * 2007-09-05 2009-08-13 Chroma Technology Corporation Light source
US20100206731A1 (en) * 2005-10-27 2010-08-19 Life Technologies Corporation Devices and methods for optoelectronic manipulation of small particles

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US88145A (en) 1869-03-23 Improvement in blind-wiring machine
US3762801A (en) 1972-02-24 1973-10-02 Polaroid Corp Compact three component objective lenses
US5212593A (en) 1992-02-06 1993-05-18 Svg Lithography Systems, Inc. Broad band optical reduction system using matched multiple refractive element materials
IL108352A (en) 1994-01-17 2000-02-29 Given Imaging Ltd In vivo video camera system
US5798222A (en) 1995-07-17 1998-08-25 Guava Technologies, Inc. Apparatus for monitoring substances in organisms
US5907425A (en) 1995-12-19 1999-05-25 The Board Of Trustees Of The Leland Stanford Junior University Miniature scanning confocal microscope
US6396941B1 (en) 1996-08-23 2002-05-28 Bacus Research Laboratories, Inc. Method and apparatus for internet, intranet, and local viewing of virtual microscope slides
EP0987985A4 (en) 1997-06-05 2009-04-29 Kairos Scient Inc CALIBRATION OF RESONANCE ENERGY TRANSFER BY FLUORESCENCE IN MICROSCOPY
US6324418B1 (en) 1997-09-29 2001-11-27 Boston Scientific Corporation Portable tissue spectroscopy apparatus and method
EP1051104B1 (en) 1998-01-26 2008-04-09 Massachusetts Institute Of Technology Fluorescence imaging endoscope
EP1079890A4 (en) 1998-05-08 2008-12-03 Genetronics Inc VASODILATION OF AN ELECTRICALLY INDUCED VESSEL
US6154282A (en) 1998-10-26 2000-11-28 Cytotelesis Inc. Semiconductor based excitation illuminator for fluorescence and phosphorescence microscopy
US6653651B1 (en) 1998-12-09 2003-11-25 Carl D. Meinhart Micron resolution particle image velocimeter
US6907390B1 (en) * 1998-12-14 2005-06-14 Smiths Detection Inc. Miniaturized opto-electronic magnifying system
US6005720A (en) 1998-12-22 1999-12-21 Virtual Vision, Inc. Reflective micro-display system
US20030170908A1 (en) 2000-07-28 2003-09-11 Bright Frank V. Method for making microsensor arrays for detecting analytes
RU2182328C2 (ru) 2000-02-17 2002-05-10 Институт молекулярной биологии им. В.А. Энгельгардта РАН Флуоресцентный микроскоп
US20060008799A1 (en) 2000-05-22 2006-01-12 Hong Cai Rapid haplotyping by single molecule detection
WO2002004929A2 (en) 2000-07-10 2002-01-17 University Health Network Method and apparatus for high resolution coherent optical imaging
WO2002007587A2 (en) 2000-07-14 2002-01-31 Xillix Technologies Corporation Compact fluorescent endoscopy video system
US8036731B2 (en) 2001-01-22 2011-10-11 Spectrum Dynamics Llc Ingestible pill for diagnosing a gastrointestinal tract
US6780584B1 (en) 2000-09-27 2004-08-24 Nanogen, Inc. Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics
US6818907B2 (en) 2000-10-17 2004-11-16 The President And Fellows Of Harvard College Surface plasmon enhanced illumination system
FR2820828B1 (fr) 2001-02-09 2003-05-02 Commissariat Energie Atomique Dispositif d'observation d'echantillons par fluorescence, notamment de facon sequentielle
US6790672B2 (en) 2001-02-19 2004-09-14 Board Of Regents The University Of Texas System Encoded molecular sieve particle-based sensors
EP1372486A2 (en) 2001-03-09 2004-01-02 Lucid, Inc. System and method for macroscopic and confocal imaging of tissue
AU2002254276A1 (en) 2001-03-19 2002-10-03 Peter H. Bartels Miniaturized microscope array digital slide scanner
US7864380B2 (en) 2001-03-19 2011-01-04 Dmetrix, Inc. Slide-borne imaging instructions
US6649402B2 (en) 2001-06-22 2003-11-18 Wisconsin Alumni Research Foundation Microfabricated microbial growth assay method and apparatus
US7297494B2 (en) 2001-06-25 2007-11-20 Georgia Tech Research Corporation Activatable probes and methods for in vivo gene detection
US7439478B2 (en) 2001-07-06 2008-10-21 Palantyr Research, Llc Imaging system, methodology, and applications employing reciprocal space optical design having at least one pixel being scaled to about a size of a diffraction-limited spot defined by a microscopic optical system
US7105795B2 (en) 2001-07-06 2006-09-12 Palantyr Research, Llc Imaging system, methodology, and applications employing reciprocal space optical design
US6850362B2 (en) * 2001-08-08 2005-02-01 Atto Bioscience Inc. Microscope optical system with a stationary sample stage and stationary viewing ports suited for viewing various fields of view of a sample
WO2003023479A1 (en) 2001-09-07 2003-03-20 Board Of Regents, The University Of Texas System Multimodal miniature microscope
US6885492B2 (en) 2001-11-08 2005-04-26 Imaginative Optics, Inc. Spatial light modulator apparatus
US6643071B2 (en) 2001-12-21 2003-11-04 Lucent Technologies Inc. Graded-index lens microscopes
JP2003260025A (ja) 2002-03-08 2003-09-16 Olympus Optical Co Ltd カプセル型内視鏡
JP3789104B2 (ja) 2002-05-13 2006-06-21 株式会社日立ハイテクノロジーズ 元素分布観察方法及び装置
US7193775B2 (en) * 2002-05-30 2007-03-20 Dmetrix, Inc. EPI-illumination system for an array microscope
US6987259B2 (en) 2002-05-30 2006-01-17 Dmetrix, Inc. Imaging system with an integrated source and detector array
US20040091465A1 (en) 2002-06-26 2004-05-13 Zachary Yim Therapeutic antiangiogenic compositions and methods
US7154598B2 (en) 2002-07-12 2006-12-26 Decision Biomarkers, Inc. Excitation and imaging of fluorescent arrays
US20040192601A1 (en) 2002-08-02 2004-09-30 Silvia Corvera Lipid binding molecules and methods of use
US7023622B2 (en) 2002-08-06 2006-04-04 Dmetrix, Inc. Miniature microscope objective lens
JP4395859B2 (ja) * 2003-01-07 2010-01-13 三星電機株式会社 携帯端末機用カメラモジュール
US7672043B2 (en) 2003-02-21 2010-03-02 Kla-Tencor Technologies Corporation Catadioptric imaging system exhibiting enhanced deep ultraviolet spectral bandwidth
US7151260B2 (en) * 2003-03-03 2006-12-19 Advanced Fuel Research, Inc. Analyzer for measuring multiple gases
US8206946B2 (en) 2003-03-24 2012-06-26 Mary Beth Tabacco Fluorescent virus probes for identification of bacteria
JPWO2004096022A1 (ja) 2003-04-25 2006-07-13 オリンパス株式会社 無線型被検体内情報取得システムおよび被検体内導入装置
CA2523290A1 (en) 2003-04-25 2004-11-11 Olympus Corporation Wireless in-vivo information acquiring system and external device
CN100446717C (zh) 2003-04-25 2008-12-31 奥林巴斯株式会社 胶囊内窥镜及胶囊内窥镜系统
US20110259744A1 (en) 2003-04-30 2011-10-27 Moyle William R Sensors for biomolecular detection and cell classification
US7372985B2 (en) * 2003-08-15 2008-05-13 Massachusetts Institute Of Technology Systems and methods for volumetric tissue scanning microscopy
WO2005043114A2 (en) 2003-10-22 2005-05-12 Ron Broide Oligonucleotide probe sets and uses thereof
WO2005057193A1 (en) 2003-11-18 2005-06-23 Applied Materials Israel, Ltd Inspection system with auto-focus
JP2007525261A (ja) * 2004-01-16 2007-09-06 ザ シティ カレッジ オブ ザ シティ ユニバーシティ オブ ニューヨーク 光学式画像化とポイント蛍光分光学とを組み合わせたインビボ医療診断のためのマイクロスケールコンパクトデバイス
JP2005294801A (ja) * 2004-03-11 2005-10-20 Advanced Lcd Technologies Development Center Co Ltd レーザー結晶化装置及びレーザー結晶化方法
WO2005112895A2 (en) 2004-05-20 2005-12-01 Spectrum Dynamics Llc Ingestible device platform for the colon
DE102004034970A1 (de) 2004-07-16 2006-02-02 Carl Zeiss Jena Gmbh Lichtrastermikroskop und Verwendung
JP4587742B2 (ja) 2004-08-23 2010-11-24 株式会社日立ハイテクノロジーズ 荷電粒子線顕微方法及び荷電粒子線応用装置
US8878924B2 (en) 2004-09-24 2014-11-04 Vivid Medical, Inc. Disposable microscope and portable display
WO2006050355A2 (en) * 2004-11-01 2006-05-11 David Jones A compact portable rugged fluorescence microscope sealed against dust and water
FR2881225B1 (fr) 2005-01-21 2007-10-26 Cypher Science Sarl Appareil de detection portable permettant de detecter sur le terrain des elements marques par fluorescence
US20060164510A1 (en) * 2005-01-24 2006-07-27 Doron Adler Sensor with narrow mounting profile
US8788021B1 (en) 2005-01-24 2014-07-22 The Board Of Trustees Of The Leland Stanford Junior Univerity Live being optical analysis system and approach
US7307774B1 (en) 2005-01-24 2007-12-11 The Board Of Trustees Of The Leland Standford Junior University Micro-optical analysis system and approach therefor
US8346346B1 (en) 2005-01-24 2013-01-01 The Board Of Trustees Of The Leland Stanford Junior University Optical analysis system and approach therefor
US7738086B2 (en) 2005-05-09 2010-06-15 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
US7224539B2 (en) 2005-05-13 2007-05-29 Schaack David F Providing optical systems having improved properties to users of catalog (stock) lenses
FR2887457B1 (fr) * 2005-06-23 2007-10-05 Fond Bettencourt Schueller Vaccination par ciblage transcutane
US20090317802A1 (en) * 2005-12-09 2009-12-24 Bhatia Sangeeta N Compositions and Methods to Monitor RNA Delivery to Cells
US7599591B2 (en) * 2006-01-12 2009-10-06 Optimedica Corporation Optical delivery systems and methods of providing adjustable beam diameter, spot size and/or spot shape
US8487326B2 (en) * 2006-04-24 2013-07-16 Cree, Inc. LED device having a tilted peak emission and an LED display including such devices
US8771261B2 (en) * 2006-04-28 2014-07-08 Topcon Medical Laser Systems, Inc. Dynamic optical surgical system utilizing a fixed relationship between target tissue visualization and beam delivery
CN101063657A (zh) * 2006-04-29 2007-10-31 中国科学院上海生命科学研究院 在活体细胞中筛选配体与受体结合的方法和系统
US8045263B2 (en) 2006-06-30 2011-10-25 The General Hospital Corporation Device and method for wide-field and high resolution imaging of tissue
US20080180790A1 (en) * 2006-08-04 2008-07-31 Ikonisys, Inc. Dynamic Scanning Automatic Microscope and Method
US20100227386A1 (en) * 2006-08-24 2010-09-09 Pavel Neuzil Compact optical detection system
US10335038B2 (en) * 2006-08-24 2019-07-02 Xenogen Corporation Spectral unmixing for in-vivo imaging
GB0617945D0 (en) 2006-09-12 2006-10-18 Ucl Business Plc Imaging apparatus and methods
US20080070311A1 (en) * 2006-09-19 2008-03-20 Vanderbilt University Microfluidic flow cytometer and applications of same
US7535991B2 (en) * 2006-10-16 2009-05-19 Oraya Therapeutics, Inc. Portable orthovoltage radiotherapy
US8624967B2 (en) * 2006-10-17 2014-01-07 Dan O'Connell Integrated portable in-situ microscope
US20090208965A1 (en) * 2006-10-25 2009-08-20 Ikonisys, Inc. Automated method for detecting cancers and high grade hyperplasias
WO2008061548A1 (en) 2006-11-22 2008-05-29 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Reconstruction and visualization of neuronal cell structures with brigh-field mosaic microscopy
WO2008073856A2 (en) * 2006-12-08 2008-06-19 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
US20080141795A1 (en) * 2006-12-13 2008-06-19 Gagnon Daniel F Micro-surface inspection tool
DE102007018922A1 (de) * 2007-02-12 2008-08-14 Leica Microsystems Cms Gmbh Mikroskop
JP5593221B2 (ja) 2007-06-15 2014-09-17 ヒストロックス，インコーポレイテッド． 顕微鏡機器を標準化するための方法およびシステム
US8294757B2 (en) 2007-06-26 2012-10-23 Agency For Science, Technology And Research Imaging chamber with window and micro-needle platform magnetically biased toward each other
US8068899B2 (en) 2007-07-03 2011-11-29 The Board Of Trustees Of The Leland Stanford Junior University Method and system of using intrinsic-based photosensing with high-speed line scanning for characterization of biological thick tissue including muscle
US9411149B2 (en) * 2007-07-17 2016-08-09 The Board Of Trustees Of The Leland Stanford Junior University Microendoscopy with corrective optics
EP2203733B1 (en) * 2007-10-25 2017-05-03 Washington University in St. Louis Confocal photoacoustic microscopy with optical lateral resolution
US7801271B2 (en) 2007-12-23 2010-09-21 Oraya Therapeutics, Inc. Methods and devices for orthovoltage ocular radiotherapy and treatment planning
WO2009088930A2 (en) * 2008-01-02 2009-07-16 The Regents Of The University Of California High numerical aperture telemicroscopy apparatus
WO2009115108A1 (en) * 2008-03-19 2009-09-24 Ruprecht-Karls-Universität Heidelberg A method and an apparatus for localization of single dye molecules in the fluorescent microscopy
US8179525B2 (en) 2008-03-31 2012-05-15 Jawaharial Nehru Centre For Advanced Scientific Research Mirror mounted inside filter block of a fluorescence microscope to perform SERS and method thereof
US8941080B2 (en) * 2008-05-20 2015-01-27 Ludwig-Maximilians-Universitat Munchen Method and device for particle analysis using thermophoresis
US8184298B2 (en) * 2008-05-21 2012-05-22 The Board Of Trustees Of The University Of Illinois Spatial light interference microscopy and fourier transform light scattering for cell and tissue characterization
US8983581B2 (en) 2008-05-27 2015-03-17 Massachusetts Institute Of Technology System and method for large field of view, single cell analysis
US20090322800A1 (en) * 2008-06-25 2009-12-31 Dolby Laboratories Licensing Corporation Method and apparatus in various embodiments for hdr implementation in display devices
US7940886B2 (en) 2008-10-03 2011-05-10 Siemens Medical Solutions Usa, Inc. 3D medical anatomical image system using 2D images
JP2010117705A (ja) 2008-10-14 2010-05-27 Olympus Corp バーチャルスライド作成システム用顕微鏡
US8551730B2 (en) 2008-10-24 2013-10-08 The Regents Of The University Of California Use of a reference source with adaptive optics in biological microscopy
US8525925B2 (en) * 2008-12-29 2013-09-03 Red.Com, Inc. Modular digital camera
US9685592B2 (en) * 2009-01-14 2017-06-20 Cree Huizhou Solid State Lighting Company Limited Miniature surface mount device with large pin pads
US20100259805A1 (en) * 2009-04-13 2010-10-14 Molecular Devices, Inc. Methods and systems for reducing scanner image distortion
JP5307629B2 (ja) 2009-05-22 2013-10-02 オリンパス株式会社 走査型顕微鏡装置
US8174761B2 (en) * 2009-06-10 2012-05-08 Universitat Heidelberg Total internal reflection interferometer with laterally structured illumination
US20110061139A1 (en) * 2009-09-04 2011-03-10 Ahmet Oral Method to measure 3 component of the magnetic field vector at nanometer resolution using scanning hall probe microscopy
US9333036B2 (en) * 2010-01-22 2016-05-10 Board Of Regents, The University Of Texas System Systems, devices and methods for imaging and surgery
JP4941566B2 (ja) * 2010-01-27 2012-05-30 ブラザー工業株式会社 プロセスカートリッジ
JP2011250835A (ja) 2010-05-31 2011-12-15 Olympus Corp 内視鏡システム
US20110312798A1 (en) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Test module with inbuilt lancet
US10027855B2 (en) 2010-06-30 2018-07-17 Ge Healthcare Bio-Science Corp. System for synchronization in a line scanning imaging microscope
EP2609742A4 (en) 2010-08-27 2015-07-08 Univ Leland Stanford Junior MICROSCOPIC IMAGING DEVICE WITH ADVANCED IMAGING FEATURES
JP6009841B2 (ja) 2011-07-12 2016-10-19 オリンパス株式会社 光学的観察装置
US9575304B2 (en) 2012-06-25 2017-02-21 Huron Technologies International Inc. Pathology slide scanners for fluorescence and brightfield imaging and method of operation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090161103A1 (en) * 2001-08-23 2009-06-25 D.N.R. Imaging Systems Ltd. Optical system and method for inspecting fluorescently labeled biological specimens
CN1623110A (zh) * 2002-03-18 2005-06-01 独立行政法人科学技术振兴机构 高稳定性光学显微镜
US20040080750A1 (en) * 2002-08-01 2004-04-29 Wolf David E. Fluorescence correlation spectroscopy instrument and method of using the same
US20050051723A1 (en) * 2003-07-23 2005-03-10 Neagle Bradley D. Examination systems for biological samples
US20100206731A1 (en) * 2005-10-27 2010-08-19 Life Technologies Corporation Devices and methods for optoelectronic manipulation of small particles
US20090201577A1 (en) * 2007-09-05 2009-08-13 Chroma Technology Corporation Light source

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