JP2013545116A - 高度なイメージング特性を有する顕微鏡イメージング装置 - Google Patents

高度なイメージング特性を有する顕微鏡イメージング装置 Download PDF

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JP2013545116A
JP2013545116A JP2013527133A JP2013527133A JP2013545116A JP 2013545116 A JP2013545116 A JP 2013545116A JP 2013527133 A JP2013527133 A JP 2013527133A JP 2013527133 A JP2013527133 A JP 2013527133A JP 2013545116 A JP2013545116 A JP 2013545116A
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microscope
imaging
optical
image
light
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JP2013545116A5 (enExample
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クナル ゴーシュ
ラウリー バーンズ
アッバス エルガマル
マーク ジェイ シュニッツァー
エリック コッカー
タット ウェイ ホ
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ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー
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  • Engineering & Computer Science (AREA)
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JP2013527133A 2010-08-27 2011-09-29 高度なイメージング特性を有する顕微鏡イメージング装置 Pending JP2013545116A (ja)

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US37759110P 2010-08-27 2010-08-27
PCT/US2011/049180 WO2012027586A2 (en) 2010-08-27 2011-08-25 Microscopy imaging device with advanced imaging properties

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JP2016001864A Division JP2016118792A (ja) 2016-01-07 2016-01-07 高度なイメージング特性を有する顕微鏡イメージング装置
JP2019003287A Division JP2019082708A (ja) 2019-01-11 2019-01-11 高度なイメージング特性を有する顕微鏡イメージング装置、落射蛍光顕微鏡装置、及び落射蛍光顕微鏡装置を使用する方法

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US (7) US9195043B2 (enExample)
EP (2) EP2609742A4 (enExample)
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CN (1) CN103765289B (enExample)
AU (2) AU2011293269B2 (enExample)
CA (3) CA2809581C (enExample)
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016191957A (ja) * 2016-08-04 2016-11-10 オリンパス株式会社 顕微鏡システム
JP2018529125A (ja) * 2015-09-02 2018-10-04 インスコピックス, インコーポレイテッド カラー撮像のためのシステムおよび方法
JP2020521171A (ja) * 2017-05-19 2020-07-16 ザ ロックフェラー ユニヴァーシティ 撮像信号抽出装置およびそれを使用する方法
US11197735B2 (en) 2015-11-05 2021-12-14 Inscopix, Inc. Systems and methods for optogenetic imaging
JP2022551472A (ja) * 2019-10-10 2022-12-09 ライカ インストゥルメンツ (シンガポール) プライヴェット リミテッド 顕微鏡および関連する装置、方法ならびにコンピュータプログラム
JP2024038065A (ja) * 2019-08-27 2024-03-19 株式会社島津製作所 イメージング方法
US12251272B2 (en) 2015-11-05 2025-03-18 Inscopix, Inc. Systems and methods for optogenetic imaging using semi-kinematic coupling

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2809581C (en) 2010-08-27 2016-11-15 The Board Of Trustees Of The Leland Stanford Junior University Microscopy imaging device with advanced imaging properties
US20120105949A1 (en) * 2010-11-02 2012-05-03 Eric B Cummings Additive Manufacturing-Based Compact Epifluorescence Microscope
WO2013033954A1 (zh) 2011-09-09 2013-03-14 深圳市大疆创新科技有限公司 陀螺式动态自平衡云台
WO2013119838A1 (en) 2012-02-10 2013-08-15 Inscopix, Inc. Systems and methods for distributed video microscopy
US9723990B2 (en) * 2012-03-21 2017-08-08 Korea Electro Technology Research Institute Transmitted light detection type measurement apparatus for skin autofluorescence
US9955871B2 (en) * 2012-03-21 2018-05-01 Korea Electrotechnology Research Institute Transmitted light detection type measurement apparatus for skin autofluorescence
CA3138752C (en) * 2012-04-03 2024-02-06 Illumina, Inc. Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing
EP2660639B1 (en) * 2012-05-02 2016-04-13 Centre National De La Recherche Scientifique Method and apparatus for single-particle localization using wavelet analysis
CA2890056A1 (en) * 2012-11-02 2014-05-15 Cesacar Participacions, S.L. Fluorescence coloring for eye surgery
WO2014071390A1 (en) * 2012-11-05 2014-05-08 Inscopix, Inc. Miniaturized imaging devices, systems and methods
GB2511483B (en) * 2013-01-15 2016-11-23 Coolled Ltd LED Illumination
JP6166049B2 (ja) * 2013-01-25 2017-07-19 浜松ホトニクス株式会社 光検出装置および光検出方法
CN103676122A (zh) * 2013-06-24 2014-03-26 张晨 小型荧光/明场光学成像系统、光学成像方法及其用途
CN104251811A (zh) * 2013-06-28 2014-12-31 西门子医疗保健诊断公司 一种数字显微镜及其图像识别方法
JP6239881B2 (ja) * 2013-07-10 2017-11-29 浜松ホトニクス株式会社 画像取得装置及び画像取得方法
US8903568B1 (en) 2013-07-31 2014-12-02 SZ DJI Technology Co., Ltd Remote control method and terminal
CN104459098B (zh) * 2013-09-23 2016-11-23 西门子医疗保健诊断公司 一种采集医学样本图像的诊断装置
JP2016541026A (ja) 2013-10-08 2016-12-28 エスゼット ディージェイアイ テクノロジー カンパニー リミテッドSz Dji Technology Co.,Ltd 安定化と振動低減のための装置および方法
WO2015171611A1 (en) * 2014-05-05 2015-11-12 Health Research, Inc. Clinical intravital microscope
US10016136B2 (en) 2014-06-20 2018-07-10 Optomak, Inc. Image relaying cannula with detachable self-aligning connector
CN105629255B (zh) * 2014-11-03 2019-02-12 信泰光学(深圳)有限公司 测距仪
US10520792B2 (en) * 2014-11-03 2019-12-31 Sintai Optical (Shenzhen) Co., Ltd. Range finder
US10292592B2 (en) 2014-11-13 2019-05-21 The Board Of Trustees Of The Leland Stanford Junior University Method and apparatus for optical recording of biological parameters in freely moving animals
EP3230776B1 (en) * 2014-12-08 2021-05-26 TRW Automotive U.S. LLC Compact modular transfer function evaluation system
US11112592B2 (en) * 2015-04-24 2021-09-07 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Fine focus microscope control
DE102015116488A1 (de) 2015-09-29 2017-03-30 Carl Zeiss Microscopy Gmbh Mikroskop sowie Beleuchtungsvorrichtung und Beleuchtungssatz für ein Mikroskop
WO2020206362A1 (en) 2019-04-04 2020-10-08 Inscopix, Inc. Multi-modal microscopic imaging
US12514670B2 (en) 2015-11-05 2026-01-06 Inscopix, Inc. Multi-modal microscopic imaging
US12527642B2 (en) 2015-11-05 2026-01-20 Inscopix, Inc. Multi-modal microscopic imaging
US9791683B2 (en) 2016-01-08 2017-10-17 Optomak, Inc. Microscope with multiple illumination channels for optogenetic stimulation and fluorescence imaging
US10274712B2 (en) 2016-01-08 2019-04-30 Optomak, Inc. Microscope for fluorescence imaging with variable focus
US9846300B2 (en) 2016-01-08 2017-12-19 Optomak, Inc. Microscope with multiple image sensors for fluorescence imaging of multiple locations and/or wavelengths
US10386623B2 (en) 2016-09-13 2019-08-20 Inscopix, Inc. Adapter for microscopic imaging
US10568695B2 (en) * 2016-09-26 2020-02-25 International Business Machines Corporation Surgical skin lesion removal
EP3624667A4 (en) * 2017-05-16 2021-01-20 Research Development Foundation Apparatus and methods for endometrial tissue identification
US11867892B2 (en) 2017-07-06 2024-01-09 The Johns Hopkins University Miniature microscope for multi-contrast optical imaging in animals
DE102017127931A1 (de) 2017-11-27 2019-05-29 Henke-Sass, Wolf Gmbh Optikanordnung für ein Endoskop und Endoskop mit einer solchen Optikanordnung
US10827164B2 (en) * 2018-03-01 2020-11-03 Google Llc Active LCD shutters for virtual and augmented reality low persistence
JP6969459B2 (ja) * 2018-03-15 2021-11-24 オムロン株式会社 センサヘッド
CN108982444A (zh) * 2018-07-04 2018-12-11 浙江大学 一种led激发的短波红外荧光显微成像系统
US12038525B2 (en) * 2018-07-16 2024-07-16 Or-Ment Llc Electromagnetic wave medical imaging system, device and methods
CN109342369A (zh) * 2018-10-26 2019-02-15 中国科学院苏州生物医学工程技术研究所 用于循环肿瘤细胞快速检测的大视场生物成像、扫描、分析装置
DE102018127339A1 (de) * 2018-11-01 2020-05-07 Leibniz-Institut für Neurobiologie Magdeburg Bilderfassungseinrichtung, System und Verfahren zur Bilderfassung
CN110018558A (zh) * 2019-05-24 2019-07-16 福州大学 一种便携式荧光显微镜及其工作方法
KR102252113B1 (ko) 2019-09-19 2021-05-17 한국과학기술연구원 다중 형광 신호 측정을 위한 신경 탐침 구조체 및 그 제조방법
WO2021216958A1 (en) * 2020-04-24 2021-10-28 The Regents Of The University Of California Devices and methods for two-dimension (2d)-based protein and particle detection
NL2027950B1 (en) * 2021-04-12 2022-10-21 Nearfield Instr B V Compact optical microscope, metrology device comprising the optical microscope and a wafer positioning metrology apparatus comprising the metrology device
EP4529435A4 (en) * 2022-05-23 2026-03-11 Massachusetts Gen Hospital NON-INVASIVE STABILIZED IMAGING SYSTEM OF MICROVASCULATURE IN THE ORAL MUCOSA
US12467939B2 (en) 2022-07-15 2025-11-11 The George Washington University Optical probe for measuring wall-shear stress
WO2024081816A1 (en) * 2022-10-14 2024-04-18 Alpenglow Biosciences, Inc. Apparatuses, systems, and methods for processing of three dimensional optical microscopy image data
CN116338930A (zh) * 2023-03-06 2023-06-27 华中科技大学 一种模块化光场成像光路镜头组
US12480839B2 (en) * 2024-01-03 2025-11-25 Viavi Solutions Inc. Köhler illumination system for inspection of radiused end connectors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011154173A (ja) * 2010-01-27 2011-08-11 Brother Industries Ltd プロセスカートリッジ
JP2013036991A (ja) * 2011-07-12 2013-02-21 Olympus Corp 光学的観察装置

Family Cites Families (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US88145A (en) 1869-03-23 Improvement in blind-wiring machine
US3762801A (en) 1972-02-24 1973-10-02 Polaroid Corp Compact three component objective lenses
US5212593A (en) 1992-02-06 1993-05-18 Svg Lithography Systems, Inc. Broad band optical reduction system using matched multiple refractive element materials
IL108352A (en) 1994-01-17 2000-02-29 Given Imaging Ltd In vivo video camera system
US5798222A (en) 1995-07-17 1998-08-25 Guava Technologies, Inc. Apparatus for monitoring substances in organisms
US5907425A (en) 1995-12-19 1999-05-25 The Board Of Trustees Of The Leland Stanford Junior University Miniature scanning confocal microscope
US6396941B1 (en) 1996-08-23 2002-05-28 Bacus Research Laboratories, Inc. Method and apparatus for internet, intranet, and local viewing of virtual microscope slides
CA2291730A1 (en) 1997-06-05 1998-12-10 Kairos Scientific Inc. Calibration of fluorescence resonance energy transfer in microscopy
US6324418B1 (en) 1997-09-29 2001-11-27 Boston Scientific Corporation Portable tissue spectroscopy apparatus and method
DE69938493T2 (de) * 1998-01-26 2009-05-20 Massachusetts Institute Of Technology, Cambridge Endoskop zur erfassung von fluoreszenzbilder
AU3973599A (en) 1998-05-08 1999-11-29 Genetronics, Inc. Electrically induced vessel vasodilation
CA2280398C (en) 1998-10-26 2009-01-20 Lothar Lilge A semiconductor based excitation illuminator for fluorescence and phosphorescence microscopy
US6653651B1 (en) 1998-12-09 2003-11-25 Carl D. Meinhart Micron resolution particle image velocimeter
US6907390B1 (en) * 1998-12-14 2005-06-14 Smiths Detection Inc. Miniaturized opto-electronic magnifying system
US6005720A (en) 1998-12-22 1999-12-21 Virtual Vision, Inc. Reflective micro-display system
US20030170908A1 (en) 2000-07-28 2003-09-11 Bright Frank V. Method for making microsensor arrays for detecting analytes
RU2182328C2 (ru) 2000-02-17 2002-05-10 Институт молекулярной биологии им. В.А. Энгельгардта РАН Флуоресцентный микроскоп
US20060008799A1 (en) 2000-05-22 2006-01-12 Hong Cai Rapid haplotyping by single molecule detection
EP1299711B1 (en) 2000-07-10 2006-05-24 University Health Network Method and apparatus for high resolution coherent optical imaging
EP1301118B1 (en) 2000-07-14 2006-09-06 Xillix Technologies Corp. Compact fluorescence endoscopy video system
US8036731B2 (en) 2001-01-22 2011-10-11 Spectrum Dynamics Llc Ingestible pill for diagnosing a gastrointestinal tract
US6780584B1 (en) 2000-09-27 2004-08-24 Nanogen, Inc. Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics
US6818907B2 (en) 2000-10-17 2004-11-16 The President And Fellows Of Harvard College Surface plasmon enhanced illumination system
FR2820828B1 (fr) 2001-02-09 2003-05-02 Commissariat Energie Atomique Dispositif d'observation d'echantillons par fluorescence, notamment de facon sequentielle
US6790672B2 (en) 2001-02-19 2004-09-14 Board Of Regents The University Of Texas System Encoded molecular sieve particle-based sensors
WO2002073246A2 (en) 2001-03-09 2002-09-19 Lucid, Inc. System and method for macroscopic and confocal imaging of tissue
US7864380B2 (en) 2001-03-19 2011-01-04 Dmetrix, Inc. Slide-borne imaging instructions
WO2002075370A2 (en) 2001-03-19 2002-09-26 Weinstein Ronald S Miniaturized microscope array digital slide scanner
US6649402B2 (en) 2001-06-22 2003-11-18 Wisconsin Alumni Research Foundation Microfabricated microbial growth assay method and apparatus
US7297494B2 (en) 2001-06-25 2007-11-20 Georgia Tech Research Corporation Activatable probes and methods for in vivo gene detection
US7439478B2 (en) 2001-07-06 2008-10-21 Palantyr Research, Llc Imaging system, methodology, and applications employing reciprocal space optical design having at least one pixel being scaled to about a size of a diffraction-limited spot defined by a microscopic optical system
US7105795B2 (en) * 2001-07-06 2006-09-12 Palantyr Research, Llc Imaging system, methodology, and applications employing reciprocal space optical design
US6850362B2 (en) * 2001-08-08 2005-02-01 Atto Bioscience Inc. Microscope optical system with a stationary sample stage and stationary viewing ports suited for viewing various fields of view of a sample
US7326938B2 (en) * 2001-08-23 2008-02-05 D.N.R. Imaging Systems Ltd. Optical system and method for inspecting fluorescently labeled biological specimens
US20030103262A1 (en) 2001-09-07 2003-06-05 Board Of Regents, The University Of Texas System Multimodal miniature microscope
US6885492B2 (en) 2001-11-08 2005-04-26 Imaginative Optics, Inc. Spatial light modulator apparatus
US6643071B2 (en) 2001-12-21 2003-11-04 Lucent Technologies Inc. Graded-index lens microscopes
JP2003260025A (ja) 2002-03-08 2003-09-16 Olympus Optical Co Ltd カプセル型内視鏡
JP4084061B2 (ja) * 2002-03-18 2008-04-30 独立行政法人科学技術振興機構 高安定性光学顕微鏡
JP3789104B2 (ja) 2002-05-13 2006-06-21 株式会社日立ハイテクノロジーズ 元素分布観察方法及び装置
US6987259B2 (en) 2002-05-30 2006-01-17 Dmetrix, Inc. Imaging system with an integrated source and detector array
US7193775B2 (en) * 2002-05-30 2007-03-20 Dmetrix, Inc. EPI-illumination system for an array microscope
US20040091465A1 (en) 2002-06-26 2004-05-13 Zachary Yim Therapeutic antiangiogenic compositions and methods
US7154598B2 (en) 2002-07-12 2006-12-26 Decision Biomarkers, Inc. Excitation and imaging of fluorescent arrays
EP1546675A4 (en) * 2002-08-01 2008-03-26 Sensor Technologies Inc METHOD FOR MEASURING MOLECULAR INTERACTIONS
AU2003261362A1 (en) 2002-08-02 2004-02-23 University Of Massachusetts Lipid binding molecules and methods of use
US7023622B2 (en) 2002-08-06 2006-04-04 Dmetrix, Inc. Miniature microscope objective lens
JP4395859B2 (ja) * 2003-01-07 2010-01-13 三星電機株式会社 携帯端末機用カメラモジュール
US7672043B2 (en) 2003-02-21 2010-03-02 Kla-Tencor Technologies Corporation Catadioptric imaging system exhibiting enhanced deep ultraviolet spectral bandwidth
US7151260B2 (en) * 2003-03-03 2006-12-19 Advanced Fuel Research, Inc. Analyzer for measuring multiple gases
US8206946B2 (en) 2003-03-24 2012-06-26 Mary Beth Tabacco Fluorescent virus probes for identification of bacteria
KR100743332B1 (ko) 2003-04-25 2007-07-26 올림푸스 가부시키가이샤 캡슐 내시경 및 캡슐 내시경 시스템
WO2004096022A1 (ja) 2003-04-25 2004-11-11 Olympus Corporation 無線型被検体内情報取得システムおよび被検体内導入装置
KR100741217B1 (ko) 2003-04-25 2007-07-19 올림푸스 가부시키가이샤 무선형 피검체 내 정보 취득 시스템 및 피검체 외부 장치
US20110259744A1 (en) 2003-04-30 2011-10-27 Moyle William R Sensors for biomolecular detection and cell classification
US20050051723A1 (en) * 2003-07-23 2005-03-10 Neagle Bradley D. Examination systems for biological samples
US7372985B2 (en) * 2003-08-15 2008-05-13 Massachusetts Institute Of Technology Systems and methods for volumetric tissue scanning microscopy
WO2005043114A2 (en) 2003-10-22 2005-05-12 Ron Broide Oligonucleotide probe sets and uses thereof
WO2005057193A1 (en) 2003-11-18 2005-06-23 Applied Materials Israel, Ltd Inspection system with auto-focus
WO2005069887A2 (en) * 2004-01-16 2005-08-04 The City College Of The University Of New York Micro-scale compact device for in vivo medical diagnosis combining optical imaging and point fluorescence spectroscopy
JP2005294801A (ja) * 2004-03-11 2005-10-20 Advanced Lcd Technologies Development Center Co Ltd レーザー結晶化装置及びレーザー結晶化方法
WO2005112895A2 (en) 2004-05-20 2005-12-01 Spectrum Dynamics Llc Ingestible device platform for the colon
DE102004034970A1 (de) 2004-07-16 2006-02-02 Carl Zeiss Jena Gmbh Lichtrastermikroskop und Verwendung
JP4587742B2 (ja) 2004-08-23 2010-11-24 株式会社日立ハイテクノロジーズ 荷電粒子線顕微方法及び荷電粒子線応用装置
US8878924B2 (en) * 2004-09-24 2014-11-04 Vivid Medical, Inc. Disposable microscope and portable display
WO2006050355A2 (en) 2004-11-01 2006-05-11 David Jones A compact portable rugged fluorescence microscope sealed against dust and water
FR2881225B1 (fr) * 2005-01-21 2007-10-26 Cypher Science Sarl Appareil de detection portable permettant de detecter sur le terrain des elements marques par fluorescence
US20060164510A1 (en) * 2005-01-24 2006-07-27 Doron Adler Sensor with narrow mounting profile
US8346346B1 (en) 2005-01-24 2013-01-01 The Board Of Trustees Of The Leland Stanford Junior University Optical analysis system and approach therefor
US8788021B1 (en) 2005-01-24 2014-07-22 The Board Of Trustees Of The Leland Stanford Junior Univerity Live being optical analysis system and approach
US7307774B1 (en) 2005-01-24 2007-12-11 The Board Of Trustees Of The Leland Standford Junior University Micro-optical analysis system and approach therefor
US7738086B2 (en) 2005-05-09 2010-06-15 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
US7224539B2 (en) 2005-05-13 2007-05-29 Schaack David F Providing optical systems having improved properties to users of catalog (stock) lenses
FR2887457B1 (fr) * 2005-06-23 2007-10-05 Fond Bettencourt Schueller Vaccination par ciblage transcutane
WO2007102839A2 (en) * 2005-10-27 2007-09-13 Applera Corporation Optoelectronic separation of biomolecules
US20090317802A1 (en) * 2005-12-09 2009-12-24 Bhatia Sangeeta N Compositions and Methods to Monitor RNA Delivery to Cells
WO2007082102A2 (en) * 2006-01-12 2007-07-19 Optimedica Corporation Optical delivery systems and methods of providing adjustable beam diameter, spot size and/or spot shape
US8487326B2 (en) * 2006-04-24 2013-07-16 Cree, Inc. LED device having a tilted peak emission and an LED display including such devices
US8771261B2 (en) * 2006-04-28 2014-07-08 Topcon Medical Laser Systems, Inc. Dynamic optical surgical system utilizing a fixed relationship between target tissue visualization and beam delivery
CN101063657A (zh) * 2006-04-29 2007-10-31 中国科学院上海生命科学研究院 在活体细胞中筛选配体与受体结合的方法和系统
US8045263B2 (en) 2006-06-30 2011-10-25 The General Hospital Corporation Device and method for wide-field and high resolution imaging of tissue
KR20090077036A (ko) * 2006-08-04 2009-07-14 아이코니시스 인코포레이티드 동적 주사 자동 현미경 및 동적 주사 방법
US10335038B2 (en) * 2006-08-24 2019-07-02 Xenogen Corporation Spectral unmixing for in-vivo imaging
JP5256201B2 (ja) * 2006-08-24 2013-08-07 エージェンシー フォー サイエンス, テクノロジー アンド リサーチ 小型光学検出システム
GB0617945D0 (en) 2006-09-12 2006-10-18 Ucl Business Plc Imaging apparatus and methods
US20080070311A1 (en) * 2006-09-19 2008-03-20 Vanderbilt University Microfluidic flow cytometer and applications of same
US7496174B2 (en) * 2006-10-16 2009-02-24 Oraya Therapeutics, Inc. Portable orthovoltage radiotherapy
US8624967B2 (en) * 2006-10-17 2014-01-07 Dan O'Connell Integrated portable in-situ microscope
US20090208965A1 (en) * 2006-10-25 2009-08-20 Ikonisys, Inc. Automated method for detecting cancers and high grade hyperplasias
US20100074486A1 (en) 2006-11-22 2010-03-25 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V., A Corporation Of Germany Reconstruction and visualization of neuronal cell structures with bright-field mosaic microscopy
WO2008073856A2 (en) * 2006-12-08 2008-06-19 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
US20080141795A1 (en) * 2006-12-13 2008-06-19 Gagnon Daniel F Micro-surface inspection tool
DE102007018922A1 (de) 2007-02-12 2008-08-14 Leica Microsystems Cms Gmbh Mikroskop
EP2162728B1 (en) 2007-06-15 2016-07-27 Novartis AG Microscope system and method for obtaining standardized sample data
WO2009002273A1 (en) 2007-06-26 2008-12-31 Agency For Science, Technology And Research Imaging chamber with window and micro-needle platform magnetically biased toward each other
US8068899B2 (en) 2007-07-03 2011-11-29 The Board Of Trustees Of The Leland Stanford Junior University Method and system of using intrinsic-based photosensing with high-speed line scanning for characterization of biological thick tissue including muscle
US9411149B2 (en) * 2007-07-17 2016-08-09 The Board Of Trustees Of The Leland Stanford Junior University Microendoscopy with corrective optics
WO2009033021A2 (en) * 2007-09-05 2009-03-12 Chroma Technology Corporation Light source with wavelength converting phosphor
EP2203733B1 (en) * 2007-10-25 2017-05-03 Washington University in St. Louis Confocal photoacoustic microscopy with optical lateral resolution
US7801271B2 (en) 2007-12-23 2010-09-21 Oraya Therapeutics, Inc. Methods and devices for orthovoltage ocular radiotherapy and treatment planning
WO2009088930A2 (en) * 2008-01-02 2009-07-16 The Regents Of The University Of California High numerical aperture telemicroscopy apparatus
WO2009115108A1 (en) * 2008-03-19 2009-09-24 Ruprecht-Karls-Universität Heidelberg A method and an apparatus for localization of single dye molecules in the fluorescent microscopy
US8179525B2 (en) 2008-03-31 2012-05-15 Jawaharial Nehru Centre For Advanced Scientific Research Mirror mounted inside filter block of a fluorescence microscope to perform SERS and method thereof
WO2009141390A1 (en) * 2008-05-20 2009-11-26 Ludwig-Maximilians-Universität München Method and device for particle analysis using thermophoresis
US8184298B2 (en) * 2008-05-21 2012-05-22 The Board Of Trustees Of The University Of Illinois Spatial light interference microscopy and fourier transform light scattering for cell and tissue characterization
US8983581B2 (en) 2008-05-27 2015-03-17 Massachusetts Institute Of Technology System and method for large field of view, single cell analysis
US20090322800A1 (en) * 2008-06-25 2009-12-31 Dolby Laboratories Licensing Corporation Method and apparatus in various embodiments for hdr implementation in display devices
US7940886B2 (en) 2008-10-03 2011-05-10 Siemens Medical Solutions Usa, Inc. 3D medical anatomical image system using 2D images
JP2010117705A (ja) 2008-10-14 2010-05-27 Olympus Corp バーチャルスライド作成システム用顕微鏡
US8551730B2 (en) 2008-10-24 2013-10-08 The Regents Of The University Of California Use of a reference source with adaptive optics in biological microscopy
US8525925B2 (en) * 2008-12-29 2013-09-03 Red.Com, Inc. Modular digital camera
US9685592B2 (en) * 2009-01-14 2017-06-20 Cree Huizhou Solid State Lighting Company Limited Miniature surface mount device with large pin pads
US20100259805A1 (en) * 2009-04-13 2010-10-14 Molecular Devices, Inc. Methods and systems for reducing scanner image distortion
JP5307629B2 (ja) 2009-05-22 2013-10-02 オリンパス株式会社 走査型顕微鏡装置
US8174761B2 (en) * 2009-06-10 2012-05-08 Universitat Heidelberg Total internal reflection interferometer with laterally structured illumination
US20110061139A1 (en) * 2009-09-04 2011-03-10 Ahmet Oral Method to measure 3 component of the magnetic field vector at nanometer resolution using scanning hall probe microscopy
WO2011091283A1 (en) * 2010-01-22 2011-07-28 Board Of Regents, The University Of Texas System Systems, devices and methods for imaging and surgery
JP2011250835A (ja) 2010-05-31 2011-12-15 Olympus Corp 内視鏡システム
US20110312781A1 (en) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Loc with digital memory to store genetic data updates
JP5897563B2 (ja) 2010-06-30 2016-03-30 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション ライン走査式顕微鏡における同期用システム
CA2809581C (en) 2010-08-27 2016-11-15 The Board Of Trustees Of The Leland Stanford Junior University Microscopy imaging device with advanced imaging properties
US9575304B2 (en) 2012-06-25 2017-02-21 Huron Technologies International Inc. Pathology slide scanners for fluorescence and brightfield imaging and method of operation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011154173A (ja) * 2010-01-27 2011-08-11 Brother Industries Ltd プロセスカートリッジ
JP2013036991A (ja) * 2011-07-12 2013-02-21 Olympus Corp 光学的観察装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KUNAL K GHOSH ET AL.: "Miniaturized integration of a fluorescence microscope", NATURE METHODS, vol. 8, no. 10, JPN6015026718, 11 September 2011 (2011-09-11), GB, pages 871 - 878, XP055894153, ISSN: 0003109832, DOI: 10.1038/nmeth.1694 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018529125A (ja) * 2015-09-02 2018-10-04 インスコピックス, インコーポレイテッド カラー撮像のためのシステムおよび方法
JP2022081541A (ja) * 2015-09-02 2022-05-31 インスコピックス, インコーポレイテッド カラー撮像のためのシステムおよび方法
US11733501B2 (en) 2015-09-02 2023-08-22 Inscopix Inc. Systems and methods for color imaging
US11197735B2 (en) 2015-11-05 2021-12-14 Inscopix, Inc. Systems and methods for optogenetic imaging
US11690696B2 (en) 2015-11-05 2023-07-04 Inscopix, Inc. Systems and methods for optogenetic imaging
US12251272B2 (en) 2015-11-05 2025-03-18 Inscopix, Inc. Systems and methods for optogenetic imaging using semi-kinematic coupling
JP2016191957A (ja) * 2016-08-04 2016-11-10 オリンパス株式会社 顕微鏡システム
JP2020521171A (ja) * 2017-05-19 2020-07-16 ザ ロックフェラー ユニヴァーシティ 撮像信号抽出装置およびそれを使用する方法
JP7159216B2 (ja) 2017-05-19 2022-10-24 ザ ロックフェラー ユニヴァーシティ 撮像信号抽出装置およびそれを使用する方法
JP2024038065A (ja) * 2019-08-27 2024-03-19 株式会社島津製作所 イメージング方法
JP2022551472A (ja) * 2019-10-10 2022-12-09 ライカ インストゥルメンツ (シンガポール) プライヴェット リミテッド 顕微鏡および関連する装置、方法ならびにコンピュータプログラム
JP7733644B2 (ja) 2019-10-10 2025-09-03 ライカ インストゥルメンツ (シンガポール) プライヴェット リミテッド 顕微鏡および関連する装置、方法ならびにコンピュータプログラム

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