CN103764138A - 紫杉烷和Abeo-紫杉烷类似物 - Google Patents

紫杉烷和Abeo-紫杉烷类似物 Download PDF

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Publication number
CN103764138A
CN103764138A CN201280027957.4A CN201280027957A CN103764138A CN 103764138 A CN103764138 A CN 103764138A CN 201280027957 A CN201280027957 A CN 201280027957A CN 103764138 A CN103764138 A CN 103764138A
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China
Prior art keywords
inhibitor
alkyl
aryl
group
composition
Prior art date
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Pending
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CN201280027957.4A
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English (en)
Chinese (zh)
Inventor
詹姆斯·D·麦克切斯尼
约翰·T·亨利
西列什·库马尔·文卡塔拉曼
马赫什·库马尔·贡德卢鲁
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Veiled Therapeutics LLC
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Arbor Therapeutics LLC
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Publication of CN103764138A publication Critical patent/CN103764138A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
CN201280027957.4A 2011-04-07 2012-04-06 紫杉烷和Abeo-紫杉烷类似物 Pending CN103764138A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161472968P 2011-04-07 2011-04-07
US61/472,968 2011-04-07
PCT/US2012/032568 WO2013106029A1 (en) 2011-04-07 2012-04-06 Taxane and abeo-taxane analogs

Publications (1)

Publication Number Publication Date
CN103764138A true CN103764138A (zh) 2014-04-30

Family

ID=48781786

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280027957.4A Pending CN103764138A (zh) 2011-04-07 2012-04-06 紫杉烷和Abeo-紫杉烷类似物

Country Status (10)

Country Link
US (1) US8912229B2 (enExample)
EP (1) EP2694055A4 (enExample)
JP (1) JP5970536B2 (enExample)
KR (1) KR20140048113A (enExample)
CN (1) CN103764138A (enExample)
AU (1) AU2012364858A1 (enExample)
CA (1) CA2832596A1 (enExample)
MX (1) MX2013011694A (enExample)
SG (2) SG194128A1 (enExample)
WO (1) WO2013106029A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013002969A1 (en) 2011-06-06 2013-01-03 Arbor Therapeutics, LLC Acid-labile lipophilic prodrugs of cancer chemotherapeutic agents
CN104650109B (zh) * 2013-11-22 2019-01-01 江苏天士力帝益药业有限公司 紫杉烷类化合物
KR20230129388A (ko) 2020-11-19 2023-09-08 스펙시스 아게 암 치료를 위한 펩타이드 cxcr4 억제제 및 탁산을 포함하는 약제학적 조합물
EP4000613A1 (en) 2020-11-19 2022-05-25 Polyphor Ag Pharmaceutical combinations comprising a peptide cxcr4 inhibitor and a taxane for treating cancer
EP4223292A1 (en) 2022-02-07 2023-08-09 Cellestia Biotech AG Pharmaceutical combinations for treating cancer

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1886400A (zh) * 2003-09-25 2006-12-27 泰普斯特医药公司 9,10－α,α－OH紫杉烷类似物及其制备方法
WO2008106621A1 (en) * 2007-02-28 2008-09-04 Tapestry Pharmaceuticals, Inc Taxane analogs for the treatment of brain cancer
WO2008121476A1 (en) * 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
US20080269319A1 (en) * 2007-02-28 2008-10-30 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment
WO2011028571A1 (en) * 2009-09-01 2011-03-10 Tapestry Pharmaceuticals, Inc. Taxane analogues, their use, pharmaceutical compositions containing them, and processes for their preparation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352806A (en) * 1992-04-17 1994-10-04 Abbott Laboratories Taxol derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1886400A (zh) * 2003-09-25 2006-12-27 泰普斯特医药公司 9,10－α,α－OH紫杉烷类似物及其制备方法
WO2008106621A1 (en) * 2007-02-28 2008-09-04 Tapestry Pharmaceuticals, Inc Taxane analogs for the treatment of brain cancer
US20080269319A1 (en) * 2007-02-28 2008-10-30 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment
WO2008121476A1 (en) * 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
WO2011028571A1 (en) * 2009-09-01 2011-03-10 Tapestry Pharmaceuticals, Inc. Taxane analogues, their use, pharmaceutical compositions containing them, and processes for their preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JAMES P. SNYDER ET AL.: "The binding conformation of Taxol in b-tubulin: A model based on electron crystallographic density", 《PNAS》, vol. 98, no. 9, 24 April 2001 (2001-04-24), pages 5312 - 5316, XP002407692, DOI: 10.1073/pnas.051309398 *

Also Published As

Publication number Publication date
EP2694055A1 (en) 2014-02-12
KR20140048113A (ko) 2014-04-23
MX2013011694A (es) 2014-05-27
SG10201602309VA (en) 2016-05-30
CA2832596A1 (en) 2013-07-18
SG194128A1 (en) 2013-11-29
US8912229B2 (en) 2014-12-16
EP2694055A4 (en) 2014-09-10
AU2012364858A1 (en) 2013-11-21
WO2013106029A1 (en) 2013-07-18
NZ617430A (en) 2016-05-27
JP2014512362A (ja) 2014-05-22
US20140093503A1 (en) 2014-04-03
JP5970536B2 (ja) 2016-08-17

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Application publication date: 20140430