KR20140048113A - 탁산 및 아베오-탁산 유사체 - Google Patents
탁산 및 아베오-탁산 유사체 Download PDFInfo
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- KR20140048113A KR20140048113A KR1020137029373A KR20137029373A KR20140048113A KR 20140048113 A KR20140048113 A KR 20140048113A KR 1020137029373 A KR1020137029373 A KR 1020137029373A KR 20137029373 A KR20137029373 A KR 20137029373A KR 20140048113 A KR20140048113 A KR 20140048113A
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- RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 description 1
- STMPXDBGVJZCEX-UHFFFAOYSA-N triethylsilyl trifluoromethanesulfonate Chemical compound CC[Si](CC)(CC)OS(=O)(=O)C(F)(F)F STMPXDBGVJZCEX-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
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Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Pulmonology (AREA)
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- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161472968P | 2011-04-07 | 2011-04-07 | |
| US61/472,968 | 2011-04-07 | ||
| PCT/US2012/032568 WO2013106029A1 (en) | 2011-04-07 | 2012-04-06 | Taxane and abeo-taxane analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20140048113A true KR20140048113A (ko) | 2014-04-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137029373A Withdrawn KR20140048113A (ko) | 2011-04-07 | 2012-04-06 | 탁산 및 아베오-탁산 유사체 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8912229B2 (enExample) |
| EP (1) | EP2694055A4 (enExample) |
| JP (1) | JP5970536B2 (enExample) |
| KR (1) | KR20140048113A (enExample) |
| CN (1) | CN103764138A (enExample) |
| AU (1) | AU2012364858A1 (enExample) |
| CA (1) | CA2832596A1 (enExample) |
| MX (1) | MX2013011694A (enExample) |
| SG (2) | SG10201602309VA (enExample) |
| WO (1) | WO2013106029A1 (enExample) |
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| KR101444693B1 (ko) | 2011-06-06 | 2014-09-26 | 아버 테라퓨틱스 엘엘씨 | 암 화학요법제의 산에 불안정한 친유성 전구약물 |
| CN104650109B (zh) * | 2013-11-22 | 2019-01-01 | 江苏天士力帝益药业有限公司 | 紫杉烷类化合物 |
| CA3199171A1 (en) | 2020-11-19 | 2022-05-27 | Spexis Ag | Pharmaceutical combinations comprising a peptide cxcr4 inhibitor and a taxane for treating cancer |
| EP4000613A1 (en) | 2020-11-19 | 2022-05-25 | Polyphor Ag | Pharmaceutical combinations comprising a peptide cxcr4 inhibitor and a taxane for treating cancer |
| EP4223292A1 (en) | 2022-02-07 | 2023-08-09 | Cellestia Biotech AG | Pharmaceutical combinations for treating cancer |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993021173A1 (en) * | 1992-04-17 | 1993-10-28 | Abbott Laboratories | Taxol derivatives |
| AU2004275881A1 (en) * | 2003-09-25 | 2005-04-07 | Tapestry Pharmaceuticals, Inc. | 9,10-alpha,alpha-OH-taxane analogs and methods for production thereof |
| WO2008121476A1 (en) * | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| WO2008109360A1 (en) * | 2007-02-28 | 2008-09-12 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
| US20080207743A1 (en) * | 2007-02-28 | 2008-08-28 | Rodger Lamb | Biologically Active Taxane Analogs and Methods of Treatment |
| WO2011028571A1 (en) * | 2009-09-01 | 2011-03-10 | Tapestry Pharmaceuticals, Inc. | Taxane analogues, their use, pharmaceutical compositions containing them, and processes for their preparation |
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2012
- 2012-04-06 CN CN201280027957.4A patent/CN103764138A/zh active Pending
- 2012-04-06 SG SG10201602309VA patent/SG10201602309VA/en unknown
- 2012-04-06 AU AU2012364858A patent/AU2012364858A1/en not_active Abandoned
- 2012-04-06 EP EP12864819.3A patent/EP2694055A4/en not_active Withdrawn
- 2012-04-06 WO PCT/US2012/032568 patent/WO2013106029A1/en not_active Ceased
- 2012-04-06 SG SG2013074919A patent/SG194128A1/en unknown
- 2012-04-06 CA CA2832596A patent/CA2832596A1/en not_active Abandoned
- 2012-04-06 KR KR1020137029373A patent/KR20140048113A/ko not_active Withdrawn
- 2012-04-06 MX MX2013011694A patent/MX2013011694A/es unknown
- 2012-04-06 JP JP2014504036A patent/JP5970536B2/ja not_active Expired - Fee Related
- 2012-04-06 US US14/110,423 patent/US8912229B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20140093503A1 (en) | 2014-04-03 |
| US8912229B2 (en) | 2014-12-16 |
| EP2694055A1 (en) | 2014-02-12 |
| CA2832596A1 (en) | 2013-07-18 |
| JP2014512362A (ja) | 2014-05-22 |
| AU2012364858A1 (en) | 2013-11-21 |
| CN103764138A (zh) | 2014-04-30 |
| SG10201602309VA (en) | 2016-05-30 |
| MX2013011694A (es) | 2014-05-27 |
| SG194128A1 (en) | 2013-11-29 |
| JP5970536B2 (ja) | 2016-08-17 |
| EP2694055A4 (en) | 2014-09-10 |
| NZ617430A (en) | 2016-05-27 |
| WO2013106029A1 (en) | 2013-07-18 |
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