CN103764121A - 用于递送rna分子的具有有用n:p比的脂质体 - Google Patents
用于递送rna分子的具有有用n:p比的脂质体 Download PDFInfo
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Landscapes
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| PCT/US2012/045829 WO2013006825A1 (en) | 2011-07-06 | 2012-07-06 | Liposomes having useful n:p ratio for delivery of rna molecules |
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| DK3243526T3 (da) | 2010-07-06 | 2020-02-17 | Glaxosmithkline Biologicals Sa | Levering af rna til at udløse flere immunsignalveje |
| EP2591114B1 (en) | 2010-07-06 | 2016-06-08 | GlaxoSmithKline Biologicals SA | Immunisation of large mammals with low doses of rna |
| BR112013000244A2 (pt) | 2010-07-06 | 2016-05-17 | Novartis Ag | lipossomas com lipídeos apresentando pka vantajoso para administração de rna |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| MX341989B (es) * | 2010-08-31 | 2016-09-09 | Novartis Ag * | Liposomas pequeños para el suministro de arn que codifica el inmunogeno. |
| RS63315B1 (sr) | 2010-08-31 | 2022-07-29 | Glaxosmithkline Biologicals Sa | Pegilovani lipozomi za isporuku rnk koja kodira imunogen |
| EP3431485B2 (en) | 2010-10-01 | 2024-09-04 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| CA2814386C (en) | 2010-10-11 | 2019-08-20 | Novartis Ag | Antigen delivery platforms |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| US20140206753A1 (en) | 2011-06-08 | 2014-07-24 | Shire Human Genetic Therapies, Inc. | Lipid nanoparticle compositions and methods for mrna delivery |
| EP4115875A1 (en) | 2011-07-06 | 2023-01-11 | GlaxoSmithKline Biologicals S.A. | Liposomes having useful n:p ratio for delivery of rna molecules |
| CA2840989A1 (en) | 2011-07-06 | 2013-01-10 | Novartis Ag | Immunogenic combination compositions and uses thereof |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| WO2013143555A1 (en) | 2012-03-26 | 2013-10-03 | Biontech Ag | Rna formulation for immunotherapy |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| AU2013243949A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of biologics and proteins associated with human disease |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| EP2885419A4 (en) | 2012-08-14 | 2016-05-25 | Moderna Therapeutics Inc | ENZYMES AND POLYMERASES FOR RNA SYNTHESIS |
| CA2892529C (en) | 2012-11-26 | 2023-04-25 | Moderna Therapeutics, Inc. | Terminally modified rna |
| AU2014204826A1 (en) * | 2013-01-10 | 2015-07-09 | Seqirus UK Limited | Influenza virus immunogenic compositions and uses thereof |
| US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| WO2014152211A1 (en) | 2013-03-14 | 2014-09-25 | Moderna Therapeutics, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| HUE042072T2 (hu) | 2013-03-15 | 2019-06-28 | Glaxosmithkline Biologicals Sa | Eljárások RNS tisztítására |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| EP3041934A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EA201690675A1 (ru) | 2013-10-03 | 2016-08-31 | Модерна Терапьютикс, Инк. | Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности |
| KR102507624B1 (ko) | 2013-11-22 | 2023-03-09 | 미나 테라퓨틱스 리미티드 | Ｃ/ｅｂｐ 알파 짧은 활성화 ｒｎａ 조성물 및 사용 방법 |
| US10842859B2 (en) | 2014-03-25 | 2020-11-24 | Yale University | Uses of parasite macrophage migration inhibitory factors |
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- 2012-07-06 EP EP12738679.5A patent/EP2729126B1/en not_active Revoked
- 2012-07-06 US US14/130,748 patent/US20140141070A1/en not_active Abandoned
- 2012-07-06 CA CA2840977A patent/CA2840977A1/en not_active Abandoned
- 2012-07-06 EP EP20214948.0A patent/EP3821879A1/en not_active Withdrawn
- 2012-07-06 EP EP22192474.9A patent/EP4115876A1/en active Pending
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- 2012-07-06 CN CN201280033241.5A patent/CN103764121A/zh active Pending
- 2012-07-06 RU RU2014104090/10A patent/RU2014104090A/ru not_active Application Discontinuation
- 2012-07-06 SG SG10201605537XA patent/SG10201605537XA/en unknown
- 2012-07-06 ES ES12738679T patent/ES2861428T3/es active Active
- 2012-07-06 JP JP2014519084A patent/JP2014520806A/ja active Pending
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- 2012-07-06 MX MX2014000053A patent/MX350764B/es active IP Right Grant
- 2012-07-06 BR BR112014000236A patent/BR112014000236A2/pt not_active Application Discontinuation
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2016
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2019
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Also Published As
| Publication number | Publication date |
|---|---|
| SG10201605537XA (en) | 2016-09-29 |
| MX350764B (es) | 2017-09-18 |
| ES2861428T3 (es) | 2021-10-06 |
| BR112014000236A2 (pt) | 2017-02-14 |
| US20200113831A1 (en) | 2020-04-16 |
| JP2014520806A (ja) | 2014-08-25 |
| RU2014104090A (ru) | 2015-08-20 |
| EP4115876A1 (en) | 2023-01-11 |
| EP3821879A1 (en) | 2021-05-19 |
| EP4115875A1 (en) | 2023-01-11 |
| JP2017002088A (ja) | 2017-01-05 |
| US20140141070A1 (en) | 2014-05-22 |
| EP2729126B1 (en) | 2020-12-23 |
| EP4014966A1 (en) | 2022-06-22 |
| MX2014000053A (es) | 2014-04-30 |
| EP2729126A1 (en) | 2014-05-14 |
| CA2840977A1 (en) | 2013-01-10 |
| WO2013006825A1 (en) | 2013-01-10 |
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