CN103750334A - 一种高效吸收的纳米级分散冬虫夏草泡腾片 - Google Patents
一种高效吸收的纳米级分散冬虫夏草泡腾片 Download PDFInfo
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Abstract
本发明公开一种纳米级分散冬虫夏草粉体泡腾片,其特征在于冬虫夏草粉体中所含1000纳米以下的冬虫夏草颗粒不少于30%,泡腾片重量份的组分为:纳米级冬虫夏草菌丝粉1-20份,稀释剂10-100份,崩解剂10-40份,润滑剂0.5-2份,甜味剂1-10份,植物酶解粉20-40份,所述稀释剂为α-糊精或者β-糊精,崩解剂为碳酸氢钠和柠檬酸,润滑剂为硬脂酸镁,甜味剂为蔗糖或其它甜味剂。本发明泡腾片利用纳米级冬虫夏草粉制成,大大提高了有效成分的吸收率;本发明产品兼具冬虫夏草粉营养特性,具备抗衰老、抗氧化、提高肌体免疫能力等功效;本发明泡腾片具有携带便利、方便饮用和适合各类体质的人群食用的特点。
Description
技术领域
本发明涉及一种保健饮料产品及其制作方法,特别是一种高效吸收的纳米级分散冬虫夏草泡腾片,属于医药保健品领域。
背景技术
冬虫夏草为冬虫夏草菌寄生在蝠蛾属昆虫幼虫子座和幼虫尸体的干燥复合体,该药始载于清代的《本草从新》,据《中国药典》2010年版记载,其性甘味平,归肺、肾经;补肾益肺,止血化痰。用于肾虚精亏,阳痿遗精,腰膝酸痛,久咳虚喘,劳嗽咯血。
研究发现冬虫夏草具有医药作用和食疗作用两大作用以及调节免疫系统功能、直接抗肿瘤作用、抗疲劳、调节心脏功能、调节肝脏功能、调节呼吸系统功能、调节肾脏功能、调节造血功能、调节血脂、调节性功能等十大功效。
冬虫夏草长期以来采用药膳、药酒、泡水等服用方式,不仅不适应现代快节奏生活方式,而且有效成分的利用率低下。为提高冬虫夏草利用率和药效,充分利用冬虫夏草的营养保健特性,发挥其抗衰老、抗氧化、提高肌体免疫能力等功效,国内外已开发了冬虫夏草的粉剂、颗粒剂、胶囊剂和片剂等制剂。
冬虫夏草固体制剂生产时首先需要低温粉碎制成冬虫夏草微粉,超微粉碎技术是近年来兴起的一种新型物料加工技术。冬虫夏草的超微粉碎不以粉体的细度为目的,而是追求细胞的破壁率,是以生物细胞破壁为目的的纯物理粉体作业。超微粉碎后的冬虫夏草微粉半径很小,表面积相应增大,有利于其有效成分的溶出和吸收。超微粉碎破壁的冬虫夏草微粉的有效成分更易于在人体消化环境内释放,小剂量冬虫夏草微粉即可达到大剂量冬虫夏草的药效。
中国专利CN102631377(2012-08-15)公开一种冬虫夏草冻干纳米粉片及其制备方法;中国专利CN102824376(2012-12-19)公开一种冬虫夏草粉及其制备方法与它的用途;中国专利CN103040877(2013-04-17)公开一种冬虫夏草微粉含片的制备方法;中国专利CN103417582(2013-12-04)公开一种冬虫夏草纯粉片及其制备方法。以上专利生产的冬虫夏草粉剂存在的主要问题是应用不够方便,而冬虫夏草片剂溶解速度低和溶出度不高,功能起效比较缓慢。
中国专利CN102960818(2013-03-13)公开一种山碴红枣板蓝根泡腾片的制备方法;通过添加冬虫夏草菌丝粉及山碴粉可以提高产品的营养价值,增加产品功能性;中国专利CN103283838(2013-09-11)公开一种含有冬虫夏草的酸奶泡腾片,口味良好,营养丰富且携带方便,只需60℃的温热水即可冲泡成酸奶。以上专利利用泡腾技术解决了产品的快速溶解问题,但存在的主要问题是添加的辅料比例过高,产品价值低,大量食用辅料存在影响冬虫夏草的贮存稳定性,添加的冬虫夏草没有进行超微粉碎破壁,不能充分发挥其疗效。
发明内容
泡腾片是含有泡腾崩解剂的一种片剂。所谓泡腾崩解剂通常是有机酸和碳酸盐、碳酸氢盐的混合物;泡腾片本身干燥不含水分,泡腾崩解剂中的两种物质未电离不能发生反应;但当泡腾片放入水中之后,两种物质发生酸碱反应,产生大量气泡,使片剂迅速崩解和融化,有时崩解产生的气泡还会使药片在水中上下翻滚,加速其崩解和融化。片剂崩解时产生的二氧化碳部分溶解于饮水中,喝入口中时有汽水般的美感。
本发明的目的是提供一种高效吸收的纳米级分散冬虫夏草泡腾片,冬虫夏草粉体中所含1000纳米以下的冬虫夏草颗粒不少于30%,泡腾片按重量份的组分为:纳米级冬虫夏草菌丝粉1-20份,稀释剂10-100份,崩解剂10-40份,润滑剂0.5-2份,甜味剂1-10份,植物酶解粉20-40份;其中稀释剂为α-淀粉酶或者p-淀粉酶,崩解剂为碳酸氢钠和柠檬酸,润滑剂为硬脂酸镁。甜味剂为蔗糖、葡萄糖、赤醉糖醇、木糖醇。植物酶解粉为α-淀粉酶或p-淀粉酶。
本发明的另一目的是提供一种高效吸收的纳米级分散冬虫夏草泡腾片的制备方法,采取的技术方案和具体步骤是:
(1)将纳米级冬虫夏草粉体与植物酶解粉、稀释剂、甜味剂水溶均质;
(2)混合均匀后加入不锈钢筒中,通过胶体磨粉碎,胶体磨操作条件为:调整胶体磨定子与转子的间隙为0. 1-2微米,胶体磨流量为1-2吨/小时;
(3)取冬虫夏草菌丝纳米粉、植物酶解粉与稀释剂、甜味剂混合均匀,加入食用酒精湿润制得复合软性材料;
(4)采用常规喷雾干燥,冷冻干燥等干燥形式造粒干燥,;
(5)加入崩解剂、润滑剂混合均匀;
(6)压片成型。
本发明的优点和有益效果体现在:
(1)本发明泡腾片利用纳米级冬虫夏草粉制成,大大提高了有效成分的吸收率;
(2)本发明泡腾片崩解快速、服用方便、起效迅速、生物利用度高,提高临床疗效;
(3)本发明泡腾片具有携带便利、方便饮用和适合各类体质的人群食用的特点。
具体实施方式
实施例1
纳米级冬虫夏草粉体泡腾片由以下重量份的组分制成: 纳米级冬虫夏草菌丝粉2份,稀释剂10份,崩解剂10份,润滑剂0. 5份,甜味剂5份,植物酶解粉20份。以上所述稀释剂为α-淀粉酶或p-淀粉酶,崩解剂为碳酸氢钠和柠檬酸,润滑剂为硬脂酸镁,甜味剂为蔗糖或赤醉糖醇。
本发明泡腾片的制备方法为:(1)取纳米级冬虫夏草粉体2份与稀释剂10份、甜味剂5份混合均匀后,加入食用酒精湿润,制成软材混合均匀;(2)加入不锈钢筒中,通过胶体磨,胶体磨操作条件为:调整胶体磨定子与转子的间隙为0. 1-2微米,胶体磨流量为1-2吨/小时;(3)造粒,干燥,整粒,干燥采用常规喷雾干燥,冷冻干燥等干燥形式;(4)加入崩解剂10份、润滑剂0. 5份、植物酶解粉20份混合均匀后,压片成型。
实施例2
纳米级冬虫夏草粉体泡腾片由以下重量份的组分制成: 纳米级冬虫夏草菌丝粉2份,稀释剂10份,崩解剂10份,润滑剂0. 5份,甜味剂5份,植物酶解粉20份。
本发明泡腾片的制备方法为:(1)取纳米级冬虫夏草粉体2份与稀释剂10份、甜味剂5份混合均匀后,加入食用酒精湿润,制成软材混合均匀;(2)加入不锈钢筒中,通过胶体磨,胶体磨操作条件为:调整胶体磨定子与转子的间隙为0. 1-2微米,胶体磨流量为1-2吨/小时;(3)造粒,干燥,整粒,干燥采用常规喷雾干燥,冷冻干燥等干燥形式;(4)加入崩解剂10份、润滑剂0. 5份、植物酶解粉20份混合均匀后,压片成型。
实施例3
纳米级冬虫夏草粉体泡腾片由以下重量份的组分制成: 纳米级冬虫夏草菌丝粉3份,稀释剂15份,崩解剂15份,润滑剂1份,甜味剂10份,植物酶解粉25份。
本发明泡腾片的制备方法为:(1)取纳米级冬虫夏草粉体2份与稀释剂10份、甜味剂5份混合均匀后,加入食用酒精湿润,制成软材混合均匀;(2)加入不锈钢筒中,通过胶体磨,胶体磨操作条件为:调整胶体磨定子与转子的间隙为0. 1-2微米,胶体磨流量为1-2吨/小时;(3)造粒,干燥,整粒,干燥采用常规喷雾干燥,冷冻干燥等干燥形式;(4)加入崩解剂10份、润滑剂0. 5份、植物酶解粉20份混合均匀后,压片成型。
实施例4
纳米级冬虫夏草粉体泡腾片由以下重量份的组分制成: 纳米级冬虫夏草菌丝粉4份,稀释剂20份,崩解剂15份,润滑剂1份,甜味剂10份,植物酶解粉25份。
本发明泡腾片的制备方法为:(1)取纳米级冬虫夏草粉体2份与稀释剂10份、甜味剂5份混合均匀后,加入食用酒精湿润,制成软材混合均匀;(2)加入不锈钢筒中,通过胶体磨,胶体磨操作条件为:调整胶体磨定子与转子的间隙为0. 1-2微米,胶体磨流量为1-2吨/小时;(3)造粒,干燥,整粒,干燥采用常规喷雾干燥,冷冻干燥等干燥形式;(4)加入崩解剂10份、润滑剂0. 5份、植物酶解粉20份混合均匀后,压片成型。
实施例5
纳米级冬虫夏草粉体泡腾片由以下重量份的组分制成: 纳米级冬虫夏草菌丝粉5份,稀释剂20份,崩解剂20份,润滑剂2份,甜味剂10份,植物酶解粉30份。
本发明泡腾片的制备方法为:(1)取纳米级冬虫夏草粉体2份与稀释剂10份、甜味剂5份混合均匀后,加入食用酒精湿润,制成软材混合均匀;(2)加入不锈钢筒中,通过胶体磨,胶体磨操作条件为:调整胶体磨定子与转子的间隙为0. 1-2微米,胶体磨流量为1-2吨/小时;(3)造粒,干燥,整粒,干燥采用常规喷雾干燥,冷冻干燥等干燥形式;(4)加入崩解剂10份、润滑剂0. 5份、植物酶解粉20份混合均匀后,压片成型。
实施例6
纳米级冬虫夏草粉体泡腾片,其特征在于,由以下重量份的组分制成: 纳米级冬虫夏草菌丝粉8份,稀释剂20份,崩解剂30份,润滑剂2份,甜味剂10份,植物酶解粉30份。
本发明泡腾片的制备方法为:(1)取纳米级冬虫夏草粉体2份与稀释剂10份、甜味剂5份混合均匀后,加入食用酒精湿润,制成软材混合均匀;(2)加入不锈钢筒中,通过胶体磨,胶体磨操作条件为:调整胶体磨定子与转子的间隙为0. 1-2微米,胶体磨流量为1-2吨/小时;(3)造粒,干燥,整粒,干燥采用常规喷雾干燥,冷冻干燥等干燥形式;(4)加入崩解剂10份、润滑剂0. 5份、植物酶解粉20份混合均匀后,压片成型。
实施例7
纳米级冬虫夏草粉体泡腾片,其特征在于,由以下重量份的组分制成: 纳米级冬虫夏草菌丝粉10份,稀释剂40份,崩解剂30份,润滑剂2份,甜味剂10份,植物酶解粉30份。
本发明泡腾片的制备方法为:(1)取纳米级冬虫夏草粉体2份与稀释剂10份、甜味剂5份混合均匀后,加入食用酒精湿润,制成软材混合均匀;(2)加入不锈钢筒中,通过胶体磨,胶体磨操作条件为:调整胶体磨定子与转子的间隙为0. 1-2微米,胶体磨流量为1-2吨/小时;(3)造粒,干燥,整粒,干燥采用常规喷雾干燥,冷冻干燥等干燥形式;(4)加入崩解剂10份、润滑剂0. 5份、植物酶解粉20份混合均匀后,压片成型。
实施例8
纳米级冬虫夏草粉体泡腾片,其特征在于,由以下重量份的组分制成: 纳米级冬虫夏草菌丝粉15份,稀释剂50份,崩解剂30份,润滑剂2份,甜味剂10份,植物酶解粉30份。
本发明泡腾片的制备方法为:(1)取纳米级冬虫夏草粉体2份与稀释剂10份、甜味剂5份混合均匀后,加入食用酒精湿润,制成软材混合均匀;(2)加入不锈钢筒中,通过胶体磨,胶体磨操作条件为:调整胶体磨定子与转子的间隙为0. 1-2微米,胶体磨流量为1-2吨/小时;(3)造粒,干燥,整粒,干燥采用常规喷雾干燥,冷冻干燥等干燥形式;(4)加入崩解剂10份、润滑剂0. 5份、植物酶解粉20份混合均匀后,压片成型。
实施例9
纳米级冬虫夏草粉体泡腾片,其特征在于,由以下重量份的组分制成: 纳米级冬虫夏草菌丝粉18份,稀释剂70份,崩解剂30份,润滑剂2份,甜味剂10份,植物酶解粉35份。
本发明泡腾片的制备方法为:(1)取纳米级冬虫夏草粉体2份与稀释剂10份、甜味剂5份混合均匀后,加入食用酒精湿润,制成软材混合均匀;(2)加入不锈钢筒中,通过胶体磨,胶体磨操作条件为:调整胶体磨定子与转子的间隙为0. 1-2微米,胶体磨流量为1-2吨/小时;(3)造粒,干燥,整粒,干燥采用常规喷雾干燥,冷冻干燥等干燥形式;(4)加入崩解剂10份、润滑剂0. 5份、植物酶解粉20份混合均匀后,压片成型。
实施例10
纳米级冬虫夏草粉体泡腾片,其特征在于,由以下重量份的组分制成: 纳米级冬虫夏草菌丝粉20份,稀释剂100份,崩解剂40份,润滑剂2份,甜味剂10份,植物酶解粉40份。
本发明泡腾片的制备方法为:(1)取纳米级冬虫夏草粉体2份与稀释剂10份、甜味剂5份混合均匀后,加入食用酒精湿润,制成软材混合均匀;(2)加入不锈钢筒中,通过胶体磨,胶体磨操作条件为:调整胶体磨定子与转子的间隙为0. 1-2微米,胶体磨流量为1-2吨/小时;(3)造粒,干燥,整粒,干燥采用常规喷雾干燥,冷冻干燥等干燥形式;(4)加入崩解剂10份、润滑剂0. 5份、植物酶解粉20份混合均匀后,压片成型。
Claims (5)
1.一种纳米级分散冬虫夏草粉体泡腾片,其特征在于冬虫夏草粉体中所含1000纳米以下的冬虫夏草颗粒不少于30%,泡腾片按重量份的组分为:纳米级冬虫夏草菌丝粉1~20份,稀释剂10~100份,崩解剂10~40份,润滑剂0.5~2份,甜味剂1~10份,植物酶解粉20~40份;其中稀释剂为α-淀粉酶或者p-淀粉酶,崩解剂为碳酸氢钠和柠檬酸,润滑剂为硬脂酸镁。
2.如权利要求1所述纳米级分散冬虫夏草粉体泡腾片,其特征在于甜味剂为蔗糖、葡萄糖、赤醉糖醇、木糖醇。
3.如权利要求1所述纳米级分散冬虫夏草粉体泡腾片,其特征在于植物酶解粉为α-淀粉酶或p-淀粉酶。
4.如权利要求1所述的纳米级分散冬虫夏草粉体泡腾片,其特征在于由以下重量份的组分制成:纳米级冬虫夏草菌丝粉2份,稀释剂10份,崩解剂10份,润滑剂0.5份,甜味剂5份,植物酶解粉20份。
5.一种权利要求1所述的纳米级分散冬虫夏草粉体泡腾片的制备方法,其特征在于制备方法包括以下步骤:
(1)将纳米级冬虫夏草粉体与植物酶解粉、稀释剂、甜味剂水溶均质;
(2)混合均匀后加入不锈钢筒中,通过胶体磨粉碎,胶体磨操作条件为:调整胶体磨定子与转子的间隙为0. 1-2微米,胶体磨流量为1-2吨/小时;
(3)取冬虫夏草菌丝纳米粉、植物酶解粉与稀释剂、甜味剂混合均匀,加入食用酒精湿润制得复合软性材料;
(4)采用常规喷雾干燥,冷冻干燥等干燥形式造粒干燥,;
(5)加入崩解剂、润滑剂混合均匀;
(6)压片成型。
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