CN1037439C - 制备具有神经保护作用的吲哚酮及有关衍生物的方法 - Google Patents

制备具有神经保护作用的吲哚酮及有关衍生物的方法 Download PDF

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Publication number
CN1037439C
CN1037439C CN91103022A CN91103022A CN1037439C CN 1037439 C CN1037439 C CN 1037439C CN 91103022 A CN91103022 A CN 91103022A CN 91103022 A CN91103022 A CN 91103022A CN 1037439 C CN1037439 C CN 1037439C
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China
Prior art keywords
hydrogen
compound
hydroxy
ethyl acetate
product
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Expired - Fee Related
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CN91103022A
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English (en)
Chinese (zh)
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CN1056497A (zh
Inventor
伯特兰·L·钱纳德
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Pfizer Inc
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Pfizer Inc
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Publication of CN1037439C publication Critical patent/CN1037439C/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN91103022A 1990-05-10 1991-05-09 制备具有神经保护作用的吲哚酮及有关衍生物的方法 Expired - Fee Related CN1037439C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52233290A 1990-05-10 1990-05-10
US522,332 1990-05-10

Publications (2)

Publication Number Publication Date
CN1056497A CN1056497A (zh) 1991-11-27
CN1037439C true CN1037439C (zh) 1998-02-18

Family

ID=24080448

Family Applications (1)

Application Number Title Priority Date Filing Date
CN91103022A Expired - Fee Related CN1037439C (zh) 1990-05-10 1991-05-09 制备具有神经保护作用的吲哚酮及有关衍生物的方法

Country Status (30)

Country Link
US (1) US5306723A (https=)
EP (1) EP0554247B1 (https=)
JP (1) JPH0699423B2 (https=)
KR (1) KR0163355B1 (https=)
CN (1) CN1037439C (https=)
AT (1) ATE192149T1 (https=)
AU (1) AU642994B2 (https=)
BR (1) BR9106432A (https=)
CA (1) CA2080475C (https=)
CZ (1) CZ280560B6 (https=)
DE (1) DE69132141T2 (https=)
DK (1) DK0554247T3 (https=)
EG (1) EG19647A (https=)
ES (1) ES2146578T3 (https=)
FI (1) FI109121B (https=)
GR (1) GR3034005T3 (https=)
HU (1) HU221193B1 (https=)
IE (1) IE911569A1 (https=)
IL (1) IL98056A (https=)
MY (1) MY107799A (https=)
NO (1) NO301979B1 (https=)
PH (1) PH29902A (https=)
PL (1) PL169267B1 (https=)
PT (1) PT97602B (https=)
RU (1) RU2068414C1 (https=)
SK (1) SK280833B6 (https=)
TW (1) TW198720B (https=)
WO (1) WO1991017156A1 (https=)
YU (1) YU48528B (https=)
ZA (1) ZA913494B (https=)

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US6255322B1 (en) 1992-06-19 2001-07-03 Pfizer Inc. 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
US5436255A (en) * 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors
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ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610736B (en) 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
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GB9624611D0 (en) * 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
WO1998025924A1 (en) 1996-11-26 1998-06-18 Zeneca Limited 8-azabicyclo[3.2.1]octane-, 8-azabicyclo[3.2.1]oct-6-ene-, 9-azabicyclo[3.3.1]nonane-, 9-aza-3-oxabicyclo[3.3.1]nonane- and 9-aza-3-thiabicyclo[3.3.1]nonane derivatives, their preparation and their use as insecticides
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CA2220649C (en) 1996-12-03 2007-02-13 F. Hoffmann-La Roche Ag 4-hydroxy-piperidine derivatives
EP1173254A2 (en) * 1999-04-27 2002-01-23 Smithkline Beecham Plc Novel treatment of neurotraumatic conditions with a raf inhibitor
EP1235572A2 (en) 1999-10-29 2002-09-04 MERCK SHARP &amp; DOHME LTD. Method to treat pain utilizing benzimidazole nmda/nr2b antagonists
US6291499B1 (en) 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
US6380205B1 (en) 1999-10-29 2002-04-30 Merck & Co., Inc. 2-cyclohexyl quinazoline NMDA/NR2B antagonists
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
US6316474B1 (en) 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
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JPS51118772A (en) * 1975-04-09 1976-10-18 Otsuka Pharmaceut Co Ltd Method for preparing carbostyryl derivatives
EP0351282A1 (fr) * 1988-07-12 1990-01-17 Synthelabo Dérivés de (hydroxy-1 pipéridinyl-2 alkyl)indolones-2, quinoléinones-2, benzo[b]azépinones-2, benzimidazolones-2 et quinazolinones-2, leur préparation et leur application en thérapeutique

Also Published As

Publication number Publication date
MY107799A (en) 1996-06-29
EG19647A (en) 1995-08-30
AU642994B2 (en) 1993-11-04
ES2146578T3 (es) 2000-08-16
NO924310D0 (no) 1992-11-09
PT97602A (pt) 1992-02-28
US5306723A (en) 1994-04-26
IL98056A (en) 1995-11-27
KR930700482A (ko) 1993-03-15
BR9106432A (pt) 1993-05-04
DE69132141T2 (de) 2000-09-21
CN1056497A (zh) 1991-11-27
KR0163355B1 (ko) 1998-12-01
WO1991017156A1 (en) 1991-11-14
FI925069A0 (fi) 1992-11-09
EP0554247B1 (en) 2000-04-26
RU2068414C1 (ru) 1996-10-27
PT97602B (pt) 1998-08-31
HUT62879A (en) 1993-06-28
IE911569A1 (en) 1991-11-20
CA2080475C (en) 2001-04-17
IL98056A0 (en) 1992-06-21
SK280833B6 (sk) 2000-08-14
ATE192149T1 (de) 2000-05-15
JPH05506433A (ja) 1993-09-22
EP0554247A1 (en) 1993-08-11
YU48528B (sh) 1998-11-05
FI925069L (fi) 1992-11-09
HU221193B1 (en) 2002-08-28
CA2080475A1 (en) 1991-11-11
ZA913494B (en) 1992-12-30
CZ280560B6 (cs) 1996-02-14
PL169267B1 (pl) 1996-06-28
TW198720B (https=) 1993-01-21
HU9203515D0 (en) 1993-01-28
CS135491A3 (en) 1992-05-13
NO924310L (no) 1992-11-09
JPH0699423B2 (ja) 1994-12-07
GR3034005T3 (en) 2000-11-30
DK0554247T3 (da) 2000-08-07
FI109121B (fi) 2002-05-31
AU7456591A (en) 1991-11-27
DE69132141D1 (de) 2000-05-31
PH29902A (en) 1996-09-16
YU81091A (sh) 1993-11-16
NO301979B1 (no) 1998-01-05

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