CN103720633A - Tremella aurantialba extract and hyaluronic acid composition, and its application in cosmetics - Google Patents
Tremella aurantialba extract and hyaluronic acid composition, and its application in cosmetics Download PDFInfo
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Abstract
The invention discloses a composition containing a Tremella aurantialba extract and hyaluronic acid, and an application of the composition in cosmetics. The cosmetics are selected from moisture retention cosmetics, anti-inflammatory cosmetics having a moisture retention efficacy, anti-ageing cosmetics having a moisture retention efficacy, or whitening cosmetics having a moisture retention efficacy. The Tremella aurantialba extract and hyaluronic acid composition can be directly used for the moisture retention of skins, and can also be added to the cosmetics as a function additive.
Description
Technical field
The present invention relates to Natural Medicine Chemistry field and cosmetic field, be specifically related to a kind of Tremella aurantialba Bandoni et Zang extract for moisturizing and hyaluronic combination, its preparation method and the application in cosmetics thereof.The invention still further relates to the cosmetic composition that comprises Tremella aurantialba Bandoni et Zang extract and hyaluronic combination.
Background technology
Skin is consisted of epidermis, corium and subcutaneus adipose tissue, and every layer all contains moisture.The number of moisture content of skin is tender, plentiful, the glossy and whether soft key of skin.The infant skin water content amount higher position delicate gloss that seems, old people's skin is because water content is lower, so seem dry, flat, the desquamation that withers, wrinkle occurs even.
Moisturizing is eternal theme, is the essential condition that guarantees skin health, slow down aging, and the wetting agent of developmental research excellent performance is the target that people seek assiduously.
On the one hand with age, skin moisture-keeping mechanism sustains damage, and skin tissue cell and intercellular moisture reduce, and when horny layer moisture drops to 10% when following, that skin will seem is dry, follow the string, wrinkling, acceleration skin aging.Skin suffers the infringements such as sweltering heat, cold, wind, cleaning agent, ultraviolet radiation on the other hand, and it is drier that top layer can become.Therefore how to keep the moisture of skin, reduce moisture loss very important.Skin moisturizer mainly comprises sealer, hygroscopic agent, hydrophilic matrix, preventing light agent and some special adding ingredients in the market.
Traditional medicine thinks, xerosis cutis is lung renal dysfunction, water liquid metabolic imbalance, and the not flourish skin of body fluid, therefore the road of skin moistening is invigorating the lung and the kidney, nourishing body fluid.In Chinese medicine document, also there is the record of skin-moisturizing, skin, and compiled Chinese medicine beauty treatment prescription, from theory into action, be all described.Some modern studies are set forth to some extent to the effect of polysaccharide component in recent years, the height water absorption of polysaccharide and good film property are perfectly in conjunction with reaching good moistening effect, be applied to just gradually skin moisture-keeping, and polysaccharide is also the contained main component of most edible fungi, these have all brought bright prospect for we find skin moisturizer safely and effectively.
China's Chinese medicine aboundresources, provides the foundation for we find superior moisturizing additive.Ancient medical book is recorded: Tremella aurantialba Bandoni et Zang, sweet in the mouth, property are flat, YIN nourishing, lung moistening, promote the production of body fluid, supplementing the brain; Cure mainly cough due to consumptive disease, hemoptysis, pulmonary tuberculosis.Tremella aurantialba Bandoni et Zang (Tremella aurantialba Bandoni et Zang), is Mycophyta door fungus, claims again Tremella mesenterica Retz ex Fr., luxuriant Ruo Seerbu (Tibetan language), golden yellow Tremella, yellow ear, brain ear.Tremella aurantialba Bandoni et Zang is a kind of Tibetan medicine, cures mainly Pulmonary Diseases.Tremella aurantialba Bandoni et Zang contains golden fungus polysaccharides, each seed amino acid, vitamin B group etc.Modern medicine research shows: Tremella aurantialba Bandoni et Zang is improved function of nervous system, adjusting body cell physiologically active, blood fat reducing, the liver protecting, raising hemopoietic function, improves the effects such as immunity.Tremella aurantialba Bandoni et Zang is a kind of edible fungi more precious than Tremella, and because yielding poorly, expensive, application person is less, knows that its person is also less.
Hyaluronic acid is a kind of acid mucopolysaccharide, and first the ophthalmology professor Meyer of Columbia Univ USA in 1934 etc. isolate this material from bovine vitreous body.Hyaluronic acid demonstrates multiple important physiological function with its unique molecular structure and physicochemical property in body, as lubricated joint, regulates the permeability of blood vessel wall, regulates protein, and Water-Electrolyte diffusion and running, promote wound healing etc.
The present invention in cosmetics, provides moisture-keeping efficacy by Tremella aurantialba Bandoni et Zang extract and hyaluronic applied in any combination, helps skin to resist dry environment, prevents moisture loss, moisturizing skin Caring.
Summary of the invention
The object of the present invention is to provide a kind of Tremella aurantialba Bandoni et Zang extract and hyaluronic compositions of comprising.In one embodiment, in described compositions, Tremella aurantialba Bandoni et Zang extract and hyaluronic weight ratio are 1:1.
The present invention also aims to provide a kind of Tremella aurantialba Bandoni et Zang extract and hyaluronic combination with moisture-keeping function, can be directly used in skin moisture-keeping.Tremella aurantialba Bandoni et Zang extract and hyaluronic combination also can be used as functional additive and join in cosmetics and use.
Tremella aurantialba Bandoni et Zang extract and hyaluronic combination have moisture-keeping efficacy, can help skin under dry environment, to resist dry damage.Tremella aurantialba Bandoni et Zang extract and hyaluronic combination are used for to cosmetics, there is the effect of moisturizing skin Caring, make skin honorable moist.
Tremella aurantialba Bandoni et Zang is applied to food and medicine field mostly at present.Hyaluronic acid is a kind of macromolecule mucopolysaccharide that is construction unit by D-N-acetylglucosamine and D-Glucose aldehydic acid, and it has fabulous moisture-keeping function, is called as desirable nature moisturizing factor.But the inventor is through research discovery, Tremella aurantialba Bandoni et Zang extract and hyaluronic combination have cooperative effect.In one embodiment, Tremella aurantialba Bandoni et Zang extract dry powder and the hyaluronate sodium dry powder consumption that reduces by half is respectively mixed and used, the moisture absorption of compositions and moistening effect are all better than the two situation about using separately.Both combinations have remarkable skin Caring effect, can resist the moisture loss under dry environment, to reach moisture-keeping efficacy.
Therefore, an object of the present invention is to provide Tremella aurantialba Bandoni et Zang extract and the hyaluronic application being combined in cosmetics.Specifically, the object of this invention is to provide Tremella aurantialba Bandoni et Zang extract and hyaluronic being combined in for the preparation of the application in the cosmetics of moisturizing.
According to of the present invention one preferred embodiment, described cosmetics can be selected from: moisture-keeping cosmetics, have the anti-inflammatory cosmetics of moisture-keeping efficacy, have the anti-aging cosmetics of moisture-keeping efficacy or have the skin-lightening cosmetic of moisture-keeping efficacy.
According to of the present invention one preferred embodiment, described cosmetics can be following forms: fancy soap, cleansing milk, bath gel, toner/smoothing toner, skin protection gel, facial treatment milk, protective skin cream, essence, eye cream, facial film, aerosol or Sprayable.
According to of the present invention one preferred embodiment, described cosmetics also comprise the acceptable adjuvant of cosmetic field.According to of the present invention one preferred embodiment, the acceptable adjuvant of described cosmetic field is selected from: solvent, solubilizing agent, antiseptic, antioxidant, pH adjusting agent, penetrating agent, liposome, wetting agent, thickening agent, chelating agen, skinfeel regulator, surfactant, emulsifying agent, propelling/propellant, essence, pigment, and other functional additives.
Preferred embodiment in Tremella aurantialba Bandoni et Zang extract and hyaluronic combination, Tremella aurantialba Bandoni et Zang extract and hyaluronic weight ratio are 1:5 to 5:1 according to one of the present invention, and more preferably weight ratio is 1:2 to 2:1, and most preferably weight ratio is 1:1.
The Tremella aurantialba Bandoni et Zang extract obtaining prepared according to the methods of the invention and hyaluronic combination can be directly used in skin moisture-keeping, also can be used as functional additive and join in cosmetics and use.Therefore, according to another object of the present invention, the invention provides a kind of cosmetic composition, described compositions contains Tremella aurantialba Bandoni et Zang extract and hyaluronic combination and the acceptable adjuvant of cosmetic field.
The acceptable adjuvant of described cosmetic field can be selected from: solvent, solubilizing agent, antiseptic, antioxidant, pH adjusting agent, penetrating agent, liposome, wetting agent, thickening agent, chelating agen, skinfeel regulator, surfactant, emulsifying agent, propelling/propellant, essence, pigment, and other functional additives.
According to of the present invention one preferred embodiment, described compositions can be fancy soap, cleansing milk, bath gel, toner/smoothing toner, skin protection gel, facial treatment milk, protective skin cream, essence, eye cream, facial film, aerosol or Sprayable.These forms can be prepared by method well known to those skilled in the art.
Tremella aurantialba Bandoni et Zang extract of the present invention can be extracted and be obtained by method well known to those skilled in the art, and for example, depletion ear is appropriate, with suitable solvent, soaks, and with suitable extracting method, extracts, and filters and obtains supernatant liquid.
According to of the present invention one preferred embodiment, suitable solvent is mainly water (comprising distilled water, deionized water etc.) or organic solvent (preferably alcohols and esters solvent); Suitable extraction and purification process be selected from following one or more: lixiviate, decoction, backflow, supercritical, precipitate with ethanol, extraction, membrance separation and column chromatography.
Tremella aurantialba Bandoni et Zang extract and hyaluronic combination have moisture-keeping efficacy, can give skin keratin cell good moisture-keeping function, help skin to keep moisture.After adding in cosmetics, there is the effect of moisturizing skin Caring, make skin honorable moist.
Accompanying drawing explanation
Fig. 1 has shown dry wettability power comparative result.
Fig. 2 has shown the comparative result of moisture-retaining capacity.
The specific embodiment
Unless otherwise defined, all technology used herein and scientific terminology have the common identical meanings of understanding of one skilled in the art of the present invention.Although can be used for implementing or testing the present invention to any method and material similar or that be equal to described herein, described herein is preferred method and material.For object of the present invention, defined following term below.
Term " about " used herein refers to compare with quantity, level, numerical value, dimension, size or the consumption of reference product, and difference can be up to 30%, 20% or 10% quantity, level, numerical value, dimension, size or consumption.
In full piece of writing description and claims, Unless Otherwise Requested, following word " comprises " and its variant " contains " and " comprising " is interpreted as meaning comprising described integral body or step, or one group of integral body or step, but do not get rid of any other integral body or step, or other one group of integral body or step.
According to the present invention, term " Tremella aurantialba Bandoni et Zang extract " refers to the extract that contains effective ingredient extracting from Tremella aurantialba Bandoni et Zang by any appropriate ways.
According to the present invention, term " cosmetics " refers to smear, sprays or other similar approach, intersperse among any position of human body surface, as skin, hair, refer to toenail, lips and teeth etc., to reach clean, maintain, improve looks, modify and to change outward appearance, or correction human scent, maintains a good state as chemical industrial product or the fine chemical product of object.According in the preferred embodiment of the present invention, described cosmetics comprise: moisture-keeping cosmetics, there are the anti-inflammatory cosmetics of moisture-keeping efficacy, and defying age or the skin-lightening cosmetic with moisture-keeping efficacy.
The present invention also provides a kind of cosmetic composition, and described compositions contains Tremella aurantialba Bandoni et Zang extract and hyaluronic combination and the acceptable adjuvant of cosmetic field.Described " the acceptable adjuvant of cosmetic field " can be selected from: solvent, solubilizing agent, antiseptic, antioxidant, pH adjusting agent, penetrating agent, liposome, wetting agent, thickening agent, chelating agen, skinfeel regulator, surfactant, emulsifying agent, propelling/propellant, essence, pigment, and other functional additives.
According in the preferred embodiment of the present invention, described cosmetic composition can be the forms such as fancy soap, cleansing milk, bath gel, toner/smoothing toner, skin protection gel, facial treatment milk, protective skin cream, essence, eye cream, facial film, aerosol or spraying.These forms of cosmetic composition can be prepared by method well known to those skilled in the art.
Tremella aurantialba Bandoni et Zang (Tremella aurantialba Bandoni et Zang), is Mycophyta door fungus, claims again Tremella mesenterica Retz ex Fr., luxuriant Ruo Seerbu (Tibetan language), golden yellow Tremella, yellow ear, brain ear.Tremella aurantialba Bandoni et Zang is a kind of Tibetan medicine, cures mainly Pulmonary Diseases.Tremella aurantialba Bandoni et Zang contains golden fungus polysaccharides, each seed amino acid, vitamin B group etc.Modern medicine research shows: Tremella aurantialba Bandoni et Zang is improved function of nervous system, adjusting body cell physiologically active, blood fat reducing, the liver protecting, raising hemopoietic function, improves the effects such as immunity.Tremella aurantialba Bandoni et Zang is a kind of edible fungi more precious than Tremella, and because yielding poorly, expensive, application person is less, knows that its person is also less.
Hyaluronic acid (Hyaluronic acid) is a kind of macromolecule mucopolysaccharide that is construction unit by D-N-acetylglucosamine and D-Glucose aldehydic acid, and commodity hyaluronic acid is generally its sodium salt, i.e. hyaluronate sodium (Sodium Hyaluronate).Hyaluronic acid is the bio-molecules extensively existing in skin and other tissue, there is fabulous moisture-keeping function, be called as desirable nature moisturizing factor (Natural MolsturlZlng Factor, NMF), in cosmetics, the normal hyaluronate sodium that adds is to strengthen the moisture-keeping efficacy to skin.
The present inventor is surprised to find that: Tremella aurantialba Bandoni et Zang extract and hyaluronic combination have collaborative moisture-keeping efficacy, can be directly used in skin moisture-keeping, also can be used as functional additive and joins in cosmetic composition and use.The Tremella aurantialba Bandoni et Zang extract making according to the inventive method and hyaluronic combination, and the cosmetic composition that comprises Tremella aurantialba Bandoni et Zang extract and hyaluronic combination, can help skin under dry environment, to resist dry damage, and moisturizing skin Caring makes skin honorable moist.
And the present inventor is also surprised to find that: Tremella aurantialba Bandoni et Zang extract can significantly suppress the activity of hyaluronidase, and this inhibitory action is concentration dependence.Therefore, applicant thinks, adds Tremella aurantialba Bandoni et Zang extract in containing hyaluronic skin care item simultaneously, can protect hyaluronic acid not by enzymolysis, makes it to reside in for more time in skin, plays the cooperative effect of skin moisture-keeping.
In one embodiment, Tremella aurantialba Bandoni et Zang extract and hyaluronic weight ratio are 1:1 during use.If added in cosmetics as additive, in the gross weight of cosmetic composition, described cosmetic composition can comprise Tremella aurantialba Bandoni et Zang extract and the hyaluronic combination of 0.001-100%.
In document, all do not relate to Tremella aurantialba Bandoni et Zang extract and the hyaluronic application being combined in cosmetics, more not mentioned Tremella aurantialba Bandoni et Zang extract and hyaluronic combination have collaborative moistening effect.Therefore, the present invention proposes first Tremella aurantialba Bandoni et Zang extract and hyaluronic combination has moisture-keeping efficacy, can be used as in the cosmetic composition that functional additive adds moisturizing, helps skin under dry environment, to resist dry damage, moisturizing skin Caring.
Tremella aurantialba Bandoni et Zang extract of the present invention can be extracted and be obtained by method well known to those skilled in the art.For example, depletion ear is appropriate, with suitable solvent, soaks, and with suitable extracting method, extracts, and filters and obtains supernatant liquid.
According to of the present invention one preferred embodiment, suitable solvent is mainly water (comprising distilled water, deionized water etc.) or organic solvent (preferably alcohols and esters solvent); Suitable extraction and purification process be selected from following one or more: lixiviate, decoction, backflow, supercritical, precipitate with ethanol, extraction, membrance separation and column chromatography.
Below in conjunction with specific embodiment, further set forth the present invention.But, should be understood that these embodiment only do not form limitation of the scope of the invention for the present invention is described.The test method of unreceipted actual conditions in the following example, conventionally according to normal condition, or the condition of advising according to manufacturer.Except as otherwise noted, all percentage ratio and umber are by mass.
Embodiment 1
The Tremella aurantialba Bandoni et Zang of getting pulverizing is appropriate, in impouring extraction pot, adds 40 times of amounts (W/V) water, and fully stirring and evenly mixing is incubated lixiviate 2 hours under 60 ℃ of conditions, filters, and discards filtering residue, and filtrate is gained.
Embodiment 2
The Tremella aurantialba Bandoni et Zang of getting pulverizing is appropriate, in impouring extraction pot, adds 20 times of amounts (W/V) water, and fully stirring and evenly mixing is incubated lixiviate 2 hours under 80 ℃ of conditions, and discontinuity stirs, and extracts 2 times; Filter, discard filtering residue, merging filtrate, filtrate heating is concentrated into appropriate, places cooling.Slowly add while stirring 95% ethanol, making ethanol final concentration is 60～75%, standing over night.Filter, get supernatant, add ethyl acetate extraction 3 times, extract is flung to solvent, adds appropriate dissolve with ethanol.
Embodiment 3
The Tremella aurantialba Bandoni et Zang of getting pulverizing is appropriate, in impouring extraction pot, adds 20 times of amounts (W/V) water, and fully stirring and evenly mixing is incubated lixiviate 2 hours under 80 ℃ of conditions, and discontinuity stirs, and extracts 2 times; Filter, discard filtering residue, merging filtrate, filtrate heating is concentrated into appropriate, places cooling.Slowly add while stirring 95% ethanol, making ethanol final concentration is 60～75%, standing over night.Filter, get filtering residue and under reduced pressure, reclaim ethanol extremely without alcohol taste, residue adds suitable quantity of water to dissolve.
Embodiment 4
The Tremella aurantialba Bandoni et Zang of getting pulverizing is appropriate, in impouring extraction pot, adds 20 times of amounts (W/V) water, abundant stirring and evenly mixing, and 1 hour post-heating of merceration, to boiling, keeps micro-and boils 2 hours, extracts 2 times; Filter, discard filtering residue, merge 2 times filtrate, filtrate heating is concentrated into appropriate, the cooling rear centrifugal sediment that discards.Supernatant adds deionized water to mix in right amount, join in pretreated D101 macroporous resin column (purchased from Tianjin insecticide factory, preprocessing process: be dipped to for several times alcoholic solution with 95% ethanol and be clear, water rushes post extremely without ethanol taste again), first with distilled water, be eluted to closely colourlessly, then with 4 times of amount 50% ethanol elutions, collect ethanol elution, eluent concentrating under reduced pressure reclaims ethanol extremely without alcohol taste, and residual liquid adds suitable quantity of water to dissolve (also can add the appropriate hydrotropy of propylene glycol).
Embodiment 5
The Tremella aurantialba Bandoni et Zang of getting pulverizing is appropriate, in impouring extraction pot, adds 30 times of amounts (W/V) water, abundant stirring and evenly mixing, and 1 hour post-heating of merceration, to boiling, keeps micro-and boils 2 hours, extracts 1～2 time; Filter, discard filtering residue, merge 2 times filtrate, upper membrane separation device (Xiamen Filter and Membrane Technology Co., Ltd., model: RNF-0460), regulate suitable pressure and flow, isolate the effective part group of molecular weight between 2000～200000 after cotton balls coarse filtration.
Embodiment 6: moisturizing experiment
Experimental principle:
Water is molecular by moisture, and molecule is being done eternal random motion.When water is liquid condition, hydrone easily moves in air, and now moisture has has just slowly scattered and disappeared.
Experimental technique:
Tremella aurantialba Bandoni et Zang extract is made to dry powder form.
Sucting wet experiment: accurately take Tremella aurantialba Bandoni et Zang extract dry powder, hyaluronate sodium dry powder (Furuida Biochemical Co., Ltd., Shandong, 1010281) and the about 0.13g of the powder mixture of the two (mass ratio 1:1) lot number:, be contained in the plate of diameter 3cm, uniform spreading launches, every kind of sample establish 3 parallel.This experiment is all carried out in 20 ℃ of isoperibols.First the plate that each is filled to sample is positioned over by saturated (NH
4)
2sO
4in the exsiccator that the relative humidity that aqueous solution is reached (R.H.) is 81%.72 hours each example weights of accurate weighing after sample reaches moisture equilibrium at dry side, are calculated the water absorption rate of every sample by the weight difference of sample before and after placing, by water absorption rate size, come comparative sample to draw the ability of extraneous moisture, and the larger expression moisture sorption effect of water absorption rate is better.
Water absorption rate (%)=(M2-M1)/M1 * 100%
Sample dry weight (g) before M1---moisture absorption
M2---example weight after moisture absorption (g)
Moisturizing experiment: by the above-mentioned sample that has reached moisture equilibrium at dry side, in the exsiccator that to transfer to the relative humidity (R.H.) reached by saturated acetic acid aqueous solutions of potassium be 62%.Within 72 hours, after sample reaches dehydration balance, accurately take each example weight, by the moisture content of still possessing in comparative sample, weigh the ability that sample is resisted moisture loss under dry environment, the larger expression moistening effect of water retention is better.
Water retention (%)=(M2-M1)/M1 * 100%
Sample dry weight (g) before M1---moisture absorption
M2---example weight after dehydration (g)
Result:
1, dry weight water suction method (water absorbing force comparison)
Tremella aurantialba Bandoni et Zang extract dry powder, hyaluronate sodium dry powder all have the ability of moisture in very strong absorption external environment, experiment finds, if by the dry powder blend of the two (mass ratio 1:1), is equivalent to the use that all reduces by half of two kinds of raw materials, its water absorbing force will significantly promote, and be better than the two and use separately.
2, weight in wet base evaporation (moisture holding capacity comparison)
Tremella aurantialba Bandoni et Zang extract dry powder, hyaluronate sodium dry powder all have the very strong ability of resisting moisture loss under dry environment, experiment finds, if by the dry powder blend of the two (mass ratio 1:1), is equivalent to the use that all reduces by half of two kinds of raw materials, its water holding capacity will be more remarkable, be better than the two and use separately.
Experiment conclusion:
Combinations thereof experiment confirms, Tremella aurantialba Bandoni et Zang extract dry powder and the hyaluronate sodium dry powder consumption that reduces by half is respectively mixed and used, and the moisture absorption of compositions and moistening effect are all better than the two to be used separately.Illustrate that Tremella aurantialba Bandoni et Zang extract and hyaluronate sodium are used jointly, be expected to become a kind of more preferably moisture-keeping composition.
Tremella aurantialba Bandoni et Zang extract and hyaluronic acid are used as cosmetics moisturizing material combination, both can promote moisture-keeping efficacy, can reduce again the cost that Tremella aurantialba Bandoni et Zang extract is used separately, more Applied economy.
Embodiment 7: hyaluronidase activity suppresses experiment
Experimental principle:
Hyaluronidase can, by the hydrolysis of substrate hyaluronic acid, change into N-acetyl glucosamine.N-acetyl glucosamine and dimethylamino benzaldehyde produce chromogenic reaction, according to shade, can determine the activity size of hyaluronidase.
Experimental technique:
The Tremella aurantialba Bandoni et Zang extract sample solution (with pH 3.5 acetate buffer preparations) that respectively adds 400ul respective concentration in sample cell and sample control tube, replaces with 400ul acetate buffer in negative control pipe and blank pipe; In sample cell and positive control pipe, add 50ul(16000U/ml) and hyaluronic acid enzymatic solution (purchased from Sigma company, lot number: 032K7052) mix, sample control tube and negative control pipe add equal-volume acetate buffer to mix, 37 ℃ of water-baths 20 minutes.Each reaction tube respectively adds 12.5mM calcium chloride 100ul, 37 ℃ of water-baths 20 minutes.Add 0.24% hyaluronate sodium (Furuida Biochemical Co., Ltd., Shandong, lot number: 070591) 250ul, 37 ℃ of water-baths 40 minutes.Add 0.4M hydrochloric acid 100ul and 0.4M sodium tetraborate 100ul, boiling water 3 minutes, is cooled to room temperature.Add 1% dimethylamino benzaldehyde solution 3ml, 37 ℃ of water-baths 20 minutes, spectrophotometric determination OD(585nm).
The suppression ratio of calculating to hyaluronidase activity: (1-(T-T
0)/(C-C
0)) * 100%
In formula: T-sample cell OD; T
0-sample control tube OD; C-negative control pipe OD; C
0-blank pipe OD.
Result:
Tremella aurantialba Bandoni et Zang extract
| Experimental concentration (mg/ml) | 0.385 | 0.193 | 0.096 |
| Suppression ratio (%) | 50.82 | 25.44 | 5.66 |
Experiment conclusion:
Hyaluronic acid (Hyaluronic acid) is a kind of macromolecule mucopolysaccharide that is construction unit by D-N-acetylglucosamine and D-Glucose aldehydic acid, and commodity hyaluronic acid is generally its sodium salt, i.e. hyaluronate sodium (Sodium Hyaluronate).Hyaluronic acid is the bio-molecules extensively existing in skin and other tissue, there is fabulous moisture-keeping function, be called as desirable nature moisturizing factor (Natural MolsturlZlng Factor, NMF), in cosmetics, the normal hyaluronate sodium that adds is to strengthen the moisture-keeping efficacy to skin.
Experiment confirmation, Tremella aurantialba Bandoni et Zang extract is hyaluronidase inhibitor significantly, and this inhibitory action is concentration dependence.For this reason, in containing hyaluronic skin care item, add Tremella aurantialba Bandoni et Zang extract simultaneously, can protect hyaluronic acid not by enzymolysis, make it to reside in for more time in skin, play the cooperative effect of skin moisture-keeping.
Claims (9)
1. a compositions, it comprises Tremella aurantialba Bandoni et Zang extract and hyaluronic acid.
2. compositions as claimed in claim 1, is characterized in that, in described compositions, Tremella aurantialba Bandoni et Zang extract and hyaluronic weight ratio are 1:5 to 5:1.
3. compositions as claimed in claim 2, is characterized in that, in described compositions, Tremella aurantialba Bandoni et Zang extract and hyaluronic weight ratio are 1:2 to 2:1.
4. compositions as claimed in claim 3, is characterized in that, in described compositions, Tremella aurantialba Bandoni et Zang extract and hyaluronic weight ratio are 1:1.
5. the application of compositions as claimed in claim 1 in cosmetics.
6. application as claimed in claim 5, is characterized in that, described cosmetics are selected from: moisture-keeping cosmetics, have the anti-inflammatory cosmetics of moisture-keeping efficacy, have the anti-aging cosmetics of moisture-keeping efficacy or have the skin-lightening cosmetic of moisture-keeping efficacy.
7. application as claimed in claim 5, is characterized in that, described cosmetics are following forms: fancy soap, cleansing milk, bath gel, toner/smoothing toner, skin protection gel, facial treatment milk, protective skin cream, essence, eye cream, facial film, aerosol or Sprayable.
8. application as claimed in claim 5, is characterized in that, described cosmetics also comprise the acceptable adjuvant of cosmetic field.
9. application as claimed in claim 8, it is characterized in that, the acceptable adjuvant of described cosmetic field is selected from: solvent, solubilizing agent, antiseptic, antioxidant, pH adjusting agent, penetrating agent, liposome, wetting agent, thickening agent, chelating agen, skinfeel regulator, surfactant, emulsifying agent, propelling/propellant, essence, pigment, and other functional additives.
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| CN113876614A (en) * | 2021-10-11 | 2022-01-04 | 广州萃普生物科技有限公司 | Glycyrrhizic anhydride and tremella polysaccharide degradation product compound composition and application thereof |
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| CN113876614A (en) * | 2021-10-11 | 2022-01-04 | 广州萃普生物科技有限公司 | Glycyrrhizic anhydride and tremella polysaccharide degradation product compound composition and application thereof |
| CN113876614B (en) * | 2021-10-11 | 2023-05-02 | 广州萃普生物科技有限公司 | Glycyrrhizin and tremella aurantialba polysaccharide degradation product compound composition and application thereof |
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