CN103649128B - 用于制造羟乙基淀粉衍生物的方法 - Google Patents

用于制造羟乙基淀粉衍生物的方法 Download PDF

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Publication number
CN103649128B
CN103649128B CN201280029882.3A CN201280029882A CN103649128B CN 103649128 B CN103649128 B CN 103649128B CN 201280029882 A CN201280029882 A CN 201280029882A CN 103649128 B CN103649128 B CN 103649128B
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China
Prior art keywords
solution
temperature
iron
hydroxyethyl starch
value
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CN201280029882.3A
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Chinese (zh)
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CN103649128A (zh
Inventor
维尔纳·齐默尔曼
扬·卢科奇克
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SERUMWERK BERNBURG AG
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SERUMWERK BERNBURG AG
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/08—Ethers
    • C08B31/12—Ethers having alkyl or cycloalkyl radicals substituted by heteroatoms, e.g. hydroxyalkyl or carboxyalkyl starch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/08—Ethers
    • C08B31/10—Alkyl or cycloalkyl ethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/18—Oxidised starch
    • C08B31/185—Derivatives of oxidised starch, e.g. crosslinked oxidised starch

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201280029882.3A 2011-06-21 2012-06-21 用于制造羟乙基淀粉衍生物的方法 Active CN103649128B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510909616.5A CN105348401A (zh) 2011-06-21 2012-06-21 用于制造羟乙基淀粉衍生物的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11170761.8 2011-06-21
EP11170761A EP2537866A1 (en) 2011-06-21 2011-06-21 Hydroxyethyl starch derivatives, method for manufacturing the same and therapeutical uses thereof
PCT/EP2012/061958 WO2012175608A1 (en) 2011-06-21 2012-06-21 Method for manufacturing hydroxyethyl starch derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510909616.5A Division CN105348401A (zh) 2011-06-21 2012-06-21 用于制造羟乙基淀粉衍生物的方法

Publications (2)

Publication Number Publication Date
CN103649128A CN103649128A (zh) 2014-03-19
CN103649128B true CN103649128B (zh) 2016-02-10

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CN201280029882.3A Active CN103649128B (zh) 2011-06-21 2012-06-21 用于制造羟乙基淀粉衍生物的方法
CN201510909616.5A Pending CN105348401A (zh) 2011-06-21 2012-06-21 用于制造羟乙基淀粉衍生物的方法

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US (2) US9181353B2 (enExample)
EP (2) EP2537866A1 (enExample)
JP (2) JP6370217B2 (enExample)
CN (2) CN103649128B (enExample)
BR (1) BR112013032901A2 (enExample)
CA (1) CA2837784C (enExample)
CY (1) CY1121976T1 (enExample)
DK (1) DK2723774T3 (enExample)
ES (1) ES2733767T3 (enExample)
HK (1) HK1220218A1 (enExample)
HR (1) HRP20191173T1 (enExample)
HU (1) HUE044428T2 (enExample)
LT (1) LT2723774T (enExample)
MX (1) MX337682B (enExample)
PL (1) PL2723774T3 (enExample)
PT (1) PT2723774T (enExample)
RS (1) RS59021B1 (enExample)
SI (1) SI2723774T1 (enExample)
SM (1) SMT201900430T1 (enExample)
TR (1) TR201909574T4 (enExample)
TW (1) TWI564010B (enExample)
WO (1) WO2012175608A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6616725B2 (ja) * 2016-03-31 2019-12-04 日本製紙株式会社 塗工紙用澱粉
AU2020206021B2 (en) 2019-01-10 2025-05-08 Pharmacosmos Holding A/S Treating iron deficiency in subjects at risk of cardiovascular adverse events and iron for the management of atrial fibrillation
CN114286682A (zh) 2019-02-09 2022-04-05 法码科思莫斯控股有限公司 治疗具有心血管不良事件风险的个体的铁缺乏以及用于治疗心房颤动的铁
JP2024529536A (ja) 2021-08-03 2024-08-06 ファーマコスモス ホールディング エー／エス コンパニオンアニマルの鉄欠乏症の治療における皮下使用のための鉄錯体化合物
CN117547549A (zh) * 2023-11-09 2024-02-13 黑龙江八一农垦大学 适用于犬arf的腹膜透析液与助清除剂的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639588A (en) * 1966-10-22 1972-02-01 Fisons Pharmaceuticals Ltd Pharmaceutical compositions containing ferric hydroxide complexed with dextran or dextrin heptonic acids
CN101262889A (zh) * 2005-09-12 2008-09-10 弗雷泽纽斯卡比德国有限公司 羟烷基淀粉与活性物质经噻唑烷通过化学连接制备的偶联物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370476A (en) * 1979-07-17 1983-01-25 Usher Thomas C Dextran polycarboxylic acids, ferric hydroxide complexes
GB8902894D0 (en) * 1989-02-09 1989-03-30 Fisons Plc Compositions
JPH0566372A (ja) * 1991-09-10 1993-03-19 Fukui Megane Kogyo Kk 金属製眼鏡フレーム部品の製造方法
JPH0776524A (ja) * 1993-07-13 1995-03-20 Takeda Chem Ind Ltd 動物用抗貧血剤
DK172860B1 (da) * 1998-03-25 1999-08-16 Pharmacosmos Holding As Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman
DK173138B1 (da) 1998-11-20 2000-02-07 Pharmacosmos Holding As Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma
WO2009024518A1 (en) * 2007-08-17 2009-02-26 Akzo Nobel N.V. Alkali metal salt of glutamic acid n,n-diacetic acid, a process to prepare such salt, and the use thereof
TWI469965B (zh) * 2008-12-22 2015-01-21 Ono Pharmaceutical Co 乙炔基吲哚化合物
JP5397991B2 (ja) * 2009-04-01 2014-01-22 学校法人東京農業大学 乳酸菌を用いたビタミンｂ１２の定量方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639588A (en) * 1966-10-22 1972-02-01 Fisons Pharmaceuticals Ltd Pharmaceutical compositions containing ferric hydroxide complexed with dextran or dextrin heptonic acids
CN101262889A (zh) * 2005-09-12 2008-09-10 弗雷泽纽斯卡比德国有限公司 羟烷基淀粉与活性物质经噻唑烷通过化学连接制备的偶联物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Iron availability and complex stability of iron hydroxyethyl starch;Nina Ternes ea tl.;《Nephrology Dialysis Transplantation》;20070607;第22卷(第10期);第2824-2830页 *

Also Published As

Publication number Publication date
US9631032B2 (en) 2017-04-25
RS59021B1 (sr) 2019-08-30
SI2723774T1 (sl) 2019-08-30
HK1220218A1 (zh) 2017-04-28
HUE044428T2 (hu) 2019-10-28
CA2837784C (en) 2019-10-15
JP2018100424A (ja) 2018-06-28
TWI564010B (zh) 2017-01-01
JP6370217B2 (ja) 2018-08-08
MX2013015075A (es) 2014-04-14
SMT201900430T1 (it) 2019-09-09
CN103649128A (zh) 2014-03-19
CY1121976T1 (el) 2020-10-14
WO2012175608A1 (en) 2012-12-27
CA2837784A1 (en) 2012-12-27
CN105348401A (zh) 2016-02-24
US20140128594A1 (en) 2014-05-08
BR112013032901A2 (pt) 2017-01-24
LT2723774T (lt) 2019-08-12
US20160046733A1 (en) 2016-02-18
MX337682B (es) 2016-03-15
EP2723774A1 (en) 2014-04-30
PT2723774T (pt) 2019-07-15
HRP20191173T1 (hr) 2019-10-04
PL2723774T3 (pl) 2019-10-31
US9181353B2 (en) 2015-11-10
ES2733767T3 (es) 2019-12-02
TR201909574T4 (en) 2019-08-21
EP2537866A1 (en) 2012-12-26
JP2014520188A (ja) 2014-08-21
DK2723774T3 (da) 2019-07-15
EP2723774B1 (en) 2019-04-03
TW201315474A (zh) 2013-04-16

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