TR201909574T4 - METHOD FOR PRODUCING HYDROXYETHYL STARCH DERIVATIVES. - Google Patents
METHOD FOR PRODUCING HYDROXYETHYL STARCH DERIVATIVES. Download PDFInfo
- Publication number
- TR201909574T4 TR201909574T4 TR2019/09574T TR201909574T TR201909574T4 TR 201909574 T4 TR201909574 T4 TR 201909574T4 TR 2019/09574 T TR2019/09574 T TR 2019/09574T TR 201909574 T TR201909574 T TR 201909574T TR 201909574 T4 TR201909574 T4 TR 201909574T4
- Authority
- TR
- Turkey
- Prior art keywords
- temperature
- value
- solution
- adjusting
- hydroxyethyl starch
- Prior art date
Links
- 229920001612 Hydroxyethyl starch Polymers 0.000 title claims abstract 9
- 229940050526 hydroxyethylstarch Drugs 0.000 title claims abstract 9
- 238000004519 manufacturing process Methods 0.000 title claims abstract 3
- 229920002472 Starch Polymers 0.000 claims abstract 3
- 235000019698 starch Nutrition 0.000 claims abstract 3
- 239000008107 starch Substances 0.000 claims abstract 3
- KWMLJOLKUYYJFJ-UHFFFAOYSA-N 2,3,4,5,6,7-Hexahydroxyheptanoic acid Chemical group OCC(O)C(O)C(O)C(O)C(O)C(O)=O KWMLJOLKUYYJFJ-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 10
- 238000010438 heat treatment Methods 0.000 claims 8
- 238000001816 cooling Methods 0.000 claims 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 150000002505 iron Chemical class 0.000 claims 2
- 150000002506 iron compounds Chemical class 0.000 claims 2
- 238000001542 size-exclusion chromatography Methods 0.000 claims 2
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical group [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims 1
- -1 cyanide compound Chemical class 0.000 claims 1
- 238000001825 field-flow fractionation Methods 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 229920001592 potato starch Polymers 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/08—Ethers
- C08B31/12—Ethers having alkyl or cycloalkyl radicals substituted by heteroatoms, e.g. hydroxyalkyl or carboxyalkyl starch
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/08—Ethers
- C08B31/10—Alkyl or cycloalkyl ethers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/18—Oxidised starch
- C08B31/185—Derivatives of oxidised starch, e.g. crosslinked oxidised starch
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11170761A EP2537866A1 (en) | 2011-06-21 | 2011-06-21 | Hydroxyethyl starch derivatives, method for manufacturing the same and therapeutical uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201909574T4 true TR201909574T4 (en) | 2019-08-21 |
Family
ID=44799422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/09574T TR201909574T4 (en) | 2011-06-21 | 2012-06-21 | METHOD FOR PRODUCING HYDROXYETHYL STARCH DERIVATIVES. |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9181353B2 (enExample) |
| EP (2) | EP2537866A1 (enExample) |
| JP (2) | JP6370217B2 (enExample) |
| CN (2) | CN105348401A (enExample) |
| BR (1) | BR112013032901A2 (enExample) |
| CA (1) | CA2837784C (enExample) |
| CY (1) | CY1121976T1 (enExample) |
| DK (1) | DK2723774T3 (enExample) |
| ES (1) | ES2733767T3 (enExample) |
| HK (1) | HK1220218A1 (enExample) |
| HR (1) | HRP20191173T1 (enExample) |
| HU (1) | HUE044428T2 (enExample) |
| LT (1) | LT2723774T (enExample) |
| MX (1) | MX337682B (enExample) |
| PL (1) | PL2723774T3 (enExample) |
| PT (1) | PT2723774T (enExample) |
| RS (1) | RS59021B1 (enExample) |
| SI (1) | SI2723774T1 (enExample) |
| SM (1) | SMT201900430T1 (enExample) |
| TR (1) | TR201909574T4 (enExample) |
| TW (1) | TWI564010B (enExample) |
| WO (1) | WO2012175608A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6616725B2 (ja) * | 2016-03-31 | 2019-12-04 | 日本製紙株式会社 | 塗工紙用澱粉 |
| SG11202107050RA (en) | 2019-01-10 | 2021-07-29 | Pharmacosmos Holding As | Treating iron deficiency in subjects at risk of cardiovascular adverse events and iron for the management of atrial fibrillation |
| EA202191858A1 (ru) | 2019-06-12 | 2021-11-12 | Фармакосмос Холдинг А/С | Лечение дефицита железа у субъектов с риском нежелательных явлений со стороны сердечно-сосудистой системы и железо для лечения фибрилляции предсердий |
| CA3226771A1 (en) | 2021-08-03 | 2023-02-09 | Pharmacosmos Holding A/S | Iron complex compounds for subcutaneous use in therapy of iron deficiency in companion animals |
| CN117547549A (zh) * | 2023-11-09 | 2024-02-13 | 黑龙江八一农垦大学 | 适用于犬arf的腹膜透析液与助清除剂的制备方法 |
| WO2026017901A1 (en) | 2024-07-18 | 2026-01-22 | Malian Biologicals Gmbh | Iron supplementation in neurodevelopmental or psychiatric disorder |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3639588A (en) * | 1966-10-22 | 1972-02-01 | Fisons Pharmaceuticals Ltd | Pharmaceutical compositions containing ferric hydroxide complexed with dextran or dextrin heptonic acids |
| US4370476A (en) * | 1979-07-17 | 1983-01-25 | Usher Thomas C | Dextran polycarboxylic acids, ferric hydroxide complexes |
| GB8902894D0 (en) * | 1989-02-09 | 1989-03-30 | Fisons Plc | Compositions |
| JPH0566372A (ja) * | 1991-09-10 | 1993-03-19 | Fukui Megane Kogyo Kk | 金属製眼鏡フレーム部品の製造方法 |
| JPH0776524A (ja) * | 1993-07-13 | 1995-03-20 | Takeda Chem Ind Ltd | 動物用抗貧血剤 |
| DK172860B1 (da) | 1998-03-25 | 1999-08-16 | Pharmacosmos Holding As | Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman |
| DK173138B1 (da) | 1998-11-20 | 2000-02-07 | Pharmacosmos Holding As | Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma |
| EP1762250A1 (en) | 2005-09-12 | 2007-03-14 | Fresenius Kabi Deutschland GmbH | Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine |
| JP5178836B2 (ja) * | 2007-08-17 | 2013-04-10 | アクゾ ノーベル ナムローゼ フェンノートシャップ | グルタミン酸ｎ，ｎ−二酢酸のアルカリ金属塩、そのような塩の調製プロセス及びその使用 |
| TWI469965B (zh) * | 2008-12-22 | 2015-01-21 | Ono Pharmaceutical Co | 乙炔基吲哚化合物 |
| JP5397991B2 (ja) * | 2009-04-01 | 2014-01-22 | 学校法人東京農業大学 | 乳酸菌を用いたビタミンｂ１２の定量方法 |
-
2011
- 2011-06-21 EP EP11170761A patent/EP2537866A1/en not_active Withdrawn
-
2012
- 2012-06-21 MX MX2013015075A patent/MX337682B/es active IP Right Grant
- 2012-06-21 EP EP12737229.0A patent/EP2723774B1/en active Active
- 2012-06-21 SM SM20190430T patent/SMT201900430T1/it unknown
- 2012-06-21 CN CN201510909616.5A patent/CN105348401A/zh active Pending
- 2012-06-21 US US14/127,766 patent/US9181353B2/en active Active
- 2012-06-21 TW TW101122208A patent/TWI564010B/zh active
- 2012-06-21 CA CA2837784A patent/CA2837784C/en active Active
- 2012-06-21 TR TR2019/09574T patent/TR201909574T4/en unknown
- 2012-06-21 ES ES12737229T patent/ES2733767T3/es active Active
- 2012-06-21 SI SI201231627T patent/SI2723774T1/sl unknown
- 2012-06-21 PL PL12737229T patent/PL2723774T3/pl unknown
- 2012-06-21 WO PCT/EP2012/061958 patent/WO2012175608A1/en not_active Ceased
- 2012-06-21 DK DK12737229.0T patent/DK2723774T3/da active
- 2012-06-21 BR BR112013032901A patent/BR112013032901A2/pt not_active Application Discontinuation
- 2012-06-21 HR HRP20191173TT patent/HRP20191173T1/hr unknown
- 2012-06-21 HU HUE12737229 patent/HUE044428T2/hu unknown
- 2012-06-21 CN CN201280029882.3A patent/CN103649128B/zh active Active
- 2012-06-21 JP JP2014516345A patent/JP6370217B2/ja active Active
- 2012-06-21 RS RS20190850A patent/RS59021B1/sr unknown
- 2012-06-21 PT PT12737229T patent/PT2723774T/pt unknown
- 2012-06-21 LT LTEP12737229.0T patent/LT2723774T/lt unknown
-
2015
- 2015-10-26 US US14/922,897 patent/US9631032B2/en active Active
-
2016
- 2016-07-12 HK HK16108112.8A patent/HK1220218A1/zh unknown
-
2018
- 2018-03-27 JP JP2018059264A patent/JP2018100424A/ja active Pending
-
2019
- 2019-07-03 CY CY20191100704T patent/CY1121976T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2837784A1 (en) | 2012-12-27 |
| US20140128594A1 (en) | 2014-05-08 |
| JP6370217B2 (ja) | 2018-08-08 |
| DK2723774T3 (da) | 2019-07-15 |
| TWI564010B (zh) | 2017-01-01 |
| CN103649128B (zh) | 2016-02-10 |
| BR112013032901A2 (pt) | 2017-01-24 |
| MX2013015075A (es) | 2014-04-14 |
| SMT201900430T1 (it) | 2019-09-09 |
| CA2837784C (en) | 2019-10-15 |
| ES2733767T3 (es) | 2019-12-02 |
| RS59021B1 (sr) | 2019-08-30 |
| WO2012175608A1 (en) | 2012-12-27 |
| PT2723774T (pt) | 2019-07-15 |
| LT2723774T (lt) | 2019-08-12 |
| US20160046733A1 (en) | 2016-02-18 |
| CN103649128A (zh) | 2014-03-19 |
| SI2723774T1 (sl) | 2019-08-30 |
| MX337682B (es) | 2016-03-15 |
| EP2537866A1 (en) | 2012-12-26 |
| EP2723774A1 (en) | 2014-04-30 |
| JP2014520188A (ja) | 2014-08-21 |
| JP2018100424A (ja) | 2018-06-28 |
| HRP20191173T1 (hr) | 2019-10-04 |
| HUE044428T2 (hu) | 2019-10-28 |
| CN105348401A (zh) | 2016-02-24 |
| US9631032B2 (en) | 2017-04-25 |
| HK1220218A1 (zh) | 2017-04-28 |
| CY1121976T1 (el) | 2020-10-14 |
| PL2723774T3 (pl) | 2019-10-31 |
| US9181353B2 (en) | 2015-11-10 |
| TW201315474A (zh) | 2013-04-16 |
| EP2723774B1 (en) | 2019-04-03 |
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