CN103610834B - Chinese medicine composition and its preparation method and application - Google Patents
Chinese medicine composition and its preparation method and application Download PDFInfo
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- CN103610834B CN103610834B CN201310603197.3A CN201310603197A CN103610834B CN 103610834 B CN103610834 B CN 103610834B CN 201310603197 A CN201310603197 A CN 201310603197A CN 103610834 B CN103610834 B CN 103610834B
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Abstract
The invention discloses a kind of Chinese medicine composition and its preparation method and application.Described Chinese medicine composition is the water of material A and/or material A or the extract of ethanol water, and described material A comprises: with parts by weight, 2-10 part Mulberry, 2-10 part Fructus Momordicae charantiae, 5-20 part Folium Camelliae sinensis, and 1-5 part Fructus Jujubae; Wherein, described Mulberry comprise in Folium Mori, Cortex Mori, Ramulus Mori, Bombyx mori L. and Fructus Mori one or more, described Folium Camelliae sinensis comprises green tea, oolong tea, black tea and Folium camelliae assamicae.Chinese medicine composition of the present invention derives from foodstuff or integration of edible and medicinal herbs, fat-reducing, blood fat reducing, hypoglycemic evident in efficacy, can long-term taking.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and its preparation method and application.
Background technology
In recent years, along with the progressively raising of the living standard of people, the sickness rate of the affluence diseases such as China's hypertension, diabetes and obesity obviously rises, and become the first killer threatening middle-aged and elderly people, hypertension, diabetes, obesity belong to the very close disease of dependency.In order to anti-obesity, the mankind take various mode, how to set about from keeping on a diet, also there is health food, also have many from theory of Chinese medical science, the research cause of disease, by the Chinese medicine preparation that scientific and reasonable composition of prescription is made, reach the object for the treatment of both the principal and secondary aspects of a disease, to realize effect of lowering blood-fat and reducing weight.
The Chinese medicine composition of now a lot of Weight-reducing and lipid-lowerings, although the effect having Weight-reducing and lipid-lowering, all containing purgatives medicine in its composition, there is the defect that toxic and side effects is large, withdraw rear easy bounce-back, long-term taking may cause drug dependence and constipation.As contained Semen Cassiae in the Chinese medicine composition of CN201210194739.1 patent application; For another example, containing Radix Et Rhizoma Rhei in the Chinese medicine composition of CN200910238679.7 patent application; And modern study shows, all containing anthraquinone component in Semen Cassiae and Radix Et Rhizoma Rhei, long-term taking may cause Melanosis coli with Semen Cassiae or the obtained medicine of Radix Et Rhizoma Rhei or claim large intestine Pseudomelanosis.This present situation is urgently to be resolved hurrily.
Summary of the invention
It is large that technical problem to be solved by this invention is to overcome Weight-reducing and lipid-lowering product toxic and side effects of the prior art, withdraw rear easy bounce-back, formula is indefinite without logos, effective ingredient target, long-term taking may cause in drug dependence and constipation, composition and may cause Melanosis coli containing purgatives medicine or claim the defect of large intestine Pseudomelanosis etc., provides a kind of Chinese medicine composition and its preparation method and application.Chinese medicine composition of the present invention derives from foodstuff or integration of edible and medicinal herbs, fat-reducing, blood fat reducing, hypoglycemic evident in efficacy, can long-term taking.
The present invention solves above-mentioned technical problem by following technical proposals:
The invention provides a kind of Chinese medicine composition, it is the water of material A and/or material A or the extract of ethanol water, and described material A comprises: with parts by weight, 2-10 part Mulberry, 2-10 part Fructus Momordicae charantiae, 5-20 part Folium Camelliae sinensis, and 1-5 part Fructus Jujubae (having another name called Fructus Jujubae); Wherein, described Mulberry comprise in Folium Mori, Cortex Mori, Ramulus Mori, Bombyx mori L. and Fructus Mori one or more, described Folium Camelliae sinensis comprises green tea, oolong tea, black tea and Folium camelliae assamicae.
Preferably, described material A comprises: with parts by weight, 5 parts, Folium Mori, 5 parts, Fructus Momordicae charantiae, Folium Camelliae sinensis 10 parts and Fructus Jujubae 3 parts.
In the present invention, in described Folium Camelliae sinensis, the mass ratio of green tea, oolong tea, black tea and Folium camelliae assamicae is preferably (0.8-1.2): (0.8-1.2): (0.8-1.2): (0.8-1.2), is more preferably 1:1:1:1.
In the present invention, one or more in described Folium Mori, Cortex Mori, Ramulus Mori, Bombyx mori L. and Fructus Mori be this area conventional said enter the Morus resource substance of Chinese crude drug form.
In the present invention, described Fructus Momordicae charantiae be this area conventional said enter the Fructus Momordicae charantiae of Chinese crude drug form.
In the present invention, described Fructus Jujubae be this area conventional said enter the Fructus Jujubae of Chinese crude drug form.
In the present invention, described Chinese medicine composition is preferably powder type.Wherein, the preparation method of described powder is that this area is conventional, preferably comprise the steps: that each component in material A and/or the water of material A or the extract of ethanol water being dried to respectively moisture mass percentage is be ground into fine powder after 2%-3%, cross 80-120 mesh sieve, or particle diameter is the superfine powder of 0.30-24 μm, carry out irradiation sterilization again, remix preparation.
Wherein, the method for described drying is the method for the dry Mulberry of this area routine, Fructus Momordicae charantiae, Folium Camelliae sinensis and Fructus Jujubae.The method of the drying of described Mulberry, Fructus Momordicae charantiae or Folium Camelliae sinensis is preferably spraying dry.Described spray-dired process conditions are that this area is conventional, are preferably: inlet temperature 160 DEG C, charging rate 9mL/min and atomizing pressure 1.05bar.The method of the drying of described Fructus Jujubae is preferably vacuum drying.Described vacuum drying process conditions are that this area is conventional, are preferably: vacuum-0.08MPa and baking temperature 70 DEG C.
In the present invention, the water of described material A or the extract of ethanol water are that the plant extraction process of this area routine extracts acquisition, preferably it comprises the steps: respectively by the Mulberry in material A, Fructus Momordicae charantiae, Folium Camelliae sinensis or Fructus Jujubae, decoct 2-3 time through water or ethanol water, filter, remerge and be condensed into extractum.
Wherein, the volumetric concentration of described ethanol water is that this area is conventional, and being preferably 45%-75%, is more preferably 65%.Described simmer down to this area routine operation is preferably vacuum concentration.The condition of described vacuum concentration is this area normal condition, and the temperature of described vacuum concentration is preferably 60-100 DEG C, is more preferably 60 DEG C; The pressure of described vacuum concentration is preferably-0.08MPa.Described is concentrated preferably for the relative density being concentrated into extractum is 1.24-1.26.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, and described preparation method is for mixing each uniform composition according to this area routine.
Wherein, the preparation method of the water of described material A or described material A or the extract of ethanol water all as previously mentioned.
The present invention also provides the application of above-mentioned Chinese medicine composition in preparation fat-reducing, blood fat reducing or hypoglycemic medicine or health food.
In the present invention, the dosage form of described medicine can be this area routine, is preferably tablet, capsule, granule, pill or oral liquid.
Wherein, described tablet, capsule, granule, pill or oral liquid comprise described Chinese medicine composition and the acceptable adjuvant of pharmacy.
Described adjuvant is pharmaceutically acceptable excipient, is preferably one or more in microcrystalline Cellulose, sodium carboxymethyl cellulose, magnesium stearate and Pulvis Talci.
On the basis meeting this area general knowledge, above-mentioned each optimum condition, can combination in any, obtains the preferred embodiments of the invention.
Agents useful for same of the present invention and raw material are all commercially.
Positive progressive effect of the present invention is: Chinese medicine composition of the present invention derives from foodstuff or integration of edible and medicinal herbs, has the absorption suppressing saccharide, stop fat, accelerates the metabolism of body fat, play fat-reducing, blood fat reducing, fall the evident in efficacy of blood, can long-term taking.
Detailed description of the invention
Mode below by embodiment further illustrates the present invention, but does not therefore limit the present invention among described scope of embodiments.The experimental technique of unreceipted actual conditions in the following example, conventionally and condition, or selects according to catalogue.
In following embodiment:
Folium Mori are purchased from Hunan Song Lingtang prepared slices of Chinese crude drugs company limited;
Fructus Jujubae is purchased from Hunan Song Lingtang prepared slices of Chinese crude drugs company limited;
Magnesium stearate is purchased from Anhui Shanhe Medical Accessary Material Co., Ltd.;
Sodium carboxymethyl cellulose is purchased from Shandong Chemical Co., Ltd. of Yanggu Hengchang;
All the other medical materials are all purchase in Hunan Song Lingtang prepared slices of Chinese crude drugs company limited.
In following embodiment, described Folium Camelliae sinensis is made up of green tea, oolong tea, black tea and Folium camelliae assamicae.In embodiment 1-3, the mass ratio of green tea, oolong tea, black tea and Folium camelliae assamicae is 1:1:1:1.
Embodiment 1
Take the raw material of following weight proportion: 8 parts, Folium Mori, 6 parts, Fructus Momordicae charantiae, Folium Camelliae sinensis 9 parts, Fructus Jujubae 2 parts.Four taste raw materials extract respectively, add the water extraction 2 times of 8-12 times amount, each 1-2h, filter, remerge and be condensed into extractum.Wherein, described simmer down to vacuum concentration.The temperature of described vacuum concentration is 60 DEG C; The pressure of described vacuum concentration is-0.08MPa.The relative density that described simmer down to is concentrated into extractum is 1.25.
Wherein Folium Mori, Fructus Momordicae charantiae, Folium Camelliae sinensis adopt spraying dry (inlet temperature 160 DEG C, charging rate 9mL/min, atomizing pressure 1.05bar), and Fructus Jujubae adopts vacuum drying (-0.08MPa, 70 DEG C).After above four extract powders mixing, granulate with one-step-granulating method, be wetting agent with water, obtain granule, granule is incapsulated, obtain capsule product.
Embodiment 2
Take the raw material of following weight proportion: 5 parts, Folium Mori, 5 parts, Fructus Momordicae charantiae, Folium Camelliae sinensis 10 parts, Fructus Jujubae 3 parts.Make granule by the method for embodiment 1, then add account for granule total amount 0.05% magnesium stearate lubricant and account for granule total amount 2% disintegrating agent carboxymethyl base sodium cellulosate, tabletting, every sheet 0.8g-1.3g, subpackage obtains tablet.
Embodiment 3
Take the raw material of following weight proportion: 4 parts, Folium Mori, 3 parts, Fructus Momordicae charantiae, Folium Camelliae sinensis 15 parts, Fructus Jujubae 4 parts.Make granule by the method for embodiment 1, then add account for granule total amount 0.05% magnesium stearate lubricant and account for granule total amount 4% disintegrating agent carboxymethyl base sodium cellulosate, tabletting, every sheet 0.9g-1.5g, subpackage obtains tablet.
Embodiment 4
Proportioning raw materials in the present embodiment is as follows: Cortex Mori 2 parts, 2 parts, Fructus Momordicae charantiae, Folium Camelliae sinensis 5 parts, Fructus Jujubae 1 part.In the present embodiment, the mass ratio of green tea, oolong tea, black tea and Folium camelliae assamicae is 0.8:0.8:1.2:1.2.And utilizing the extract of the ethanol water of material A to obtain oral liquid product, the volumetric concentration of the ethanol water adopted is 45%, and remaining process conditions and step are all with embodiment 1.
Embodiment 5
Proportioning raw materials in the present embodiment is as follows: Ramulus Mori 10 parts, 10 parts, Fructus Momordicae charantiae, Folium Camelliae sinensis 20 parts, Fructus Jujubae 5 parts.In the present embodiment, the mass ratio of green tea, oolong tea, black tea and Folium camelliae assamicae is 1.2:1.2:0.8:0.8.And utilizing material A and its to obtain pellet product at the extract of ethanol water, the volumetric concentration of the ethanol water adopted is 65%, and remaining process conditions and step are all with embodiment 1.
Embodiment 6
Proportioning raw materials in the present embodiment is as follows: Bombyx mori L. 10 parts, 10 parts, Fructus Momordicae charantiae, Folium Camelliae sinensis 20 parts, Fructus Jujubae 5 parts, and utilizes material A and its to obtain pellet product at the extract of ethanol water, and the volumetric concentration of the ethanol water adopted is 65%.The preparation method of the powder of material A is: material A being dried to moisture mass percentage is be ground into fine powder after 2%, crosses 100 mesh sieves, then carries out 60Coradiation sterilizing.Remaining process conditions and step are all with embodiment 1.
Embodiment 7
Proportioning raw materials in the present embodiment is as follows: Fructus Mori 10 parts, 10 parts, Fructus Momordicae charantiae, Folium Camelliae sinensis 20 parts, Fructus Jujubae 5 parts, and utilizes material A to obtain pellet product, and the volumetric concentration of the ethanol water adopted is 65%; The preparation method of the powder of material A is: material A being dried to moisture mass percentage is be ground into fine powder after 3%, gets the superfine powder that particle diameter is 0.30-24 μm, then carries out 60Coradiation sterilizing.Remaining process conditions and step are all with embodiment 1.
Effect example 1
In order to confirm that Chinese medicine composition of the present invention has obvious fat-reducing, effect for reducing fat, the mice of high heat food being brought out to animal obesity has carried out pharmacodynamic experiment, test formulation uses Chinese medicine composition of the present invention, is set to the raw material ratio in group 1, group 2, the corresponding embodiment 1-3 of group 3(difference respectively).Wherein, the composition organizing is: the mixture of 8 parts, Folium Mori, 6 parts, Fructus Momordicae charantiae, Folium Camelliae sinensis 9 parts and Fructus Jujubae 2 parts; The composition of group two is: the mixture of 5 parts, Folium Mori, 5 parts, Fructus Momordicae charantiae, Folium Camelliae sinensis 10 parts and Fructus Jujubae 3 parts; The composition of group three is: the mixture of 4 parts, Folium Mori, 3 parts, Fructus Momordicae charantiae, Folium Camelliae sinensis 15 parts and Fructus Jujubae 4 parts.
Experimental technique is as follows:
Male ICR mouse to be fed under experimental enviroment normal diet 1 week, weigh.Be divided into 5 groups at random: Normal group feeds (gavage gives distilled water) from on-test to end normal diet, all the other animals are all fed nutrient fodder (normal feedstuff 80%, Adeps Sus domestica 10%, yolk powder 10%); Model control group gavage gives distilled water.Give continuously by reagent 42 days, every day, 0.4g/Kg, weighed weekly 1 time.
Index determining method and result as follows:
Last gives, by after reagent, to weigh, measure the length of mice nose to anus, and calculate Lee ' S index to each group of mice; Meanwhile, eyeball is plucked to mice and gets blood, separation of serum, measure TC(serum total cholesterol), TG(triglyceride), HDL-C(HDL-C), LDL-C(low density cholesterol) concentration; Cut open the belly and get body fat (epididymis and perirenal fat pad) and weigh, calculate body fat ratio.Test result is as shown in table 1, table 2 and table 3.
Table 1 is by the impact of reagent on Nutritive obesity mice body weight and Lee ' S index
| Group | Starting weight/g | Weight/g eventually | Lee ' S index |
| Normal group | 21.45±0.48 | 35.02±2.48 * | 316.12±10.48 * |
| Model control group | 22.05±0.32 | 38.14±2.23 | 327.82±11.47 |
| Group 1 | 22.65±0.41 | 35.25±2.51 * | 314.76±10.62 * |
| Group 2 | 21.90±0.48 | 34.68±2.23 ** | 311.42±10.36 * |
| Group 3 | 21.79±0.42 | 35.72±2.64 * | 314.98±13.25 * |
(note: compared with model control group,
*, p < 0.05,
*, p < 0.01)
The result of table 1 shows: Lee ' the S index that all can reduce Nutritive obesity mice by reagent group, and group 1, group 2 compare with model control group, and data have significant difference.
Table 2 is subject to reagent on the impact of the fatty weight in wet base of Nutritive obesity mice
(note: compared with model control group,
*, p < 0.05,
*, p < 0.01)
The result of table 2 shows: by the fatty weight in wet base of reagent group lower than model control group, and body fat is than higher than model control group, and group 1, group 2 compare with model control group, and kidney peripheral adipose weight in wet base and body fat compare significant difference.
Table 3 is subject to reagent on the impact of Nutritive obesity mice blood lipid level
(note: compared with model control group,
*, p < 0.05,
*, p < 0.01)
The result of table 3 shows: compared with Normal group, and model control group mice serum TC, TG and LDL-C significantly raise, and HDL-C significantly reduces.Group 1, group 2 all significantly can reduce mice serum TC, TG and LDL-C concentration, raise HDL-C concentration.
Visible, all can reduce Lee ' S exponential sum fat index by reagent, wherein organize 1, group 2 compares with model control group and have significant difference, and the effect organizing 2 is better than group 1.Above-mentioned description of test, Folium Mori of the present invention, Fructus Momordicae charantiae, Folium Camelliae sinensis, Fructus Jujubae proportioning use, and have synergistic function, can be used for hyperlipemia again while fat-reducing.
Comparative example 1
Adopt the material in the component of the Chinese medicine composition be not particularly limited in the present invention to carry out within 30 days and 42 days, feeding and body weight test to Nutritive obesity mice, feedstuff kind and method of testing are with effect example 1, and test result is as shown in table 4.
Table 4 is by the impact of reagent on Nutritive obesity mice body weight and Lee ' S index
(note: compared with model control group,
*, p < 0.05,
*, p < 0.01)
Belong to trophophase owing to buying mice, add the weight feed of feedstuff, body weight increase is inevitable trend.As can be drawn from Table 4, group 2 is fed mice and is contrasted with nutrient fodder group after 42 days, there is significant differences, other 7 groups of data, except Fructus Jujubae nursing group does not separately have significant difference, remaining 6 groups all have significant difference, best with effect of the present invention, prompting, after combination and compatibility, has the effect of potentiation.
The present invention makes full use of Chinese medical theory and modern medicine study achievement carries out prescription, for saccharide, fats in absorption of human body metabolic process, act on disease from multiple links such as decrease uptake, quickening metabolism, confirm the effect with obvious Weight-reducing and lipid-lowering through animal experiment.The pharmacology that compositions of the present invention has and health-care effect, can be used as medicine, also can be used as health food.
Claims (17)
1. a Chinese medicine composition, it is characterized in that, described Chinese medicine composition is the water of material A and/or material A or the extract of ethanol water, and described material A is made up of following compositions: with parts by weight, 2-10 part Mulberry, 2-10 part Fructus Momordicae charantiae, 5-20 part Folium Camelliae sinensis, and 1-5 part Fructus Jujubae; Wherein, described Mulberry is one or more in Folium Mori, Cortex Mori, Ramulus Mori, Bombyx mori L. and Fructus Mori, and described Folium Camelliae sinensis is green tea, oolong tea, black tea and Folium camelliae assamicae.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that, described material A is made up of following compositions: with parts by weight, 5 parts, Folium Mori, 5 parts, Fructus Momordicae charantiae, Folium Camelliae sinensis 10 parts and 3 parts, Fructus Jujubae; In described Folium Camelliae sinensis, the mass ratio of green tea, oolong tea, black tea and Folium camelliae assamicae is 0.8-1.2:0.8-1.2:0.8-1.2:0.8-1.2.
3. Chinese medicine composition as claimed in claim 2, it is characterized in that: in described Folium Camelliae sinensis, the mass ratio of green tea, oolong tea, black tea and Folium camelliae assamicae is 1:1:1:1.
4. Chinese medicine composition as claimed in claim 1, is characterized in that: described Chinese medicine composition is powder type.
5. Chinese medicine composition as claimed in claim 4, it is characterized in that, the preparation method of described powder comprises the steps: that each component in material A and/or the water of material A or the extract of ethanol water being dried to respectively moisture mass percentage is be ground into fine powder after 2%-3%, cross 80-120 mesh sieve, or particle diameter is the superfine powder of 0.30-24 μm, carry out irradiation sterilization again, remix preparation.
6. Chinese medicine composition as claimed in claim 3, is characterized in that, the method for the drying of described Mulberry, Fructus Momordicae charantiae or Folium Camelliae sinensis is spraying dry; The method of the drying of described Fructus Jujubae is vacuum drying.
7. Chinese medicine composition as claimed in claim 6, it is characterized in that, described spray-dired process conditions are: inlet temperature 160 DEG C, charging rate 9mL/min and atomizing pressure 1.05bar; Described vacuum drying process conditions are: vacuum-0.08MPa and baking temperature 70 DEG C.
8. the Chinese medicine composition as described in any one of claim 1 ~ 7, is characterized in that, respectively by the Mulberry in material A, Fructus Momordicae charantiae, Folium Camelliae sinensis or Fructus Jujubae, decocts 2-3 time, filter, remerge and be condensed into extractum through water or ethanol water.
9. Chinese medicine composition as claimed in claim 8, it is characterized in that, the volumetric concentration of described ethanol water is 45%-75%; Described simmer down to vacuum concentration.
10. Chinese medicine composition as claimed in claim 9, is characterized in that: the volumetric concentration of described ethanol water is 65%; The temperature of described vacuum concentration is 60-100 DEG C; The pressure of described vacuum concentration is-0.08MPa; The relative density that described simmer down to is concentrated into extractum is 1.24-1.26.
11. Chinese medicine compositions as claimed in claim 10, is characterized in that: the temperature of described vacuum concentration is 60 DEG C.
The preparation method of 12. 1 kinds of Chinese medicine compositions as described in any one of claim 1-11, is characterized in that, described preparation method is by described Chinese medicine composition Homogeneous phase mixing.
13. 1 kinds of application in preparation fat-reducing, blood fat reducing or hypoglycemic medicine or health food of the Chinese medicine composition as described in any one of claim 1-11.
14. apply as claimed in claim 13, it is characterized in that, the dosage form of described medicine is tablet, capsule, granule, pill or oral liquid.
15. apply as claimed in claim 14, it is characterized in that, described tablet, capsule, granule or pill are made up of described Chinese medicine composition and the acceptable adjuvant of pharmacy.
16. apply as claimed in claim 15, it is characterized in that; Described adjuvant is one or more in microcrystalline Cellulose, sodium carboxymethyl cellulose, magnesium stearate and Pulvis Talci.
17. apply as claimed in claim 14, it is characterized in that, described oral liquid is made up of described Chinese medicine composition and the acceptable adjuvant of pharmacy.
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| CN106962545A (en) * | 2017-03-31 | 2017-07-21 | 安徽新华学院 | Health care lipid-loweringing worm tea and preparation method thereof |
| CN107333931A (en) * | 2017-07-31 | 2017-11-10 | 季敬洪 | Health tea composition and preparation method thereof |
| CN108125236A (en) * | 2017-12-19 | 2018-06-08 | 重庆海田林业科技有限公司 | Mulberry tree concentrate and its preparation process |
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