CN109549193A - A kind of Chinese medicine compound prescription improves the health food and preparation method thereof of sleep - Google Patents
A kind of Chinese medicine compound prescription improves the health food and preparation method thereof of sleep Download PDFInfo
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- CN109549193A CN109549193A CN201710886335.1A CN201710886335A CN109549193A CN 109549193 A CN109549193 A CN 109549193A CN 201710886335 A CN201710886335 A CN 201710886335A CN 109549193 A CN109549193 A CN 109549193A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The embodiment of the present invention provides a kind of health food and preparation method thereof of Chinese medicine compound prescription improvement sleep, it is related to field of health care products, it is proved through animal function test, extend dosage hypnosis experiment under extension yellow Jackets sleeping time of mouse, amobarbital sodium valves, that barbital sodium Sleep latency tests binomial in three experiments is positive, and acted on without obvious directly sleep, having improves sleep function effect and non-evident effect.The Chinese medicine compound prescription improves the weight percent of raw material and the raw material that sleep health food includes are as follows: Poria extract 6 ~ 30%, milkwort extract 5 ~ 25%, Schisandra chinens P.E 5 ~ 25%, Wild jujube seeds extract 6 ~ 50%, wherein, the summation of the weight percent of the raw material is no more than 100%.
Description
Technical field
The present invention relates to health food and its preparation sides that field of health care products more particularly to a kind of Chinese medicine compound prescription improve sleep
Method.
Background technique
With the development of society, the pressure of people's Working Life is increasing, the anxiety that generates therewith, insomnia are continuous
Annoying the normal life of people.Most people has night to have difficulty in going to sleep, early awakening or easily awake sleep disturbance in sleeping.The people of insomnia
It will feel within second day dizzy, dizzy, out of strength, the overall performance of people is also poor, seriously affects the quality of life of the people.World sleep
An extensive opinion poll of the foundation in the U.S. finds that 56% American has several evenings at least once in one week
The symptom of insomnia feels the symptoms such as unclear including difficulty falling asleep or night awakening or early awakening or after waking up.
Insomnia refers to lasting sleep quality state unsatisfactory, and serious person even influences social function on daytime, faces
Bed show as difficulty falling asleep, sleep is not deep, easily wake up with a start, early awakening, dreaminess, wake up after it is tired, or lack it is awake feel, alertness, energy,
Cognitive function, behavior and variation of mood etc..It belong to dysautonomia be overexcited so as to cause cerebral cortex and occur one
The ill symptom of kind.Insomnia referred to as " is insomnia " in Chinese medicine, and basic pathogenesis is imbalance of yin and yang, disharmony between ying and wei, brains dystrophy, the mind
Not peaceful, due to qi-blood disharmony, the imbalance of yin and yang of internal organs, and then it is feeding and confused and worried to cause the heart to be become homeless.Had according to different card marquis
The therapy of body has: help is in, and invigorating the spleen yin-nourishing, calming the liver is soothing the liver, vital energy regualting and blood circulation-promoting, clearing damp resolving sputum, heat-clearing etc..
Sleep makes the brain and body of people be rested, rested and reorganized and restored, and facilitates the working and learning of people.Section
It learns and improves sleep quality, be the guarantee of people's efficiency operation learning life.In recent years, the research for improving sleep emerges one after another,
Much concentrate on that Western medicine is such as stable and epiphysin etc., although having the effect of certain, taking for a long time can be generated
Certain dependence and side effect.Semen ziziphi spinosae is the healthy food material of integration of drinking and medicinal herbs, for being dried to for rhamnaceae plant wild jujube
Ripe seed, sweet in flavor and neutral in nature, return heart, spleen, liver, gallbladder channel have the effect of nourishing the liver, calming heart, tranquilizing the mind, arrest sweating.Deficiency dysphoric insomnia is cured mainly,
It palpitates with fear alarmed and panicky, polydipsia, abnormal sweating is the common heart-nourishing tranquilizer of traditional Chinese medicine in treating insomnia.Fushen is the dry of polyporaceae fungus
Dry sclerotium surrounds the part of pine stump and life, is the Chinese medicine of the common tranquilizing and allaying excitement in China, and fushen is sweet in flavor, light, mild-natured, return heart,
Lung, the spleen channel, there is the effect of antitoxic heart-soothing and sedative, strengthening spleen and middle warmer.Radix Polygalae is the root of milk wort Radix Polygalae, and bitter, pungent, slightly warm in nature is returned
The heart, kidney, lung channel are usually used in insomnia and dreamful sleep caused by breakdown of the normal physiological coordination between the heart and the kidney, amnesia and pavor, and despicable, main composition is remote
Will saponin(e, and often with semen ziziphi spinosae, fushen with use.Schisandra chinensis is the maturation of the perennial fallen leaves bejuco Schisandra chinensis of Magnoliaceae
The effect of fruit, sour, sweet, warm-natured, return lung, the heart, kidney channel have astringing lung-QI nourshing kidney, and promote the production of body fluid arrest sweating, antitoxic heart-soothing and sedative, " Bie Lu " is supported
The five internal organs, except heat, flesh in raw yin.Document also turns out that it has the function of improving sleep, therefore by semen ziziphi spinosae, fushen, Radix Polygalae, the five tastes
Son is processed into the health food for improving sleep function, and not only edible safety is reliable, and obvious effect.
Nowadays the health food type for improving sleep in society is more, kind is many and diverse, and successfully application is special for many products
Benefit, such as: " a kind of health care medicinal and preparation method thereof for improving sleep quality " (number of patent application CN201310447648.9) is
Using jujube kernel, ginger, Radix Glycyrrhizae, lotus seeds, Radix Astragali, dry Chinese grooseberry, Flos Albiziae as primary raw material, add suitable water boiling, filtering, it is dense
Contracting, it is cooling, raw material honey is added, uniformly mix, be concentrated, it is dry, obtain dry extract, regrind into powdered, fill capsule, sterilization,
It examines, finished product；The invention proposes method with water, and through filtering and concentrating after boiling, this technique has extraction process simple, effect
The low shortcoming of constituents extraction rate；
" a kind of health care product for improving sleep " (number of patent application CN200710064852.7) is with semen ziziphi spinosae, Chinese yam, campanulaceae, Ah
The Chinese herbal medicines such as glue, Radix Polygalae, Radix Paeoniae Alba, the seed of Oriental arborvitae, radix glycyrrhizae preparata, lily are made of raw material, and the invention improves sleep principle and makees purposes
Diameter is single, and functional component statement is indefinite.
Summary of the invention
The embodiment of the invention provides the health food and preparation method thereof that a kind of Chinese medicine compound prescription improves sleep, present invention fortune
Theory is researched and developed with theory of traditional Chinese medical science combination Western medicine, screens numerous natural plants with improvement sleep, orientation extracts crude drug
The effect of eating homologous fushen, Radix Polygalae, Schisandra chinensis, semen ziziphi spinosae ingredient (total saposins, Thick many candies), to insomnic rats brain tissue paddy ammonia
The influence of sour (Glu), γ-aminobutyric acid (GABA) and GABAA expression of receptor, to achieve the purpose that improve sleep.It mentions
Sleep is acted on and improved for a kind of directly sleep of nothing, raw material diversification, one kind without other side effects healthy and safe effectively change
Kind sleep health food.
In order to achieve the above objectives, the embodiment of the present invention adopts the following technical scheme that
A kind of Chinese medicine compound prescription improves the health food of sleep, the Chinese medicine compound prescription improve the raw material that the health food of sleep includes and
The weight percent of the raw material are as follows: Poria extract 6 ~ 30%, milkwort extract 5 ~ 25%, Schisandra chinens P.E 5 ~ 25%, wild jujube
Benevolence extract 6 ~ 50%, wherein the summation of the weight percent of the raw material is no more than 100%.
Further, the health food that the Chinese medicine compound prescription improves sleep further includes auxiliary material, and the auxiliary material is dextrin, tristearin
Sour magnesium and film coating agent.
Further, the Chinese medicine compound prescription improves the weight percent of raw material and the raw material that the health food of sleep includes
Than are as follows: Poria extract 10%, milkwort extract 5%, Schisandra chinens P.E 5%, Wild jujube seeds extract 15%.
Further, it is that 5~10%, Thick many candies contain that the Chinese medicine compound prescription, which improves the total saponin content in sleep health food,
Amount is 10~14%.
Further, the raw material and the auxiliary material are counted in mass ratio, the raw material: the auxiliary material=(2~8): (8~
2).
Further, it is tablet that the Chinese medicine compound prescription, which improves the dosage form of the health food of sleep,.
A kind of Chinese medicine compound prescription improves the preparation method for the health food slept, and the preparation method is used to prepare Chinese medicine compound prescription
Improve the health food of sleep, which comprises
1) it mixes: being by weight 2:1:1:3 by Poria extract, milkwort extract, Schisandra chinens P.E, Wild jujube seeds extract
It is pre-mixed, cornstarch, carboxyrnethyl starch sodium is added, mixes 20min in trough type mixing machine CH-200, mixed powder is made；
2) pelletize: ethyl alcohol will be added in the mixed powder in the step 1) and be used as wetting agent, above-mentioned mixed powder and ethyl alcohol press than
Example mixing uses YK-160 type oscillating granulator using trough type mixing machine softwood after stirring, 12 mesh screens of installation carry out wet
Method granulation；
3) dry: by the wet granular in the step 2, the hot air circulation drying oven for being put into model CT-C-1 carries out hot wind and follows
Ring drying carries out wet granular drying, and drying temperature is 60 ± 5 DEG C, 4~6 h of drying time, and dry particle uses 14 mesh after drying
Sieve is sieved；
4) tabletting: resulting material is mixed with magnesium stearate, is added to the V-Mixer of VGH-500, mixes 30~40 min；
ZP-17 tablet press machine carries out tabletting, suppresses the disk of 0.6g/ piece；
5) it is coated: film coating agent (hydroxypropyl methyl cellulose, polyethylene glycol) is expected by weight with 80% ethyl alcohol and coating
It configured, be coated for 10:1, seed-coating machine parameter are as follows: compressed air pressure 0.3Mpa, revolving speed 6-8 turn/min.
6) pack: the finished product after coating obtains tablet after being put into racking machine packing, packaging.
Further, the wet granulation step in the step 2 specifically includes: 85% ethyl alcohol is added as wetting agent, second
Alcohol and mixed powder ratio are 5:1, use trough type mixing machine CH-200 softwood first, and mixing time is 8~20 min；Then it adopts
Wet granulation is carried out with the oscillating granulator of 12 meshes of installation.
Of the invention formula is scientific and reasonable, and major ingredient is pure Chinese medicine, and primary efficacy is as follows:
Semen ziziphi spinosae is the key medicine of Chinese medicine tranquilizing the mind, has significant curative effect for dysphoria, insomnia, palpitaition, all diseases of body void hidrosis, and has
Tonifying liver, calming heart, arrest sweating, the effect promoted the production of body fluid, Shennong's Herbal are classified as top grade, and Compendium of Material Medica is classified as this category,
" Chinese pharmacology " is classified as mental-tranquilization class medicine.Modern medicine study also indicates that semen ziziphi spinosae has sedative-hypnotic effect.Jujuboside is
The principle active component of semen ziziphi spinosae, wherein mainly containing Saponin A, B.Jujuboside belongs to tetracyclic triterpenes soap
Glycosides.Jujuboside is one of the main component of semen ziziphi spinosae sedative-hypnotic effect, has good effect to the improvement of sleep.
Fushen says first recorded in Shennong's Herbal, Compendium of Material Medica: " fushen is sweet flat, nontoxic, eliminating turbid pathogens, treats the dizzy wind void of wind,
Exhaustion or lesion of the five internal organs dry, stop palpitate with fear are enraged, are forgetful, happy intelligence development, pacify soul, support spirit ... ", and it is listed in top grade.Modern study table
Ming fushen is containing polysaccharide, triterpene, natural gum, protein and fatty acid etc., and there are also ergosterol, choline, adenine, lecithin, group ammonia
The inorganic elements such as acid, pachyman catabolic enzyme, protease and calcium, magnesium, phosphorus, iron, sodium, potassium, manganese.With calmness, hypnosis, nourishing heart,
The effect of tranquilizing the mind can fight excitatory state caused by caffeine, be accordingly used in the diseases such as neurasthenia, insomnia, dreaminess.
The effective component of Schisandra chinensis mainly has lignanoid, Fructus Schisandrae Chinensis volatile oil and Fructus Schisandrae Polysaccharide.Wherein lignanoid's centering
Pivot nervous system has the effects of calmness, hypnosis, anticonvulsion and protection cranial nerve cell, and total content is 2% ~ 8%.We are to Schisandra chinensis
Tranquilizing the mind effect test, the results showed that Chinese magnoliavine fruit super fine powder decocting liquid can significantly extend yellow Jackets induced mice and sleep
It sleeps the time.On this experiment basis, daily 4.5h electroencephalography has been carried out to rat is move freely.By to rat electroencephalogram
Analysis, determine influence of the Schisandra chinensis to Sleep in Rats phase.The result shows that schisandra fruit decoction can be obviously prolonged rat
TST and SWSZ, on SWSI and REMS without influence.This experimental studies results, on the one hand illustrating Schisandra chinensis improves sleep effect
Mechanism enriches traditional Chinese medical theory；On the other hand, increase SWS for Future Development and developing selective, while can guarantee REMS
The new sleeping drug object of normal rates provides experiment basis.It is bright that pharmacological research shows that Schisandra chinensis has in terms of improving sleep
Aobvious curative effect, and have no adverse reaction.The effect of Schisandra chinensis Central nervous system mainly has calmness, hypnosis, anticonvulsion and protection
Cranial nerve cell promotes intracerebral protein synthesis and other effects.Ge Huiqi etc. has studied the effect of Schisandra chinensis processed product tranquilizing soporific；
Wang Wenwen etc. has studied calm, syngignoscism the influence to mouse of south, Radix Schisandrae Bicolori extract.
Radix Polygalae is common Chinese medicine, first recorded in Shennong's Herbal, is classified as top grade, is considered as supporting the key medicine of life." middle traditional Chinese medicines
Allusion quotation " (2000 editions) recorded 2 kinds of Original plants: Radix Polygalae and ovum leaf Radix Polygalae, medicinal part is root, this product bitter, pungent, warm, return heart,
Kidney, the spleen channel have effects that tranquilize the mind and promote the intelligence, eliminating the phlegm, detumescence, all of a sudden for insomnia and dreamful sleep, amnesia and pavor, mind caused by breakdown of the normal physiological coordination between the heart and the kidney
Hu etc..Chen Qin etc. intends obtaining in neuromorphopathology Changeement in AD rat brain in Radix Polygalae soap former times to brain locating injection A β l-40
Out while basal nuclei injects A β, continuous gavage, which is given, can dramatically ground antagonism A β for Radix Polygalae soap general 74.0mg.kg-30 days to nerve
The toxic effect of cell.
The present invention is include at least the following beneficial effects:
(1) Chinese medicine compound prescription provided improves sleep health food, selects four kinds of Chinese medical extracts, carries out scientific composition compatibility, institute
The raw material used meet the regulation of the Pharmacopoeia of the People's Republic of China, and safety is without side-effects；
(2) Chinese medicine compound prescription provided improves sleep health food, researches and develops theory with theory of traditional Chinese medical science combination Western medicine, screens numerous tools
There are the natural plants for improving sleep effect, according to the result judgement in " health food is examined and assessment technique specification 2003 editions "
Method is tested: the experimental results showed that product is to yellow Jackets sleep experiments, the experiment of barbital sodium Sleep latency
The positive, and acted on without obvious directly sleep, determine that product sleep function effect results of animal is positive, having improves sleep function
It can effect.
(3) Chinese medicine compound prescription provided improves sleep health food, animal experiments prove that, there is safe and nontoxic, nothing directly
It sleeps and does not reduce physical strength, so that reaching health improves the beneficial effect slept；
Further advantage, target and feature of the invention will be partially reflected by the following instructions, and part will also be by the present invention
Research and practice and be understood by the person skilled in the art.
Detailed description of the invention
Fig. 1 is that the Chinese medicine compound prescription of the invention improves sleep health food product to mouse extension yellow Jackets sleeping time
Experiment influences schematic diagram；
Fig. 2 is that Chinese medicine compound prescription of the present invention improves sleep health food product to mouse barbital sodium Sleep latency experiment shadow
Ring schematic diagram.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention is described in detail.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein do not allot one or more
The presence or addition of a other elements or combinations thereof.
Example 1
Chinese medicine compound prescription improves sleep health food, and the Chinese medicine compound prescription, which is made, improves the raw material of effective component of sleep health food
And its weight percentage of each component are as follows: Poria extract 10%, milkwort extract 5%, Schisandra chinens P.E 5%, Wild jujube seeds extract
15%, remaining is auxiliary material.
Above-mentioned Chinese medicine compound prescription improve sleep health food the preparation method is as follows:
1) it mixes: being by weight 2:1:1:3 by Poria extract, milkwort extract, Schisandra chinens P.E, Wild jujube seeds extract
It is pre-mixed, cornstarch, carboxyrnethyl starch sodium is added, mixes 20min in trough type mixing machine CH-200, mixed powder is made；
2) it pelletizes: 85% ethyl alcohol will be added in the mixed powder in the step 1) as wetting agent, above-mentioned mixed powder and ethyl alcohol are pressed
Ratio 5:1 mixing, using trough type mixing machine CH-200 softwood, mixing time is waved after being 8~20 min using YK-160 type
Formula granulator, 12 mesh screens of installation carry out wet granulation；
3) dry: by the wet granular in the step 2, the hot air circulation drying oven for being put into model CT-C-1 carries out hot wind and follows
Ring drying carries out wet granular drying, and drying temperature is 60 ± 5 DEG C, 4~6 h of drying time, and dry particle uses 14 mesh after drying
Sieve is sieved；
4) tabletting: resulting material is mixed with magnesium stearate, is added to the V-Mixer of VGH-500, mixes 30~40 min；
ZP-17 tablet press machine carries out tabletting, suppresses the disk of 0.6g/ piece；
5) it is coated: film coating agent (hydroxypropyl methyl cellulose, polyethylene glycol) is expected by weight with 80% ethyl alcohol and coating
It configured, be coated for 10:1, seed-coating machine parameter are as follows: compressed air pressure 0.3Mpa, revolving speed 6-8 turn/min.
6) pack: the finished product after coating obtains tablet after being put into racking machine packing, packaging.
Example 2
Chinese medicine compound prescription improves sleep health food, and the Chinese medicine compound prescription, which is made, improves the raw material of effective component of sleep health food
And its weight percentage of each component are as follows: Poria extract 8.55%, milkwort extract 4.29%, Schisandra chinens P.E 4.32%, wild jujube
Benevolence extract 12.84%, remaining is auxiliary material.
Above-mentioned Chinese medicine compound prescription improves sleep health food, and the preparation method is the same as that of Example 1.
Example 3
Chinese medicine compound prescription improves sleep health food, and the Chinese medicine compound prescription, which is made, improves the raw material of effective component of sleep health food
And its weight percentage of each component are as follows: Poria extract 12%, milkwort extract 7%, Schisandra chinens P.E 7%, Wild jujube seeds extract
18%, remaining is auxiliary material.
Above-mentioned Chinese medicine compound prescription improves sleep health food, and the preparation method is the same as that of Example 1.
Example 4
Chinese medicine compound prescription improves sleep health food, and the Chinese medicine compound prescription, which is made, improves the raw material of effective component of sleep health food
And its weight percentage of each component are as follows: Poria extract 28.5%, milkwort extract 14.3%, Schisandra chinens P.E 14.4%, wild jujube
Benevolence extract 42.8%, remaining is auxiliary material.
Above-mentioned Chinese medicine compound prescription improves sleep health food, and the preparation method is the same as that of Example 1.
Example 5
The Chinese medicine compound prescription of embodiment 1 improves sleep health food, and the detection of following several respects is carried out to it:
(1) the oral safety experiment test experience of animal acute toxicity
Screening male and female mouse each 10, mouse weight 17-22g, male and female sub-cage rearing.With reference to " health food is examined and evaluation
Technical specification " method of once limiting the quantity in (2003 editions) acute toxicity test operating method, with the dosage of 20 mL/kg by product to be checked
Corresponding experimental animal is acted in a manner of stomach-filling.3~4 h of fasting after stomach-filling.Then observe and record animal
General state, toxicity performance and dead animal number.Experimental result: it by intragastric administration on mice acute toxicity testing, observes 14 days, test
Animal is without death, and all animal mental states are good, and behavior is normal, and Normal-weight increases, and has no adverse reaction, it was demonstrated that this product
Be it is nontoxic, safe, meet " Biological evaluation " requirement, as subordinate list 1 be the oral safety experiment of animal acute toxicity
Test experience result.
From upper table 1, it can be seen that embodiment 1 Chinese medicine compound prescription improve sleep health food be it is nontoxic, safe, meet " biology
Learn safety evaluatio " it requires.
(2) product tests influence the effect of mice sleep
Experimental animal: Kunming small white mouse female, 18-22g.4 groups, every group 6 are randomly divided by weight.
Experimental group and product give the time: experiment sets three dosage groups and a negative control group, three dosage components
Not are as follows: low dose group (84.9mg/kgBW), middle dose group (169.8 mg/kg BW), high dose group (509.4mg/kg BW).
Tested material is prepared with ultrapure water, and it is 4 weeks, total 28 days that tested material, which gives the time,.Feed basal feed, normal water supply.
1, direct sleep experiments of the product to mouse:
Experimental method: each group mouse carries out stomach-filling after taking the tested material of various dose to dissolve with distilled water simultaneously, and stomach-filling volume is
20mL/Kg. BW, negative control group carry out stomach-filling, daily weighing 1 time, continuous 4 w with same volume distilled water.It carries out afterwards direct
Sleep experiments observe the product that tested group of animal gives 3 dosage, after negative control group gives same volume ultrapure water, if go out
It now sleeps phenomenon.
Experimental result: using righting reflex loss as index, tested group of animal gives the product of 3 dosage, and control group is given
After same volume solvent, occur without sleep phenomenon.
2, product extends the experiment of yellow Jackets sleeping time to mouse
Experimental method: after animal last gives solvent and various concentration product, there is peak and act on first 15 minutes, give groups of animals abdomen
It is 10mg/ml that chamber, which injects yellow Jackets 50mg/kg(concentration), injection volume 0.15ml/30g.BW is with righting reflex loss
Can index, observation product extend yellow Jackets sleeping time.
Experimental result: experimental result is as shown in Fig. 1, low dose group compared with negative control group, not significant (the P > of difference
0.05)；Compared with negative control group, otherness is significant (P≤0.05) for middle dose group；High dose group compared with negative control group,
Anisotropic significant (P≤0.05).Middle and high dosage group experimental result compared with negative control group, there is significant difference, sleeping time
Extension has conspicuousness, then experimental result is the positive, shows that product can extend yellow Jackets sleep sleep, to play improvement
Sleep effect.
3, product tests mouse barbital sodium Sleep latency
Experimental method: 15min after last stomach-filling, 300 mg/kg(of barbital sodium is injected intraperitoneally in groups of animals makes through trial test determination
Animal 100% falls asleep, and does not make sleeping time too long barbital sodium dosage), mouse injection volume is 0.015ml/g.BW, bar ratio
Appropriate na concn is 20mg/ml, using righting reflex loss as index, observes influence of the product to barbital sodium Sleep latency.
Experimental result: experimental result is as shown in Fig. 2, is learnt according to result, and low dose group is compared with negative control group, poor
Different not significant (P > 0.05)；Compared with negative control group, otherness is significant (P≤0.05) for middle dose group；High dose group and yin
Property control group compare, it is anisotropic significant (P≤0.05).Middle and high dosage group experimental result compared with negative control group, there is conspicuousness
Difference, shortening Sleep latency has conspicuousness, then experimental result is positive, shows that product can shorten barbital sodium Sleep latency
Experiment, to play improvement sleep effect.
In conclusion the Chinese medicine compound prescription in the present invention improves sleep health food, safety is without side-effects, demonstrate,proves through zoopery
Bright, the present invention is safe and nontoxic, influences without directly sleep, extends yellow Jackets sleeping time, shortens barbital sodium sleep latency
Time phase, to achieve the effect that health improves sleep.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (8)
1. the health food that a kind of Chinese medicine compound prescription improves sleep, which is characterized in that the Chinese medicine compound prescription improves the health care food of sleep
The weight percent of raw material and the raw material that product include are as follows: Poria extract 6 ~ 30%, milkwort extract 5 ~ 25%, Schisandra chinensis mention
Take object 5 ~ 25%, Wild jujube seeds extract 6 ~ 50%, wherein the summation of the weight percent of the raw material is no more than 100%.
2. the health food that Chinese medicine compound prescription as described in claim 1 improves sleep, which is characterized in that the Chinese medicine compound prescription improves
The health food of sleep further includes auxiliary material, and the auxiliary material is dextrin, magnesium stearate and film coating agent.
3. the health food that Chinese medicine compound prescription as claimed in claim 1 or 2 improves sleep, which is characterized in that the Chinese medicine compound prescription
Improve the weight percent of raw material and the raw material that the health food slept includes are as follows: Poria extract 10%, milkwort extract
5%, Schisandra chinens P.E 5%, Wild jujube seeds extract 15%.
4. Chinese medicine compound prescription as claimed in claim 1 or 2 improves sleep health food, wherein the Chinese medicine compound prescription improves sleep
Total saponin content in health food is 5~10%, Thick many candies content is 10~14%.
5. the health food that Chinese medicine compound prescription as claimed in claim 2 improves sleep, which is characterized in that the raw material and described auxiliary
Material is counted in mass ratio, the raw material: the auxiliary material=(2~8): (8~2).
6. the health food that Chinese medicine compound prescription as claimed in claim 1 or 2 improves sleep, which is characterized in that the Chinese medicine compound prescription
The dosage form for improving the health food of sleep is tablet 2.
7. the preparation method that a kind of Chinese medicine compound prescription improves the health food of sleep, which is characterized in that the preparation method is for making
The standby health food for improving sleep such as Chinese medicine compound prescription according to any one of claims 1 to 6, which comprises
1) it mixes: being by weight 2:1:1:3 by Poria extract, milkwort extract, Schisandra chinens P.E, Wild jujube seeds extract
It is pre-mixed, cornstarch, carboxyrnethyl starch sodium is added, mixes 20min in trough type mixing machine CH-200, mixed powder is made；
2) pelletize: ethyl alcohol will be added in the mixed powder in the step 1) and be used as wetting agent, above-mentioned mixed powder and ethyl alcohol press than
Example mixing uses YK-160 type oscillating granulator using trough type mixing machine softwood after stirring, 12 mesh screens of installation carry out wet
Method granulation；
3) dry: by the wet granular in the step 2, the hot air circulation drying oven for being put into model CT-C-1 carries out hot wind and follows
Ring drying carries out wet granular drying, and drying temperature is 60 ± 5 DEG C, 4~6 h of drying time, and dry particle uses 14 mesh after drying
Sieve is sieved；
4) tabletting: resulting material is mixed with magnesium stearate, is added to the V-Mixer of VGH-500, mixes 30~40 min；
ZP-17 tablet press machine carries out tabletting, suppresses the disk of 0.6g/ piece；
5) it is coated: film coating agent (hydroxypropyl methyl cellulose, polyethylene glycol) is expected by weight with 80% ethyl alcohol and coating
It configured, be coated for 10:1, seed-coating machine parameter are as follows: compressed air pressure 0.3Mpa, revolving speed 6-8 turn/min；
6) pack: the finished product after coating obtains tablet after being put into racking machine packing, packaging.
8. the preparation method that Chinese medicine compound prescription as claimed in claim 7 improves the health food of sleep, which is characterized in that the step
It is rapid 2) in wet granulation step specifically include: 85% ethyl alcohol is added as wetting agent, ethyl alcohol and mixed powder ratio are 5:1, first
Using trough type mixing machine CH-200 softwood, mixing time is 8~20 min；Then using the swing particle of 12 meshes of installation
Machine carries out wet granulation.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112314819A (en) * | 2020-10-30 | 2021-02-05 | 成都致耀医药科技有限公司 | Plant beverage for improving sleep and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102793165A (en) * | 2012-07-20 | 2012-11-28 | 惠州市鑫福来实业发展有限公司 | Health care deep sleep capsule for improving sleep quality and preparation method thereof |
| CN104666563A (en) * | 2013-11-30 | 2015-06-03 | 董淑华 | Method for treating insomnia by traditional Chinese medicine |
| CN105582091A (en) * | 2014-10-22 | 2016-05-18 | 潘绍芳 | Traditional Chinese medicinal formula for treating insomnia with symptom of heart-spleen deficiency |
-
2017
- 2017-09-27 CN CN201710886335.1A patent/CN109549193A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102793165A (en) * | 2012-07-20 | 2012-11-28 | 惠州市鑫福来实业发展有限公司 | Health care deep sleep capsule for improving sleep quality and preparation method thereof |
| CN104666563A (en) * | 2013-11-30 | 2015-06-03 | 董淑华 | Method for treating insomnia by traditional Chinese medicine |
| CN105582091A (en) * | 2014-10-22 | 2016-05-18 | 潘绍芳 | Traditional Chinese medicinal formula for treating insomnia with symptom of heart-spleen deficiency |
Non-Patent Citations (1)
| Title |
|---|
| 古春青,等: "归脾汤加减治疗失眠临床研究", 《中医学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112314819A (en) * | 2020-10-30 | 2021-02-05 | 成都致耀医药科技有限公司 | Plant beverage for improving sleep and preparation method thereof |
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Address after: 710042 room 112, floor 1, building A2, standard workshop community, Xi'an Textile Industrial Park, Baqiao District, Xi'an City, Shaanxi Province Applicant after: Shaanxi bairuiheng Health Technology Co.,Ltd. Address before: 523808 room 10, 1st floor, building 1, Dongguan Taiwan Biotechnology cooperation center, No.1 Taoyuan Road, Taiwan hi tech park, Songshanhu hi tech Industrial Development Zone, Dongguan City, Guangdong Province Applicant before: DONGGUAN NATURAL SALUTEM HEALTH TECHNOLOGY CO.,LTD. |
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