CN101461896A - Chinese medicinal composition assistant for reducing blood fat and preparation method thereof - Google Patents
Chinese medicinal composition assistant for reducing blood fat and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for aiding blood fat reduction and a preparation method thereof. The method comprises: selecting 2 to 6 grams of lucid ganoderma and 1 to 4 grams of gen-seng, using 8 to 12 times of 50 to 80 percent ethanol to reflux and extract the raw materials twice, filtering the extracts respectively, combining the filtrates into filtrate I, and volatilizing the ethanol in medicine dregs for standby; decocting 1 to 3 grams of sealwort, 1 to 3 grams of polygonatum and the lucid ganoderma and gen-seng dregs by adding 6 to 10 times of water and extracting the decoction twice, filtering the extracts respectively, and combining the filtrates; decompressing and condensing the filtrate, adding ethanol into the condensed liquid, stirring the mixture evenly, keeping the mixture standing, and taking supernatant fluid II; selecting 2 to 6 grams of notoginseng, 2 to 6 grams of kudzuvine root, and 1 to 3 grams of hawthorn, using 8 to 12 times of 50 to 80 percent ethanol to reflux and extract the raw materials twice, filtering the extracts respectively, and combining the filtrates into filtrate III; and combining the filtrate I, the supernatant fluid II and the filtrate III respectively, reclaiming the ethanol by reducing pressure and condensing the combined mixture to be in shape of thick paste, drying the combined mixture in vacuum to obtain dry paste, crushing the dry paste, and sieving the dry paste by a 80-mesh sieve to obtain the composition. The traditional Chinese medicine composition has the advantages of rich raw traditional Chinese medicine, low cost, simple preparation method and process, good safety of prepared products, no any toxic and side effects, remarkable function of blood fat reduction, and stable and controllable product quality.
Description
Technical field
The present invention relates to Chinese medicine composition of a kind of auxiliary antilipemic and preparation method thereof.
Background technology
Hyperlipidemia is cholesterol, the neutral fat that constitutes fat in the human body, promptly triglyceride too high due to.Being the frequently-occurring disease of middle-aged and elderly people, is to cause the heart disease epochmaking reason that causes death.The data that Ministry of Public Health is announced shows that China has 3,000,000 people to die from cardiovascular disease every year approximately, and every day, about 8000 people were roughly equal to 1 of per 10 second.Annual New Development myocardial infarction and hemiplegic patient are respectively 500,000 and 2,000,000.In addition, just announce in " the Chinese residents nutrition in 2002 and the Health Situation investigation report " of Ministry of Public Health issue that national dyslipidemia now trouble number is estimated to reach 1.6 hundred million.According to Epidemiological study, the prevalence of China's hyperlipemia is more than 7%, in the middle of the adult of the whole nation more than 30 years old, the higher ratio of blood fat greatly about about 10%-20%, general trend be the north greater than south, the city is greater than the rural area.China has hyperlipemia 9,000 ten thousand people approximately at present, and its key population mainly concentrates on male more than 40 years old, menopause women, obesity, xanthoma is arranged, and dyslipidemia and cardiovascular and cerebrovascular disease family history person are arranged.At present, hyperlipidemia crowd increases fast, and age distribution also further shifts to an earlier date.In addition, show in the U.S. 0.72 hundred million child is arranged according to investigations, wherein the teenager below 270,000 19 years old and child's blood fat are higher.
In view of being used for the treatment of at present in the higher pharmaceutical market of blood fat, the chemical medicine market share is bigger, and mainly based on statins.The medicine and the health food of some Chinese medicine blood fat reducing classes are also arranged on the market, but all act on not obvious or have certain side effect.The present invention is intended to invent a kind of pure natural, without any side effects, auxiliary antilipemic outstanding effect health-oriented products on the basis of fully investigation, understanding and analysis.
Summary of the invention
The purpose of this invention is to provide a kind ofly have no side effect, the Chinese medicine composition of auxiliary antilipemic outstanding effect auxiliary antilipemic and preparation method thereof.
For solving the problems of the technologies described above, it is as follows to the invention provides technical scheme:
A kind of Chinese medicine composition of auxiliary antilipemic, its effective ingredient is made up of the crude drug of following day dose: Ganoderma 2-6g, Radix Panacis Quinquefolii 1-4g, Radix Notoginseng 2-6g, Radix Puerariae 2-6g, Fructus Crataegi 1-3g, Rhizoma Polygonati 1-3g, Rhizoma Polygonati Odorati 1-3g.
As preferred version, its effective ingredient is made up of the crude drug of following day dose: Ganoderma 4g, Radix Panacis Quinquefolii 2g, Radix Notoginseng 3g, Radix Puerariae 4g, Fructus Crataegi 2g, Rhizoma Polygonati 2g, Rhizoma Polygonati Odorati 2g.
The preparation method of the Chinese medicine composition of a kind of auxiliary antilipemic of the present invention, it comprises following steps: gets Ganoderma, Radix Panacis Quinquefolii, doubly measures the 50-80% alcohol reflux 2 times with 8-12, each 2 hours, filter respectively, merge into filtrate I, it is standby that medicinal residues volatilize ethanol; Get Rhizoma Polygonati, Rhizoma Polygonati Odorati and Ganoderma, Radix Panacis Quinquefolii medicinal residues and add 6-10 times of water gaging and decoct and extract 2 times, each 2 hours, filter merging filtrate respectively; It is 1.10-1.20 that filtrate decompression is concentrated into 50 ℃ of relative densities, and concentrated solution adds ethanol to be made and contain alcohol amount and reach 40-70%, stirs, and leaves standstill, and gets supernatant II; Get Radix Notoginseng, Radix Puerariae, Fructus Crataegi and doubly measure the 50-80% alcohol reflux 2 times with 8-12, each 2 hours, filter respectively, merge into filtrate II I; Difference merging filtrate I, supernatant II, filtrate II I three part solution, decompression recycling ethanol also is concentrated into the thick paste shape, and 60-80 ℃, vacuum drying under the 0.070-0.085MPa gets dry extract, and pulverizes, and crosses 80 mesh sieves, promptly.
The Chinese medicine composition extract powder adds the adjuvant that meets the pharmaceutical preparation needs, is prepared into the various dosage forms of clinical needs, comprises tablet, capsule and granule etc.
Ganoderma, Radix Panacis Quinquefolii can be ground into coarse powder and feed intake; Rhizoma Polygonati, Rhizoma Polygonati Odorati and Radix Notoginseng, Radix Puerariae, Fructus Crataegi adopt decoction pieces to feed intake respectively.
Ganoderma, Radix Panacis Quinquefolii, the most handy 10 times of amount 70% alcohol reflux 2 times, each 2 hours; Rhizoma Polygonati, Rhizoma Polygonati Odorati and Ganoderma, Radix Panacis Quinquefolii medicinal residues preferably adopt 8 times of water gagings to decoct and extract each 2 hours 2 times; And the most handy 10 times of amount 60 alcohol reflux of Radix Notoginseng, Radix Puerariae, Fructus Crataegi 2 times, each 2 hours.
The extracting solution of Rhizoma Polygonati, Rhizoma Polygonati Odorati and Ganoderma, Radix Panacis Quinquefolii medicinal residues, through filtering, filtrate decompression is concentrated into 50 ℃ of relative densities 1.10, concentrated solution adds ethanol to be made and contains alcohol amount and reach 40-70%, preferably makes to contain the alcohol amount and reach 45%, stirs, standing over night, preferably time of repose is 24 hours, gets supernatant II.
Concentrated solution is condensed into thick paste, carries out vacuum drying, and its vacuum drying parameter should be: 70 ℃ of temperature, vacuum are 0.085Mpa.
Advantage of the present invention is: its Chinese medicine composition Central Plains material medicine aboundresources, and low price, preparation method technology is simple, and the Product Safety of preparing is good, and is without any side effects, effect for reducing blood fat is obvious, constant product quality is controlled.
The specific embodiment
Embodiment 1
Get Ganoderma 4kg, Radix Panacis Quinquefolii 2kg pulverize separately becomes coarse powder, with 10 times of amount 60% alcohol reflux 2 times, each 2 hours, filter respectively, it is standby that merging filtrate I, medicinal residues volatilize ethanol.Other gets Rhizoma Polygonati decoction pieces 2kg, Rhizoma Polygonati Odorati decoction pieces 2kg and adds 8 times of water gagings decoction extractions 2 times with Ganoderma, Radix Panacis Quinquefolii medicinal residues, each 2 hours, filters merging filtrate respectively.Filtrate decompression is concentrated into 50 ℃ of relative densities 1.10, and concentrated solution adds ethanol to be made and contain alcohol amount and reach 45%, stirs, and leaves standstill 24 hours, gets supernatant II.Get notoginseng decoction piece 4kg, Radix Puerariae decoction pieces 4kg, Fructus Crataegi decoction pieces 1kg with 8 times of amount 60% alcohol reflux 2 times, each 2 hours, filter merging filtrate III respectively.Difference merging filtrate I, supernatant II, filtrate II I, decompression recycling ethanol also is concentrated into the thick paste shape, and at 80 ℃, vacuum drying under the 0.085Mpa gets dry extract.Pulverize, cross 80 mesh sieves, promptly get powder.Get extract powder, add adjuvant suitable on the medicament, mixing, granulation, tabletting, the bag film-coat is prepared into the tablet that needs clinically.
Embodiment 2
Get Ganoderma 3kg, Radix Panacis Quinquefolii 2kg pulverize separately becomes coarse powder, with 10 times of amount 60% alcohol reflux 2 times, each 2 hours, filter respectively, it is standby that merging filtrate I, medicinal residues volatilize ethanol.Other gets Rhizoma Polygonati decoction pieces 1.5kg, Rhizoma Polygonati Odorati decoction pieces 1.5kg and adds 8 times of water gagings decoction extractions 2 times with Ganoderma, Radix Panacis Quinquefolii medicinal residues, each 2 hours, filters merging filtrate respectively.Filtrate decompression is concentrated into 50 ℃ of relative densities 1.10, and concentrated solution adds ethanol to be made and contain alcohol amount and reach 45%, stirs, and standing over night is got supernatant II.Get notoginseng decoction piece 3kg, Radix Puerariae decoction pieces 3kg, Fructus Crataegi decoction pieces 1.5kg with 8 times of amount 60% alcohol reflux 2 times, each 2 hours, filter merging filtrate III respectively.Difference merging filtrate I, supernatant II, filtrate II I, decompression recycling ethanol also is concentrated into the thick paste shape, and 80 ℃, vacuum drying under the 0.085Mpa gets dry extract.Pulverize, cross 80 mesh sieves, promptly get powder.Get extract powder, add adjuvant suitable on the medicament, mix, granulation, dry, filled capsules are prepared into the capsule that needs clinically.
Embodiment 3
Get Ganoderma 4kg, Radix Panacis Quinquefolii 2kg pulverize separately becomes coarse powder, with 10 times of amount 60% alcohol reflux 2 times, each 2 hours, filter respectively, it is standby that merging filtrate I, medicinal residues volatilize ethanol.Other gets Rhizoma Polygonati decoction pieces 2kg, Rhizoma Polygonati Odorati decoction pieces 2kg and adds 8 times of water gagings decoction extractions 2 times with Ganoderma, Radix Panacis Quinquefolii medicinal residues, each 2 hours, filter respectively, merging filtrate, filtrate decompression is concentrated into 50 ℃ of relative densities to 1.10, and concentrated solution adds ethanol to be made and contain alcohol amount and reach 45%, stirs, left standstill 24 hours, and got supernatant II.Get Radix Notoginseng 3kg, Radix Puerariae decoction pieces 4kg, Fructus Crataegi decoction pieces 2kg with 8 times of amount 60% alcohol reflux 2 times, each 2 hours, filter merging filtrate III respectively.Difference merging filtrate I, supernatant II, filtrate II I, decompression recycling ethanol also is concentrated into the thick paste shape, and 80 ℃, vacuum drying under the 0.085Mpa gets dry extract.Pulverize, cross 80 mesh sieves, promptly get powder.Get extract powder. add adjuvant suitable on the medicament, mixing, granulation, dry, packing are prepared into the granule that needs clinically.
Embodiment 4
Get Ganoderma 3kg, Radix Panacis Quinquefolii 2kg pulverize separately becomes coarse powder, with 10 times of amount 60% alcohol reflux 2 times, each 2 hours, filter respectively, it is standby that merging filtrate I, medicinal residues volatilize ethanol.Other gets Rhizoma Polygonati decoction pieces 2kg, Rhizoma Polygonati Odorati decoction pieces 1kg and adds 8 times of water gagings decoction extractions 2 times with Ganoderma, Radix Panacis Quinquefolii medicinal residues, each 2 hours, filter respectively, merging filtrate, filtrate decompression is concentrated into 50 ℃ of relative densities to 1.10, and concentrated solution adds ethanol to be made and contain alcohol amount and reach 45%, stirs, left standstill 24 hours, and got supernatant II.Get Radix Notoginseng 2kg, Radix Puerariae decoction pieces 2kg, Fructus Crataegi decoction pieces 2kg with 8 times of amount 60% alcohol reflux 2 times, each 2 hours, filter merging filtrate III respectively.Difference merging filtrate I, supernatant II, filtrate II I, decompression recycling ethanol also is concentrated into the thick paste shape, and 80 ℃, vacuum drying under the 0.085Mpa gets dry extract.Pulverize, cross 80 mesh sieves, promptly get powder.Get extract powder.Add adjuvant suitable on the medicament, mixing, granulation, tabletting, bag film-coat are prepared into the tablet that needs clinically.
Embodiment 5
Get Ganoderma 4kg, Radix Panacis Quinquefolii 4kg pulverize separately becomes coarse powder, with 10 times of amount 60% alcohol reflux 2 times, each 2 hours, filter respectively, merging filtrate (I), it is standby that medicinal residues volatilize ethanol.Other gets Rhizoma Polygonati decoction pieces 2kg, Rhizoma Polygonati Odorati decoction pieces 2kg and adds 8 times of water gagings decoction extractions 2 times with Ganoderma, Radix Panacis Quinquefolii medicinal residues, each 2 hours, filters merging filtrate respectively.Filtrate decompression is concentrated into relative density to 1.10 (50 ℃), and concentrated solution adds ethanol to be made and contain alcohol amount and reach 45%, stirs, and leaves standstill 24 hours, gets supernatant (II).Get notoginseng decoction piece 6kg, Radix Puerariae decoction pieces 4kg, Fructus Crataegi decoction pieces 2kg with 8 times of amount 60% alcohol reflux 2 times, each 2 hours, filter merging filtrate (III) respectively.Merge I, II, III, three part solution respectively, decompression recycling ethanol also is concentrated into the thick paste shape, vacuum drying (80 ℃ 0.085MPa), get dry extract.Pulverize, cross 80 mesh sieves, promptly.Get the Chinese medicine composition extract powder, add adjuvant suitable on the medicament, mixing, granulation, tabletting, bag film-coat are prepared into the tablet that needs clinically.
Below further specify beneficial effect of the present invention by experiment.
One, prevents and treats the hyperlipemia clinical observation
This research is mainly analyzed the present invention to the clinical efficacy of hyperlipidemia patient and to the influence of blood lipid level by the human clinical trial.
1. case is selected
1.1. the experimenter includes standard in
The experimenter is the crowd of non-simple dyslipidemia of being in hospital, the voluntary participation test, keep usual diet, blood sampling is 2 times in half a year, be 〉=5.2mmol/L or serum triglycerides (TG) 〉=1.65mmol/L as twice serum total cholesterol (TC), all can be used as alternative objects, have following situation person to foreclose: (1) age is under-18s or over-65s person; (2) gestation or women breast-feeding their children are to the health food allergy sufferers; (3) merge to have the inclination, serious diseases such as liver, kidney and hemopoietic system, the psychotic; (4) take the article relevant in a short time, have influence on judgement person the result with being tried function; (5) do not meet the standard of including in, edible in accordance with regulations given the test agent can't be judged effect or data not umbra sound effect or safety judgement person.
2. Therapeutic Method
The treatment group is taken the tablet in the embodiment of the invention 4, and each four, every day 3 times, 30 days is 1 course of treatment.Matched group is taken XUEZHIKANG JIAONANG, and is through dosage conversion PROCESS FOR TREATMENT that profile, color, abnormal smells from the patient, dose is all consistent with treatment group medicine, and 30 days is 1 course of treatment.
3. efficacy assessment standard
Observe serum total cholesterol (TC) effective percentage, triglyceride (TG) effective percentage, HDL-C (HDL-C) effective percentage and total effective rate.
Produce effects: TC reduces 〉=20%; TG reduces 〉=40%; HDL-C rises〉0.26mmol/L.
Effectively: TC reduces by 10%～20%; TG reduces by 15%～40%; HDL-C rises〉0.104mmol/L～0.26mmol/L.
Invalid: as not reach effective standard person.
4. result
4.1 two groups of clinical efficacies relatively
Treatment group total effective rate is 63.3%, and matched group is 5%, and the treatment group obviously is better than matched group, through X
2Check, there is significant difference P＜0.01, sees Table 1.
Table 1 treatment group and matched group clinical efficacy be (example) relatively
*Compare with matched group P＜0.05
4.2 two groups of blood fat and improving situations relatively
The result is as shown in table 2.Compare P＜0.05 before and after the treatment group, explanation can obviously reduce TC, TG and P＜0.05, HDL-C. treatment of control group front and back that can significantly raise, and does not have significant difference.
Blood fat and improving comparison before and after the table 2 liang group treatment (mmol/L, x ± s)
*Compare with matched group P＜0.05
5. conclusion
Clinical observation shows that product of the present invention can reduce TG and TC to a certain extent, and rising HDL-C has good regulating action to the blood fat and the lipoprotein of hyperlipemia, and its effect is definite, in prevention or treatment hyperlipemia good prospect should be arranged; Also have vessel softening simultaneously, improve effects such as insomniac's sleep quality.
Two, to the experimentation of hyperlipidemia rat blood fat reducing
This experiment mainly is to inquire into its influence to high blood lipid model rat fat level, further verifies its drug action.
1 material and method
1.1 laboratory animal Wistar rat is male, the scale of construction (200-220) g is provided by Nanfang Medical Univ's Experimental Animal Center.23 ± 2 ℃ of raising temperatures, lighting hours 12h/d (7:00-19:00).Rat feeding experimentized after one week.
1.2 experimental drug
Chinese medicine composition of the present invention (tablet in the inventive embodiments 4).
XUEZHIKANG JIAONANG, available from the Beijing WBL Peking University Biotech Co., Ltd, lot number: 20060513.
Cholesterol is gone up the production of sea blue season development in science and technology company limited, lot number: 060625.
Cholate (No. 3), triumphant bio tech ltd product, lot number: 050120 are encircled in Guangdong.
Serum TC, TG, HDL-C and LDL-C test kit are available from Beijing Leadman Biochemistry Technology Co., Ltd..
Adeps Sus domestica, yolk powder are the commercially available prod.
1.3 analytical tool 3-18K type desk type high speed refrigerated centrifuger (Sartorius,
Germany), CX4 PRO type semi-automatic biochemical analyzer (Bechman).
1.4 50 of experimental technique extracting male Wistar rats, be divided into 5 groups at random, be blank group, high blood lipid model group, Chinese medicine composition object height of the present invention (10 times of amounts of adult's consumption), low (5 times of amounts of adult's consumption) dosage group, positive drug Xuezhikang matched group (equivalent of adult's consumption), every group of 10 animals.Except that the blank group gave normal feedstuff, other each groups all used high lipid food (78.8% normal feedstuff, 1% cholesterol, 10% yolk powder, 10% Adeps Sus domestica, 0.2% cholate) to feed.Animal freely drinks water.Giving high lipid food after 2 weeks, blank group and model group rat give with the capacity normal saline, Chinese medicine composition high and low dose group of the present invention is irritated stomach Chinese medicine composition object height of the present invention (1g/kg), low dosage (0.5g/kg), positive drug control group rat oral gavage Xuezhikang (0.1g/kg) respectively.Each administration group continuous irrigation stomach raised for 4 weeks.Weigh in once weekly.After the last administration 24 hours, at 10% chloral hydrate anesthesia (35mg/kg, ip) under,, measure the content of serum total cholesterol (TC), triglyceride (TG), HDL-C (HDL-C) and low-density lipoprotein cholesterol (LDL-C) from the rat abdominal aortic blood.
1.5 the statistical procedures experimental data represents that with x ± s the detection data all adopt SPSS software to carry out one factor analysis of variance and add up.
2 results
2.1 the variation of rat body weight
As shown in table 3.Compare with the blank group, after high fat raised for 6 weeks, the rat body weight of respectively organizing of feed high lipid food all obviously increased, and significant difference is all arranged, P＜0.01.Each administration group and model group are not seen significant difference, P〉0.05.
The variation of table 3 rat body weight (x ± s, n=10)
Annotate: * * P＜0.01, compare with the blank group.
2.2 Chinese medicine composition of the present invention is to the influence of Serum TC, TG, HDL-C and LDL-C content
As shown in table 4.Compare with the blank group, the model group Serum TC of feed high lipid food, TG, LDL-C content obviously increase (P＜0.05), HDL-C content decline (P＜0.05).Compare with model group, positive drug control group and Chinese medicine composition administration group of the present invention all have some improvement to TC, the TG of the inductive hyperlipemia rat of high lipid food, the rising of LDL-C content, and the level of the HDL-C that can raise.Chinese medicine composition high dose administration group wherein of the present invention is compared TC, TG, HDL-C, LDL-C with model group content all has significant difference (P＜0.05).
Table 4 Chinese medicine composition of the present invention to the influence of Serum TC, TG, HDL-C and LDL-C content (x ± s, n=10)
Annotate: * P＜0.05, compare with the blank group * * P＜0.01;
#Compare with the high blood lipid model group P＜0.05.
3 conclusions
Hyperlipemia (hyperlipidemia, HLP) be owing to lipid metabolism or running make unusually cholesterol (TC), triglyceride (TG) and (or) low density lipoprotein, LDL (LDL) too high and (or) the low a kind of disease that causes of high density lipoprotein (HDL) mistake.Studies show that hyperlipemia and hypertension, hyperglycemia and aging have confidential relation, and the closest with the cause of coronary heart disease relation, pathogenesis belongs to deficiency in origin and excess in superficiality more.But because most synthetic drugs are based on the mechanism of action of single target spot, it is difficult to obtain satisfied curative effect to the modern disease as cause of disease complexity such as hyperlipemias, and Chinese medicine can be brought into play the synergistic characteristics of its many target spots multicomponent, the clinical method treatments such as blood circulation promoting and blood stasis dispelling, nourishing the liver and kidney, strengthening the body resistance, benefiting QI for activating blood circulation, spleen invigorating expectorant, blood stasis dispelling of adopting more.
Existing diet absorption and the blood lipid metabolism of studies confirm that has unusual substantial connection, so this experiment adopts the high lipid food feed to induce rat to set up hyperlipemia model.Compare with the blank group, the TC of model group, TG and LDL-C value raise and have significance, prove hyperlipemia animal model modeling success.Can obviously reduce animal serum TC, TG and LDL-C content after the Chinese medicine composition administration of the present invention, and the content of the HDL-C that can raise, wherein high dose group is compared with model group and is all had the significance difference opposite sex, and experimental result shows that Chinese medicine composition of the present invention can improve the blood lipid level of test rat effectively.
Claims (8)
1, a kind of Chinese medicine composition of auxiliary antilipemic is characterized in that: its effective ingredient is made up of the crude drug of following day dose: Ganoderma 2-6g, Radix Panacis Quinquefolii 1-4g, Radix Notoginseng 2-6g, Radix Puerariae 2-6g, Fructus Crataegi 1-3g, Rhizoma Polygonati 1-3g, Rhizoma Polygonati Odorati 1-3g.
2, the Chinese medicine composition of a kind of auxiliary antilipemic according to claim 1 is characterized in that: its effective ingredient is made up of the crude drug of following day dose: Ganoderma 4g, Radix Panacis Quinquefolii 2g, Radix Notoginseng 3g, Radix Puerariae 4g, Fructus Crataegi 2g, Rhizoma Polygonati 2g, Rhizoma Polygonati Odorati 2g.
3, a kind of method for preparing the Chinese medicine composition of the described auxiliary antilipemic of claim 1, it is characterized in that: it comprises following steps: get Ganoderma, Radix Panacis Quinquefolii, doubly measure the 50-80% alcohol reflux 2 times with 8-12, each 2 hours, filter respectively, merge into filtrate I, it is standby that medicinal residues volatilize ethanol; Get Rhizoma Polygonati, Rhizoma Polygonati Odorati and Ganoderma, Radix Panacis Quinquefolii medicinal residues and add 6-10 times of water gaging and decoct and extract 2 times, each 2 hours, filter merging filtrate respectively; It is 1.10-1.20 that filtrate decompression is concentrated into 50 ℃ of relative densities, and concentrated solution adds ethanol to be made and contain alcohol amount and reach 40-70%, stirs, and leaves standstill, and gets supernatant II; Get Radix Notoginseng, Radix Puerariae, Fructus Crataegi and doubly measure the 50-80% alcohol reflux 2 times with 8-12, each 2 hours, filter respectively, merge into filtrate II I; Difference merging filtrate I, supernatant II, filtrate II I three part solution, decompression recycling ethanol also is concentrated into the thick paste shape, and 60-80 ℃, vacuum drying under the 0.070-0.085MPa gets dry extract, and pulverizes, and crosses 80 mesh sieves, promptly gets powder.
4, the preparation method of the Chinese medicine composition of a kind of auxiliary antilipemic according to claim 3 is characterized in that: Ganoderma, Radix Panacis Quinquefolii powder are broken into coarse powder and feed intake; Rhizoma Polygonati, Rhizoma Polygonati Odorati and Radix Notoginseng, Radix Puerariae, Fructus Crataegi adopt decoction pieces to feed intake respectively.
5, the preparation method of the Chinese medicine composition of a kind of auxiliary antilipemic according to claim 4 is characterized in that: Ganoderma, Radix Panacis Quinquefolii, measure 70% alcohol reflux 2 times, each 2 hours with 10 times; Rhizoma Polygonati, Rhizoma Polygonati Odorati and Ganoderma, Radix Panacis Quinquefolii medicinal residues adopt 8 times of water gagings to decoct and extract each 2 hours 2 times; Radix Notoginseng, Radix Puerariae, Fructus Crataegi are measured 60 alcohol reflux 2 times, each 2 hours with 10 times.
6, the preparation method of the Chinese medicine composition of a kind of auxiliary antilipemic according to claim 4, it is characterized in that: the extracting solution of Rhizoma Polygonati, Rhizoma Polygonati Odorati and Ganoderma, Radix Panacis Quinquefolii medicinal residues, through filtering, filtrate decompression is concentrated into 50 ℃ of relative densities 1.10, concentrated solution adds ethanol to be made and contains alcohol amount and reach 45%, stir, left standstill 24 hours, get supernatant II.
7, the preparation method of the Chinese medicine composition of a kind of auxiliary antilipemic according to claim 4 is characterized in that: the vacuum drying parameter is: 70 ℃ of temperature, vacuum are 0.085Mpa.
8, the preparation method of the Chinese medicine composition of a kind of auxiliary antilipemic according to claim 4 is characterized in that: the powder of extract, add as meeting the adjuvant of pharmaceutical preparation needs, and be prepared into tablet, capsule or the granule of clinical needs.
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