CN106421132A - Pollen pini composition with weight losing effect and preparation method thereof - Google Patents

Pollen pini composition with weight losing effect and preparation method thereof Download PDF

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Publication number
CN106421132A
CN106421132A CN201610909099.6A CN201610909099A CN106421132A CN 106421132 A CN106421132 A CN 106421132A CN 201610909099 A CN201610909099 A CN 201610909099A CN 106421132 A CN106421132 A CN 106421132A
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China
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extract
weight
composition
green tea
weight portions
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CN201610909099.6A
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Inventor
陈超
李永强
温霖
张红
李颖
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Guozhen Health Science and Technology (Beijing) Co., Ltd.
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NEW AGE HEALTH INDUSTRY(GROUP) CO Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a pollen pini composition with the weight losing effect and a preparation method thereof. The composition is composed of effective components of broken wall pine pollen, extracts from pueraria, extracts from emblic leafflower fruits and extracts from green tea and auxiliary materials allowed in drugs and food, wherein the composition is prepared from, by weight, 300-600 parts of broken wall pine pollen, 50-120 parts of extracts from pueraria, 45-102 parts of extracts from emblic leafflower fruits and 100-420 parts of extracts from green tea. Animal experiments prove that the composition can quite remarkably lower the weight of a rat fed by high-fat diet, can remarkably lower the content of CHO and TG in serum and the content of fat in a body, and has the weight losing effect.

Description

A kind of have pine pollen composition of effect of weight reducing and preparation method thereof
Technical field
The present invention relates to a kind of have pine pollen composition of effect of weight reducing and preparation method thereof.
Background technology
Obesity (obesity) is a kind of chronic disease.Estimate that it is the appearance that the mankind face at present according to World Health Organization (WHO) Easily ignored, but sickness rate is in a kind of disease steeply rising.In addition to the mankind, many house pets also can suffer from obesity.Suckling is moved Thing storage (including people) hyperliposis, so that health is affected.
Obesity (obesity) is one group of common, ancient metabolism disease group.When human body feed heat is more than consumption of calorie When, with storage as fat in internal, its amount exceedes normal physiological requirement to waste heat, and reaches and then develop into fertilizer during certain value Fat disease.The 15%～18% of Normal Male Adults adipose tissue mass about percentage of liveweight, women accounts for 20%～25%.Increase with the age Long, body fat proportion accordingly increases.Because body fat increase makes body weight be above standard body weight 20% or Body Mass Index [BMI=body weight (Kg)/(height)2(m2)] it is referred to as obesity more than 24.As the no obvious cause of disease person of seeking can claim simple obesity；Have clearly Cause of disease person is referred to as secondary obesity.
The traditional Chinese medical science thinks the cause of obesity, has four broad aspect：(1) natural endowment is relevant, and such as Chen Xiuyuan is said：" on the whole element is reported Sheng ", i.e. inherited genetic factorss described in modern medicine；(2) addiction greasy and surfeit flavour, diet excess, nutritional labeling, drug on the market, that is, 《Huang di's Canon of Medicine》Described " fertile high official, the disease of fat meat and fine grain "；(3) drowsiness moves less, so that physical consumption is substantially reduced, and causes overnutrition, Make fat fill cause fat in skin fat；(4) visceral dysfunction, stagnation of QI due to depression of the liver, insufficiency of the spleen mistake fortune, kidney deficiency gasification dereliction of duty, internal injury is long Disease, the turbid interior life of expectorant, or it is subject to damp outward, so that phlegm-damp is accumulated fat in vivo.
Method for the treatment of is determined according to the cause of disease, the method for fat-reducing is when with invigorating the spleen and benefiting QI, dispelling phlegm and eliminating dampness, soothing the liver circulation of qi promoting, blood circulation promoting and blood stasis dispelling, tonification Based on kidney qi, loosening bowel to relieve constipation, it is aided with promoting the circulation of qi helps digestion, lipid-loweringing expectorant, unclogs and readjusts the methods such as three Jiao, thus reconciling whole body function, plus The unnecessary in vivo steatolysiss of speed, reach fat-reducing and disappear fat purpose.
The Western medicine drug of existing treatment obesity mainly has diethylpropion, Fenfluramine, thyroxin, adiposine Deng, but possible using these medicines, drug side effect is big and easily produces drug resistance, there is potentially danger to the health of patient. History with traditional Chinese medicine capable of reducing weight is of long standing and well established in China, and traditional Chinese medicine capable of reducing weight is according to the different body constitution of slimmer according to Chinese medical discrimination theory Dialectical treat, suit the remedy to the case.Weight-losing Chinese patent medicine in the market is few, and existing medicine belongs to a bit cures the symptoms, not the disease, some Using expensive composition, some interrupt because uncertain therapeutic efficacy is cut using in application process.Additionally, fat-reducing be one long The process of phase, treatment by Chinese herbs obesity contains the catharsis medicine such as Radix Et Rhizoma Rhei, Folium Sennae mostly, long-term taking unsatisfactory curative effect, and for a long time Take catharsis medicine and be easily caused function of intestinal canal imbalance.
Content of the invention
The purpose of the present invention is for problem of the prior art, provide a kind of pine pollen composition with effect of weight reducing and Its preparation method, said composition determined curative effect, safe ready, Small side effects.
For achieving the above object, the present invention includes following technical scheme：
A kind of pine pollen composition with effect of weight reducing, it is to be extracted by breaking cellular wall Pollen Pini, Radix Puerariae extract, Fructus Phyllanthi Thing and green tea extract are active component and allow the adjuvant composition using in medicine and food；Wherein, breaking cellular wall Pollen Pini, 300～600 weight portions；Radix Puerariae extract, 50～120 weight portions；Fructus Phyllanthi extract 45～102 weight portion；Green tea extract, 100～420 weight portions.
Pine pollen composition as above is it is preferable that described breaking cellular wall Pollen Pini, 390～500 weight portions；Radix Puerariae extracts Thing, 70～100 weight portions；Fructus Phyllanthi extract 50～75 weight portion；Green tea extract, 200～300 weight portions.
Pine pollen composition as above is it is preferable that described breaking cellular wall Pollen Pini, 449 weight portions；Radix Puerariae extract, 82 Weight portion；Fructus Phyllanthi extract 67 weight portion；Green tea extract, 250 weight portions.
Pine pollen composition as above is it is preferable that described green tea is Folium Bambusae Folium Camelliae sinensis.
Pine pollen composition as above is it is preferable that the extracting method of described each extract is as follows：
Green tea extract：With water by 1 after Folium Camelliae sinensis are pulverized: the weight ratio of (15～90) mixes, extract at 40 DEG C～90 DEG C 0.5 hour～4 hours, filter, adjust pH value to be neutrality, concentrating under reduced pressure at 45 DEG C, lyophilization, obtain final product green tea extract；
Radix Puerariae extract：Take Radix Puerariae to add 4～water of 10 times of weight, boil extraction 2～3 times, each 0.5-3 hour, decompression Water, lyophilization are evaporated off, obtain final product Radix Puerariae and take thing；
Fructus Phyllanthi extract：Take Fructus Phyllanthi, using the extraction of 45%-75% ethanol solution, 40-70 DEG C of extraction temperature, extraction Time 1～4h, extracts 1～3 time, and feed liquid weight ratio is for 1: (15-30)；Remove solvent, lyophilization under reduced pressure, obtain final product Fructus Phyllanthi and take Thing.
Pine pollen composition as above is it is preferable that described allow the adjuvant using to be selected from sugarcane in medicine and food Sugar, xylitol, Sorbitol, hydroxyl isomaltulose, isomaltulose, Mannitol, starch, dextrin, Microcrystalline Cellulose, Lactose, One or more of hydroxypropyl methylcellulose, Semen Lini oil, Rhizoma amorphophalli powder, phospholipid, magnesium stearate.
On the other hand, the present invention provides the preparation method of pine pollen composition as above, and the method includes following step Suddenly：
Described active component is uniformly mixed with the adjuvant of 1.5-6 times of weight, adds the ethanol solution of 75-95% to do moistening Agent soft material, granulation of sieving；Wet granular at 35-75 DEG C, aeration-drying；Sieve granulate, obtains final product.
Have on the one hand, the present invention provides pine pollen composition as above to have the health food of effect of weight reducing in preparation Or the application in medicine.
Apply it is preferable that described pine pollen composition is in terms of the total amount of active component as above, oral dose is 5-15g/ days.
The beneficial effects of the present invention is：The pine pollen composition of the present invention selects four kinds of medicine-food two-purpose compositions through Reasonable 5 form, and its lipid-loweringing loss of weight effect is apparently higher than single medicine.To high lipid food nutrition purposes, especially for feeding animals model test result indicate that, this The pine pollen composition of invention can significantly reduce rat body weight in pole, and can significantly reduce CHO and TG and body fat in serum Content.
Specific embodiment
The primary raw material of the present invention is Pollen Pini, Radix Puerariae, Fructus Phyllanthi and green tea.
Pollen Pini：Sweet in the mouth warm in nature, Return liver, spleen channel.There are astringing to arrest bleeding, eliminating dampness and astringing soreses.Modern study shows, Pollen Pini is inhaled Can expand after water, make one satiety, food can be extended in gastric residence time, so that sugared absorbed speed is slowed down, from And avoid unexpected Hyperglycemia, improve the degree of the resistance to sugar of human body；This external enwergy absorbs moisture softer stool, makes defecation smooth, It is directly entered large intestine.
Radix Puerariae：Sweet in the mouth, pungent, cool in nature, attach to the lung and stomach meridians.There is resolving heat and reducing pathogenic fire, promoting the production of body fluid to quench thirst, nourishing YIN and invigorating YANG.To controlling Treat and prevention chest and diaphragm dysphoria with smothery sensation, middle wind headache, hypertension, coronary heart disease, and blood fat reducing, blood sugar lowering, anticancer, fat-reducing all have special work( Effect.
Fructus Phyllanthi：Sweet in the mouth, acid, puckery, cool in nature, return lung warp, stomach.There is the effect of relieving sore-throat by clearing away heat, nourishing the lung to arrest cough.For feeling Emit heating, throat pain, cough, mouth thousand excessive thirst, otalgia, Vitamin C deficiency disease.
Green tea：Green tea has aid digestion and drops low-fat important effect, contributes to losing weight.Caffeine in green tea can improve The secretory volume of gastric juice, can help digest.In addition, containing abundant catechin in green tea, contribute to slimming the abdomen.
Several specific embodiment of pine pollen composition with effect of weight reducing that the present invention exemplified below provides：
The preparation method of the extract used in following examples is as follows：
(1) preparation method of Radix Puerariae extract is as follows：
Take Radix Puerariae to add the water of 8 times amount, extract 2 times, 1.5 hours every time, remove water, lyophilization under reduced pressure, obtain final product Radix Puerariae and take Thing.
(2) preparation method of Fructus Phyllanthi extract is as follows：
Take Fructus Phyllanthi, extracted using 55% ethanol solution, 55 DEG C of extraction temperature, extraction time 2h, extract 2 times, feed liquid matter Amount ratio is 1: 20；Remove solvent, lyophilization under reduced pressure, obtain final product Fructus Phyllanthi and take thing.
(3) preparation method of green tea extract is as follows：
Green tea extract：Mix by 1: 20 weight ratio with water after Folium Camelliae sinensis are pulverized, extract 2 hours at 60 DEG C, filter, adjust pH It is worth for 7, concentrating under reduced pressure at 45 DEG C, lyophilization, obtain final product green tea extract.
Embodiment 1：There is the pine pollen composition () of effect of weight reducing
Breaking cellular wall Pollen Pini, 449 weight portions；Radix Puerariae extract, 82 weight portions；Fructus Phyllanthi extract 67 weight portion；Trimeresurus stejnegeri Tea extract, 250 weight portions.Each component is uniformly mixed, adds 95% ethanol solution to do wetting agent soft material, cross sieve series Grain；Wet granular at 55 DEG C, aeration-drying；Sieve granulate, obtains final product.
Embodiment 2：There is the pine pollen composition (two) of effect of weight reducing
Breaking cellular wall Pollen Pini, 495 weight portions；Radix Puerariae extract, 75 weight portions；Fructus Phyllanthi extract, 55 weight portions；Trimeresurus stejnegeri Tea extract, 223 weight portions.Each component is uniformly mixed, adds 95% ethanol solution to do wetting agent soft material, cross sieve series Grain；Wet granular at 55 DEG C, aeration-drying；Sieve granulate, obtains final product.
Embodiment 3：There is the pine pollen composition (three) of effect of weight reducing
Breaking cellular wall Pollen Pini, 415 weight portions；Radix Puerariae extract, 90 weight portions；Fructus Phyllanthi extract 70 weight portion；Trimeresurus stejnegeri Tea extract, 273 weight portions.Each component is uniformly mixed, adds 95% ethanol solution to do wetting agent soft material, cross sieve series Grain；Wet granular at 55 DEG C, aeration-drying；Sieve granulate, obtains final product.
Comparative example 1
Breaking cellular wall Pollen Pini, 449 weight portions；Radix Puerariae extract, 82 weight portions；Fructus Phyllanthi extract 67 weight portion.By each group Divide and uniformly mix, add 95% ethanol solution to do wetting agent soft material, granulation of sieving；Wet granular at 55 DEG C, aeration-drying； Sieve granulate, obtains final product.
Experimental example 1 pine pollen composition high lipid food feeds the experiment of rat improvement result
One. test principle：
This test adopts high lipid food to feed rat, inquires into the improvement work that each Weight reducing compound feeds rat to high lipid food With.
Two. test material：
Laboratory animal：Male SD rat, purchased from Beijing company limited of dimension tonneau China, quality certification number：SCXK (capital) 2014- 0001, raise in China Medical Sciences Academy Medical Plants Institute SPF level Animal House, credit number：SYXK (capital) 2013- 0023,22 ± 2 DEG C of room temperature, relative humidity 60%RH.
High lipid food：Containing 10% Adeps Sus domestica, 10% yolk powder and 80% normal feedstuff, limited by magnificent Fukang biotechnology share Company provides.
Test sample：The pine pollen composition of embodiment 1-3 preparation, the compositionss of comparative example 1 preparation, breaking cellular wall Pollen Pini, bamboo Leaf Folium Camelliae sinensis extract.
People takes daily standard dose (middle dosage)：The pine pollen composition 10.3g of embodiment 1-3 preparation, comparative example 1 is made Standby compositionss 10.3g.
Make light of one's life by commiting suicide the fat ball that disappears, Beijing Tongrentang Technology Development Co.ltd. Pharmaceutical Factory, batch number：14030049.
Reagent：Serum triglycerides (TG), cholesterol (CHO), low-density lipoprotein cholesterol (LDL) and high density lipoprotein level White cholesterol (HDL) test kit, by Beijing, Zhongsheng Beikong Biological Science ＆ Technology Co., Ltd. provides.
Three. test method：
Animal packet：Using male SD rat, every group 10.Experiment sets 12 groups：Normal control, model comparison, enforcement Example 1-3 pine pollen composition low dosage (0.325g/kg), middle dosage (0.65g/kg), high dose (1.3g/kg), 1 group of comparative example Compound low dosage (0.325g/kg), middle dosage (0.65g/kg), high dose (1.3g/kg) (be respectively equivalent to people's consumption 2.5, 5 and 10 times), breaking cellular wall Pollen Pini group (1.3g/kg), Trimeresurus stejnegeri tea extract group (0.325g/kg), (making light of one's life by commiting suicide, it is fat to disappear for positive control Ball, 750mg/kg) (being equivalent to 5 times of people's consumption).
Test method：
Feed by giving high lipid food after body weight packet, except normal and model group, start gastric infusion one month.
1. weigh weekly twice, measure food ration.
2. after off-test, weigh body fat (testis and perirenal fat pad).
Lipids detection：Measure serum oil three esters (TG), cholesterol (CHO), low-density lipoprotein cholesterol (LDL) and highly dense Degree lipoprotein cholesterol (HDL) level.
Four. statistical method
Measurement data data is represented with meansigma methodss ± standard error (mean ± standard error), comparison in difference between each group Using t inspection, completed by EXCEL statistical software.P ＜ 0.05 is that there were significant differences, and p ＜ 0.01 is to have pole significant difference.
Five. result of the test：
(1) diet products feed the impact of rat outward appearance to high lipid food：
Observe weekly the behavior state of every rat, emotional response, active degree, diet, skin and hair, sleep, stool, Compare with Normal group, high lipid food is fed rat and shown no obvious abnormalities.
(2) impact to high fat diet rat body weight for the diet products：
The results are shown in Table 1, compare with normal group, after 2 weeks, model group rats body weight increase starts to carry feeding rats high lipid food Height, is compared with model group, and embodiment 1,2,3 high dose group body weight all occurs pole to significantly reduce, the basic, normal, high dosage group of embodiment 1 Surrounding reduces body weight 6.60% (p ＜ 0.01), 6.40% (p ＜ 0.05), 9.40% (p ＜ 0.01) respectively.
The impact (g, X ± SD) (n=10) to rat body weight for table 1 diet products
Compared with normal group,##P ＜ 0.01,#P ＜ 0.05
Compare with model control group,*P ＜ 0.05, has significant difference,*P ＜ 0.01, has pole significant difference
(3) impact to high fat diet rat food ration for the diet products：
Compare with model group, embodiment 1-3 rat has reduced in the food ration of 3w, but 4w gradually recovers.
The impact (g, X ± SD) (n=10) to rat food ration for table 2 diet products
(4) impact to high fat diet rat fat and fat mass for the diet products：
The results are shown in Table 3, feeding rats high lipid food, after 4 weeks, is compared with normal group, TG (glycerol in model group rats serum Three esters) content increase.Compare with model group, embodiment 1,2,3 high dose group change of serum C HO (T-CHOL), TG content are all notable Reduce, wherein, 1 group of embodiment reduces 13.01% (p ＜ 0.05) change of serum C HO content and 23.64% (p ＜ 0.05) serum TG Content.
Compare with normal group, model group rats fat content dramatically increases.Compare with model group, the high agent of embodiment 1,2,3 Amount group fat mass all significantly reduces, and wherein, embodiment 1 high dose can substantially reduce 22.5% fat mass (p ＜ 0.05).
The effect (mmol/L, X ± SD) (n=10) to high fat diet rat fat and fat mass for table 3 diet products
Compare with Normal group,##P ＜ 0.01, has pole significant difference to compare with model control group,*P ＜ 0.05, has Significant difference,*P ＜ 0.01, has pole significant difference
6th, conclusion
Embodiment 1,2,3 high dose group can significantly reduce CHO and TG and body fat content in serum.Result above table Bright embodiment 1-3 pine pollen composition has regulation improvement result to high fat diet rat hyperlipidemia and fat content, has and subtracts Fertile effect.

Claims (9)

1. a kind of pine pollen composition with effect of weight reducing it is characterised in that its be by breaking cellular wall Pollen Pini, Radix Puerariae extract, Fructus Phyllanthi extract and green tea extract are active component and allow the adjuvant composition using in medicine and food；Wherein, Breaking cellular wall Pollen Pini, 300～600 weight portions；Radix Puerariae extract, 50～120 weight portions；Fructus Phyllanthi extract 45～102 weight portion； Green tea extract, 100～420 weight portions.
2. pine pollen composition as claimed in claim 1 is it is characterised in that described breaking cellular wall Pollen Pini, 390～500 weight portions； Radix Puerariae extract, 70～100 weight portions；Fructus Phyllanthi extract 50～75 weight portion；Green tea extract, 200～300 weight portions.
3. pine pollen composition as claimed in claim 1 is it is characterised in that described breaking cellular wall Pollen Pini, 449 weight portions；Radix Puerariae Extract, 82 weight portions；Fructus Phyllanthi extract 67 weight portion；Green tea extract, 250 weight portions.
4. pine pollen composition as claimed in claim 1 is it is characterised in that described green tea is Folium Bambusae Folium Camelliae sinensis.
5. pine pollen composition as claimed in claim 1 is it is characterised in that the extracting method of described each extract is as follows：
Green tea extract：With water by 1 after Folium Camelliae sinensis are pulverized: the weight ratio of (15～90) mixes, little in 40 DEG C～90 DEG C extractions 0.5 When～4 hours, filter, adjust pH value to be neutrality, concentrating under reduced pressure at 45 DEG C, lyophilization, obtain final product green tea extract；
Radix Puerariae extract：Take Radix Puerariae to add 4～water of 10 times of weight, boil extraction 2～3 times, each 0.5-3 hour, remove under reduced pressure Water, lyophilization, obtain final product Radix Puerariae and take thing；
Fructus Phyllanthi extract：Take Fructus Phyllanthi, using the extraction of 45%-75% ethanol solution, 40-70 DEG C of extraction temperature, extraction time 1 ～4h, extracts 1～3 time, and feed liquid weight ratio is for 1: (15-30)；Remove solvent, lyophilization under reduced pressure, obtain final product Fructus Phyllanthi and take thing.
6. the pine pollen composition according to any one of claim 1-5 it is characterised in that described in medicine and food The adjuvant using is allowed to be selected from sucrose, xylitol, Sorbitol, hydroxyl isomaltulose, isomaltulose, Mannitol, starch, paste One of essence, Microcrystalline Cellulose, Lactose, hydroxypropyl methylcellulose, Semen Lini oil, Rhizoma amorphophalli powder, phospholipid, magnesium stearate or several Kind.
7. the preparation method of the pine pollen composition as any one of claim 1-6 is it is characterised in that the method includes Following steps：
Described active component is uniformly mixed with the adjuvant of 1.5-6 times of weight, adds the ethanol solution of 75-95% to do wetting agent system Soft material, granulation of sieving；Wet granular at 35-75 DEG C, aeration-drying；Sieve granulate, obtains final product.
8. the pine pollen composition described in any one of claim 1-6 is in health food or the medicine that preparation has effect of weight reducing Application.
9. as claimed in claim 8 application it is characterised in that described pine pollen composition is in terms of the total amount of active component, Oral dose is 5-15g/ days.
CN201610909099.6A 2016-10-18 2016-10-18 Pollen pini composition with weight losing effect and preparation method thereof Pending CN106421132A (en)

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王磊等: "幼年雄性SD大鼠营养性肥胖模型的建立", 《药物研究》 *
陈巾宇等: "肥胖模型大鼠锌营养状态指标的检测及意义", 《中国实验诊断学》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110089596A (en) * 2018-01-29 2019-08-06 周凯亮 A kind of health alternative tea

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