CN106110072A - A kind of Herba Lophatheri compositions with effect of weight reducing and preparation method thereof - Google Patents
A kind of Herba Lophatheri compositions with effect of weight reducing and preparation method thereof Download PDFInfo
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Abstract
A kind of Herba Lophatheri compositions with effect of weight reducing and preparation method thereof, said composition is active component by Herba Lophatheri extract, Herba Taraxaci extract, Flos Sophorae extract, Semen Armeniacae Amarum extract, Fructus Momordicae extract, Poria extract, Semen Coicis extract, Pericarpium Citri Reticulatae extract, Fructus Crataegi extract, Semen Raphani extract and Folium Nelumbinis extract and allows the adjuvant used to form in medicine and food.Zoopery shows, the present composition can significantly reduce in serum CHO, LDL and TG content and can reduce certain body fat content, illustrates that said composition has antiobesity action.
Description
Technical field
The present invention relates to a kind of Herba Lophatheri compositions with effect of weight reducing and preparation method thereof.
Background technology
Obesity (obesity) is a kind of chronic disease.Estimate that it is the appearance that the mankind face at present according to World Health Organization (WHO)
The most out in the cold, but sickness rate is in a kind of disease steeply risen.In addition to the mankind, many house pets also can suffer from obesity.Suckling is moved
Thing (including people) storage hyperliposis, to such an extent as to health is affected.
Obesity is one group of common, ancient metabolism disease group.When human body feed heat is more than consumption of calorie, many waste heats
Amount is with storage as fat in internal, and its amount exceedes normal physiological requirement, and then develops into obesity when reaching certain value.Normally
The 15%～18% of male adult adipose tissue mass about percentage of liveweight, women accounts for 20%～25%.Increase with the age, body fat institute
Accounting example increases accordingly.Because body fat increase makes body weight be above standard body weight 20% or Body Mass Index [BMI=body weight (Kg)/(body
High)2(m2)] it is referred to as obesity more than 24.As the person of seeking simple obesity can be claimed without the obvious cause of disease；There is clear and definite cause of disease person claim
For secondary obesity.
The traditional Chinese medical science thinks the cause of obesity, has four broad aspect: (1) natural endowment is relevant, as Chen Xiuyuan is said: " on the whole element is reported
Sheng ", i.e. inherited genetic factors described in modern medicine；(2) addiction greasy and surfeit flavour, diet excess, drug on the market for nutritional labeling, i.e.
" fertile high official, the disease of fat meat and fine grain is also " described in Huangdi's Internal Classics；(3) drowsiness moves less, makes physical consumption substantially reduce, and causes overnutrition,
Make fat fill in skin to cause fat fat；(4) visceral dysfunction, stagnation of QI due to depression of the liver, insufficiency of the spleen mistake fortune, gasification dereliction of duty of suffering from a deficiency of the kidney, internal injury is long
Disease, the turbid interior life of expectorant, or outer by damp, make phlegm-damp accumulation internal and fat.
Determining method for the treatment of according to the cause of disease, fat-reducing rule for the treatment of is when with invigorating the spleen and benefiting QI, dispelling phlegm and eliminating dampness, soothing the liver circulation of qi promoting, blood circulation promoting and blood stasis dispelling, tonification
Kidney qi, loosening bowel to relieve constipation are main, are aided with circulation of qi promoting and help digestion, blood fat reducing expectorant, unclog and readjust the methods such as three Jiao, thus reconcile whole body function, add
The internal unnecessary steatolysis of speed, reaches fat-reducing and disappears fat purpose.
The Western medicine drug of existing treatment obesity mainly has diethylpropion, Fenfluramine, thyroxin, adiposine
Deng, but use these medicines may produce greatly and easily drug resistance by drug side effect, be there is potential danger in the health of patient.With
The history of traditional Chinese medicine capable of reducing weight is of long standing and well established in China, and traditional Chinese medicine capable of reducing weight is to debate according to the body constitution that slimmer is different according to Chinese medical discrimination theory
Card treats, and suits the remedy to the case.Weight-losing Chinese patent medicine in the market is few, and existing medicine belongs to a bit cures the symptoms, not the disease, and some makes
Using expensive composition, some interrupts owing to uncertain therapeutic efficacy is cut using in application process.Additionally, fat-reducing be one long-term
Process, treatment by Chinese herbs obesity mostly contains the catharsis medicine such as Radix Et Rhizoma Rhei, Folium Sennae, long-term taking unsatisfactory curative effect, and takes for a long time
It is easily caused function of intestinal canal imbalance with catharsis medicine.
Summary of the invention
It is an object of the invention to provide a kind of Herba Lophatheri compositions with effect of weight reducing and preparation method thereof.
For achieving the above object, the present invention includes following technical scheme:
A kind of Herba Lophatheri compositions with effect of weight reducing, it is to be carried by Herba Lophatheri extract, Herba Taraxaci extract, Flos Sophorae
Take thing, Semen Armeniacae Amarum extract, Fructus Momordicae extract, Poria extract, Semen Coicis extract, Pericarpium Citri Reticulatae extract, Fructus Crataegi extract,
Semen Raphani extract and Folium Nelumbinis extract are active component and allow the adjuvant composition used in medicine and food；Wherein,
Herba Lophatheri extract, 10～40 weight portions；Herba Taraxaci extract, 80～200 weight portions；Flos Sophorae extract, 50～160 weight
Part；Semen Armeniacae Amarum extract, 10～40 weight portions；Fructus Momordicae extract, 10～20 weight portions；Poria extract, 10～25 weight
Part；Semen Coicis extract, 20～50 weight portions；Pericarpium Citri Reticulatae extract, 20～50 weight portions；Fructus Crataegi extract, 30～80 weight portions；
Semen Raphani extract, 15～45 weight portion and Folium Nelumbinis extracts, 15～45 weight portions.
Compositions as above, it is preferable that described Herba Lophatheri extract, 15～25 weight portions；Herba Taraxaci extract,
100～150 weight portions；Flos Sophorae extract, 80～110 weight portions；Semen Armeniacae Amarum extract, 15～25 weight portions；Fructus Momordicae extracts
Thing, 12～16 weight portions；Poria extract, 15～20 weight portions；Semen Coicis extract, 30～40 weight portions；Pericarpium Citri Reticulatae extract,
30～40 weight portions；Fructus Crataegi extract, 40～60 weight portions；Semen Raphani extract, 20～30 weight portions；Folium Nelumbinis extract, 20
～30 weight portions.
Compositions as above, it is preferable that described Herba Lophatheri extract, 20 weight portions；Herba Taraxaci extract, 110 weights
Amount part；Flos Sophorae extract, 90 weight portions；Semen Armeniacae Amarum extract, 20 weight portions；Fructus Momordicae extract, 14 weight portions；Poria extracts
Thing, 15 weight portions；Semen Coicis extract, 37.5 weight portions；Pericarpium Citri Reticulatae extract, 37.5 weight portions；Fructus Crataegi extract, 45 weight
Part；Semen Raphani extract, 25 weight portions；Folium Nelumbinis extract, 27.5 weight portions.
Compositions as above, it is preferable that the extracting method of described each extract is as follows:
Pericarpium Citri Reticulatae crude drug raw material first collects volatile oil through steam distillation, then uses decocting cooking method to obtain extract, and
Volatile oil is merged with extract；
Herba Lophatheri, Herba Taraxaci, Flos Sophorae, Semen Armeniacae Amarum, Poria, Semen Coicis, Fructus Crataegi, Semen Raphani, Fructus Momordicae and Folium Nelumbinis all use
Decocting cooking method obtains extract.
Compositions as above, it is preferable that the described adjuvant allowing to use in medicine and food is selected from sucrose, xylose
Alcohol, Sorbitol, hydroxyl isomaltulose, isomaltulose, mannitol, starch, dextrin, microcrystalline Cellulose, lactose, hydroxypropyl
One or more in cellulose, Semen Lini oil, Rhizoma amorphophalli powder, phospholipid, magnesium stearate and green tea.
On the other hand, the present invention provides the preparation method of compositions as above, and the method comprises the following steps:
Take medicinal substances extract and the adjuvant of 1.5～4 times of medicinal substances extract weight, uniformly mix；Add 75～95v%
Ethanol solution does wetting agent soft material, granulation of sieving；Wet granular at 35～75 DEG C, aeration-drying；Sieve granulate, to obtain final product.
Another aspect, the present invention provides compositions as above to have health food and the medicine of effect of weight reducing in preparation
In application.
Application as above, it is preferable that described compositions in terms of the total amount of active component, oral dose be 5～
15g/ days.
In the compositions of effect of weight reducing of the present invention, the extract of each component preferably employs following method and prepares:
Method 1:
The preparation method of Herba Lophatheri extract is as follows:
Take Herba Lophatheri decoction pieces, add 5～the soak by water secondary of 12 times of weight every time, 0.5～1.5 hour for the first time, for the second time
0.5～1 hour, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.04～1.06 (75～80 DEG C), according to
Herba Lophatheri decoction pieces and maltodextrin weight ratio are to clear paste in add maltodextrin at 100: 1-100: 7, stir evenly, are spray-dried, mixed
Even, to obtain final product.
The preparation method of Herba Taraxaci extract is as follows:
Take Herba Taraxaci decoction pieces, add 6～the soak by water secondary of 12 times of weight every time, 0.5～1.5 hour for the first time, for the second time
0.5～1.5 hour, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.08～1.10 (75～80 DEG C), stirs
Even, it is spray-dried, mixing, to obtain final product.
The preparation method of Flos Sophorae extract is as follows:
Take Flos Sophorae decoction pieces, add 6～the soak by water secondary of 12 times of weight every time, 0.5～1.5 hour for the first time, for the second time 0.5
～1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.06～1.08 (75～80 DEG C), stirs evenly, spray
Mist is dried, mixing, to obtain final product.
The preparation method of Semen Armeniacae Amarum extract is as follows:
Take Semen Armeniacae Amarum decoction pieces, add 5～the soak by water secondary of 12 times of weight every time, 1.5～2.5 hours for the first time, for the second time 1
～2 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.05～1.07 (75～80 DEG C), stirs evenly, spray
Mist is dried, mixing, to obtain final product.
The preparation method of Poria medicament extract is as follows:
Poria decoction pieces adds 4-10 times amount water boil and extracts 0.5-2 hour, extracts 1-3 time, and extracting solution filters, and merges filtrate
Standby；Filtrate concentrates, and is concentrated into proportion 1.06-1.14；Concentrated solution centrifuge, extracting centrifugal liquid is standby；Centrifugal liquid adds
Being dried to spray dryer after entering the 30-40% maltodextrin mix homogeneously of output, spray dryer inlet temperature is
180-205 DEG C, leaving air temp is 90-105 DEG C；Take spray drying gained dried cream powder broken, cross 80 mesh, obtain Poria extract.
The preparation method of Semen Coicis extract is as follows:
Semen Coicis decoction pieces adds 4-10 times amount water boil and extracts 0.5-2 hour, extracts 1-3 time, and extracting solution filters, and merges and filters
Liquid is standby；Filtrate concentrates, and is concentrated into proportion 1.06-1.14；Concentrated solution centrifuge, extracting centrifugal liquid is standby；Centrifugal liquid
Being dried to spray dryer after adding the 30-40% maltodextrin mix homogeneously of output, spray dryer inlet temperature is
180-205 DEG C, leaving air temp is 90-105 DEG C；Take spray drying gained dried cream powder broken, cross 80 mesh, obtain Semen Coicis extract.
The preparation method of Pericarpium Citri Reticulatae extract is as follows:
Pericarpium Citri Reticulatae decoction pieces, adds 4-10 times amount water boil and extracts 0.5-2 hour, extract 1-3 time, and extracting solution filters, and merges and filters
Liquid is standby；Filtrate concentrates, and is concentrated into proportion 1.06-1.14；Concentrated solution centrifuge, extracting centrifugal liquid is standby；Centrifugal liquid
Being dried to spray dryer after adding the 35-45% maltodextrin mix homogeneously of output, spray dryer inlet temperature is
180-205 DEG C, leaving air temp is 90-105 DEG C；Take spray drying gained dried cream powder broken, cross 80 mesh, obtain Pericarpium Citri Reticulatae extract.
The preparation method of Fructus Crataegi extract is as follows:
Fructus Crataegi, adds 4-10 times amount water boil and extracts 0.5-2 hour, extract 1-3 time, and extracting solution filters, and merges filtrate
Standby；Filtrate concentrates, and is concentrated into proportion 1.06-1.14；Concentrated solution centrifuge, extracting centrifugal liquid is standby；Centrifugal liquid adds
Being dried to spray dryer after entering the 5-15% maltodextrin mix homogeneously of output, spray dryer inlet temperature is 180-
205 DEG C, leaving air temp is 90-105 DEG C；Take spray drying gained dried cream powder broken, cross 80 mesh, obtain Fructus Crataegi extract.
The preparation method of Semen Raphani extract is as follows:
Semen Raphani decoction pieces adds 5-12 times amount water boil and extracts 1-3 hour, extracts 1-3 time, and extracting solution filters, and merges filtrate
Standby；Filtrate concentrates, and is concentrated into proportion 1.06-1.14；Concentrated solution centrifuge, extracting centrifugal liquid is standby；Centrifugal liquid adds
Being dried to spray dryer after entering the 15-25% maltodextrin mix homogeneously of output, spray dryer inlet temperature is
180-205 DEG C, leaving air temp is 90-105 DEG C；Take spray drying gained dried cream powder broken, cross 80 mesh, obtain Semen Raphani extract.
The preparation method of Folium Nelumbinis extract is as follows:
Folium Nelumbinis decoction pieces adds 5-12 times amount water boil and extracts 1-3 hour, extracts 1-3 time, and extracting solution filters, and merges filtrate standby
With；Filtrate concentrates, and is concentrated into proportion 1.06-1.14；Concentrated solution centrifuge, extracting centrifugal liquid is standby；Centrifugal liquid adds
Being dried to spray dryer after the 25-35% maltodextrin mix homogeneously of output, spray dryer inlet temperature is 180-
205 DEG C, leaving air temp is 90-105 DEG C；Take spray drying gained dried cream powder broken, cross 80 mesh, obtain Folium Nelumbinis extract.
The preparation method of Fructus Momordicae extract is as follows:
Fructus Momordicae raw material adds 2～the water of 6 times amount, boils extraction 1-3 hour, extracts 1～3 time, merging filtrate, is dried.
Preferably method: Fructus Momordicae is pulverized, and adds the water of 3 times amount, boils extraction 1-3 hour, extracts 2 times, merging filtrate, mistake
Filtrate concentrates, and is concentrated into proportion 1.06-1.14；Concentrated solution centrifuge, extracting centrifugal liquid is standby；Centrifugal liquid adds output
30% maltodextrin mix homogeneously after be dried in spray dryer, spray dryer inlet temperature is 180-205 DEG C, air-out
Temperature is 90-105 DEG C；Take spray drying gained dried cream powder broken, cross 80 mesh, obtain Fructus Momordicae extract.
The beneficial effects of the present invention is: the invention provides the health care that a kind of determined curative effect, safe ready, side effect are little
Product compositions.High lipid food nutrition purposes, especially for feeding animals model is tested by the compositions of the application present invention, and experiment shows, of the present invention group
Compound can significantly reduce in serum CHO, LDL and TG content and can reduce certain body fat content, and this combination is described
Thing has effect of weight reducing.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
The primary raw material of the present invention be Herba Lophatheri, Herba Taraxaci, Flos Sophorae, Semen Armeniacae Amarum, Fructus Momordicae, Poria, Semen Coicis, Pericarpium Citri Reticulatae,
Fructus Crataegi, Semen Raphani and Folium Nelumbinis.
Herba Lophatheri: sweet, light, cold.GUIXIN, stomach, small intestine meridian.Have that dampness removing heat conduction is descending, effect of diuresis.For antipyretic,
Diuresis, aphtha of the mouth and tongue.
Herba Taraxaci: bitter, sweet, cold.Return liver, stomach warp.Having heat-clearing and toxic substances removing, effect of dispersing swelling and dissipating binds, for pathopyretic ulcer, Huang
Subcutaneous ulcer, pyretic stranguria, conjunctival congestion and swelling pain.
Flos Sophorae: bitter, be slightly cold.Return liver, large intestine channel.There is effect of clearing qi and cooling blood, liver heat removing and eyesight improving.For heat in blood go out blood disorder,
The conjunctival congestion and swelling pain of flaming up of liver-fire, feeling of fullness in the head are had a headache.
Semen Armeniacae Amarum: bitter, tepor.Return lung, large intestine channel.There is promoting the circulation of QI machine removing dampness, relieving cough and asthma, effect of loosening bowel to relieve constipation, use
In multiple cough, dryness of the intestine constipation.
Poria: property slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is promoting diuresis to eliminate damp pathogen, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Fu
Siberian cocklebur mild in medicine property and, both can be eliminating evil, again can righting, mend and the highest, profit and the most violent.Ancients think that Poria diuretic is not just hindered, actually
Inducing diuresis to remove edema key medicine.Poria can strengthening spleen and middle warmer again can eliminating dampness by diuresis antidiarrheal, make wet without being gathered, expectorant is had no way of life, suitable phlegm syndrome and phlegm retention
Card, therefore Poria has the effect of giving consideration to both the incidental and fundamental.
Semen Coicis: property slightly sweet flavor is slightly cold, and returns spleen, stomach, lung meridian.There is the merit of promoting diuresis to eliminate damp pathogen, spleen invigorating, eliminating impediment, clearing away heat and discharging pus
Effect.Semen Coicis is splendid beauty treatment food materials, and often food can keep human body skin gloss fine and smooth, the U.S. such as light speckles, beautification and white, skin moistening smoothing wrinkle
Hold moistening face.
Pericarpium Citri Reticulatae: another name: Pericarpium Citri Reticulatae, expensive old, Folium Styracis Suberifoliae, yellow Pericarpium Citri Reticulatae, Pericarpium citri reticuatae chachiensis, Pericarpium Citri tangerinae, Citrus chachiensis Hort. C. Suavissima Tanaka, Pericarpium citri reticuatae chachiensis.Warm in nature, acrid in the mouth,
Bitter in the mouth.Enter spleen channel, stomach warp, lung meridian.Pericarpium Citri Reticulatae temperature can support spleen, pungent can be amusing, bitter can spleen invigorating.There is regulating qi-flowing for strengthening spleen, solve greasy and in, dry
Effect of humidifying expectorant stopping nausea and vomiting by lowering the adverse flow of QI.
Fructus Crataegi: have another name called Fructus Crataegi cuneatae, Crataegi cuneatae, Fructus Crataegi, fruitlet mountain list, little Fructus Crataegi, crataegus cuneata, red pawl in fact, red claw, Chinese bush cherry
Kerria's, Chinese bush cherry ball, green pears.Sour in the mouth, sweet, slightly warm in nature.Return spleen, stomach, Liver Channel.Appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, reduce phlegm
Circulation of qi promoting.For meat stagnant long-pending, lump in the abdomen, abdominal distention feeling of fullness, stasis blocking stomachache, phlegm retention, have loose bowels, discharging fresh blood stool etc..
Semen Raphani: have another name called Radix Raphani, sieve clothes.Property flat, acrid in the mouth, sweet.Return lung, spleen, stomach warp.Help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm, cough-relieving
Relieving asthma.Breath with cough for retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots.Owing to the de-swelling effect that helps digestion is notable, therefore
There is the title of " rush wall fall wall ".
Folium Nelumbinis: toil is micro-puckery, cool in nature, GUIXIN, liver, spleen channel；There is summer heat relieving and dampness eliminating, yang invigorating of being amusing, effect of dissipating blood stasis hemostasis；
Cure mainly summer-heat excessive thirst, dizziness of having a headache, edema, lack of appetite abdominal distention, dysentery, leucorrhea, proctoptosis, spit blood, epistaxis, spitting of blood, have blood in stool, metrorrhagia,
Post partum longtime lochia, traumatic blood stasis.
Fructus Momordicae: sweet in the mouth cool in nature, returns lung, large intestine channel, has effect of nourishing the lung to arrest cough, promoting the production of body fluid to quench thirst.For lung-heat or the dryness of the lung
Cough, pertussis and summer-heat impairment of body fluid are thirsty, in addition with effect of loosening bowel to relieve constipation.
Several specific embodiment of the compositions with effect of weight reducing that the present invention exemplified below provides:
The preparation method of the extract used in following example is as follows:
(1) preparation method of Herba Lophatheri extract is as follows:
Taking Herba Lophatheri decoction pieces, add the soak by water 1 hour of 8 times of weight for the first time, second time adds the soak by water 0.5 of 6 times of weight
Hour, merging secondary decocting liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.04～1.06 (80 DEG C), according to Herba Lophatheri
Decoction pieces and maltodextrin weight ratio are to clear paste in add maltodextrin at 100: 3, stir evenly, are spray-dried, and mixing to obtain final product.Often make
Standby 1g extract uses the about 14g Herba Lophatheri prepared slices of Chinese crude drugs.
(2) preparation method of Flos Sophorae extract is as follows:
Taking Flos Sophorae decoction pieces, add the soak by water 1 hour of 8 times of weight for the first time, second time adds the soak by water 1 hour of 8 times of weight,
Merging secondary decocting liquid, filter, filtrate is concentrated into the clear paste of relative density 1.06～1.08 (80 DEG C), stirs evenly, and is spray-dried, mixed
Even, to obtain final product.Often prepare 1g extract and use the about 7g Flos Sophorae prepared slices of Chinese crude drugs.
(3) preparation method of Semen Armeniacae Amarum extract is as follows:
Taking Semen Armeniacae Amarum decoction pieces, add the soak by water 2 hours of 10 times of weight for the first time, second time adds the soak by water 1.5 of 8 times of weight
Hour, merging secondary decocting liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.07 (80 DEG C), stirs evenly, and is spray-dried, mixed
Even, to obtain final product.Often prepare 1g extract and use the about 14g Semen Armeniacae Amarum prepared slices of Chinese crude drugs.
(4) preparation method of Herba Taraxaci extract is as follows:
Taking Herba Taraxaci decoction pieces, add the soak by water secondary of 8 times of weight the most for the first time, 1 hour for the first time, second time added 8 times
The soak by water of weight 1 hour, merges secondary decocting liquid, filters, and it is the clear of 1.08～1.10 (80 DEG C) that filtrate is concentrated into relative density
Cream, stirs evenly, and is spray-dried, and mixing to obtain final product.Often prepare 1g extract and use the about 11g Herba Taraxaci prepared slices of Chinese crude drugs.
(5) preparation method of Poria extract
Poria decoction pieces adds 8 times amount water boils and extracts 1.5 hours, and extracting solution filters, and medicinal residues add 6 times amount water boils, and to extract 1 little
Time, extracting solution filters, and merges filtrate standby.Filtrate concentrates, and is concentrated into proportion 1.06-1.14；Concentrated solution centrifuge from
The heart, extracting centrifugal liquid is standby；It is dried to spray dryer after 35% maltodextrin mix homogeneously of centrifugal liquid addition output, spray
Mist exsiccator inlet temperature is 180-205 DEG C, and leaving air temp is 90-105 DEG C；Take spray drying gained dried cream powder broken, cross 80 mesh,
Obtain Poria extract.Through above-mentioned steps, every 100 weight portion crude drug raw materials obtain extract about 5 weight portion.
(6) preparation method of Semen Coicis extract
Semen Coicis, adds 8 times amount water boils and extracts 1.5 hours, and extracting solution filters, and medicinal residues add 6 times amount water boils, and to extract 1 little
Time, extracting solution filters, and merges filtrate standby.Filtrate concentrates, and is concentrated into proportion 1.06-1.14；Concentrated solution centrifuge from
The heart, extracting centrifugal liquid is standby；It is dried to spray dryer after 35% maltodextrin mix homogeneously of centrifugal liquid addition output, spray
Mist exsiccator inlet temperature is 180-205 DEG C, and leaving air temp is 90-105 DEG C；Take spray drying gained dried cream powder broken, cross 80 mesh,
Obtain Semen Coicis extract.Through above-mentioned steps, every 100 weight portion crude drug raw materials obtain extract about 12.5 weight portion.
(7) preparation method of Pericarpium Citri Reticulatae extract
Pericarpium Citri Reticulatae medical material, adds 8 times amount water boils and extracts 1.5 hours, and extracting solution filters, and medicinal residues add 6 times amount water boils, and to extract 1 little
Time, extracting solution filters, and merges filtrate standby.Filtrate concentrates, and is concentrated into proportion 1.06-1.14；Concentrated solution centrifuge from
The heart, extracting centrifugal liquid is standby；It is dried to spray dryer after 40% maltodextrin mix homogeneously of centrifugal liquid addition output, spray
Mist exsiccator inlet temperature is 180-205 DEG C, and leaving air temp is 90-105 DEG C；Take spray drying gained dried cream powder broken, cross 80 mesh,
Obtain Pericarpium Citri Reticulatae extract.Through above-mentioned steps, every 100 weight portion crude drug raw materials obtain extract about 25 weight portion.
(8) preparation method of Fructus Crataegi extract
Fructus Crataegi, adds 8 times amount water boils and extracts 1.5 hours, and extracting solution filters, and medicinal residues add 6 times amount water boils, and to extract 1 little
Time, extracting solution filters, and merges filtrate standby.Filtrate concentrates, and is concentrated into proportion 1.06-1.14；Concentrated solution centrifuge from
The heart, extracting centrifugal liquid is standby；It is dried to spray dryer after 10% maltodextrin mix homogeneously of centrifugal liquid addition output, spray
Mist exsiccator inlet temperature is 180-205 DEG C, and leaving air temp is 90-105 DEG C；Take spray drying gained dried cream powder broken, cross 80 mesh,
Obtain Fructus Crataegi extract.Through above-mentioned steps, every 100 weight portion crude drug raw materials obtain extract about 33.3 weight portion.
(9) preparation method of Semen Raphani extract
Semen Raphani, coarse crushing, to about 1cm size, adds 8 times amount water boils and extracts 2.0 hours, and extracting solution filters, and medicinal residues add 8
Times amount water boil extracts 1.5 hours, and extracting solution filters, and merges filtrate standby.Filtrate concentrates, and is concentrated into proportion 1.06-
1.14；Concentrated solution centrifuge, extracting centrifugal liquid is standby；After centrifugal liquid adds 20% maltodextrin mix homogeneously of output
Being dried to spray dryer, spray dryer inlet temperature is 180-205 DEG C, and leaving air temp is 90-105 DEG C；Take spray dried
Dry gained dried cream powder is broken, crosses 80 mesh, obtains Semen Raphani extract.Through above-mentioned steps, every 100 weight portion crude drug raw materials obtain extract
About 10 weight portions.
(10) preparation method of Folium Nelumbinis extract
Folium Nelumbinis, coarse crushing, to about 1cm length, adds 10 times amount water boils and extracts 2.0 hours, and extracting solution filters, and medicinal residues add 8 times
Amount water boil extracts 2.0 hours, and extracting solution filters, and merges filtrate standby.Filtrate concentrates, and is concentrated into proportion 1.06-1.14；
Concentrated solution centrifuge, extracting centrifugal liquid is standby；To spray after 30% maltodextrin mix homogeneously of centrifugal liquid addition output
Being dried in mist exsiccator, spray dryer inlet temperature is 180-205 DEG C, and leaving air temp is 90-105 DEG C；Take spray drying institute
Get dry extract pulverizing, crosses 80 mesh, obtains Folium Nelumbinis extract.Through above-mentioned steps, every 100 weight portion crude drug raw materials obtain extract about 11.1
Weight portion.
(11) preparation method of Fructus Momordicae extract
Fructus Momordicae is pulverized, and with the water of 3 times amount, extracts 2 times, merging filtrate, and filtrate concentrates, and is concentrated into proportion 1.06-
1.14；Concentrated solution centrifuge, extracting centrifugal liquid is standby；After centrifugal liquid adds 30% maltodextrin mix homogeneously of output
Being dried to spray dryer, spray dryer inlet temperature is 180-205 DEG C, and leaving air temp is 90-105 DEG C；Take spray dried
Dry gained dried cream powder is broken, crosses 80 mesh, obtains Fructus Momordicae extract.
Embodiment 1: there is the compositions () of effect of weight reducing
(1) raw material composition: Herba Lophatheri extract, 20 weight portions；Herba Taraxaci extract, 110 weight portions；Flos Sophorae extract,
90 weight portions；Semen Armeniacae Amarum extract, 20 weight portions；Fructus Momordicae extract, 14 weight portions；Poria extract, 15 weight portions；Semen Coicis
Core extract, 37.5 weight portions；Pericarpium Citri Reticulatae extract, 37.5 weight portions；Fructus Crataegi extract, 45 weight portions；Semen Raphani extract, 25
Weight portion；Folium Nelumbinis extract, 27.5 weight portions.
Adjuvant: dextrin, 704 weight portions；Lactose, 176 weight portions.
(2) preparation process:
Take each extract and adjuvant, cross 80 mesh sieves, uniformly mix；The ethanol solution adding 90v% does wetting agent soft material,
Cross 14 mesh sieves to pelletize；Wet granular at 55 DEG C, aeration-drying 1 hour；Cross 14 mesh sieve granulate, to obtain final product.
Embodiment 2: there is the compositions (two) of effect of weight reducing
(1) raw material composition: Herba Lophatheri extract, 25 weight portions；Herba Taraxaci extract, 100 weight portions；Flos Sophorae extract,
110 weight portions；Semen Armeniacae Amarum extract, 15 weight portions；Fructus Momordicae extract, 12 weight portions；Poria extract, 20 weight portions；The heart of a lotus seed
Semen Coicis extract, 30 weight portions；Pericarpium Citri Reticulatae extract, 40 weight portions；Fructus Crataegi extract, 40 weight portions；Semen Raphani extract, 30 weights
Amount part；Folium Nelumbinis extract, 20 weight portions.
Adjuvant: microcrystalline Cellulose, 216 weight portions；Sorbitol, 32 weight portions；Rhizoma amorphophalli powder, 539 weight portions；Sucrose, 97
Weight portion.
(2) preparation process:
Take each extract and adjuvant, cross 80 mesh sieves, uniformly mix；The ethanol solution adding 90v% does wetting agent soft material,
Cross 14 mesh sieves to pelletize；Wet granular at 55 DEG C, aeration-drying 1 hour；Cross 14 mesh sieve granulate, to obtain final product.
Embodiment 3: there is the compositions (three) of effect of weight reducing
(1) raw material composition: Herba Lophatheri extract, 15 weight portions；Herba Taraxaci extract, 150 weight portions；Flos Sophorae extract,
80 weight portions；Semen Armeniacae Amarum extract, 25 weight portions；Fructus Momordicae extract, 16 weight portions；Poria extract, 15 weight portions；Semen Coicis
Core extract, 40 weight portions；Pericarpium Citri Reticulatae extract, 30 weight portions；Fructus Crataegi extract, 60 weight portions；Semen Raphani extract, 20 weight
Part；Folium Nelumbinis extract, 30 weight portions.
Adjuvant: starch, 840 weight portions, xylitol, 120 weight portions.
(2) preparation process:
Take each extract and adjuvant, cross 80 mesh sieves, uniformly mix；The ethanol solution adding 90v% does wetting agent soft material,
Cross 14 mesh sieves to pelletize；Wet granular at 55 DEG C, aeration-drying 1 hour；Cross 14 mesh sieve granulate, to obtain final product.
Comparative example 1
(1) raw material composition: Herba Lophatheri extract, 20 weight portions；Herba Taraxaci extract, 110 weight portions；Flos Sophorae extract,
90 weight portions；Semen Armeniacae Amarum extract, 20 weight portions；Fructus Momordicae extract, 14 weight portions.
Adjuvant: dextrin, 400 weight portions；Lactose, 100 weight portions.
(2) preparation process:
Take each extract and adjuvant, cross 80 mesh sieves, uniformly mix；The ethanol solution adding 90v% does wetting agent soft material,
Cross 14 mesh sieves to pelletize；Wet granular at 55 DEG C, aeration-drying 1 hour；Cross 14 mesh sieve granulate, to obtain final product.
Comparative example 2
(1) raw material composition: Fructus Momordicae extract, 14 weight portions；Poria extract, 15 weight portions；Semen Coicis extract,
37.5 weight portions；Pericarpium Citri Reticulatae extract, 37.5 weight portions；Fructus Crataegi extract, 45 weight portions；Semen Raphani extract, 25 weight portions；Lotus
Leaf extract, 27.5 weight portions.
Adjuvant: dextrin, 320 weight portions；Lactose, 80 weight portions.
(2) preparation process:
Take each extract and adjuvant, cross 80 mesh sieves, uniformly mix；The ethanol solution adding 90v% does wetting agent soft material,
Cross 14 mesh sieves to pelletize；Wet granular at 55 DEG C, aeration-drying 1 hour；Cross 14 mesh sieve granulate, to obtain final product.
Experimental example 1 compositions high lipid food feeds the experiment of rat improvement result
One. test principle:
This test uses high lipid food to feed rat, inquires into Weight reducing compound and high lipid food is fed the improvement work of rat
With.
Two. test material:
Laboratory animal: male SD rat, purchased from Beijing company limited of dimension tonneau China, the quality certification number: SCXK (capital) 2014-
0001, raise in China Medical Sciences Academy Medical Plants Institute SPF level Animal House, credit number: SYXK (capital) 2013-
0023, room temperature 22 ± 2 DEG C, relative humidity 60%RH.
High lipid food: containing 10% Adeps Sus domestica, 10% yolk powder and 80% normal feedstuff, limited by China's Fukang biotechnology share
Company provides.
Test sample: compositions prepared by embodiment 1-3, compositions prepared by comparative example 1-2.
People takes standard dose every day (middle dosage): compositions 10.3g prepared by embodiment 1-3, prepared by comparative example 1-2
Compositions 10.3g.
Make light of one's life by commiting suicide the fat ball that disappears, Beijing Tongrentang Technology Development Co.ltd. Pharmaceutical Factory, batch number: 14030049.
Reagent: serum triglycerides (TG), cholesterol (CHO), low-density lipoprotein cholesterol (LDL) and high density lipoprotein level
White cholesterol (HDL) test kit, by Beijing, Zhongsheng Beikong Biological Science & Technology Co., Ltd. provides.
Three. test method:
Animal is grouped: use male SD rat, often group 10.Test and set 15 groups: normal control, model comparison, enforcement
Example 1-3 compositions low dosage (0.325g/kg), middle dosage (0.65g/kg), high dose (1.3g/kg), comparative example 1-2 compositions
Low dosage (0.325g/kg), middle dosage (0.65g/kg), high dose (1.3g/kg) (be respectively equivalent to the 2.5 of people's consumption, 5 and
10 times), positive control (the fat ball that disappears of making light of one's life by commiting suicide, 750mg/kg) (being equivalent to 5 times of people's consumption).
Test method:
Give high lipid food after being grouped by body weight to feed, except normal and model group, start gastric infusion one month.
Weigh the most weekly twice, measure food ration.
2. after off-test, weigh body fat (testis and perirenal fat pad).
Lipids detection: measure serum oil three esters (TG), cholesterol (CHO), low-density lipoprotein cholesterol (LDL) and highly dense
Degree lipoprotein cholesterol (HDL) level.
Four. statistical method
Measurement data data meansigma methods ± standard error (mean ± standard error) represents, each group difference compares
Use t inspection, EXCEL statistical software complete.P ＜ 0.05 is that there were significant differences, and p ＜ 0.01 is for there being pole significant difference.
Five. result of the test:
(1) diet products impact on high lipid food nursing rat outward appearance:
Observe weekly the behavior state of every rat, emotional response, active degree, diet, skin and hair, sleep, defecate,
Comparing with Normal group, high lipid food is fed rat and is shown no obvious abnormalities.
(2) high fat is fed the impact of rat body weight the results detailed in Table 1 by diet products:
Comparing with normal group, feeding rats high lipid food is after 2 weeks, and model group rats body weight increases and starts to improve.With model
Group compares, and embodiment 1 high dose group surrounding reduces body weight 6.28% (p ＜ 0.01).Embodiment 2 high dose group surrounding reduces body weight
6.04% (p ＜ 0.01).Embodiment 3 high dose group surrounding reduces body weight 6.38% (p ＜ 0.01).
The impact (g, X ± SD) (n=10) on rat body weight of table 1 diet products
Compared with normal group,##P ＜ 0.01,#P ＜ 0.05
Compare with model control group,*P ＜ 0.05, has significant difference,*P ＜ 0.01, has pole significant difference
(3) high fat is fed the impact of rat fat and fat mass the results detailed in Table 2 by diet products:
After feeding rats high lipid food 4 weeks, comparing with normal group, in model group rats serum, TG content increases.With model
Group compares, and embodiment 1 middle and high dosage group reduces 19.18%, 21.92% (p ＜ 0.01) change of serum C HO content, 30.91% (p
＜ 0.05), 50.91% (p ＜ 0.01) serum TG content and 16.39% (p ＜ 0.05), 26.22% serum LDL content (p ＜
0.01)。
Comparing with normal group, model group rats fat content dramatically increases.Compare with model group, embodiment 1 high dose group
Can reduce by 12.5% fat mass.
High fat is fed rat fat and the effect (mmol/L, X ± SD) (n=10) of fat mass by table 2 diet products
Compare with Normal group,##P ＜ 0.01, has pole significant difference to compare with model control group,*P ＜ 0.05, has
Significant difference,*P ＜ 0.01, has pole significant difference
Six, conclusion
Embodiment 1,2,3 high dose group all can substantially reduce rat body weight, the middle and high dosage group of embodiment 1,2,3
To significantly reduce in serum CHO, LDL and TG content and certain body fat content can be reduced.
Result above shows that high fat is fed rat hyperlipidemia by embodiment 1-3 compositions and fat content has regulation and improves
Effect, has antiobesity action.
Claims (8)
1. a Herba Lophatheri compositions with effect of weight reducing, it is characterised in that it is to be extracted by Herba Lophatheri extract, Herba Taraxaci
Thing, Flos Sophorae extract, Semen Armeniacae Amarum extract, Fructus Momordicae extract, Poria extract, Semen Coicis extract, Pericarpium Citri Reticulatae extract, mountain
Short, bristly hair or beard extract, Semen Raphani extract and Folium Nelumbinis extract are active component and allow the adjuvant group used in medicine and food
Become；Wherein, Herba Lophatheri extract, 10～40 weight portions；Herba Taraxaci extract, 80～200 weight portions；Flos Sophorae extract, 50～
160 weight portions；Semen Armeniacae Amarum extract, 10～40 weight portions；Fructus Momordicae extract, 10～20 weight portions；Poria extract, 10～
25 weight portions；Semen Coicis extract, 20～50 weight portions；Pericarpium Citri Reticulatae extract, 20～50 weight portions；Fructus Crataegi extract, 30～80
Weight portion；Semen Raphani extract, 15～45 weight portion and Folium Nelumbinis extracts, 15～45 weight portions.
2. compositions as claimed in claim 1, it is characterised in that described Herba Taraxaci extract, 100～150 weight portions；Flos Sophorae
Extract, 80～110 weight portions；Semen Armeniacae Amarum extract, 15～25 weight portions；Herba Lophatheri extract, 15～25 weight portions；Arhat
Berry extract, 12～16 weight portions；Poria extract, 15～20 weight portions；Semen Coicis extract, 30～40 weight portions；Pericarpium Citri Reticulatae
Extract, 30～40 weight portions；Fructus Crataegi extract, 40～60 weight portions；Semen Raphani extract, 20～30 weight portions；Folium Nelumbinis carries
Take thing, 20～30 weight portions.
3. compositions as claimed in claim 1, it is characterised in that described Herba Taraxaci extract, 110 weight portions；Flos Sophorae extracts
Thing, 90 weight portions；Semen Armeniacae Amarum extract, 20 weight portions；Herba Lophatheri extract, 20 weight portions；Fructus Momordicae extract, 14 weight
Part；Poria extract, 15 weight portions；Semen Coicis extract, 37.5 weight portions；Pericarpium Citri Reticulatae extract, 37.5 weight portions；Fructus Crataegi is extracted
Thing, 45 weight portions；Semen Raphani extract, 25 weight portions；Folium Nelumbinis extract, 27.5 weight portions.
4. compositions as claimed in claim 1, it is characterised in that the extracting method of described each extract is as follows:
Pericarpium Citri Reticulatae crude drug raw material first collects volatile oil through steam distillation, then uses decocting cooking method to obtain extract, and will wave
Hair oil merges with extract；
Herba Taraxaci, Flos Sophorae, Semen Armeniacae Amarum, Herba Lophatheri, Poria, Semen Coicis, Fructus Crataegi, Semen Raphani, Fructus Momordicae and Folium Nelumbinis all use decocting
Cooking method obtains extract.
5. according to the compositions according to any one of claim 1-4, it is characterised in that described allow to make in medicine and food
Adjuvant selected from sucrose, xylitol, Sorbitol, hydroxyl isomaltulose, isomaltulose, mannitol, starch, dextrin, micro-
One or several in crystalline cellulose, lactose, hydroxypropyl methylcellulose, Semen Lini oil, Rhizoma amorphophalli powder, phospholipid, magnesium stearate and green tea
Kind.
6. the preparation method of the compositions according to any one of claim 1-5, it is characterised in that the method includes following
Step:
Take medicinal substances extract and the adjuvant of 1.5～4 times of medicinal substances extract weight, uniformly mix；Add the ethanol of 75～95v%
Solution does wetting agent soft material, granulation of sieving；Wet granular at 35～75 DEG C, aeration-drying；Sieve granulate, to obtain final product.
7. the answering in preparing the health food and medicine with effect of weight reducing of the compositions described in any one of claim 1-5
With.
Apply the most as claimed in claim 7, it is characterised in that described compositions in terms of the total amount of active component, oral agents
Amount is 5～15g/ days.
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| CN103520551A (en) * | 2013-10-24 | 2014-01-22 | 新时代健康产业（集团）有限公司 | Damp heat constitution type health-care food and preparation method thereof |
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