CN103604786B - 用于高灵敏度荧光分析的检测系统和方法 - Google Patents

用于高灵敏度荧光分析的检测系统和方法 Download PDF

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Publication number
CN103604786B
CN103604786B CN201310549211.6A CN201310549211A CN103604786B CN 103604786 B CN103604786 B CN 103604786B CN 201310549211 A CN201310549211 A CN 201310549211A CN 103604786 B CN103604786 B CN 103604786B
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probe
fluorescence
sensing surface
ficoll
molecule
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CN103604786A (zh
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谭洪
罗伯特·F·祖克
谭玉山
曹二华
夏明�
陈骏
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Access Medical Systems Ltd
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Polyethers (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201310549211.6A 2009-03-03 2010-03-02 用于高灵敏度荧光分析的检测系统和方法 Active CN103604786B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US20911609P 2009-03-03 2009-03-03
US61/209,116 2009-03-03
US29952510P 2010-01-29 2010-01-29
US61/299,525 2010-01-29
US30356710P 2010-02-11 2010-02-11
US61/303,567 2010-02-11
CN201080010177XA CN102341696B (zh) 2009-03-03 2010-03-02 用于高灵敏度荧光分析的检测系统和方法

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US (5) US8309369B2 (enExample)
EP (1) EP2404162B1 (enExample)
JP (3) JP5775004B2 (enExample)
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WO (1) WO2010101931A2 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050118727A1 (en) * 2003-12-01 2005-06-02 Carsten Schelp Conjugates and their use in detection methods
EP2404162B1 (en) * 2009-03-03 2017-12-27 Access Medical System Co., Ltd. Detection system and method for high sensitivity fluorescent assays
US9804179B2 (en) 2011-01-08 2017-10-31 Access Medical Systems, Ltd. Systems for immunoassay tests
CN103430024B (zh) * 2011-01-08 2016-06-29 万迈医疗仪器有限公司 用于免疫分析检测的系统
WO2012145270A2 (en) 2011-04-20 2012-10-26 Access Medical Systems, Ltd. Luminescent polymer cyclic amplification
US9568431B2 (en) 2012-04-16 2017-02-14 Access Medical Systems, Ltd. Luminescent immunoassays for quantitating analytes having a wide concentration range
US20130330711A1 (en) * 2012-06-06 2013-12-12 National Taiwan University Sensor for detection of a target of interest
WO2016077486A1 (en) * 2014-11-12 2016-05-19 Becton, Dickinson And Company Polymeric dye specific binding members and methods of making and using the same
GB201506992D0 (en) * 2014-11-14 2015-06-10 Nplex Pty Ltd A portable in-vitro diagnostic detector
JP6810055B2 (ja) * 2015-05-11 2021-01-06 アクセス メディカル システムズ，リミティド イムノアッセイにおける試験プローブおよび試薬の再利用方法
CN104990907B (zh) 2015-07-01 2018-05-08 上海睿钰生物科技有限公司 自动多通道类流式图像荧光分析系统
JP6820319B2 (ja) 2015-08-26 2021-01-27 アクセス メディカル システムズ，リミティド 増強された感度を有するイムノアッセイ
US10379049B2 (en) 2015-10-15 2019-08-13 Lumos Diagnostics IP Pty Ltd Device for reading an IVD assay
CN110036276A (zh) * 2016-10-11 2019-07-19 万迈医疗仪器有限公司 使用干涉仪的生物分子光学传感器
CN110023756B (zh) * 2016-10-31 2023-06-30 万迈医疗仪器有限公司 基于干涉测量在免疫测定中重复使用测试探针和试剂的方法
CN106841133A (zh) * 2016-12-31 2017-06-13 必欧瀚生物技术（合肥）有限公司 一种基于荧光免疫层析技术的定量检测计算方法
EP3679343B1 (en) * 2017-09-06 2023-06-07 Clemson University Research Foundation Coupon design for enhanced color sensitivity for colorimetric-based chemical analysis of liquids
WO2019050976A1 (en) 2017-09-06 2019-03-14 Access Medical Systems, Ltd. FERROMAGNETIC ROTORS FOR STIRRING A LIQUID IN A MICROCAVITY
WO2019165014A1 (en) * 2018-02-21 2019-08-29 Dots Technology Corp. Systems and methods for allergen detection
JP7035972B2 (ja) * 2018-11-09 2022-03-15 横河電機株式会社 核酸配列計測用デバイス
CN109765407B (zh) * 2019-01-10 2020-03-17 西安交通大学 一种基于一维纳米材料的大长径比探针制备方法
CN113710365B (zh) 2019-04-03 2023-12-19 万迈医疗仪器有限公司 用于在免疫测定中重复使用半抗原涂覆的探针的方法
CN114245873B (zh) * 2019-07-30 2025-05-09 匹思灵公司 同时分析多种生物标志物的设备和同时分析多种生物标志物的方法
EP4136141A4 (en) 2020-04-17 2024-09-11 IDEXX Laboratories, Inc. Fluorescence quenching immunossay
US20240302386A1 (en) * 2020-12-23 2024-09-12 Access Medical Systems, Ltd. Detection method using both fluorescence and chemiluminescence labels
CN113125421B (zh) * 2021-04-09 2022-07-12 华中农业大学 一种光纤生物传感器及其在均相化学发光生物检测中的应用
US12241834B2 (en) * 2021-07-14 2025-03-04 Sartorius Bioanalytical Instruments, Inc. Articles and methods for performing assays
CN118076895A (zh) * 2021-10-08 2024-05-24 万迈医疗仪器有限公司 在生化测定中重复使用测试固体表面的方法
CN119452254A (zh) * 2022-04-18 2025-02-14 万迈医疗仪器有限公司 用于确定dna病毒中的dna浓度的方法
KR20240092833A (ko) * 2022-12-15 2024-06-24 광운대학교 산학협력단 정밀 면역 검사 자동화 시스템
WO2025034604A1 (en) * 2023-08-04 2025-02-13 Access Medical Systems, Ltd. Method for determining dna concentration by biolayer interferometry
CN117269473B (zh) * 2023-08-16 2024-09-20 星童医疗技术(苏州)有限公司 用于放大信号的生物探针包被方法

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3300474A (en) * 1964-02-12 1967-01-24 Pharmacia Ab Sucrose ether copolymerizates
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4272510A (en) * 1976-04-26 1981-06-09 Smith Kendall O Magnetic attraction transfer process for use in solid phase radioimmunoassays and in other assay methods
AT343822B (de) * 1976-08-20 1978-06-26 Immuno Ag Radioimmunologisches verfahren und einrichtung zur bestimmung von antigenen
US4200613A (en) * 1977-06-03 1980-04-29 Ramco Laboratories Inc. Radioimmunoassay apparatus
US4208479A (en) * 1977-07-14 1980-06-17 Syva Company Label modified immunoassays
CA1219824A (en) 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
US4434150A (en) * 1981-10-19 1984-02-28 Ortho Diagnostic Systems, Inc. Immunological reagents employing polymeric backbone possessing reactive functional groups
US4447546A (en) * 1982-08-23 1984-05-08 Myron J. Block Fluorescent immunoassay employing optical fiber in capillary tube
US4483925A (en) * 1982-12-30 1984-11-20 Becton, Dickinson And Company Liquid removal device
US4599315A (en) * 1983-09-13 1986-07-08 University Of California Regents Microdroplet test apparatus
EP0155224A3 (en) * 1984-03-15 1987-05-06 CHROMAGENICS, Inc. Solid-borne complex bearing chromagen responsive functionality for antibody, antigen, receptor, or ligand detection
DE3416933A1 (de) * 1984-05-04 1985-11-07 Dora 1000 Berlin Köhler Mit antigenen oder antikoerpern beschichteter traeger
SE456346B (sv) * 1984-07-23 1988-09-26 Pharmacia Ab Gel for att forhindra adhesion mellan kroppsvevnader och sett for dess framstellning
US4828979A (en) 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US4778751A (en) * 1986-05-12 1988-10-18 Diagnostic Products Corporation Method for measuring antigens or antibodies in biological fluids using ligand labeled antigens or ligand labeled antibodies
US5252494A (en) * 1986-06-25 1993-10-12 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held within a polymeric reaction matrix
US4891321A (en) * 1987-10-21 1990-01-02 Hubscher Thomas T Apparatus for performing determinations of immune reactants in biological fluids
JP2711332B2 (ja) * 1988-04-15 1998-02-10 株式会社ヤトロン 非水溶性物質の透明な水溶液が得られる凍結乾燥品の製造方法
JP3130513B2 (ja) * 1989-04-19 2001-01-31 イビデン株式会社 生体活性物質測定用装置
JP3025078B2 (ja) * 1990-11-26 2000-03-27 イビデン株式会社 蛍光分析法
US5244636A (en) * 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
US5244813A (en) * 1991-01-25 1993-09-14 Trustees Of Tufts College Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample
US5250264A (en) * 1991-01-25 1993-10-05 Trustees Of Tufts College Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample
US5320814A (en) * 1991-01-25 1994-06-14 Trustees Of Tufts College Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample
JP3107649B2 (ja) * 1991-12-20 2000-11-13 イビデン株式会社 蛍光免疫測定装置
FI930440A0 (fi) * 1993-02-01 1993-02-01 Labsystems Oy Bestaemningsfoerfarande
US5981172A (en) * 1994-02-14 1999-11-09 Abbott Laboratories Non-A, non-B, non-C, non-D, non-E Hepatitis reagents and methods for their use
PL316940A1 (en) 1994-05-02 1997-02-17 Ciba Geigy Ag System of optical sensing elements for determining ph values and ionic strength
US5690894A (en) * 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5650334A (en) 1995-08-31 1997-07-22 First Medical, Inc. Fluorescent labelling compositions and methods for their use
US5814524A (en) * 1995-12-14 1998-09-29 Trustees Of Tufts College Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations
US6210910B1 (en) * 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
AU755968B2 (en) * 1998-07-30 2003-01-02 Oakville Hong Kong Co., Limited Method for preparing water-soluble cross-linked conjugates
US20020119581A1 (en) 2001-01-05 2002-08-29 Daniloff George Y. Detection of analytes
JP3429282B2 (ja) * 2001-02-02 2003-07-22 リサーチ・インターナショナル・インコーポレーテッド 自動化されたシステム、及びサンプルの分析方法
JP2002236223A (ja) * 2001-02-09 2002-08-23 Olympus Optical Co Ltd ファイバープローブ光検出器
AU2002345847B2 (en) * 2001-06-21 2008-05-29 Dynavax Technologies Corporation Chimeric immunomodulatory compounds and methods of using the same
EP1456357B1 (en) * 2002-02-06 2008-06-04 Stiftung CAESAR Pluripotent embryonic-like stem cells derived from teeth and uses thereof
CN2559982Y (zh) * 2002-08-27 2003-07-09 中国科学院光电技术研究所 具有均匀照明系统的ccd生物芯片检测仪
AU2003266899B2 (en) * 2002-09-20 2008-02-28 Queen's University At Kingston Detection of biological molecules by differential partitioning of enzyme substrates and products
CN1200269C (zh) * 2003-02-28 2005-05-04 中国科学院上海光学精密机械研究所 多探头光纤倐逝波生物传感器
JP3986451B2 (ja) * 2003-03-11 2007-10-03 富士通株式会社 免疫測定装置
TW200526253A (en) * 2003-11-14 2005-08-16 Chugai Pharmaceutical Co Ltd Cross-linked polysaccharide microparticles and process for producing the same
JP4949038B2 (ja) * 2003-12-01 2012-06-06 ダコ デンマーク アクティーゼルスカブ 免疫組織化学的検出のための方法および組成物
US20050221399A1 (en) * 2004-03-30 2005-10-06 Sysmex Corporation Method for screening cervical cancer
EP1790665B1 (en) * 2004-09-07 2014-11-05 Chugai Seiyaku Kabushiki Kaisha Process for producing water-soluble modified hyaluronic acid
FR2878241B1 (fr) 2004-11-21 2007-01-12 Agroquip Sarl Soc D Expl Des E Machine automatique pour la formation d'un noeud a l'aide d'une ficelle en extremite d'une gaine tubulaire en vue de l'obturer par constriction sous l'effet du serrage du noeud
US8741813B2 (en) * 2005-12-15 2014-06-03 General Electric Company Composition, device and associated method
EP1989547A1 (en) * 2006-02-28 2008-11-12 Medical Research Council Targeted iron oxide nanoparticles
GB2443694B (en) * 2006-11-10 2011-09-14 Platform Diagnostics Ltd Analyte saturation assay, methods and kits and devices
CA2697656C (en) * 2007-08-23 2017-10-03 Mitsubishi Chemical Medience Corporation Non-specific reaction inhibitor
CN101251469A (zh) * 2007-08-24 2008-08-27 港龙生物技术（深圳）有限公司 诊断人乳头瘤病毒感染的荧光pcr方法
CN101118216A (zh) * 2007-09-07 2008-02-06 中国科学院长春光学精密机械与物理研究所 一种光纤生物探针及其制作方法和用途
EP2404162B1 (en) * 2009-03-03 2017-12-27 Access Medical System Co., Ltd. Detection system and method for high sensitivity fluorescent assays
US9568431B2 (en) * 2012-04-16 2017-02-14 Access Medical Systems, Ltd. Luminescent immunoassays for quantitating analytes having a wide concentration range

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JP6461732B2 (ja) 2019-01-30
WO2010101931A2 (en) 2010-09-10
JP2012519850A (ja) 2012-08-30
US8309369B2 (en) 2012-11-13
CN103604786A (zh) 2014-02-26
US10379116B2 (en) 2019-08-13
CN102341696B (zh) 2013-12-11
US20160370363A1 (en) 2016-12-22
EP2404162B1 (en) 2017-12-27
US20130052081A1 (en) 2013-02-28
US8492139B2 (en) 2013-07-23
JP6737856B2 (ja) 2020-08-12
WO2010101931A3 (en) 2011-01-06
EP2404162A4 (en) 2012-08-29
EP2404162A2 (en) 2012-01-11
JP5775004B2 (ja) 2015-09-09
CN102341696A (zh) 2012-02-01
US20110312105A1 (en) 2011-12-22
US9434789B2 (en) 2016-09-06
US8415172B2 (en) 2013-04-09
US20140128596A1 (en) 2014-05-08
US20130041141A1 (en) 2013-02-14
JP2019048986A (ja) 2019-03-28
JP2015166750A (ja) 2015-09-24

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