CN103550321A - External patch for auxiliary treatment of insomnia - Google Patents
External patch for auxiliary treatment of insomnia Download PDFInfo
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- CN103550321A CN103550321A CN201310563226.8A CN201310563226A CN103550321A CN 103550321 A CN103550321 A CN 103550321A CN 201310563226 A CN201310563226 A CN 201310563226A CN 103550321 A CN103550321 A CN 103550321A
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Abstract
The invention discloses an external patch for auxiliary treatment of insomnia. According to the external patch, coptis having the function of clearing heart fire, cinnamon having the functions of warming Yang and tonifying kidney and tuber fleeceflower stem having the functions of nourishing heart, dredging collaterals and soothing nerves are selected, the components are extracted and processed and are added into a hollow substrate to prepare a cataplasm for application, the external patch is adhered on Yongquan acupoint, Neiguan acupoint and Sanyinjiao acupoint in combination with an acupoint application therapy to treat insomnia, the external patch has the advantages of convenience for use, few side effect, good skin compatibility and the like and has a good curative effect on patients with mild to moderate insomnia.
Description
Technical field
The invention belongs to the research field of preparation technique of traditional Chinese medicine, be specifically related to a kind of external use plaster of auxiliary treatment insomnia.
Background technology
Insomnia is the able-bodied common disease of serious harm.In recent years, along with Chinese society is fast-developing, insomniac's showed increased, has seriously affected social productive forces and the common people physically and mentally healthy, has brought huge pressure to patient and family, society.Cure for insomnia, although current cognitive psychological therapy and pharmacotherapy can help patient to obtain part curative effect, most of patient to untoward reaction such as the Liver and kidney toxicity of sedative hypnotic drug and dependencies with fear.Using Chinese medicine control insomnia is the large characteristic of China one, is also that Chinese traditional treatment has one of disease kind of good effect.Tradition dosage form for oral administration makes many patients be difficult to adhere to for a long time owing to using trouble and having some side effect, and for patient can conveniently be used, Acupoint Application in Treating insomnia has obtained certain application.Point application therapy is a kind of interior disease outer treating method safely and effectively in traditional medicine, it is to melt the plyability Therapeutic Method that meridians, acupuncture point, medicine are integrated, and can bring into play better Advantages of TCM, and prescription compatibility used forms and meridians select cave to come from Long-term clinical experience, through clinical verification, evident in efficacy, and without wound no pain, to the person that fears pin, the body of old children's weakness, in reinforcing and reducing difficulty is executed, the disease that the people that be unwilling to take medicine maybe can not take medicine, particularly suitable.
Cataplasma (Cataplasmata) is coated the emplastrum of making on back lining materials after referring to medicinal substances extract, medical material and suitable hydrophilic matrix being mixed.The composition and structure of cataplasma has determined that it compares and have unique advantage with traditional plaster: 1., owing to adopting water soluble polymer substrate, stick comfortable, good permeability, skin noresidue, not pollution clothes; 2. drug dose is accurate, and drug loading is larger, and absorption area is little, and blood drug level is stable, applied widely, can be used for water solublity or fat-soluble medicine, Chinese drugs powder and extract; 3. produce without " three wastes ", avoid completely with an organic solvent; 4. water content is larger, and moisture retention is good, can promote skin hydration, is beneficial to active component percutaneous and absorbs; 5. easy to use, can repeatedly notice to several nonirritants of skin and sensitization.The transdermal administration that is comparatively applicable to Chinese medicine because of cataplasma is paid close attention to widely, becomes Novel external a kind of applied widely, easy to use and sticks agent.Have been reported the preparation technology of meridians note cataplasma is studied, but the at present domestic external use plaster that there is no Chinese medicine patcher class Cure for insomnia comes out.
Summary of the invention
The object of the present invention is to provide a kind of external use plaster of auxiliary treatment insomnia, it selects Rhizoma Coptidis clearing heart fire, Cortex Cinnamomi temperature male wind-supplying kidney, being equipped with the Caulis Polygoni Multiflori dredging collateral that nourishes heart calms the nerves, in conjunction with the Acupoint Application in Treating choice specimen of calligraphy, in Yongquan acupoint, Neiguan acupoint and sp 6, play the effect of Cure for insomnia, have easy to use, the advantages such as side effect is little, and skin tracing ability is better, have good therapeutical effect to light moderate insomniac.
For achieving the above object, the present invention adopts following technical scheme:
An external use plaster for auxiliary treatment insomnia, is characterized in that: described external use plaster is to using Rhizoma Coptidis, Caulis Polygoni Multiflori and Cortex Cinnamomi powder as pharmaceutical formulation, after extracting processing, joins blank substrate, makes the cataplasma for applying ointment or plaster.
The preparation method of the external use plaster of auxiliary treatment insomnia comprises the following steps:
The extraction of step 1) ointment: first by Rhizoma Coptidis and Caulis Polygoni Multiflori 2:1 mix homogeneously in mass ratio, the alcoholic solution that the mass fraction that adds 8 times of amounts of medical material volume is 70%, at 80 ~ 87 ℃, water-bath reflux, extract, is twice, each extraction 2 hours, collect backflow sucking filtration, each backflow needs sucking filtration 2 times, to remove residue; Filtrate is placed in to 40 ~ 50 ℃, on the Rotary Evaporators under 0.09 ~ 0.10MPa pressure, is concentrated into pulpous state;
Step 2) preparation of patch: will concentrate ointment heating in water bath, and add in the mixed liquor of glycerol, propylene glycol, Cortex Cinnamomi powder, stirring and evenly mixing forms A phase, then adds one by one sodium polyacrylate, dihydroxyaluminum aminoacetate, EDTA, and stirring and evenly mixing forms B phase; Carbomer is scattered in to mortar body bottom, then adds water slowly to stir, after carbomer granule water suction crystallization diffusion, less power stirring and evenly mixing forms C phase; By mixed B repeatedly add on a small quantity mutually C mutually in, stirring and evenly mixing forms D phase; Azone, water, tartaric acid, PVP are dissolved to mix successively and form E phase; By E repeatedly add on a small quantity mutually D mutually in, stirring and evenly mixing, coating slabbing, dries, and the lamellar medical material drying is cut into applicable shape, puts into blank patch, forms medical patch.
Step 2) in, the mass ratio of each component is: concentrated ointment: Cortex Cinnamomi powder: glycerol: propylene glycol: sodium polyacrylate: dihydroxyaluminum aminoacetate: EDTA: carbomer: azone: tartaric acid: PVP: water=1:0.33:10-12:1.22:1.5-2:0.05-0.07:0.02:0.5-0.67:1.22:0.0 5-0.07:1.33-1.6:20-23.33.
Described external use plaster is mainly applied to any place of Yongquan acupoint, Neiguan acupoint and sp 6 above and onset.
remarkable advantage of the present invention is:
(1) the present invention be take Rhizoma Coptidis, Caulis Polygoni Multiflori and Cortex Cinnamomi as medical material formula, has developed a kind of cataplasma class external use plaster of auxiliary treatment insomnia, there is no this series products at home at present on market.
(2) the present invention's substrate used has the suitable performance of sticking, residual without film, and skin tracing ability is better.
(3) the present invention can be used for point application, easy to use, side effect is little, and light moderate insomniac is had to good therapeutical effect.
Accompanying drawing explanation
Fig. 1 is the process chart that the present invention prepares patch.
The specific embodiment
embodiment 1
An external use plaster for auxiliary treatment insomnia, its preparation method comprises the following steps:
The extraction of step 1) ointment: take Rhizoma Coptidis 100g, Caulis Polygoni Multiflori 50g, first by Rhizoma Coptidis and Caulis Polygoni Multiflori mix homogeneously, the alcoholic solution that the mass fraction that adds 8 times of amounts of medical material volume is 70%, at 80 ℃, water-bath reflux, extract, is twice, each extraction 2 hours, collect backflow sucking filtration, each backflow needs sucking filtration 2 times, to remove residue; Filtrate is placed in to 50 ℃, on the Rotary Evaporators under 0.09MPa pressure, is concentrated into pulpous state;
Step 2) preparation of patch: get concentrated ointment 10g heating in water bath, add in the mixed liquor of glycerol 100g, propylene glycol 12.2g, Cortex Cinnamomi powder 3.3g, stirring and evenly mixing forms A phase, then adds one by one sodium polyacrylate 15g, dihydroxyaluminum aminoacetate 0.7g, EDTA 0.2g, and stirring and evenly mixing forms B phase; Carbomer 5g is scattered in to mortar body bottom, then adds water 80g slowly to stir, after carbomer granule water suction crystallization diffusion, less power stirring and evenly mixing forms C phase; By mixed B repeatedly add on a small quantity mutually C mutually in, stirring and evenly mixing forms D phase; Azone 12.2g, water 120g, tartaric acid 0.7g, PVP 16g are dissolved to mix successively and form E phase; By E repeatedly add on a small quantity mutually D mutually in, stirring and evenly mixing, coating slabbing, dries, and the lamellar medical material drying is cut into applicable shape, puts into blank patch, forms medical patch.
External use plaster is applied to Yongquan acupoint, Neiguan acupoint, any place of sp 6 above and onset.
embodiment 2
An external use plaster for auxiliary treatment insomnia, its preparation method comprises the following steps:
The extraction of step 1) ointment: take Rhizoma Coptidis 200g, Caulis Polygoni Multiflori 100g, first by Rhizoma Coptidis and Caulis Polygoni Multiflori mix homogeneously, the alcoholic solution that the mass fraction that adds 8 times of amounts of medical material volume is 70%, at 87 ℃, water-bath reflux, extract, is twice, each extraction 2 hours, collect backflow sucking filtration, each backflow needs sucking filtration 2 times, to remove residue; Filtrate is placed in to 45 ℃, on the Rotary Evaporators under 0.09MPa pressure, is concentrated into pulpous state;
Step 2) preparation of patch: get concentrated ointment 20g heating in water bath, add in the mixed liquor of glycerol 200g, propylene glycol 24.4g, Cortex Cinnamomi powder 6.6g, stirring and evenly mixing forms A phase, then adds one by one sodium polyacrylate 30g, dihydroxyaluminum aminoacetate 1.4g, EDTA 0.4g, and stirring and evenly mixing forms B phase; Carbomer 10g is scattered in to mortar body bottom, then adds water 160g slowly to stir, after carbomer granule water suction crystallization diffusion, less power stirring and evenly mixing forms C phase; By mixed B repeatedly add on a small quantity mutually C mutually in, stirring and evenly mixing forms D phase; Azone 24.4g, water 240g, tartaric acid 1.4g, PVP 32g are dissolved to mix successively and form E phase; By E repeatedly add on a small quantity mutually D mutually in, stirring and evenly mixing, coating slabbing, dries, and the lamellar medical material drying is cut into applicable shape, puts into blank patch, forms medical patch.
External use plaster is applied to Yongquan acupoint, Neiguan acupoint, any place of sp 6 above and onset.
embodiment 3
An external use plaster for auxiliary treatment insomnia, its preparation method comprises the following steps:
The extraction of step 1) ointment: take Rhizoma Coptidis 400g, Caulis Polygoni Multiflori 200g, first by Rhizoma Coptidis and Caulis Polygoni Multiflori mix homogeneously, the alcoholic solution that the mass fraction that adds 8 times of amounts of medical material volume is 70%, at 85 ℃, water-bath reflux, extract, is twice, each extraction 2 hours, collect backflow sucking filtration, each backflow needs sucking filtration 2 times, to remove residue; Filtrate is placed in to 40 ℃, on the Rotary Evaporators under 0.10MPa pressure, is concentrated into pulpous state;
Step 2) preparation of patch: get concentrated ointment 30g heating in water bath, add in the mixed liquor of glycerol 300g, propylene glycol 36.6g, Cortex Cinnamomi powder 13.2g, stirring and evenly mixing forms A phase, then adds one by one sodium polyacrylate 45g, dihydroxyaluminum aminoacetate 2.1g, EDTA 0.6g, and stirring and evenly mixing forms B phase; Carbomer 15g is scattered in to mortar body bottom, then adds water 240g slowly to stir, after carbomer granule water suction crystallization diffusion, less power stirring and evenly mixing forms C phase; By mixed B repeatedly add on a small quantity mutually C mutually in, stirring and evenly mixing forms D phase; Azone 36.6g, water 360g, tartaric acid 2.1g, PVP 48g are dissolved to mix successively and form E phase; By E repeatedly add on a small quantity mutually D mutually in, stirring and evenly mixing, coating slabbing, dries, and the lamellar medical material drying is cut into applicable shape, puts into blank patch, forms medical patch.
External use plaster is applied to Yongquan acupoint, Neiguan acupoint, any place of sp 6 above and onset.
Patient's journey so-and-so, female, 59 years old, with have a sleepless night 2 years medical, with difficulty falling asleep, sleep shallow, dreaminess is feature, and with headache, the symptom that weak, xerostomia is bitter, emotion is poor; Give separately after two courses for the treatment of of treatment by Chinese herbs, sleep state takes a turn for the better to some extent, but other symptoms are not improved; Give Chinese medicine and coordinate external use plaster treatment of the present invention after 14 days, sleep quality takes a turn for the better, and above-mentioned symptom all alleviates.
Patient Liu so-and-so, man, 57 years old, medical with the February of having a sleepless night, patient have fear cold, worry too much, the symptom of feverish sensation in the palms and soles; Give separately after the course for the treatment of of treatment by Chinese herbs, sleep state takes a turn for the better to some extent, but other symptoms are not improved; Give Chinese medicine and coordinate external use plaster treatment of the present invention after 11 days, sleep quality improves, and above-mentioned symptom alleviates to some extent.
Patient Lin, female 45 years old, with have a sleepless night 2 years medical, with difficulty falling asleep, dreaminess is feature, and with dizzy, order is puckery, the symptom of dry stool; Give separately after two courses for the treatment of of treatment by Chinese herbs, sleep state takes a turn for the better to some extent, but other symptoms are not improved; Give Chinese medicine and coordinate external use plaster treatment of the present invention after 11 days, sleep quality takes a turn for the better, and above-mentioned symptom alleviates to some extent.
The foregoing is only preferred embodiment of the present invention, all equalizations of doing according to the present patent application the scope of the claims change and modify, and all should belong to covering scope of the present invention.
Claims (4)
1. an external use plaster for auxiliary treatment insomnia, is characterized in that: described external use plaster is to using Rhizoma Coptidis, Caulis Polygoni Multiflori and Cortex Cinnamomi powder as pharmaceutical formulation, after extracting processing, joins blank substrate, makes the cataplasma for applying ointment or plaster.
2. a preparation method for the external use plaster that auxiliary treatment as claimed in claim 1 is had a sleepless night, is characterized in that: preparation method comprises the following steps:
The extraction of step 1) ointment: first by Rhizoma Coptidis and Caulis Polygoni Multiflori 2:1 mix homogeneously in mass ratio, the alcoholic solution that the mass fraction that adds 8 times of amounts of medical material volume is 70%, at 80 ~ 87 ℃, water-bath reflux, extract, is twice, each extraction 2 hours, collect backflow sucking filtration, each backflow needs sucking filtration 2 times, to remove residue; Filtrate is placed in to 40 ~ 50 ℃, on the Rotary Evaporators under 0.09 ~ 0.10MPa pressure, is concentrated into pulpous state;
Step 2) preparation of patch: will concentrate ointment heating in water bath, and add in the mixed liquor of glycerol, propylene glycol, Cortex Cinnamomi powder, stirring and evenly mixing forms A phase, then adds one by one sodium polyacrylate, dihydroxyaluminum aminoacetate, EDTA, and stirring and evenly mixing forms B phase; Carbomer is scattered in to mortar body bottom, then adds water slowly to stir, after carbomer granule water suction crystallization diffusion, less power stirring and evenly mixing forms C phase; By mixed B repeatedly add on a small quantity mutually C mutually in, stirring and evenly mixing forms D phase; Azone, water, tartaric acid, PVP are dissolved to mix successively and form E phase; By E repeatedly add on a small quantity mutually D mutually in, stirring and evenly mixing, coating slabbing, dries, and the lamellar medical material drying is cut into applicable shape, puts into blank patch, forms external use plaster.
3. the external use plaster of auxiliary treatment according to claim 2 insomnia, is characterized in that: step 2) in the mass ratio of each component be: concentrated ointment: Cortex Cinnamomi powder: glycerol: propylene glycol: sodium polyacrylate: dihydroxyaluminum aminoacetate: EDTA: carbomer: azone: tartaric acid: PVP: water=1:0.33:10-12:1.22:1.5-2:0.05-0.07:0.02:0.5-0.67:1.22:0.0 5-0.07:1.33-1.6:20-23.33.
4. a using method for the external use plaster of auxiliary treatment insomnia as claimed in claim 1, is characterized in that: described external use plaster is mainly applied to any place of Yongquan acupoint, Neiguan acupoint and sp 6 above and onset.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310563226.8A CN103550321B (en) | 2013-11-14 | 2013-11-14 | External patch for auxiliary treatment of insomnia |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310563226.8A CN103550321B (en) | 2013-11-14 | 2013-11-14 | External patch for auxiliary treatment of insomnia |
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| CN103550321B CN103550321B (en) | 2015-06-17 |
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| CN201310563226.8A Active CN103550321B (en) | 2013-11-14 | 2013-11-14 | External patch for auxiliary treatment of insomnia |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398703A (en) * | 2014-12-19 | 2015-03-11 | 青岛百瑞吉生物工程有限公司 | Traditional Chinese medicine preparation for treating insomnia as well as preparation method and application thereof |
| CN105641519A (en) * | 2016-01-27 | 2016-06-08 | 时启梅 | Traditional Chinese medicine plaster for improving sleep and preparation method thereof |
| CN110882360A (en) * | 2019-12-31 | 2020-03-17 | 上海市静安区大宁路街道社区卫生服务中心 | Traditional Chinese medicine acupoint application for treating senile insomnia and preparation method thereof |
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| CN1660310A (en) * | 2004-12-31 | 2005-08-31 | 邓小安 | Plaster of Chinese traditional medicine for treating sleep disorder and preparation method |
| CN1990011A (en) * | 2005-12-30 | 2007-07-04 | 陈茜 | Dripping pills for improving sleep quality and its preparation process |
| CN102552449A (en) * | 2010-12-15 | 2012-07-11 | 张娜 | Chinese herbal medicine preparation for treating insomnia and preparation method thereof |
| DE102011116417A1 (en) * | 2011-10-18 | 2013-04-18 | Kurt Lucas | Cinnamon bark extract useful for treating symptoms including e.g. chronic rhinitis, secretion production with metallic, sour taste, inflammation of the paranasal sinuses, swelling of the nasal passages, seizure-like sneezing |
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2013
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660310A (en) * | 2004-12-31 | 2005-08-31 | 邓小安 | Plaster of Chinese traditional medicine for treating sleep disorder and preparation method |
| CN1990011A (en) * | 2005-12-30 | 2007-07-04 | 陈茜 | Dripping pills for improving sleep quality and its preparation process |
| CN102552449A (en) * | 2010-12-15 | 2012-07-11 | 张娜 | Chinese herbal medicine preparation for treating insomnia and preparation method thereof |
| DE102011116417A1 (en) * | 2011-10-18 | 2013-04-18 | Kurt Lucas | Cinnamon bark extract useful for treating symptoms including e.g. chronic rhinitis, secretion production with metallic, sour taste, inflammation of the paranasal sinuses, swelling of the nasal passages, seizure-like sneezing |
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| 李勇: "交泰丸敷脐治疗失眠症临床观察", 《上海针灸杂志》 * |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398703A (en) * | 2014-12-19 | 2015-03-11 | 青岛百瑞吉生物工程有限公司 | Traditional Chinese medicine preparation for treating insomnia as well as preparation method and application thereof |
| CN105641519A (en) * | 2016-01-27 | 2016-06-08 | 时启梅 | Traditional Chinese medicine plaster for improving sleep and preparation method thereof |
| CN110882360A (en) * | 2019-12-31 | 2020-03-17 | 上海市静安区大宁路街道社区卫生服务中心 | Traditional Chinese medicine acupoint application for treating senile insomnia and preparation method thereof |
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| CN103550321B (en) | 2015-06-17 |
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Address after: 350003 No. 54, 282, Fuzhou, Fujian Patentee after: Fujian College of traditional Chinese Medicine Address before: 350003 No. 54, 282, Fuzhou, Fujian Patentee before: FUJIAN INSTITUTE OF TRADITIONAL CHINESE MEDICINE |
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Effective date of registration: 20200715 Address after: 350009 office-10b, 8th floor, Bailian building, east of Lianjiang middle road and Shuguang Branch Road, Aofeng street, Taijiang District, Fuzhou City, Fujian Province Patentee after: Fuzhou Guoyi Kangjian Biotechnology Co.,Ltd. Address before: 350003 No. 54, 282, Fuzhou, Fujian Patentee before: Fujian College of traditional Chinese Medicine |
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Effective date of registration: 20230803 Address after: No. 180 Dazhong North Road, Dongbian Village, Guantou Town, Lianjiang County, Fuzhou City, Fujian Province, 350501 Patentee after: Liu Xiuqin Address before: 350009 office-10b, 8th floor, Bailian building, east side of Lianjiang middle road and Shuguang Branch Road, Aofeng street, Taijiang District, Fuzhou City, Fujian Province Patentee before: Fuzhou Guoyi Kangjian Biotechnology Co.,Ltd. |