CN104398703A - Traditional Chinese medicine preparation for treating insomnia as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine preparation for treating insomnia as well as preparation method and application thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating insomnia. The traditional Chinese medicine preparation includes the following components by mass: 10-15 g of radix salviae miltiorrhizae, 10-15 g of polygala tenuifolia, 10-15 g of the rhizoma coptidis, 8-10 g of cinnamon, 5-8 g of acorus gramineus soland, 5-8 g of cortex albiziae, and 5-8 g of caulis polygoni multiflori. Meanwhile, the invention further discloses a preparation method and application of the traditional Chinese medicine preparation. Through the medicinal values and the compatibility effect of all components in the traditional Chinese medicine preparation, the traditional Chinese medicine preparation has the effects of effectively tonifying the kidney, calming the heart, tranquilizing the mind, promoting the intelligence, nourishing the spleen and stomach, clearing heat, calming the liver, benefiting qi and strengthening the middle warmer, and has the advantages of good curative effect, low cost, and no toxic or side effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof and application, Chinese medicine preparation of especially a kind of Cure for insomnia and preparation method thereof and application, belong to Chinese medicine formula and applied technical field.
Background technology
Insomnia refers to fall asleep and maybe cannot keep sleep state, thus causes not having enough sleep.Be also called DIMS (DIMS).The reason of having a sleepless night is caused to mainly contain environmental factors, individual factors, health, the mental status, emotion etc.The traditional Chinese medical science is then thought: the reason of insomnia is in disorder, the especially warming YANG function of the heart and the YIN nourishing function of kidney can not be coordinated, deficiency of qi and blood, imbalance of YIN and YANG etc. of internal organs mainly.With the quickening pace of modern life, operating pressure increases, and insomnia has become the cardiopathia of numerous urbanite, and insomnia can cause body immunity go down and accelerate human senility.Chronic insomnia, it is dizzy heavy easily to cause, lassitude, aprosexia, and can cause various chronic disease.Be at present allow patient take to have the medicine of certain hypnotic effect for the remission method of insomnia, this kind of mode not only can not effective Cure for insomnia, and can have been formed since sleeping pill, and long-term taking, can cause other diseases.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide that a kind of side effect is little, good effect, expense are low, therapeutic effect be significantly used for the treatment of insomnia Chinese medicine preparation and preparation method thereof and application.
For solving the problems of the technologies described above, technical scheme of the present invention is:
Radix Salviae Miltiorrhizae: 10-15g;
Radix Polygalae: 10-15g;
Rhizoma Coptidis: 10-15g;
Cortex Cinnamomi: 8-10g;
Rhizoma Acori Graminei: 5-8g;
Cortex Albiziae: 5-8g;
Caulis Polygoni Multiflori: 5-8g.
Preferably, the formula composition of every agent Chinese medicine preparation comprises following component and the quality of each component is respectively: Radix Salviae Miltiorrhizae: 15g; Radix Polygalae: 15g; Rhizoma Coptidis: 10g; Cortex Cinnamomi: 8g; Rhizoma Acori Graminei: 8g; Cortex Albiziae: 5g; Caulis Polygoni Multiflori: 5g.
Further, the above-mentioned Chinese medicine preparation being used for the treatment of insomnia, also comprises Borneolum Syntheticum powder: 5-10g.
Preferably, the formula composition of every agent Chinese medicine preparation comprises following component and the quality of each component is respectively: Radix Salviae Miltiorrhizae: 15g; Radix Polygalae: 15g; Rhizoma Coptidis: 10g; Cortex Cinnamomi: 8g; Rhizoma Acori Graminei: 8g; Cortex Albiziae: 5g; Caulis Polygoni Multiflori: 5g; Borneolum Syntheticum powder: 10g.
The above-mentioned manufacture method being used for the treatment of the Chinese medicine preparation of insomnia, it is characterized in that, after the described quality proportioning being used for the treatment of each component in the Chinese medicine preparation of insomnia is mixed, carry out pulverizing and grind to form fine powder, cross 80-100 mesh sieve, then the fine powder after sieving is dropped in mixing and blending machine and fully mix, and for subsequent use according to the metering, distributing, packaging of every agent.
And above-mentioned Chinese medicine preparation is preparing the application on medicament for treating insomnia.
Beneficial effect of the present invention is: the present invention is by the medical value of each component in Chinese medicine preparation, and compatibility effect each other, can effectively kidney calming, Fructus Alpiniae Oxyphyllae of calming the nerves, spleen reinforcing nourishing the stomach, heat clearing away suppressing the hyperactive liver, QI invigorating invigorating middle warmer, there is the advantage that good effect, cost are low, have no side effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be described in detail.
As follows for the pharmacology analysis situation of component in Chinese medicine preparation of the present invention:
Fang Zhong:
Radix Salviae Miltiorrhizae: bitter, is slightly cold, GUIXIN, Liver Channel; Have promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, effect of nourishing blood to tranquillize the mind;
Radix Polygalae: nature and flavor are bitter, pungent, warm, GUIXIN, kidney, lung meridian, have Fructus Alpiniae Oxyphyllae of calming the nerves, effect of resolving depression, effectively can treat neurasthenia, forgetful cardiopalmus, and dreaminess is had a sleepless night;
Rhizoma Coptidis: bitter in the mouth, cold, can eliminating heart-fire, except damp and hot in taste;
Cortex Cinnamomi: control that deficiency of kidney-QI is weary, limbs asthenia, internal organs are uncomfortable;
Rhizoma Acori Graminei: acrid in the mouth, hardship, slightly warm in nature; GUIXIN, liver, spleen channel, with Radix Polygalae compatibility, effectively can treat forgetful dreaminess, cardiopalmus is unhappy;
Cortex Albiziae: with Radix Salviae Miltiorrhizae, Radix Polygalae compatibility, induced insomnia person, malaise etc. for the unsuccessful melancholy of feelings will
Caulis Polygoni Multiflori: sweet in the mouth, micro-hardship, property is put down; GUIXIN, Liver Channel, have effect of energy tranquilizing by nourishing the heart, dispelling wind and removing obstruction in the collateral, cure mainly insomnia and dreamful sleep, blood deficiency general pain etc.;
Borneolum Syntheticum powder: acrid in the mouth is bitter, is slightly cold, enters the heart, Liver Channel, have refreshment of having one's ideas straightened out, malicious effect is fallen apart in heat clearing away, with Rhizoma Coptidis compatibility, and can waking up the patient from unconsciousness by clearing away heat.
All medicines share above, can effectively kidney calming, Fructus Alpiniae Oxyphyllae of calming the nerves, spleen reinforcing nourishing the stomach, heat clearing away suppressing the hyperactive liver, QI invigorating invigorating middle warmer, to Cure for insomnia, there is significant curative effect, especially effectively can improve excessive thinking, lassitude, feel dizzy, the disease such as insomnia and dreamful sleep, palpitation and amnesia.
embodiment 1:
The component be used for the treatment of in the Chinese medicine preparation of insomnia by described: Radix Salviae Miltiorrhizae: 10g; Radix Polygalae: 10g; Rhizoma Coptidis: 15g; Cortex Cinnamomi: 10g; Rhizoma Acori Graminei: 5g; Cortex Albiziae: 8g; Caulis Polygoni Multiflori: 8g carries out pulverizing and grinds to form fine powder after mixing, and crosses 80 mesh sieves, is then dropped in mixing and blending machine by the fine powder after sieving and fully mixes, by fine powder every day of every agent Chinese medicine preparation at twice, take after mixing it with water in half an hour ante cibum with warm water.
embodiment 2:
The component be used for the treatment of in the Chinese medicine preparation of insomnia by described: Radix Salviae Miltiorrhizae: 12g; Radix Polygalae: 12g; Rhizoma Coptidis: 12g; Cortex Cinnamomi: 10g; Rhizoma Acori Graminei: 6g; Cortex Albiziae: 6g; Caulis Polygoni Multiflori: 6g carries out pulverizing and grinds to form fine powder after mixing, and crosses 100 mesh sieves, is then dropped in mixing and blending machine by the fine powder after sieving and fully mixes, by fine powder every day of every agent Chinese medicine preparation at twice, take after mixing it with water in half an hour ante cibum with warm water.
embodiment 3:
The component be used for the treatment of in the Chinese medicine preparation of insomnia by described: Radix Salviae Miltiorrhizae: 15g; Radix Polygalae: 15g; Rhizoma Coptidis: 10g; Cortex Cinnamomi: 8g; Rhizoma Acori Graminei: 8g; Cortex Albiziae: 5g; Caulis Polygoni Multiflori: 5g carries out pulverizing and grinds to form fine powder after mixing, and crosses 90 mesh sieves, is then dropped in mixing and blending machine by the fine powder after sieving and fully mixes, by fine powder every day of every agent Chinese medicine preparation at twice, take after mixing it with water in half an hour ante cibum with warm water.
embodiment 4:
The component be used for the treatment of in the Chinese medicine preparation of insomnia by described: Radix Salviae Miltiorrhizae: 12g; Radix Polygalae: 12g; Rhizoma Coptidis: 12g; Cortex Cinnamomi: 10g; Rhizoma Acori Graminei: 6g; Cortex Albiziae: 6g; Caulis Polygoni Multiflori: 6g; Borneolum Syntheticum powder: 5g carries out pulverizing and grinds to form fine powder after mixing, and crosses 100 mesh sieves, is then dropped in mixing and blending machine by the fine powder after sieving and fully mixes, by fine powder every day of every agent Chinese medicine preparation at twice, take after mixing it with water in half an hour ante cibum with warm water.
embodiment 5:
The component Scorpio be used for the treatment of in the Chinese medicine preparation of insomnia by described: Radix Salviae Miltiorrhizae: 15g; Radix Polygalae: 15g; Rhizoma Coptidis: 10g; Cortex Cinnamomi: 8g; Rhizoma Acori Graminei: 8g; Cortex Albiziae: 5g; Caulis Polygoni Multiflori: 5g; Borneolum Syntheticum powder: 10g carries out pulverizing and grinds to form fine powder after mixing, and crosses 80 mesh sieves, is then dropped in mixing and blending machine by the fine powder after sieving and fully mixes, by fine powder every day of every agent Chinese medicine preparation at twice, take after mixing it with water in half an hour ante cibum with warm water.
For verifying the clinical effectiveness of invention formulation, carry out clinical experiment.
1, case selection standard:
A, main suit length of one's sleep is few and sleep quality is not good enough;
B, there is the symptoms such as fatigue and weak on daytime, lassitude, giddy, feeling of fullness in the head.
2, diagnostic criteria
(1) difficulty falling asleep: dropping asleep latency extends (being longer than 30 minutes);
(2) sleep disorder: the awakening time increases (every night more than 30 minutes); The actual length of one's sleep reduces (every night less than 6.5 hours); The awakening time accounts for the length of one's sleep more than 10%;
(3) sleep table is shallow: refer to that the 3-4 phase that NREM sleeps visits minimizing of sleeping, and the minimizing of 10%, the REM sleep ratio of not enough sleep total time, also shows that Depth of sleep is not enough;
(4) early awakening: sleep has been waken up the time more normal time advance 30 minutes of having waken up;
(5) do not have enough sleep: adult's sleep total time was less than 6.5 hours, or Sleep efficiency (ratio of namely sleep full night total time and writing time)≤80%.
3, therapeutic scheme
Treatment group 40 example takes the Chinese medicine preparation described in the embodiment of the present invention 4, every day potion, every day twice 10 days is a course for the treatment of, take 2 courses for the treatment of, matched group 40 example takes estazolam 2mg, decoction being taken at a draught every night, within 10 days, is a course for the treatment of, take 2 courses for the treatment of, follow up a case by regular visits to 1 year, through statistical analysis, two groups of case-data there was no significant differences (P<0.05).
4, the course for the treatment of evaluation criteria:
Cure: transference cure, recover normal the length of one's sleep or Nighttime sleep more than 6 hours, sleep deep, hale and hearty after wakeing up;
Effective: remission, sack time increases by 3 hours, and Depth of sleep increases;
Effective: symptom is improved, each less than 3 hour of the comparatively front increase length of one's sleep;
Invalid: symptom does not have any improvement, insomnia is without improving or increasing the weight of.
5, therapeutic effect:
Specifically in table 1.
A table 1 liang group therapeutic effect compares
| Group | Number of cases | Cure | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 40 | 20 | 14 | 5 | 1 | 97.5 |
| Matched group | 40 | 10 | 11 | 13 | 6 | 85.0 |
The present invention is by the medical value of each component in Chinese medicine preparation, and compatibility effect each other, can effectively kidney calming, Fructus Alpiniae Oxyphyllae of calming the nerves, spleen reinforcing nourishing the stomach, heat clearing away suppressing the hyperactive liver, QI invigorating invigorating middle warmer, there is the advantage that good effect, cost are low, have no side effect.
Above detailed description of the invention does not limit the present invention in any form, and every technical scheme obtained in the mode of equivalent replacement or equivalent transformation, all drops in protection scope of the present invention.
Claims (6)
1. be used for the treatment of the Chinese medicine preparation of insomnia, it is characterized in that, the formula composition of every agent Chinese medicine preparation comprises following component and the quality of each component is respectively:
Radix Salviae Miltiorrhizae: 10-15g;
Radix Polygalae: 10-15g;
Rhizoma Coptidis: 10-15g;
Cortex Cinnamomi: 8-10g;
Rhizoma Acori Graminei: 5-8g;
Cortex Albiziae: 5-8g;
Caulis Polygoni Multiflori: 5-8g.
2. the Chinese medicine preparation being used for the treatment of insomnia according to claim 1, is characterized in that, the formula composition of every agent Chinese medicine preparation comprises following component and the quality of each component is respectively: Radix Salviae Miltiorrhizae: 15g; Radix Polygalae: 15g; Rhizoma Coptidis: 10g; Cortex Cinnamomi: 8g; Rhizoma Acori Graminei: 8g; Cortex Albiziae: 5g; Caulis Polygoni Multiflori: 5g.
3. the Chinese medicine preparation being used for the treatment of insomnia according to claim 1, is characterized in that, also comprise Borneolum Syntheticum powder: 5-10g.
4. the Chinese medicine preparation being used for the treatment of insomnia according to claim 3, is characterized in that, the formula composition of every agent Chinese medicine preparation comprises following component and the quality of each component is respectively: Radix Salviae Miltiorrhizae: 15g; Radix Polygalae: 15g; Rhizoma Coptidis: 10g; Cortex Cinnamomi: 8g; Rhizoma Acori Graminei: 8g; Cortex Albiziae: 5g; Caulis Polygoni Multiflori: 5g; Borneolum Syntheticum powder: 10g.
5. the manufacture method being used for the treatment of the Chinese medicine preparation of insomnia according to claim 1, it is characterized in that, after the described quality proportioning being used for the treatment of each component in the Chinese medicine preparation of insomnia is mixed, carry out pulverizing and grind to form fine powder, cross 80-100 mesh sieve, then the fine powder after sieving is dropped in mixing and blending machine and fully mix, and for subsequent use according to the metering, distributing, packaging of every agent.
6. Chinese medicine preparation according to claim 5 is preparing the application on medicament for treating insomnia.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105341580A (en) * | 2015-11-12 | 2016-02-24 | 南宁隆盛农业科技有限公司 | Beverage for improving fatigue syndromes and preparation method thereof |
| CN107802711A (en) * | 2017-11-10 | 2018-03-16 | 东莞市广易中医药发展有限公司 | A kind of nanometer promotees patch and preparation method thereof of sleeping |
| CN109847024A (en) * | 2019-04-01 | 2019-06-07 | 重庆三峡医药高等专科学校 | A kind of Chinese medicine composition that treating insomnia and its navel paster of preparation |
| CN110179953A (en) * | 2019-07-11 | 2019-08-30 | 上海市静安区中医医院 | A kind of Chinese medicine composition of relieving mental strain and helping sleep and its application |
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| CN1840044A (en) * | 2006-01-26 | 2006-10-04 | 王信锁 | Medicine for treating insomnia and preparation method thereof |
| CN101632760A (en) * | 2009-06-11 | 2010-01-27 | 杭州六易科技有限公司 | Method for preparing tea for relieving uneasiness |
| CN102366501A (en) * | 2011-10-16 | 2012-03-07 | 广东养美医药投资有限公司 | Self-heated traditional Chinese medicine (TCM) emplastrum for improving sleep quality |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105341580A (en) * | 2015-11-12 | 2016-02-24 | 南宁隆盛农业科技有限公司 | Beverage for improving fatigue syndromes and preparation method thereof |
| CN107802711A (en) * | 2017-11-10 | 2018-03-16 | 东莞市广易中医药发展有限公司 | A kind of nanometer promotees patch and preparation method thereof of sleeping |
| CN109847024A (en) * | 2019-04-01 | 2019-06-07 | 重庆三峡医药高等专科学校 | A kind of Chinese medicine composition that treating insomnia and its navel paster of preparation |
| CN110179953A (en) * | 2019-07-11 | 2019-08-30 | 上海市静安区中医医院 | A kind of Chinese medicine composition of relieving mental strain and helping sleep and its application |
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Application publication date: 20150311 |