CN110302270B

CN110302270B - Acupoint plaster for treating diabetic neuropathy and preparation method thereof

Info

Publication number: CN110302270B
Application number: CN201910721961.4A
Authority: CN
Inventors: 郑帅; 郑旭琴; 杨涛
Original assignee: Jiangsu Province Hospital First Affiliated Hospital With Nanjing Medical University
Current assignee: Jiangsu Province Hospital First Affiliated Hospital With Nanjing Medical University
Priority date: 2019-08-06
Filing date: 2019-08-06
Publication date: 2021-07-16
Anticipated expiration: 2039-08-06
Also published as: CN110302270A

Abstract

The invention discloses an acupoint plaster for treating diabetic neuropathy and a preparation method thereof, the acupoint plaster comprises a loofah sponge carrier layer for carrying medicine and a traditional Chinese medicine attached to the loofah sponge carrier layer for treating diabetic neuropathy, and the traditional Chinese medicine is prepared from the following medicinal materials in parts by mass: 8-12 parts of codonopsis pilosula, 8-12 parts of astragalus membranaceus, 8-12 parts of angelica sinensis, 8-12 parts of ligusticum wallichii, 8-12 parts of radix paeoniae alba, 8-12 parts of cassia twig, 4-8 parts of raw liquorice, 15-25 parts of lycopodium clavatum, 15-25 parts of garden balsam stem, 2-4 parts of fructus evodiae and 8-12 parts of folium artemisiae argyi. The acupoint plaster has simple preparation method, scientific compatibility and obvious medicinal effect under the guidance of the theory of traditional Chinese medicine. By using the loofah sponge as a medicine carrier, the skin can be well cared for preventing discomfort symptoms such as allergy and the like. The loofah sponge acupoint is pasted on the Yongquan acupoint and the Zusanli acupoint to be applied with medicinal materials for improving diabetic neuropathy, so that the therapeutic purpose is achieved, the use is convenient, and the clinical popularization and application are facilitated.

Description

Acupoint plaster for treating diabetic neuropathy and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an acupoint plaster for treating diabetic neuropathy and a preparation method thereof.

Background

Diabetic peripheral neuropathy is one of the most common complications of diabetics, and the incidence rate is continuously increased along with the prolonging of the course of disease. The main clinical manifestations are numbness of limbs, pain and other paresthesia, which can finally cause foot infection, ulcer, gangrene and amputation, and the morbidity and mortality are high. The results of the study show that 50% of diabetic patients have neuropathy with different degrees in the course of disease, and 80% of diabetic foot patients caused by diabetic peripheral neuropathy finally have amputation. The traditional Chinese medicine considers that the peripheral neuropathy of diabetes is located in the veins and internal organs such as liver, kidney, spleen and the like, and the symptoms are that deficiency of qi and blood is taken as the basis and blood stasis blocks collaterals. The existing treatment on diabetic peripheral neuropathy mostly adopts medicaments for nourishing nerves, improving microcirculation, resisting oxidation and the like, but the clinical effect is not good enough.

The acupoint application therapy is a commonly used external treatment method in clinic, is an organic combination of acupuncture therapy and drug therapy, and is a comprehensive treatment method integrating meridians, acupoints and drugs. The medicine is pasted on certain acupuncture points, and the pasted medicine directly acts on body surface acupuncture points, so that on one hand, local blood vessels are expanded, blood circulation is accelerated, and the effects of promoting blood circulation to remove blood stasis, clearing heat and removing toxicity, relieving pain and diminishing inflammation and improving surrounding tissue nutrition are achieved; on the other hand, the medicine can penetrate through skin and hair striae from exterior to interior, and pass through meridians and collaterals to act on viscera and communicate exterior and interior, thereby playing a strong role in regulating the whole body. With the increase of toxic and side effects and drug resistance of oral medication, acupoint application therapy is increasingly receiving attention from the same people in the medical field. Transdermal drug delivery has the unique advantages of reducing drug toxicity and side effects, maintaining stable and lasting blood drug concentration and reducing drug administration times without the first pass effect of the liver and the damage of the gastrointestinal tract. The acupoint application therapy proposed according to the meridian theory has the effects of meridians and acupoints and the transdermal absorption dual treatment characteristics of medicines, the medicines stimulate the acupoints to locally generate the relative advantages of medicine concentration, can stimulate the meridian qi, and can strengthen the medicine concentration of a specific part through the absorption and the transmission of tiny blood vessels, thereby expanding the method and the thought for clinically treating various diseases. Moreover, due to the administration at the acupuncture points, the medicinal ingredients influence the physiological functions of multiple layers through the sensory transmission of meridians, and mutual excitation and coordination can be generated among the medicinal ingredients, so that the physiological amplification effect is caused, and the external treatment effect of the medicament is better than the internal treatment effect.

The cellulose from plant is the most abundant renewable resource on the earth, and has the characteristics of low price, degradability, environmental friendliness and the like. The high-quality natural cellulose is the vascular bundle of dried fruit of Luffa cylindrica of Cucurbitaceae, also called Luffa cylindrica and Luffa tendon. The loofah sponge has oleophylic and hydrophilic chemical structures, the cross section of the loofah sponge is provided with a plurality of cavities, and the periphery of each cavity is provided with a plurality of layers of criss-cross reticular fiber bundle structures; each bundle of fiber consists of many single fibers, dense holes are distributed in the inner space of the single fibers, and the fiber has a unique porous structure, strong adsorption force and air permeability and good effect of bearing foreign substances. Meanwhile, the loofah sponge has the function of dredging collaterals, is a good medicine carrier and medium for treating diabetic neuropathy, and no technology for treating the diabetic neuropathy by using the loofah sponge as the medium exists at present.

Zusanli acupoint, which has the effects of strengthening spleen and stomach, strengthening body resistance and cultivating primordial qi, clearing and activating the channels and collaterals, and ascending and descending qi activity, and is a whole body strengthening acupoint; the Sanyinjiao acupoint, which is the intersection of the three yin meridians of foot (liver, spleen and kidney meridians), has the efficacy of tonifying the liver and kidney; yongquan point is the origin of kidney qi, and kidneys store essence and dominate qi, which is the innate root. The medicinal materials for improving diabetic neuropathy are applied to the acupuncture points by adopting the loofah sponge as a medium, so that the purpose of treatment is achieved.

Disclosure of Invention

The invention aims to provide an acupoint plaster for treating diabetic neuropathy and a preparation method thereof, and explores a new method for treating diabetic peripheral neuropathy.

In order to achieve the purpose, the invention provides the following technical scheme:

an acupoint plaster for treating diabetic neuropathy comprises a loofah sponge carrier layer for carrying medicine and a traditional Chinese medicine attached to the loofah sponge carrier layer for treating diabetic neuropathy, wherein the traditional Chinese medicine is prepared from the following medicinal materials in parts by mass; wherein:

the traditional Chinese medicine is prepared from the following medicinal materials in parts by mass: 8-12 parts of codonopsis pilosula, 8-12 parts of astragalus membranaceus, 8-12 parts of angelica sinensis, 8-12 parts of ligusticum wallichii, 8-12 parts of radix paeoniae alba, 8-12 parts of cassia twig, 4-8 parts of raw liquorice, 15-25 parts of lycopodium clavatum, 15-25 parts of garden balsam stem, 2-4 parts of fructus evodiae and 8-12 parts of folium artemisiae argyi.

As a preferred technical scheme, the traditional Chinese medicine is prepared from the following medicinal materials in parts by mass: 10 parts of codonopsis pilosula, 10 parts of astragalus membranaceus, 10 parts of angelica sinensis, 10 parts of ligusticum wallichii, 10 parts of radix paeoniae alba, 10 parts of cassia twig, 6 parts of raw liquorice, 20 parts of lycopodium clavatum, 20 parts of garden balsam stem, 3 parts of fructus evodiae and 10 parts of folium artemisiae argyi.

As a preferred technical scheme, the bottom of the loofah sponge carrier layer is provided with a substrate layer which mainly plays a role in fixing, and in the use process of the acupoint plaster, the loofah sponge carrier layer attached with the medicine is pasted on the skin through the substrate layer by means of external force, so that the use is convenient. Preferably, the base layer is one of a non-woven fabric, an elastic fabric, a polyester cotton fabric and a chemical fabric.

As a preferred technical scheme, a protective layer which is removed when in use is attached to the loofah sponge carrier layer, and the protective layer is used for preventing impurities such as external dust and the like from polluting the medicine, so that the acupuncture point patch is convenient to store.

The invention also aims to provide a preparation method of the acupoint plaster, which comprises the following steps:

(1) weighing the medicines according to the proportion, placing the medicines into an extraction container, and adding the extracting solution to immerse the medicines;

(2) heating the extraction container to make the temperature of the extraction liquid be 70-90 deg.C, keeping the temperature for 2-5h, and repeatedly leaching for multiple times;

(3) transferring the leaching solution to a rotary evaporator, concentrating under reduced pressure, and recovering the extractive solution until the medicine is in paste form;

(4) pressing retinervus Luffae fructus, and alternately pressing to obtain retinervus Luffae fructus carrier layer, and coating the pasty medicine on the carrier layer to obtain the final product.

Preferably, in the step (1), the extracting solution is an ethanol solution with a mass fraction of 60-80%.

As a preferable technical scheme, in the step (3), the rotating speed of the rotary evaporator is 20r/min, the temperature of the reduced pressure concentration is 50-75 ℃, and the pressure is-0.09 Mpa.

As a preferable technical scheme, in the step (4), the thickness of the loofah sponge carrier layer is 1-2 mm.

The pharmacological actions of the raw materials of the invention are as follows:

1. codonopsis pilosula: sweet in flavor and neutral in nature, and entering spleen and lung meridians. The efficacy is as follows: invigorating spleen qi, tonifying lung qi, nourishing blood, and promoting salivation. The pharmacological mechanism is as follows: has effects in resisting stress, improving hemopoiesis function and enhancing immunity.

2. Astragalus root: sweet in flavor and slightly warm in nature, entering lung, spleen, liver and kidney meridians. The efficacy is as follows: tonify qi to strengthen superficies. The pharmacological mechanism is as follows: the astragalus polysaccharide can increase the expression of nerve regeneration NGF protein and promote angiogenesis in nerves, thereby promoting nerve repair.

3. Chinese angelica: sweet and pungent in flavor and warm in nature, enter liver, heart and spleen meridians. The efficacy is as follows: to enrich and activate blood. The pharmacological mechanism is as follows: is helpful for promoting erythropoiesis, dilating peripheral blood vessel, improving immunity, relieving inflammation, and relieving pain.

4. Ligusticum wallichii: pungent and warm in flavor, it enters liver, gallbladder and heart meridians. The efficacy is as follows: activate blood and move qi, dredge meridians and alleviate pain. The pharmacological mechanism is as follows: improving coronary artery blood flow, reducing blood flow resistance and blood pressure, resisting inflammation, resisting platelet aggregation and thrombosis, resisting oxygen free radical, and protecting nerve.

5. White peony root: bitter and sour in flavor, slightly cold in nature, entering liver and spleen meridians. The efficacy is as follows: nourishing liver, relieving pain, tonifying deficiency, and invigorating spleen and stomach. The pharmacological mechanism is as follows: relieving pain, relieving spasm, and resisting oxidation.

6. Cassia twig: sweet and pungent in flavor and warm in nature, enter heart, lung and bladder meridians. The efficacy is as follows: induce sweating to expel pathogenic factors from the muscles, warm and dredge meridians, strengthen yang and transform qi. The pharmacological mechanism is as follows: antipyretic, dilating blood vessel, promoting blood circulation, and relieving pain.

7. Raw licorice root: sweet in flavor and neutral in nature, and entering spleen, stomach and lung meridians. The efficacy is as follows: tonify qi, strengthen middle-jiao, and harmonize the recipe.

8. B, common clubmoss herb: bitter and pungent in flavor, warm in nature and entering liver meridian. The efficacy is as follows: dispelling pathogenic wind, removing dampness, relieving rigidity of muscles and activating collaterals. The pharmacological mechanism is as follows: antiinflammatory, antibacterial, analgesic, active oxygen free radical scavenging, antioxidant, acetylcholinesterase inhibiting, and platelet aggregation inhibiting effects.

9. Garden balsam stem: sweet and pungent in flavor and warm in nature, enter lung and liver meridians. The efficacy is as follows: dispel wind-damp, activate blood and dredge collaterals. The pharmacological mechanism is as follows: analgesic, antiinflammatory, antibacterial, and antiallergic effects.

10. Evodia fruit: being pungent and bitter with warm flavor, it enters liver, spleen, stomach and kidney meridians. The efficacy is as follows: dispel cold and alleviate pain. The pharmacological mechanism is as follows: dilating blood vessel of lower limb, and resisting atherosclerosis and ulcer.

11. Folium artemisiae argyi: it is pungent and bitter with warm property, entering liver, spleen and kidney meridians. The efficacy is as follows: pungent and warm in property. The pharmacological mechanism is as follows: antibacterial, antiviral, hemostatic, anticoagulant, analgesic, complement activating, and antioxidant effects.

The invention has the beneficial effects that:

(1) the selected medicinal materials are the traditional Chinese medicine for improving diabetic neuropathy by percutaneous absorption, and the record in the Jinkui Yao & Xuebi Xuanlao (general article for treatment of blood deficiency) is as follows: blood arthralgia, slight yin and yang, slight cunkou, small and tight in the middle-jiao, and exterior syndrome manifested as wind arthralgia, which is the main herb of Huangqi Guizhi Wu Tang. It is indicated that the cause of blood impediment is yang qi obstruction and malnutrition of the meridians, which is consistent with the symptoms of diabetic peripheral neuropathy. The five-ingredient decoction of astragalus and cassia twig comprises astragalus, white paeony root and cassia twig which supplement each other and coordinate yingfen and weifen, benefit qi and nourish blood, and promote blood circulation and remove meridian obstruction. On the basis of the three medicines, other traditional Chinese medicines for stimulating the menstrual flow, relieving pain, enriching and activating blood and strengthening the spleen and stomach are added, and the three medicines are prepared into ointment which is coated on a loofah sponge carrier layer to prepare an acupoint plaster which is pasted on two acupoints, namely Yongquan acupoint and Zusanli acupoint, so that the effect of effectively treating diabetic peripheral neuropathy can be achieved.

(2) The loofah sponge is used for bearing the medicine, and the loofah sponge has a unique porous structure, so that the loofah sponge has good adsorption and bearing effects on the medicine, and the medicine can be stably attached to the surface of the loofah sponge; meanwhile, the porous structure of the loofah sponge enables the loofah sponge to have certain air permeability, the skin can be effectively prevented from being allergic and the like under the condition of long-time application, the acupuncture point patch can be used for a long time, the skin can be well cared, the discomfort symptoms such as allergy and the like can be prevented, and the treatment effect is improved. In addition, the loofah sponge has the function of dredging collaterals, is a good medicine carrier and medium for treating diabetic neuropathy, has a certain external stimulation effect on acupuncture points due to the uneven structure formed by irregular pores on the surface layer of the loofah sponge, and has a treatment effect by taking the loofah sponge as the medicine carrier.

(3) The Chinese medicinal formula for treating diabetic neuropathy is matched with the loofah sponge carrier layer, the acupoint plaster is simple in preparation method, scientific in compatibility under the guidance of the theory of traditional Chinese medicine, remarkable in medicinal effect, externally used, capable of being used for a long time, free of obvious adverse reaction and toxic or side effect, good in safety, convenient to use and beneficial to clinical popularization and application.

Drawings

FIG. 1 is a schematic structural view of the acupoint plaster of the present invention;

reference numerals: 1-basal layer, 2-loofah carrier layer, 3-traditional Chinese medicine and 4-protective layer.

Detailed Description

The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

As shown in fig. 1, which is a schematic structural view of the acupoint patch for treating diabetic neuropathy of the present invention, the acupoint patch comprises a substrate layer 1 and a loofah sponge carrier layer 2 for carrying medicine, wherein a traditional Chinese medicine 3 for treating diabetic neuropathy is attached to the loofah sponge carrier layer 2, and a protective layer 4 which is removed when the traditional Chinese medicine 3 is used is attached to the traditional Chinese medicine 3. The substrate layer 1 is one of non-woven fabric, stretch fabric, polyester cotton fabric and chemical fiber fabric. The substrate layer 1 mainly plays a role in fixing, and the loofah sponge carrier layer attached with the medicine is pasted on the skin through the substrate layer by means of external force in the using process of the acupoint plaster, so that the acupoint plaster is convenient to use. The loofah sponge carrier layer 2 is made of a plurality of layers of loofah sponges by flattening and pressing in a staggered way. The protective layer 4 is used for preventing impurities such as external dust and the like from polluting the medicine, so that the acupoint plaster is convenient to store. When in use, the protective layer 4 adhered on the traditional Chinese medicine 3 is removed, the medicine is adhered on the acupuncture points, and then the acupuncture point adhesive is fixed at the corresponding position of the body through the basal layer 1. The acupoint patch has simple structure and convenient use, and the loofah sponge carrier layer can better care skin and prevent discomfort symptoms such as allergy and the like, and has treatment effect.

Example 1

The preparation method of the acupoint plaster for treating diabetic neuropathy comprises the following steps:

(1) weighing the following medicines in proportion: 10 parts of codonopsis pilosula, 10 parts of astragalus membranaceus, 10 parts of angelica sinensis, 10 parts of ligusticum wallichii, 10 parts of radix paeoniae alba, 10 parts of cassia twig, 6 parts of raw liquorice, 20 parts of lycopodium clavatum, 20 parts of garden balsam stem, 3 parts of fructus evodiae and 10 parts of folium artemisiae argyi, placing the mixture into an extraction container, and adding 70% ethanol as an extracting solution to immerse the medicinal materials;

(2) heating the extraction container to make the temperature of the extraction liquid reach 80 ℃, preserving the heat for 3 hours, and repeatedly leaching for three times;

(3) transferring the leaching solution into a rotary evaporator at rotation speed of 20r/min, vacuum concentrating at 75 deg.C under-0.09 Mpa, and recovering extractive solution to obtain paste;

Example 2

(1) weighing the following medicines in proportion: 8 parts of codonopsis pilosula, 12 parts of astragalus membranaceus, 12 parts of angelica sinensis, 8 parts of ligusticum wallichii, 12 parts of radix paeoniae alba, 8 parts of cassia twig, 4 parts of raw liquorice, 15 parts of lycopodium clavatum, 15 parts of garden balsam stem, 2 parts of fructus evodiae and 8 parts of folium artemisiae argyi are placed in an extraction container, and 60% ethanol is added to serve as an extracting solution to immerse the medicinal materials;

(2) heating the extraction container to make the temperature of the extraction liquid be 90 ℃, preserving the heat for 2 hours, and repeatedly leaching for three times;

(3) transferring the leaching solution into a rotary evaporator at rotation speed of 20r/min, and concentrating under reduced pressure at 50 deg.C and-0.09 Mpa, and recovering the extractive solution to obtain paste;

Example 3

(1) weighing the following medicines in proportion: 12 parts of codonopsis pilosula, 8 parts of astragalus membranaceus, 8 parts of angelica sinensis, 12 parts of ligusticum wallichii, 8 parts of radix paeoniae alba, 12 parts of cassia twig, 8 parts of raw liquorice, 25 parts of lycopodium clavatum, 25 parts of garden balsam stem, 4 parts of fructus evodiae and 12 parts of folium artemisiae argyi, placing the mixture into an extraction container, and adding 80% ethanol as an extracting solution to immerse the medicinal materials;

(2) heating the extraction container to make the temperature of the extraction liquid be 70 ℃, preserving the heat for 5 hours, and repeatedly leaching for three times;

(3) transferring the leaching solution into a rotary evaporator at a rotation speed of 20r/min, concentrating under reduced pressure at 60 deg.C and-0.09 Mpa, and recovering the extractive solution to obtain paste;

Clinical data

90 diabetic peripheral neuropathy patients were recruited in the study and randomly assigned to one of the following three treatment regimens of 1:1:1 for treatment, using the acupuncture point patch prepared in example 1 as the treatment, and the patients applied the acupuncture point patch 3 hours per day to the corresponding acupuncture points for a period of 14 days.

The first group of treatment regimens: the acupoint plaster is pasted on the Yongquan acupoints on both sides;

the second group of treatment regimens: the acupoint plaster is pasted on Zusanli acupoints on both sides;

a third group of treatment regimens: the acupoint patch is applied to the Sanyinjiao acupoint on both sides.

And (3) judging the curative effect:

the treatment effect evaluation adopts a Toronto Clinical Scoring System (TCSS), and comprises 3 parts of neurological symptoms, neuroreflexes and sensory function examination scores. (1) Neurological symptoms including numbness of lower limbs, pain, needle-prick-like sensation, weakness, unstable gait, and similar symptoms of upper limbs, normally counted at 0 point, and each symptom counted at 1 point; (2) the nerve reflex, including ankle reflex and knee reflex, is scored on both sides, normally for 0 min, weakened for 1 min and disappeared for 2 min; (3) sensory function tests including pain sensation, temperature sensation, touch pressure sensation, vibration sensation and position sensation are normally counted for 0 point and abnormally counted for 1 point. The total score is 0-19. Finally, the efficacy index is judged as (total integral before treatment-total integral after treatment)/total integral before treatment x 100%.

The evaluation results are divided into the following three cases, and the effects are shown: the clinical symptoms and physical signs are obviously improved, and the curative effect index is more than or equal to 70 percent; the method has the following advantages: the clinical symptoms and physical signs are improved, and the curative effect index is more than or equal to 30 percent; and (4) invalidation: the clinical symptoms and physical signs are not obviously improved or even aggravated, and the curative effect index is less than 30 percent. The treatment results are shown in table 1 below:

TABLE 1 statistical treatment results

As can be seen from table 1, the acupuncture point patch prepared by the invention has a good treatment effect when acting on the yongquan acupuncture point and the tsusanli acupuncture point, and the total effective rates are 66.67% and 63.33%, respectively, but the acupuncture point patch has a less significant treatment effect on the sanyinjiao acupuncture point, so that when the acupuncture point patch is used for treating diabetic neuropathy, appropriate acupuncture points need to be matched for treatment, and the treatment effect of the acupuncture point patch is exerted to the greatest extent.

Typical cases

One, Li's certain, female, 60 years old, type 2 diabetes mellitus has been associated with peripheral neuropathy for 8 years, recent blood sugar control is good, numbness, pain, soreness and weakness of both lower limbs, and occasionally ataxia during walking. Bilateral dorsum of foot artery pulsation is weakened, bilateral knee reflex and ankle reflex are weakened, and pain sensation and vibration sensation are reduced. After the acupoint plaster is applied to Yongquan acupoint for 14 days, numbness, pain and ataxia are obviously improved, and pain sense is recovered.

II, a certain person, a woman, 58 years old, type 2 diabetes mellitus 6 years old, recent blood sugar control is good, and electromyogram prompts: sensory nerve abnormalities of the lower limbs. The patients have numbness, stabbing pain, cold sensation and weakness of the lower limbs at both sides for more than 1 year, the pain sensation and temperature sensation are slightly reduced, and the upper limbs occasionally have numbness and stabbing pain, which is diagnosed as diabetic peripheral neuropathy. After the acupoint plaster is pasted on Zusanli acupoint for 14 days, the symptoms are obviously relieved.

Although the present description is described in terms of embodiments, not every embodiment includes only a single embodiment, and such description is for clarity only, and those skilled in the art should be able to integrate the description as a whole, and the embodiments can be appropriately combined to form other embodiments as will be understood by those skilled in the art. Therefore, the above description is only a preferred embodiment of the present application, and is not intended to limit the scope of the present application; all changes which come within the meaning and range of equivalency of the claims are to be embraced within their scope.

Claims

1. An acupoint plaster for treating diabetic neuropathy is characterized in that: comprises a loofah sponge carrier layer (2) for carrying medicine and a traditional Chinese medicine (3) which is attached on the loofah sponge carrier layer and is used for treating diabetic neuropathy; wherein:

the traditional Chinese medicine is prepared from the following medicinal materials in parts by mass: 8-12 parts of codonopsis pilosula, 8-12 parts of astragalus membranaceus, 8-12 parts of angelica sinensis, 8-12 parts of ligusticum wallichii, 8-12 parts of radix paeoniae alba, 8-12 parts of cassia twig, 4-8 parts of raw liquorice, 15-25 parts of lycopodium clavatum, 15-25 parts of garden balsam stem, 2-4 parts of fructus evodiae and 8-12 parts of folium artemisiae argyi;

the acupoint plaster acts on Yongquan acupoint or Zusanli acupoint.

2. The acupoint plaster of claim 1, wherein: the traditional Chinese medicine is prepared from the following medicinal materials in parts by mass: 10 parts of codonopsis pilosula, 10 parts of astragalus membranaceus, 10 parts of angelica sinensis, 10 parts of ligusticum wallichii, 10 parts of radix paeoniae alba, 10 parts of cassia twig, 6 parts of raw liquorice, 20 parts of lycopodium clavatum, 20 parts of garden balsam stem, 3 parts of fructus evodiae and 10 parts of folium artemisiae argyi.

3. The acupoint plaster of claim 1, wherein: the bottom of the loofah sponge carrier layer (2) is provided with a basal layer (1).

4. The acupoint plaster of claim 3, wherein: the substrate layer (1) is one of non-woven fabric, elastic fabric, polyester cotton cloth and chemical fiber cloth.

5. The acupoint plaster of claim 1, wherein: the traditional Chinese medicine (3) is attached with a protective layer (4) which is removed when in use.

6. The method for preparing the acupoint plaster according to claim 1, wherein the method comprises the following steps: the method comprises the following steps:

(1) weighing the medicines according to the proportion, placing the medicines into an extraction container, and adding the extracting solution to immerse the medicines; the extracting solution is an ethanol solution with the mass fraction of 60-80%;

(4) pressing retinervus Luffae fructus, and alternately pressing to obtain retinervus Luffae fructus carrier layer, and coating the pasty medicine on the retinervus Luffae fructus carrier layer to obtain the final product.

7. The method of claim 6, wherein: in the step (3), the rotating speed of the rotary evaporator is 20r/min, the temperature of the reduced pressure concentration is 50-75 ℃, and the pressure is-0.09 Mpa.

8. The method of claim 6, wherein: in the step (4), the thickness of the loofah sponge carrier layer is 1-2 mm.