CN102266408B - Use of gardenia extract and borneol effective ingredients in Chinese medicine preparation for intervening in cutaneous prutitus - Google Patents
Use of gardenia extract and borneol effective ingredients in Chinese medicine preparation for intervening in cutaneous prutitus Download PDFInfo
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- CN102266408B CN102266408B CN 201010192657 CN201010192657A CN102266408B CN 102266408 B CN102266408 B CN 102266408B CN 201010192657 CN201010192657 CN 201010192657 CN 201010192657 A CN201010192657 A CN 201010192657A CN 102266408 B CN102266408 B CN 102266408B
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Abstract
The invention provides a safe and effective Chinese medicine preparation for intervening in cutaneous prutitus and a preparation method thereof. Active components of the Chinese medicine preparation comprise borneol and cape jasmine extract, glycerin and glacial acetic acid are added as accessories into the active components, and the mixture is prepared with water as a solvent into spraying agents for utilization. The preparation method is simple; the Chinese medicine preparation is safe to use, and can effectively control pruritus for a long time, especially uremic pruritus or senile cutaneous prutitus.
Description
Technical field
The present invention relates to the application of the effective ingredient of Fructus Gardeniae extract and Borneolum Syntheticum composition, relate in particular to the application of effective ingredient in the Chinese medicine preparation of intervening skin pruritus that Fructus Gardeniae extract and Borneolum Syntheticum are formed.
Background technology
Skin pruritus is a kind of conscious pruritus and do not have the dermatosis of primary lesion, is a kind of skin neurosis illness, and the traditional Chinese medical science is referred to as pruritus caused by wind pathogen, is the commonly encountered diseases of department of dermatologry, and its clinical manifestation is primary symptom with the whole skin pruritus; Skin pruritus has polytype, and is wherein common with the geroderma pruritus.According to statistics, China more than 60 years old in the elderly population prevalence of skin pruritus reach 68%.In pathogenic process, owing to often scratch, scratch, exfoliation can appear in illing skin, cause blood crusts, pigmentation, lichenification etc. then, the course of disease secondary infection such as folliculitis, furuncle, lymphadenitis that also may occur together for a long time the time; Simultaneously, because the skin pruritus course of disease is touching, prolongedly do not heal, and pruritus is often particularly evident with night, make the patient must not sleep peacefully for a long time, thereby cause neurasthenic symptoms such as emotion agitation, dizziness, depressed, inappetence, have a strong impact on patient's body Health and Living quality.Therefore, skin pruritus has become a health care issues that can not be ignored.
But the cause of disease of skin pruritus does not understand that still medical circle be it is generally acknowledged relevant with some disease, as diabetes, hepatopathy, nephropathy etc., and uremia's skin pruritus etc. especially; Also stimulate with some extraneous factors simultaneously as cold, warm, chemical ﹠ blended fabric etc. relevant; It is of a great variety to add skin pruritus, and therefore treatment is got up very difficult.
In the prior art, the medicine for the treatment of skin pruritus is a lot, but be generally Western medicine, the doctor trained in Western medicine routine is with corticosteroid hormone, calcium preparation, the antihistaminic medicine is treated, the most common with the antiallergic oral liquid, and can obtain better curative effect, be medicine and the method for people's report in " Neurotropin is treated chronic dialysis and merged the skin pruritus efficacy analysis " (Chinese Journal of New Drugs and Clinical Remedies, 1988 (1)) such as filling as: sheet hilllock, the disclosed a kind of heterocyclic carbamate derivatives of Chinese patent CN1150588A (BBA), and patent WO1993JP00298, WO2010004367, WO2006EP04811, disclosed medicine such as WO2008US00425 etc.But no matter Western medicine is injection, systemic administration or external local application such as oral, and its onset is slow, can not improve the patient skin degree of drying or can not effectively alleviate secondary lesion of skin, and its curative effect disappears along with stopping using of medicine; And doctor trained in Western medicine conventional medicine, antiallergic oral medicine the most commonly used especially, can bring toxic and side effects behind the life-time service, as drowsiness, weak etc., can bring infringement on certain health to the patient, chronic patient also is difficult to adhere to treatment with it.
Modes such as employing hemodialysis also can be treated uremia's skin pruritus, as Guan Yuzhen at " hemodialysis associating hemoperfusion treatment intractable uremia property skin pruritus " (Chinese blood purification, 2006,5 (3)), people such as Li Jiusheng is in " hemoperfusion associating hemodialysis uremia skin pruritus " (Chinese critical illness emergency medicine, 2005,17 (4)) Therapeutic Method of report has all played effect preferably in; Also has the irradiation of some other interference methods such as ultraviolet (UVA, UVB), procaine intravenous sealing or cimetidine intravenous drip etc.; But because needs use specific instrument and use under given conditions, therefore in treatment significant limitation is arranged.
Than above-mentioned expensive Therapeutic Method, low-cost external-applied ointment commonly used comprises urea frost and Calamine Lotion etc.; In addition, publication number is that the Chinese patent of CN1146339A and CN1152437A discloses a kind of inorganic salt that adopts respectively as the technology of medicine for external use, and is with low cost, but tends to bring big side effect, even has toxicity.
The traditional Chinese medical science thinks, ailment said due to cold or exposure, damp, pathogenic heat, blood deficiency, worm are excessive etc. is the main cause that skin pruritus is caused a disease, and treatment should be principle with dispelling wind damp eliminating, heat-clearing and toxic substances removing, blood enriching and dryness moistening, blood circulation promoting and blood stasis dispelling, sets upright antipruritic effect to reach to get rid of evils.Zheng Jianyu is at " the acupuncture point autohemotherapy cooperates auricular-seed-pressing ruling by law to treat skin pruritus 68 example reports " (National Medical College Of Right Rivers's journal, 2006,28 (3)) in report a kind of integrate acupuncture, blood-letting, from the therapeutic method of acupuncture and moxibustion of the multiple action at blood, pelleting, acupuncture point, and application number is 200610112866.7,200610112865.2,200610112879.4 the disclosed Chinese medicine preparation of Chinese patent, all obtained certain therapeutic effect.
Chinese medicine is Chinese pharmacy development result in several thousand, and its curative effect has not only withstood the check of long term medical practice, and is confirmed by modern scientific research; Than Western medicine, Chinese medicine has that toxic and side effects is little, treatment advantage more completely, therefore aspect the treatment skin pruritus, especially for chronic patient, have great significance; Because the Chinese medicine pharmaceutical formulation is more, quality, character often have larger difference in addition, make decocting method and decocting time have nothing in common with each other, and decoct is very inconvenient, have brought certain difficulty in the use for patient, especially gerontal patient.Chinese patent medicine can solve the problem of Chinese medicine decoct difficulty, as Guo Peiling at " the 29 routine clinical observations of Herba Artemisiae Scopariae Decoction treatment hemodialysis patients intractable skin pruritus " (Journal of Traditional Chinese Medicine 1998 (9)), the identical people of Ouyang is at " clinical observation of Sang Long antipruritic pill treatment deficiency of YIN wind Sheng type skin pruritus " (Chinese combination of Chinese and Western medicine magazine, 2002,1 (1)), application number is respectively 200810105842.8,200710118352.7,200710118351.2,200710118350.8,200710118349.5,200510012208.6,200510200031.2,98101955.2 Chinese patent in the medicine reported, and people such as He Hong is at " observation of curative effect of FUFANG DANSHEN ZHUSHEYE treatment senile dermatosis pruritus " (Chinese combination of Chinese and Western medicine magazine, 2001,21 (12)) method of the employing FUFANG DANSHEN ZHUSHEYE of report and antihistaminic medicine associating in.
Because oral or the injectable drug onset is slow, can not control the pruritus symptom immediately, so people have paid a large amount of effort to medicine for external use as the research of intervening the skin pruritus medicine, Chinese medicine medicine for external use commonly used generally adopts Chinese herbal medicine such as Herba Menthae as antipruritic; As: people such as Bai Yanping are at " the chronic dialysis patient of sharp skin cream external curing merges the clinical curative effect analysis of skin pruritus " (Chinese combination of Chinese and Western medicine magazine, 2002,22 (4)), people such as Lv Mingzhuan is at " the clinical and experimental study of celestial side's face care cream treatment skin pruritus " (Yunnan Chinese medicine magazine, 1998,19 (4)) medicine of reporting in and application number are 200810230908.6,200710179507.8,03117113.3,02128121.1,97103291.2, the disclosed Chinese medicine preparation of Chinese patent of 98113291.X etc.But the Chinese medicine of much intervening skin pruritus, or pharmaceutical formulation is too many, or modulation is complicated is that 02111150.2 Chinese patent is disclosed a kind of disinfection attendance liquid prepared as: application number, has adopted to reach over one hundred kind of Chinese herbal medicine, concentrates by working procedures and makes; In addition, the skin pruritus pathogenesis differs, and also needs to suit the remedy to the case for different types.
Cold in nature, the bitter in the mouth of Fructus Gardeniae, has eliminating fire and detoxication, clearing away heat-damp and promoting diuresis, functions such as cool the blood dissipate blood stasis, be applicable to diseases such as calentura hyperpyrexia, dysphoria and insomnia, jaundice, conjunctival congestion, epistaxis, pathopyretic ulcer, all have a wide range of applications in many aspects such as treatment infectious hepatitis, favism, traumatic injury, acute toothache.Be to be used for treating gynaecopathia in the international monopoly of PCT/CN2004/000778 as: application number; Be used for treating hypertension among Chinese patent 200810160140.X, the 200710060524.X; Be used for treating hemorrhoid in the Chinese patent 200810048317.7; Be used for treating cancer in the Chinese patent 200810106129.5; Be used for treating herpes in the Chinese patent 200710159989.0; Be used for treating cervical vertebra, lumbar vertebra slight illness in the Chinese patent 200710070352.4; Be used for treating gastroesophageal reflux disease in the Chinese patent 200610147857.1; Be used for treating burn and scald etc. in the Chinese patent 200710016332.9.It is to be added in face-lifting or the beauty treatment medicine, as patent CN101112487, JP2009040694, JP2008094739, KR20040099711 etc. that the Fructus Gardeniae another kind is used comparatively widely.But, Fructus Gardeniae is used for intervening the research of skin pruritus aspect, rare report.
Summary of the invention
The invention provides the application of effective ingredient in the Chinese medicine preparation of intervening skin pruritus that Fructus Gardeniae extract and Borneolum Syntheticum are formed, adopt Chinese herbal medicine Borneolum Syntheticum and Fructus Gardeniae extract to make spray as effective ingredient, can play promotion skin metabolism, heat-clearing and toxic substances removing, it is antipruritic to preserve moisture, and repairs damaged effect.
The invention provides the application of effective ingredient in the Chinese medicine preparation of intervening skin pruritus that Fructus Gardeniae extract and Borneolum Syntheticum are formed, wherein, described Chinese medicine preparation is formed effective ingredient with Fructus Gardeniae extract and Borneolum Syntheticum, also comprises adjuvant.
Wherein, described Chinese medicine preparation is that solvent is made spray with water.
Wherein, Fructus Gardeniae extract mass percent 〉=40% in the described effective ingredient.
Further, described adjuvant is glacial acetic acid and glycerol.
Further, the application of the effective ingredient that Fructus Gardeniae extract and Borneolum Syntheticum are formed in the Chinese medicine preparation of intervening uremic pruritus's disease or senile skin pruritus, wherein, described Chinese medicine preparation is formed effective ingredient with Fructus Gardeniae extract and Borneolum Syntheticum.
The preparation method of the Chinese medicine preparation of intervention skin pruritus provided by the invention, its preparation method is as follows:
Step (one): get the Fructus Gardeniae water and decoct after-filtration, get its filtrate and make Fructus Gardeniae extract;
Step (two): get described Fructus Gardeniae extract, Borneolum Syntheticum mixes with adjuvant; Wherein, described Fructus Gardeniae extract and Borneolum Syntheticum are effective ingredient; The gained mixture is added the water after-filtration that stirs, make Chinese medicine preparation.
Wherein, described preparation method is further comprising the steps of: be that solvent is made spray with water with described Chinese medicine preparation, in the spray bottle of packing into.
Wherein, described adjuvant is glycerol and glacial acetic acid
Wherein, Fructus Gardeniae water decocting time is 1 hour described in the step ().
Wherein, in the effective ingredient proportioning described in the step (two), make Fructus Gardeniae extract mass percent 〉=40%.
The Chinese medicine preparation of intervention skin pruritus provided by the invention, its effective ingredient are Fructus Gardeniae extract, and Fructus Gardeniae is the fruit of Maguireothamnus speciosus Fructus Gardeniae, cold in nature, bitter in the mouth, function pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, cooling is arranged, calmness, analgesic activity also has antimicrobial effect, various pathogens and various skin pathomycete there are inhibitory action, are highly suitable for diseases such as skin pathopyretic ulcer; Borneolum Syntheticum can play antiinflammatory, pain relieving, antiseptical effect, to help to repair skin lesion; Glacial acetic acid can improve and regulate the metabolism of human body, contains acidic materials and aldehyde compound in the glacial acetic acid and can make telangiectasis, skin is had soft stimulation, and acidic materials is in the effect of dissolving cutin in addition; Glycerol (being glycerol) has increases the Transdermal absorption effect, its warm in nature and, non-stimulated to skin, thus can also help the epidermis enzyme reaction to help the smooth metabolism of horny layer, to play moisture-keeping function, especially be adapted to the skin of old people's drying; Glacial acetic acid and glycerol mixing energy distend the blood vessels, and increase cutaneous circulation, and can kill some antibacterials on the skin.
Raw medicinal material involved in the present invention is recorded Chinese medicine by Chinese Pharmacopoeia one one of version in 2000, and meets the pharmacopeia prescription.
Description of drawings
Fig. 1 is Chinese medicine preparation of the present invention and control drug are carried out clinical trial to 23 routine patients skin skin lesion comparison diagram mean repair time;
Fig. 2 is Chinese medicine preparation of the present invention and control drug are carried out clinical trial to 23 routine patients medicine comparison diagram of average onset time;
Fig. 3 is Chinese medicine preparation of the present invention and control drug are carried out clinical trial to 23 routine patients the average duration of efficacy comparison diagram of medicine.
The specific embodiment
The Chinese medicine preparation of intervention skin pruritus provided by the invention comprises effective ingredient and adjuvant.
Wherein, described effective ingredient is Borneolum Syntheticum, Fructus Gardeniae extract, and described adjuvant is glacial acetic acid and glycerol; In this Chinese medicine reagent effective ingredient, Fructus Gardeniae extract mass percent 〉=40%, its preferred value is 40%.
Embodiment (one):
The preparation method of the Chinese medicine preparation of intervention skin pruritus provided by the invention comprises the steps:
Step (one): get Fructus Gardeniae 100g water and decoct 1 hour after-filtration, get its filtrate and make Fructus Gardeniae extract; Add water to 1000ml, the stock solution of system;
Step (two): with described stock solution 250ml, Borneolum Syntheticum 10g, glacial acetic acid 100ml, glycerol 250ml mixes;
Step (three): described mixture is added water to 1000ml, and the after-filtration that stirs is made spray;
Step (four): described spray is packed in the 100ml spray bottle.
Embodiment (two):
Get Fructus Gardeniae 100g, glacial acetic acid 100ml, glycerol 250ml mixes each composition according to the described preparation method of embodiment (); Make spray.
Embodiment (three)
Get Fructus Gardeniae 100g, Borneolum Syntheticum 10g, mix according to the described preparation method of embodiment (); Make spray.
Embodiment (four):
Get the 25g Borneolum Syntheticum, 100g Fructus Gardeniae, 30g glycerol, 30g glacial acetic acid mix each composition according to the described preparation method of embodiment (); Make spray.
Embodiment (five):
Get the 25g Borneolum Syntheticum, the 100g Fructus Gardeniae mixes according to the described preparation method of embodiment (); Make spray.
Embodiment (six):
Borneolum Syntheticum 100g, Fructus Gardeniae 150g, glycerol 150ml, glacial acetic acid 100ml mixes each composition according to the described preparation method of embodiment (); Make spray.
With the treatment of the prepared Chinese medicine preparation of embodiment (six) for uremic pruritus's disease and senile skin pruritus, carry out clinical trial; The contents are as follows:
(1) diagnostic criteria: the doctor trained in Western medicine standard diagnostics is pruritus; Tcm diagnosis is the pruritus caused by wind pathogen card.
Clinical manifestation: skin pruritus in various degree, and the skin lesion sign occurs as scratch, blood crusts/squama, exfoliation, pigmentation, or lichenification, or secondary infection such as the folliculitis that occurs together, furuncle, lymphadenitis.
(2) include standard in: 16～80 years old age; Get rid of gestation and women breast-feeding their children, merging large area skin pyogenic infection person.
(3) medicament selection:
Chinese medicine preparation of the present invention: Borneolum Syntheticum 100g, Fructus Gardeniae 150g, glycerol 150ml, glacial acetic acid 100ml is according to the described spray of making of embodiment ().
Control drug is conventional medicine carbamide ointment and Calamine Lotion.
(4) external method:
Chinese medicine preparation of the present invention: be sprayed on the pruritus position 3～5 times every day, and smoothen to help absorption with the hands massage, add in case of necessity with 1～2 time; Every day, average access times were 3.4 times.14 days per courses for the treatment of.
Control drug: carbamide ointment or Calamine Lotion evenly are applied to the pruritus position, every day 3～5 times, add usefulness in case of necessity; Carbamide ointment and Calamine Lotion average access times every day are respectively 4.5 and 3.7 times.14 days per courses for the treatment of.
(5) observed content: observe pruritus degree and sleep state every day, measure the skin lesion situation 2 times weekly, record skin lesion position and degree, the onset time after the record drug use.
(6) result:
Adopt the SPSS statistical software to analyze, measurement data adopts paired t-test and independent sample t check, and enumeration data adopts X
2Check.The result is as follows:
Use Chinese medicine preparation of the present invention that the 8 routine disease patient of uremic pruritus (CDK5 phase) clinical observations are used, average onset time is 4.5 ± 4.2 minutes, and the pruritus control time is 7.2 ± 1.5 hours, and skin complete repair time is 8.4 ± 1.8 days;
Use Chinese medicine preparation of the present invention that 15 routine senile skin pruritus patient clinical observations are used, average onset time is 2.3 ± 2.2 minutes, and the pruritus control time is 6.2 ± 2.7 hours, and skin complete repair time is 6.6 ± 3.9 days;
Above-mentioned 23 routine patients are altogether carried out clinical trial, compare with control drug:
With reference to Fig. 1, than control drug, the Chinese medicine preparation skin repair time of the present invention obviously shortens, and illustrates that Chinese medicine preparation of the present invention can repair skin lesion fast;
With reference to Fig. 2, than control drug, Chinese medicine preparation of the present invention onset time obviously shortens, and the control skin pruritus symptom that Chinese medicine preparation of the present invention can be very fast is described;
With reference to Fig. 3, than control drug, the time of Chinese medicine preparation of the present invention control pruritus is longer, illustrates that Chinese medicine preparation of the present invention can for a long time, effectively control the skin pruritus symptom.
And, from clinical trial, Chinese medicine preparation effective percentage height provided by the invention, lasting medicine, have no side effect; The patient reflects that generally sleep improves, and conscious agitation alleviates.
More than specific embodiments of the invention are described in detail, but it is just as example, the present invention is not restricted to specific embodiment described above.To those skilled in the art, any equivalent modifications that the present invention is carried out and substituting also all among category of the present invention.Therefore, not breaking away from impartial conversion and the modification of doing under the spirit and scope of the present invention, all should contain within the scope of the invention.
Claims (4)
1. the application of the effective ingredient of Fructus Gardeniae extract and Borneolum Syntheticum composition in the Chinese medicine preparation of preparation intervention skin pruritus is characterized in that described Chinese medicine preparation is formed effective ingredient with Fructus Gardeniae extract and Borneolum Syntheticum; In the described effective ingredient, Fructus Gardeniae extract mass percent 〉=40%; Wherein, get the Fructus Gardeniae water and decoct after-filtration, get its filtrate and make Fructus Gardeniae extract, decocting time is 1 hour.
2. application according to claim 1 is characterized in that, described Chinese medicine preparation is that solvent is made spray with water.
3. application according to claim 1 is characterized in that, described Chinese medicine preparation also contains adjuvant, and described adjuvant is glacial acetic acid and glycerol.
4. the application of the effective ingredient of Fructus Gardeniae extract and Borneolum Syntheticum composition in the Chinese medicine preparation of preparation intervention uremic pruritus's disease or senile skin pruritus, it is characterized in that described Chinese medicine preparation adopts the Chinese medicine preparation of claim 1,2 or 3 described intervention skin pruritus.
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| CN 201010192657 CN102266408B (en) | 2010-06-04 | 2010-06-04 | Use of gardenia extract and borneol effective ingredients in Chinese medicine preparation for intervening in cutaneous prutitus |
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| CN 201010192657 CN102266408B (en) | 2010-06-04 | 2010-06-04 | Use of gardenia extract and borneol effective ingredients in Chinese medicine preparation for intervening in cutaneous prutitus |
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| CN103585231B (en) * | 2013-11-27 | 2016-05-18 | 呼和浩特市第一医院 | A kind of medicine that alleviates geroderma itch |
| CN105288070A (en) * | 2015-11-24 | 2016-02-03 | 山东大学第二医院 | Traditional Chinese medicine composition for treating skin itch of patients with uremia |
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Non-Patent Citations (5)
| Title |
|---|
| 中药苍耳子、浮萍、冰片对皮肤瘙痒症作用机理的探讨;罗爱白,0;《华夏医学》;19980630;第11卷(第03期) * |
| 孙定人等.复方栀子膏.《最新国产新药手册》.2004,465. * |
| 曹来安,0.皮肤瘙痒首选中药治疗.《长寿》.2004,(第01期),19. |
| 皮肤瘙痒首选中药治疗;曹来安,0;《长寿》;20040101(第01期);19 * |
| 罗爱白,0.中药苍耳子、浮萍、冰片对皮肤瘙痒症作用机理的探讨.《华夏医学》.1998,第11卷(第03期), |
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