CN104491828B - A kind of temperature leads to Traditional Chinese medicine used as analgesic preparation and its paste preparation method - Google Patents

Abstract

The invention discloses a Wentongzhitong traditional Chinese medicine preparation. The monarch medicine includes Zhinxychon; the ministerial medicine includes Clematis, Zhichuanwu, Zhicaowu, Zanthoxylum bungeanum, Zedoary, Sanleng and dried ginger; Adjuvant drugs include Radix Paeoniae Alba, Radix Scutellariae, Smilax Smilax, Chonglou, Xu Changqing. A preparation method of Wentong Zhitong ointment, comprising the following steps: the first step, weighing various traditional Chinese medicines according to the proportion, powdering and sieving respectively; the second step, sterilizing and drying the medicinal powder for use; the third step, mixing castor oil, The powder is heated and stirred until it melts, then the powder is added, and the ointment is applied on the medical adhesive tape, and the finished ointment is obtained. On the basis of Wanying Ointment, the present invention applies the theory of modern Chinese medicine and innovates the formula, and has remarkable clinical therapeutic effect on rheumatoid arthritis, rheumatoid arthritis and other diseases belonging to cold-damp arthralgia patients, and the ointment preparation of the present invention The method is simple and easy to produce on a large scale, and the finished ointment is easily digested and absorbed by patients.

Description

A kind of Wentong analgesic traditional Chinese medicine preparation and its ointment preparation method

technical field

The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine preparation for warming and relieving pain and a preparation method thereof.

Background technique

The pathogenesis of cold-damp arthralgia syndrome is deficiency of righteousness, invasion of wind-cold-damp exogenous pathogens, blockage of meridians, and poor circulation of QI and blood. The clinical manifestations are muscle and joint pain or swelling or poor flexion and extension of the extremities, heaviness or weakness all over the body, aggravated by cold, relieved by warm pain, pale tongue with white or greasy coating, and stringy and tense pulse. Since the Qing Dynasty "Yi Zong Jin Jian" established "Wan Ying Ointment" to treat cold-damp arthralgia, it is highly praised by later generations of doctors. However, the existing "Wanying Ointment" has a general curative effect and cannot meet the needs of patients.

Contents of the invention

In order to overcome the defect in the prior art that the therapeutic effect of the medicinal preparation for treating cold-damp arthralgia is not significant, a traditional Chinese medicine preparation for warming and relieving pain and a preparation method of the ointment are provided.

The present invention realizes by following scheme:

A traditional Chinese medicine preparation for warming and relieving pain. The Chinese medicine preparation includes a monarch drug, a subject drug and an adjuvant drug, in parts by mass, and the monarch drug includes 15-20 parts of Semen Nuxtrix;

The ministerial medicines include 25-35 parts of Clematis, 10-15 parts of Zhichuanwu, 10-15 parts of Zhicaowu, 15-20 parts of Zanthoxylum bungeanum, 10-15 parts of Curcuma, 15-20 parts of Sanleng, dried ginger 15-20 copies;

The adjuvant includes 10-15 parts of Radix Paeoniae Alba, 15-20 parts of Scutellaria baicalensis, 15-20 parts of Smilax smilax, 15-20 parts of Rhododendron chinensis, and 25-35 parts of Xu Changqing;

The traditional Chinese medicine preparation also includes auxiliary materials, which include castor oil, sesame oil, turpentine oil, and amber powder.

In parts by mass, the castor oil is 220-330 parts, the sesame oil is 12-25 parts, the turpentine oil is 110-170 parts, and the amber powder is 120-180 parts.

A preparation method of Wentong Zhitong ointment, comprising the following steps:

The first step is to grind the traditional Chinese medicines of Strychnis chinensis, Zanthoxylum bungeanum, Chuanwu, Zhicaowu, Clematis, Curcuma, Sanleng, dried ginger, Scutellaria baicalensis, Baishao, Smilax, Chonglou, Xu Changqing, etc. 120-mesh sieve, and the required powder is obtained after mixing;

The second step is to sterilize and dry the medicinal powder for use;

The third step is to add castor oil, sesame oil, and turpentine into the sterilized dispensing barrel, then add an appropriate amount of amber powder during heating and stirring, and add the second amber powder after the castor oil, sesame oil, turpentine, and amber powder are molten. The medicinal powder after step disinfection and drying is stirred evenly to obtain an ointment, and the ointment is applied on the medical plaster to obtain the finished ointment.

In the second step, the disinfection adopts high-temperature disinfection, the temperature of the high-temperature disinfection is 90-110 degrees Celsius, and the disinfection time lasts for 20-40 minutes.

In the third step, the dispensing barrel is sterilized with 75% ethanol by volume and sterilized by ultraviolet rays, and the sterilization time is 1 hour.

The dosages of the traditional Chinese medicines are as follows: 15-20 parts of Nuxychia, 25-35 parts of Clematis, 10-15 parts of Aconitum, 10-15 parts of Aconitum, 15-20 parts of Zanthoxylum bungeanum, 10-15 parts of Curcuma 15-20 parts of Sanleng, 15-20 parts of dried ginger, 10-15 parts of white peony root, 15-20 parts of Scutellaria baicalensis, 15-20 parts of Smilax smilax, 15-20 parts of Chonglou, 25-35 parts of Xu Changqing.

The amounts of the castor oil, sesame oil, turpentine and amber powder are as follows: castor oil is 220-330 parts, sesame oil is 12-25 parts, turpentine is 110-170 parts, and the amber powder is 120-180 parts.

The beneficial effects of the present invention are: on the basis of Wanying ointment, modern Chinese medicine theory is applied, and the formula is innovated to treat rheumatoid arthritis, rheumatoid arthritis, ankylosing arthritis, osteoarthritis, wind-cold-damp lumbago disease, cervical spondylosis, periarthritis of shoulder, old soft tissue injury and other diseases belong to the clinical treatment effect of cold-damp arthralgia patients, and the ointment preparation method of the present invention is simple and easy to produce on a large scale, and the ointment finished product is easily digested and absorbed by patients. .

Detailed ways

The present invention is further described below in conjunction with specific embodiment:

Example 1

A traditional Chinese medicine preparation for warming and relieving pain, the Chinese medicine preparation includes a monarch drug, a subject drug and an adjuvant drug, in parts by mass, and the monarch drug includes 15 parts of Nuxebra chinensis;

The ministerial medicine comprises 25 parts of Clematis, 10 parts of Aconitum aconitum, 10 parts of Aconitum aconiti, 15 parts of Zanthoxylum bungeanum, 10 parts of Curcuma, 15 parts of Sanleng, and 15 parts of dried ginger;

The adjuvant includes 10 parts of Radix Paeoniae Alba, 15 parts of Radix Scutellariae, 15 parts of Smilax Smilax, 15 parts of Chrysanthemum chinensis, and 25 parts of Xu Changqing;

The traditional Chinese medicine preparation also includes auxiliary materials, which include castor oil, sesame oil, turpentine oil, and amber powder. The castor oil is 220 parts, the sesame oil is 12 parts, the turpentine oil is 110 parts, and the amber powder is 120 parts.

A preparation method of Wentong Zhitong ointment, comprising the following steps:

The first step, according to the above proportions, respectively weigh Zhinxuezi, Zanthoxylum bungeanum, Zhichuanwu, Zhicaowu, Clematis, Curcuma, Sanleng, Dried Ginger, Scutellaria, Baishao, Smilax, Chonglou, Xu Changqing, Then powder the various traditional Chinese medicines and pass through a 120-mesh sieve, and mix well to obtain the required medicinal powder;

The second step is to sterilize and dry the medicinal powder for use, wherein the disinfection adopts high-temperature disinfection, the temperature of the high-temperature disinfection is 90 degrees Celsius, and the disinfection time lasts for 20 minutes;

The 3rd step, take the castor oil of proportion according to proportion and add in the sterilized dispensing barrel, the disinfection and sterilization of described dispensing barrel adopts the ethanol disinfection of 75% volume fraction, sterilizes with ultraviolet light, and sterilization time is 1 hour Add castor oil, sesame oil, and turpentine into the dispensing barrel, heat and stir, and add amber powder at the same time. After the castor oil, sesame oil, turpentine, and amber powder are in a molten state, add the medicated powder after the second step of disinfection and drying, and get an ointment after stirring evenly. Apply the ointment on the medical adhesive tape, and the result is the finished ointment.

Example 2

A traditional Chinese medicine preparation for warming and relieving pain, the Chinese medicine preparation includes a monarch drug, a subject drug and an adjuvant drug, in parts by mass, and the monarch drug includes 20 parts of Semen Nyxtrix;

The ministerial medicine comprises 35 parts of Clematis, 15 parts of Zhichuanwu, 15 parts of Zhicaowu, 20 parts of Zanthoxylum bungeanum, 15 parts of Curcuma, 20 parts of Sanleng, and 20 parts of dried ginger;

The adjuvant includes 15 parts of Radix Paeoniae Alba, 20 parts of Radix Scutellariae, 20 parts of Smilax Smilax, 20 parts of Chrysanthemum chinensis, and 35 parts of Xu Changqing;

The traditional Chinese medicine preparation also includes auxiliary materials, which include castor oil, sesame oil, turpentine oil, and amber powder. Described castor oil is 330 parts, and sesame oil is 25 parts, and turpentine oil is 170 parts, and described amber powder is 180 parts.

A preparation method of Wentong Zhitong ointment, comprising the following steps:

The first step, according to the above proportions, respectively weigh Zhinxuezi, Zanthoxylum bungeanum, Zhichuanwu, Zhicaowu, Clematis, Curcuma, Sanleng, Dried Ginger, Scutellaria, Baishao, Smilax, Chonglou, Xu Changqing, Then powder the various traditional Chinese medicines and pass through a 120-mesh sieve, and mix well to obtain the required medicinal powder;

The second step is to sterilize and dry the medicinal powder for use, wherein the disinfection adopts high-temperature disinfection, the temperature of the high-temperature disinfection is 110 degrees Celsius, and the disinfection time lasts for 40 minutes;

The 3rd step, take the castor oil of proportion according to proportion and add in the sterilized dispensing barrel, the disinfection and sterilization of described dispensing barrel adopts the ethanol disinfection of 75% volume fraction, sterilizes with ultraviolet light, and sterilization time is 1 hour Add castor oil, sesame oil, and turpentine into the dispensing barrel, heat and stir, and add amber powder at the same time. After the castor oil, sesame oil, turpentine, and amber powder are in a molten state, add the medicated powder after the second step of disinfection and drying, and get an ointment after stirring evenly. Apply the ointment on the medical adhesive tape, and the result is the finished ointment.

Example 3

A traditional Chinese medicine preparation for warming and relieving pain, the Chinese medicine preparation includes a monarch drug, a subject drug and an adjuvant drug, in parts by mass, and the monarch drug includes 17 parts of Nuxe chinensis;

The ministerial medicines include 30 parts of Clematis, 13 parts of Zhichuanwu, 12 parts of Zhicaowu, 17 parts of Zanthoxylum bungeanum, 12 parts of Curcuma, 17 parts of Sanleng, and 17 parts of dried ginger;

The adjuvant includes 12 parts of Radix Paeoniae Alba, 17 parts of Radix Scutellariae, 16 parts of Smilax Smilax, 17 parts of Chrysanthemum chinensis, and 31 parts of Xu Changqing;

The traditional Chinese medicine preparation also includes auxiliary materials, which include castor oil, sesame oil, turpentine oil, and amber powder. Described castor oil is 275 parts, and sesame oil is 19 parts, and turpentine oil is 140 parts, and described amber powder is 150 parts.

A preparation method of Wentong Zhitong ointment, comprising the following steps:

The first step, according to the above proportions, respectively weigh Zhinxuezi, Zanthoxylum bungeanum, Zhichuanwu, Zhicaowu, Clematis, Curcuma, Sanleng, Dried Ginger, Scutellaria, Baishao, Smilax, Chonglou, Xu Changqing, Then powder the various traditional Chinese medicines and pass through a 120-mesh sieve, and mix well to obtain the required medicinal powder;

The second step is to sterilize and dry the medicinal powder for use, wherein the disinfection adopts high-temperature disinfection, the temperature of the high-temperature disinfection is 90 degrees Celsius, and the disinfection time lasts for 20 minutes;

The 3rd step, take the castor oil of proportion according to proportion and add in the sterilized dispensing barrel, the disinfection and sterilization of described dispensing barrel adopts the ethanol disinfection of 75% volume fraction, sterilizes with ultraviolet light, and sterilization time is 1 hour Add castor oil, sesame oil, and turpentine into the dispensing barrel, heat and stir, and add amber powder at the same time. After the castor oil, sesame oil, turpentine, and amber powder are in a molten state, add the medicated powder after the second step of disinfection and drying, and get an ointment after stirring evenly. Apply the ointment on the medical adhesive tape, and the result is the finished ointment.

A Zhitong Chinese medicine preparation of the present invention can be a granule, a decoction, a capsule or an ointment. In the following toxicity experiments and clinical typical examples, the Wentong Zhitong ointment is a Zhitong Chinese medicine preparation of the present invention.

1. The functions and indications of each component

Nuxychia, also known as Kushi, Pangea, and Maqianzi, is the seed of the Strychaceae plant Nux. Cold in nature, bitter in taste, poisonous. Return liver, spleen channel. Efficacy Dispersing stagnation, reducing swelling, dredging collaterals and relieving pain, traditionally used for rheumatism intractable numbness, numbness, paralysis, ulcers, swelling and pain, bruises, etc. "Medical Hearts in Shenxilu" says that Nuxychia "opens the meridians and penetrates the joints far better than other medicines". Nuxychnium has been used in clinical practice for nearly a thousand years, which shows that it has remarkable effects, and it can be described as "poisonous and powerful medicine that is good at causing serious illness". But at the same time, because it is blindly "poison", it also limits its clinical application. Although Nuxynum is very poisonous, it has a certain curative effect. Nuxychnium must be processed in a standardized manner during clinical application, and the dosage must be accurate. Nuxychia can dredge meridians and relieve pain. It is mostly used clinically to treat rheumatic pain and meridian spasm. Qianzi has the effect of reducing swelling and relieving pain, and can treat stasis, swelling and pain such as injury from falls and fractures, so it is the king drug in this prescription.

Zanthoxylum bungeanum can warm the middle and dispel cold, dehumidify, relieve pain, and treat wind-cold-damp arthralgia. ...cold-damp arthralgia, lower qi." "Bie Lu": "In addition to coldness in the six viscera, typhoid fever, warm malaria, strong wind and no sweating, the heart and abdomen stay to drink... Open the interstitial muscles, unblock the blood vessels, strengthen the teeth and hair, regulate the joints, In cold and heat, it can be used as a plaster." Aconitum sichuanensis is warm in nature, poisonous, can dispel wind and dampness, warm meridian and relieve pain. An essential medicine for wind-cold-damp arthralgia and arthralgia, clematis pungent, salty, warm, poisonous, expelling wind and dampness, dredging collaterals and relieving pain, mainly treating gouty arthralgia, rheumatism arthralgia, numbness of limbs, cold pain in waist and knees, spasm of tendons and arteries , Unfavorable flexion and extension, etc. Sanleng and curcuma break blood and promote qi, and can treat bruises, swelling and pain. Dried ginger is pungent in taste, hot in nature, warms the middle and dispels cold, restores yang and unblocks the veins, treats cold-damp arthralgia, and can relieve the poison of Clematis, Zhichuanwu, and Zhicaowu. Above all medicines are assisted to make Fructus Nuxygae for reducing swelling and relieving pain, warming the meridians and expelling cold.

Scutellaria baicalensis is bitter and cold in nature, clearing away heat and dampness, purging fire and detoxifying, Zhonglou clearing away heat and detoxifying and promoting dampness, Xu Changqing dispelling wind and relieving pain, promoting blood circulation and detoxifying, white peony root is bitter and sour, slightly cold in nature, can relieve acute pain, Smilax tuckahoe is sweet and mild in nature, It can dispel wind and overcome dampness, and restrict warm and hot medicines to prevent it from being too hot and hurting yin.

2. Toxicity test

2.1 Acute toxicity test

Complete skin preparation: Rats were shaved on both sides of the dorsal spine 24 hours before dosing. The dehaired area is about 4cm×6cm ² . Damaged skin preparation: The method is the same as that of complete skin preparation. Disinfect after 24 hours of hair removal, and scratch the skin with a needle to stab the epidermis without injuring the dermis, with slight bleeding.

The rats were divided into a blank control group and an experimental group, and the experimental group was further divided into a complete skin group and a damaged skin group, each with 3 dosage groups, 4 rats in each group, half male and half male. Apply Wentong Zhitong ointment evenly to the depilated area on the back of the animal for 24 hours, wash off the test ointment after 24 hours, and observe continuously for 7 days. Within 7 days, none of the 24 mice died or had obvious poisoning reaction.

2.2 Skin allergy test

18 rats were randomly divided into 3 groups, that is, the blank matrix group; the high-dose Wentongzhitong ointment group; the 1% 2,4-dinitrochlorobenzene group; each group was divided into males and females. Anesthetized by intraperitoneal injection of 1% pentobarbital sodium at 30 mg/kg, shaved off the hair on both sides of the back of the rat 24 hours before giving the test substance, the range of the depilated area was about 4cm × 6cm2 on each side, and the blank base paste lg/ In the high-dose group, high-dose Wentongzhitong ointment lg/piece, and 1% 2,4-dinitrochlorobenzene 0.2ml/piece, were applied to the left depilatory area of each group of animals for 6 hours, and on the 7th day , 14 days each repeated once, on the 28th day with the same method to apply high-dose Wentong Zhitong ointment and 1% 2,4-dinitrochlorobenzene to the right depilatory area, and remove the test substance after 6 hours of stimulation. Observe the skin allergies for 24, 48, and 72 hours. No skin allergic reaction.

2.3 Skin irritation test

Twelve rats were randomly divided into two groups, that is, the intact skin group and the damaged skin group; each group had half male and half male. Anesthetized by intraperitoneal injection of 1% pentobarbital sodium at 30 mg/kg, high-dose Wentong Zhitong ointment was applied to the depilated area on the left side of the back of the rats in each group, and the same area was applied to the depilated area on the right side of the back of each rat. The matrix ointment was administered once every 24 hours for 7 consecutive days, and the residual ointment on the back of the rats was removed. The animals in each group had normal diet and activities, and no abnormal mental state such as irritability and symptoms of systemic poisoning.

3. Typical clinical examples

Zhao ××, female, 62 years old, a retired worker, came to our hospital on June 7, 2011 for medical treatment, and complained of repeated swelling and pain in the right knee joint for more than 3 months. The patient felt soreness in the right knee joint three months ago, and the pain was severe in the morning. The swelling and pain in the right knee joint occurred repeatedly, which aggravated after being exposed to cold and fatigue, and the pain was worse at night, and it was slightly relieved after rest. Physical examination: Pain and swelling on the medial side of the right knee joint and both knees, obvious tenderness, limited flexion and extension of the right knee joint, positive patella grinding test, negative floating patella test, negative McBurney's sign, negative drawer test, and negative lateral test. X-ray shows: hyperplasia and degeneration of right knee joint. Diagnosis: Traditional Chinese Medicine: Gubi (Knee Bi). Western medicine: right knee osteoarthritis. That is, apply Wentong Pain Relief Ointment to the painful part of the right knee, once a day, and use it for 7 consecutive days as a course of treatment, and at the same time, perform appropriate massage before applying the medicine. , The swelling of the knee joint was significantly relieved. I only felt a little soreness in the right knee joint when going up and down the stairs, and it was a little difficult to squat down. After continuing to treat according to the original plan for a course of treatment, the patient had no obvious discomfort when walking on the right knee joint.

Although the technical solutions of the present invention have been elaborated and listed in detail, it should be understood that for those skilled in the art, it is necessary for those skilled in the art to make modifications to the above-mentioned embodiments or adopt equivalent alternatives. Obviously, the modifications or improvements made on the basis of not departing from the spirit of the present invention all belong to the protection scope of the present invention.

Claims (6)

1. a kind of logical Traditional Chinese medicine used as analgesic preparation of temperature, the raw material of the Chinese medicine preparation are made of monarch drug in a prescription, ministerial drug and adjutant, it is characterised in that： In terms of mass parts, the monarch drug in a prescription is 15-20 parts of Semen Strychni (processed)；

The ministerial drug is 25-35 parts of the root of Chinese clematis, 10-15 parts of aconiti preparata,radix, 10-15 parts of wild aconite root, 15-20 parts of Chinese prickly ash, curcuma zedoary 10-15 Part, 15-20 parts of trigone, 15-20 parts of rhizoma zingiberis；

The adjutant is 10-15 parts of Radix Paeoniae Alba, 15-20 parts of radix scutellariae, 15-20 parts of smilax, 15-20 parts of Paris polyphylla, paniculate swallowwort 25-35 Part；

The Chinese medicine preparation further includes auxiliary material, and the auxiliary material is castor oil, sesame oil, turpentine oil and amber powder；

The formulation of the Chinese medicine preparation is paste.

A kind of 2. logical Traditional Chinese medicine used as analgesic preparation of temperature according to claim 1, it is characterised in that：In terms of mass parts, the castor-oil plant Oil is 220-330 parts, 12-25 parts of sesame oil, 110-170 parts of turpentine oil, and the amber powder is 120-180 parts.

3. a kind of logical analgesic plaster preparation method of temperature, it is characterised in that comprise the following steps：

The first step, by Semen Strychni (processed), Chinese prickly ash, aconiti preparata,radix, wild aconite root, the root of Chinese clematis, curcuma zedoary, trigone, rhizoma zingiberis, radix scutellariae, Radix Paeoniae Alba, soil Fu The all taste Chinese medicine of Siberian cocklebur, Paris polyphylla, paniculate swallowwort beats powder and crosses 120 mesh sieves respectively, is required medicinal powder after mixing；

Second step, will be stand-by after medicinal powder sterilization and drying；

3rd step, add castor oil, sesame oil, turpentine oil in the compounding bin of sterilization, then in heating stirring mistake Suitable amber powder is added in journey, second step disinfection is added after castor oil, sesame oil, turpentine oil and amber powder to molten condition Dried medicinal powder, ointment is obtained after stirring evenly, and ointment is applied in medical rubberizing, and gained is paste finished product；

In the first step, the dosage of all taste Chinese medicine is as follows：15-20 parts of vomiting nut, 25-35 parts of the root of Chinese clematis, aconiti preparata,radix 10-15 Part, 10-15 parts of wild aconite root, 15-20 parts of Chinese prickly ash, 10-15 parts of curcuma zedoary, 15-20 parts of trigone, 15-20 parts of rhizoma zingiberis, 10-15 parts of Radix Paeoniae Alba, 15-20 parts of radix scutellariae, 15-20 parts of smilax, 15-20 parts of Paris polyphylla, 25-35 parts of paniculate swallowwort.

A kind of 4. logical analgesic plaster preparation method of temperature according to claim 3, it is characterised in that：It is described in second step Disinfection uses high-temperature sterilization, and the temperature of the high-temperature sterilization is 90-110 degrees Celsius, and disinfecting time is continuously 20-40 minutes.

A kind of 5. logical analgesic plaster preparation method of temperature according to claim 3, it is characterised in that：In the third step, it is described The sterilization of compounding bin uses the ethanol disinfection of 75% volume fraction, with ultraviolet disinfection, sterilization time for 1 it is small when.

6. according to the logical analgesic plaster preparation method of one kind temperature described in claim 3, it is characterised in that：The castor oil, sesame oil, Turpentine oil, the amount of amber powder are as follows：Castor oil is 220-330 parts, 12-25 parts of sesame oil, 110-170 parts of turpentine oil, the amber Amber powder is 120-180 parts.