CN110302270A - Acupoint plaster for treating diabetic neuropathy and preparation method thereof - Google Patents

Acupoint plaster for treating diabetic neuropathy and preparation method thereof Download PDF

Info

Publication number
CN110302270A
CN110302270A CN201910721961.4A CN201910721961A CN110302270A CN 110302270 A CN110302270 A CN 110302270A CN 201910721961 A CN201910721961 A CN 201910721961A CN 110302270 A CN110302270 A CN 110302270A
Authority
CN
China
Prior art keywords
parts
acupoint
acupoint plaster
carrier layer
luffa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201910721961.4A
Other languages
Chinese (zh)
Other versions
CN110302270B (en
Inventor
郑帅
郑旭琴
杨涛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Province Hospital First Affiliated Hospital Of Nanjing Medical University
Original Assignee
Jiangsu Province Hospital First Affiliated Hospital Of Nanjing Medical University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Province Hospital First Affiliated Hospital Of Nanjing Medical University filed Critical Jiangsu Province Hospital First Affiliated Hospital Of Nanjing Medical University
Priority to CN201910721961.4A priority Critical patent/CN110302270B/en
Publication of CN110302270A publication Critical patent/CN110302270A/en
Application granted granted Critical
Publication of CN110302270B publication Critical patent/CN110302270B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/754—Evodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses an acupoint plaster for treating diabetic neuropathy and a preparation method thereof, the acupoint plaster comprises a loofah sponge carrier layer for carrying medicine and a traditional Chinese medicine attached to the loofah sponge carrier layer for treating diabetic neuropathy, and the traditional Chinese medicine is prepared from the following medicinal materials in parts by mass: 8-12 parts of codonopsis pilosula, 8-12 parts of astragalus membranaceus, 8-12 parts of angelica sinensis, 8-12 parts of ligusticum wallichii, 8-12 parts of radix paeoniae alba, 8-12 parts of cassia twig, 4-8 parts of raw liquorice, 15-25 parts of lycopodium clavatum, 15-25 parts of garden balsam stem, 2-4 parts of fructus evodiae and 8-12 parts of folium artemisiae argyi. The acupoint plaster has simple preparation method, scientific compatibility and obvious medicinal effect under the guidance of the theory of traditional Chinese medicine. By using the loofah sponge as a medicine carrier, the skin can be well cared for preventing discomfort symptoms such as allergy and the like. The loofah sponge acupoint is pasted on the Yongquan acupoint and the Zusanli acupoint to be applied with medicinal materials for improving diabetic neuropathy, so that the therapeutic purpose is achieved, the use is convenient, and the clinical popularization and application are facilitated.

Description

A kind of acupoint plaster and preparation method thereof for treating diabetic neuropathy
Technical field
The invention belongs to technical field of traditional Chinese medicines more particularly to a kind of acupoint plaster for treating diabetic neuropathy and its preparations Method.
Background technique
Diabete peripheral herve pathology is one of most common complication of diabetic, and disease incidence extends not with the course of disease It is disconnected to increase.Main clinical manifestation is the cacesthesias such as extremity numbness, pain, finally can lead to foot infection, ulcer, gangrene even Amputation, morbidity and mortality are higher.There is result of study to show, 50% diabetic will appear in various degree in the course of disease Neuropathy, and 80% patient with diabetic feet as caused by diabete peripheral herve pathology eventually results in amputation.Chinese medicine is recognized For diabete peripheral herve pathology sick position in train of thought, the internal organs such as interior and liver,kidney,spleen, with deficiency of qi and blood for this, extravasated blood resistance network is Mark.The existing treatment about diabete peripheral herve pathology mostly uses trophic nerve, improves the drugs such as microcirculation, anti-oxidant Treatment, but clinical effectiveness is not good enough.
Point application therapy is a kind of clinically used external therapy, is the combination with acupuncture and moxibustion treatment and medicinal treatment, Its essence is it is a kind of melt channels and collaterals, the comprehensive therapy method that acupuncture point, drug are integrated.Finger sticks drug on certain acupuncture point, It sticks drug and directly acts on body surface point, on the one hand make local vessel expansion, blood circulation accelerates, and plays activating microcirculation and removing stasis medicinal, clear Hot drawing poison, analgesic antiphlogistic, the effect for improving surrounding tissue nutrition；On the other hand drug can be made to from superficies to interior through fur space between skin and muscles, By channels and collaterals, internal organs are acted on, links up in table, plays stronger whole body corrective action, modern medicine proves, drug completely can be with It is absorbed from skin.With the increase of endo-medicine therapy toxicity and drug resistance, point application therapy is increasingly subject to medical field The attention of colleague.Cutaneous penetration has particular advantages, it can be dropped without " first pass effect " of liver and the destruction of gastrointestinal tract Low drug toxicity and side effect maintain stable, lasting blood concentration, reduce administration number of times.The cave proposed according to meridian theory Position application therapy has the effect of meridian point and the percutaneous absorbtion double treatment characteristic of drug, medicine irritation acupuncture point, in office Portion generates the relative advantage of drug concentration, and can stimulating Qi of meridian, conveyed by the absorptions of tiny blood vessels, strengthen the medicine of privileged site Object concentration has expanded method and thinking for a variety of diseases of clinical treatment.And due to point medicine, drug ingedient passes through channels and collaterals sense Passing influences multi-level physiological function, there may be mutual excitation and coordinative role between them, amplification physiologically is caused to be imitated It answers, the outer effect of controlling of drug is made to be better than effect for oral administration.
The cellulose of plant origin is the most abundant renewable resource on the earth, is had inexpensive, degradable and environmental-friendly The features such as.The vascular bundle of cucurbitaceous plant sponge gourd dry fruit, also known as luffa, vegetable sponge etc. are exactly this good natural Cellulose.Luffa has oleophylic and hydrophilic chemical structure, and cross section has a plurality of cavities, be around cavity multilayer in length and breadth Staggered reticular fibre binding structure；Every clump of fibre bundle is made of many single fibers again, and the inner space of single fiber is dispersed with The hole of level of confidentiality, unique cellular structure, adsorption capacity and gas permeability are strong, have the function of the good external substance of carrying. Luffa has dredging collateral effect simultaneously, is the good pharmaceutical carrier and medium for treating diabetic neuropathy, does not have still at present There is technology that luffa is used to treat diabetic neuropathy as medium.
Point st 36, the cave have the effect of strengthening the spleen and stomach, righting training member, clearing and activating the channels and collaterals, lifting mechanism of qi, are that whole body is strong Cave；SANYINJIAO acupoint, the cave are the caves that crosses of Three Yin Channels of Foot (liver,spleen,kidney warp), have effects that tonify the liver and kidney；Yongquan acupoint is kidney The origin of gas, the main gas of kidney storing essence are the congenital foundation.On these acupuncture points, using luffa as medium, it is coated with improvement diabetes The medicinal material of neuropathy, achievees the purpose that treatment.
Summary of the invention
The purpose of the present invention is to provide a kind of acupoint plaster and preparation method thereof for treating diabetic neuropathy, exploration is controlled Treat the new method of diabete peripheral herve pathology.
To achieve the above object, the invention provides the following technical scheme:
A kind of acupoint plaster for treating diabetic neuropathy, including for medicament-carried luffa carrier layer and being attached to In luffa carrier layer for treating the Chinese medicine of diabetic neuropathy, the Chinese medicine prepared by following medicinal materials by mass parts and At；Wherein:
The Chinese medicine is prepared by following medicinal materials by mass parts: 8-12 parts of Radix Codonopsis, 8-12 parts of Radix Astragali, and 8-12 parts of Radix Angelicae Sinensis, 8-12 parts of Rhizoma Chuanxiong, 8-12 parts of Radix Paeoniae Alba, 8-12 parts of ramulus cinnamomi, 4-8 parts of licorice, 15-25 parts of lycopodium calvatum, 15-25 parts of lopseed, Wu Zhu 2-4 parts of cornel, 8-12 parts of folium artemisiae argyi.
The Chinese medicine is prepared by following medicinal materials by mass parts as a preferred technical solution: 10 parts of Radix Codonopsis, Radix Astragali 10 Part, 10 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiong, 10 parts of Radix Paeoniae Alba, 10 parts of ramulus cinnamomi, 6 parts of licorice, 20 parts of lycopodium calvatum, 20 parts of lopseed, evodia rutaecarpa 3 parts, 10 parts of folium artemisiae argyi.
Luffa carrier layer bottom is equipped with basal layer as a preferred technical solution, and basal layer mainly plays fixed work With, in acupoint plaster use process, the luffa carrier layer for being attached with drug is sticked on the skin by basal layer by external force, It is convenient to use.It is further preferred that the basal layer is one of non-woven fabrics, stretch fabric, polyester-mixed cotton cloth and chemical fabric.
As a preferred technical solution, with the protective layer being broken away when using, protective layer in the luffa carrier layer Effect be to prevent the impurity such as extraneous dust pollution drug, make acupoint plaster convenient for storage.
It is a further object to provide the preparation methods of acupoint plaster described above, comprising the following steps:
(1) drug is weighed according to the ratio and is placed in extraction vessel, and extracting solution is added and submerges medicinal material；
(2) heating extraction container makes 70-90 DEG C of extracting solution temperature, keeps the temperature 2-5h, repeats to extract multiple；
(3) leaching liquor is transferred in Rotary Evaporators, is concentrated under reduced pressure, recycling extracting solution to drug is in paste；
(4) luffa flattened, staggeredly compress luffa carrier layer is made, by cream drug be coated on face to get Finished product.
As a preferred technical solution, in step (1), the extracting solution is the ethanol solution that mass fraction is 60-80%.
As a preferred technical solution, in step (3), the revolving speed of the Rotary Evaporators is 20r/min, and the decompression is dense The temperature of contracting is 50-75 DEG C, and pressure is -0.09Mpa.
As a preferred technical solution, in step (4), the luffa carrier layer with a thickness of 1-2mm.
The pharmacological action of the various bulk pharmaceutical chemicals of the present invention is as follows:
1, Radix Codonopsis: sweet in flavor, mild-natured, returns spleen, lung channel.Effect: invigorating the spleen gas, replenishing and restoring lung qi, nourishes blood and promotes the production of body fluid.Pharmacological mechanism: tool There are resisting stress, enhancing hematopoiesis function and immunity of organisms.
2, Radix Astragali: sweet in flavor, slightly warm in nature, return lung, spleen, liver and kidney channel.Effect: invigorating qi for strengthening superficies.Pharmacological mechanism: astragalus polyose can To increase the expression of regenerating nerve NGF albumen, promote angiogenesis in nerve, to promote neural restoration.
3, Radix Angelicae Sinensis: it is acrid-sweet flavor, warm-natured, return liver, the heart, the spleen channel.Effect: replenishing and activating blood.Pharmacological mechanism: it peomotes red thin Born of the same parents generate, and expand peripheral blood vessel, improve immunity of organisms, anti-inflammatory analgetic.
4, Rhizoma Chuanxiong: it is acrid flavour, warm-natured, return liver, gallbladder, the heart channel of Hang-Shaoyin.Effect: blood-activating and qi-promoting, it is inducing meastruation to relieve menalgia.Pharmacological mechanism: improve hat Shape artery blood flow reduces resistance of blood flow and blood pressure, anti-inflammatory, platelet aggregation-against and thrombosis, antioxidant radical, patron saint Through.
5, Radix Paeoniae Alba: bitter acid, cold nature return liver, the spleen channel.Effect: soft liver analgesic, complement void, strengthening the spleen and stomach.Pharmacological mechanism: It is analgesia, spasmolysis, anti-oxidant.
6, ramulus cinnamomi: acrid-sweet flavor, warm-natured, return heart, lung, bladder meridian.Effect: sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi.Medicine Reason mechanism: antipyretic, expansion blood vessel, the effects of promoting blood circulation, easing pain.
7, licorice: sweet in flavor, mild-natured, returns spleen, stomach, lung channel.Effect: invigorating middle warmer and replenishing QI, coordinating the drug actions of a prescription.
8, lycopodium calvatum: bitterly, warm-natured, return liver warp.Effect: dispelling wind and eliminating dampness, relaxing tendons and activating collaterals.Pharmacological mechanism: anti-inflammatory, anti- Bacterium, analgesia, scavenging capacity oxygen radical and anti-oxidant, acetylcholinesterase inhibition, the effect of anti-platelet aggregation.
9, lopseed: acrid-sweet flavor, warm-natured, return lung, Liver Channel.Effect: wind-damp dispelling, promoting blood circulation and removing obstruction in channels.Pharmacological mechanism: analgesia resists The effects of inflammation, antibacterial, antiallergy.
10, evodia rutaecarpa: acrid flavour is bitter, property is hot, returns liver, spleen, stomach, kidney channel.Effect: eliminating cold to stop pain.Pharmacological mechanism: expansion lower limb The effects of blood vessel, antiatherosclerosis, antiulcer.
11, folium artemisiae argyi: acrid flavour is bitter, warm-natured, and liver,spleen,kidney is returned to pass through.Effect: pungent scattered temperature is logical,.Pharmacological mechanism: antibacterial, it is antiviral, Hemostasis with anticoagulation, analgesia, activating complement, it is anti-oxidant the effects of.
The beneficial effects of the present invention are:
(1) medicinal material that the present invention selects is the improvement diabetic neuropathy Chinese medicine of Transdermal absorption, " Synopsis Golden Chamber blood-arthralgia A consumptive disease piece " in record: " blood-arthralgia, faintness in both YIN and YANG, feeble pulse at GUAN portion, CHI-pulse being slightly tense, outer card body numbness, symptoms similar to the migratory arthralgia, Radix Astragali osmanthus Branch five object soup masters it ".The cause of disease for illustrating blood-arthralgia is yang-energy occlusion, channels and collaterals dystrophy, the symptom phase with diabete peripheral herve pathology It coincide.It include Radix Astragali, Radix Paeoniae Alba, ramulus cinnamomi in Huangqi Guizhi Wuwu Tang, three complements each other, harmonizing yingfen and weifen, nourishing qi and blood, promoting blood circulation Dredging collateral.The present invention is herein on the basis of three kinds of medicines, adds with other inducing meastruation to relieve menalgia, replenishing and activating bloods, strengthening the spleen and stomach Chinese medicine, is made into medicine It, can when cream is coated in being made acupoint plaster in luffa carrier layer, and sticking on Yongquan acupoint and the two acupuncture points of point st 36 Achieve the effect that effectively to treat diabete peripheral herve pathology.
(2) present invention selects luffa for medicament-carried, is to make it because luffa has unique cellular structure There is good absorption and carrying effect to drug, allow medicament to stable be attached to its surface；Luffa is porous simultaneously Structure makes it have certain air permeability, under the conditions of sticking for a long time, effectively skin can be avoided situations such as allergy occur, make this cave Position patch can use for a long time, preferably can prevent the malaise symptoms such as allergy by skin care, improve therapeutic effect.In addition, silk Melon network has dredging collateral effect, is to treat a good pharmaceutical carrier and medium for diabetic neuropathy, and luffa surface layer is not The scraggly structure that the hole of rule is formed also has certain external stimulus effect to acupuncture point, and the present invention is made by luffa For pharmaceutical carrier, therapeutic effect is had both.
(3) acupoint plaster of the present invention passes through the Chinese medicine preparation of luffa carrier layer partner treatment diabetic neuropathy, preparation Method is simple, and under the guidance of theory of traditional Chinese medical science, compatibility science, drug effect is significant, is external application, can be used for a long time, without obvious bad Reaction and toxic side effect, safety is good, easy to use, is conducive to clinical application.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of acupoint plaster of the present invention；
Appended drawing reference: 1- basal layer, 2- luffa carrier layer, 3- Chinese medicine, 4- protective layer.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical solution of the present invention is clearly and completely described, it is clear that Described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on the implementation in the present invention Example, every other embodiment obtained by those of ordinary skill in the art without making creative efforts belong to The scope of protection of the invention.
As shown in Figure 1, the structural schematic diagram of the acupoint plaster for present invention treatment diabetic neuropathy, including basal layer 1, For medicament-carried luffa carrier layer 2, the Chinese medicine for treating diabetic neuropathy is attached in luffa carrier layer 2 3, with the protective layer 4 being broken away when using on Chinese medicine 3.Basal layer 1 is in non-woven fabrics, stretch fabric, polyester-mixed cotton cloth and chemical fabric One kind.Basal layer 1 mainly plays fixed function, in acupoint plaster use process, will be attached with drug by basal layer by external force Luffa carrier layer stick on the skin, be easy to use.Luffa carrier layer 2 is flattened by multilayer luffa, is staggeredly compressed It is made.The effect of protective layer 4 is to prevent the impurity such as extraneous dust pollution drug, makes acupoint plaster convenient for storage.In use, will patch Protective layer 4 on Chinese medicine 3 is taken off, and drug is sticked on acupuncture point, and acupoint plaster is then fixed on body by basal layer 1 Corresponding position.This acupoint plaster structure is simple, easy to use, and luffa carrier layer can preferably skin care prevent Quick equal malaise symptoms, and have both therapeutic effect.
Embodiment 1
The preparation method for treating the acupoint plaster of diabetic neuropathy, comprising the following steps:
(1) each drug is weighed by following specific gravity: 10 parts of Radix Codonopsis, 10 parts of Radix Astragali, 10 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiong, Radix Paeoniae Alba 10 Part, 10 parts of ramulus cinnamomi, 6 parts of licorice, 20 parts of lycopodium calvatum, 20 parts of lopseed, 10 parts of folium artemisiae argyi, are placed in extraction vessel by 3 parts of evodia rutaecarpa It is interior, 70% ethyl alcohol is added as extracting solution and submerges medicinal material；
(2) heating extraction container makes 80 DEG C of extracting solution temperature, keeps the temperature 3h, repeats extraction three times；
(3) leaching liquor is transferred in Rotary Evaporators, the revolving speed of Rotary Evaporators is 20r/min, the temperature of reduced pressure Degree is 75 DEG C, and pressure is -0.09Mpa, is concentrated under reduced pressure, and recycling extracting solution to drug is in paste；
(4) luffa flattened, staggeredly compress luffa carrier layer is made, by cream drug be coated on face to get Finished product.
Embodiment 2
The preparation method for treating the acupoint plaster of diabetic neuropathy, comprising the following steps:
(1) each drug is weighed by following specific gravity: 8 parts of Radix Codonopsis, 12 parts of Radix Astragali, 12 parts of Radix Angelicae Sinensis, 8 parts of Rhizoma Chuanxiong, 12 parts of Radix Paeoniae Alba, 8 parts of ramulus cinnamomi, 4 parts of licorice, 15 parts of lycopodium calvatum, 15 parts of lopseed, 8 parts of folium artemisiae argyi, are placed in extraction vessel, add by 2 parts of evodia rutaecarpa Enter 60% ethyl alcohol as extracting solution and submerges medicinal material；
(2) heating extraction container makes 90 DEG C of extracting solution temperature, keeps the temperature 2h, repeats extraction three times；
(3) leaching liquor is transferred in Rotary Evaporators, the revolving speed of Rotary Evaporators is 20r/min, the temperature of reduced pressure Degree is 50 DEG C, and pressure is -0.09Mpa, is concentrated under reduced pressure, and recycling extracting solution to drug is in paste；
(4) luffa flattened, staggeredly compress luffa carrier layer is made, by cream drug be coated on face to get Finished product.
Embodiment 3
The preparation method for treating the acupoint plaster of diabetic neuropathy, comprising the following steps:
(1) each drug is weighed by following specific gravity: 12 parts of Radix Codonopsis, 8 parts of Radix Astragali, 8 parts of Radix Angelicae Sinensis, 12 parts of Rhizoma Chuanxiong, 8 parts of Radix Paeoniae Alba, 12 parts of ramulus cinnamomi, 8 parts of licorice, 25 parts of lycopodium calvatum, 25 parts of lopseed, 12 parts of folium artemisiae argyi, are placed in extraction vessel by 4 parts of evodia rutaecarpa, 80% ethyl alcohol is added as extracting solution and submerges medicinal material；
(2) heating extraction container makes 70 DEG C of extracting solution temperature, keeps the temperature 5h, repeats extraction three times；
(3) leaching liquor is transferred in Rotary Evaporators, the revolving speed of Rotary Evaporators is 20r/min, the temperature of reduced pressure Degree is 60 DEG C, and pressure is -0.09Mpa, is concentrated under reduced pressure, and recycling extracting solution to drug is in paste；
(4) luffa flattened, staggeredly compress luffa carrier layer is made, by cream drug be coated on face to get Finished product.
Clinical data
90 diabetic peripheral neuropathy patients are recruited in this research, are assigned randomly to following three groups of therapeutic schemes by 1:1:1 In one group of receiving treatment, for the acupoint plaster being prepared using embodiment 1 as therapeutant, patient uses the acupoint plaster 3 hours daily In corresponding acupuncture point, entire research process 14 days by a definite date.
First group of therapeutic scheme: acupoint plaster is affixed on bilateral Yongquan acupoint；
Second group of therapeutic scheme: acupoint plaster is affixed on bilateral point st 36；
Third group therapeutic scheme: acupoint plaster is affixed on bilateral SANYINJIAO acupoint.
Curative effect is judged:
Curative effect, which is judged, uses Toronto clinical scoring system (TCSS), including nervous symptoms, neural reflex, sensory function are examined Look into 3 parts of scoring.(1) nervous symptoms, including numbness of lower limbs, pain, needle pricked feeling, out of strength, instability of gait, the similar disease of upper limb Shape, normal 0 point of meter, each symptom meter 1 divides；(2) neural reflex, including ankle jerk, knee jerk score for bilateral, normally count 0 Point, weaken 1 point of meter, disappear 2 points of meter；(3) sensory examination, including the pain sensation, temperature sensation, touch-pressure sensation, seismesthesia, topesthesia, Normal 0 point of meter, abnormal 1 point of meter.Total score is 0-19 points.It is finally judged with therapeutic index, therapeutic index=(treat preceding total mark- Total mark after treatment)/treat preceding total mark × 100%.
Evaluation result is divided into following three kinds of situations, and effective: clinical symptoms, sign are obviously improved, therapeutic index >=70%；Have Effect: clinical symptoms, sign take a favorable turn, therapeutic index >=30%；Invalid: clinical symptoms, sign are not improved, even plus Weight, therapeutic index < 30%.Treatment results are as shown in table 1 below:
1 treatment results statistical form of table
It can be seen that by above-mentioned table 1, therapeutic effect when acupoint plaster prepared by the present invention acts on Yongquan acupoint and point st 36 Preferably, total effective rate is respectively 66.67%, 63.33%, but this acupoint plaster is less significant for the therapeutic effect of SANYINJIAO acupoint, Therefore, acupoint plaster of the invention needs that acupuncture point appropriate is cooperated to be treated, with maximum journey when treating diabetic neuropathy The therapeutic effect of this acupoint plaster of the performance of degree.
Typical case
One, Mr. Li, female, 60 years old, diabetes B merging in 18 years peripheral neuropathy 8 years, recent glycemic control was good, , occasionally there are incoordination in double lower limb numbness, pain, aching and limp inability, when walking.Bilateral pulsation of foot dorsal artery weaken, bilateral knee jerk and Ankle jerk weakens, and the pain sensation, vibration sense lower.After acupuncture point is affixed on Yongquan acupoint treatment 14 days, numbness, pain, incoordination are obviously good Turn, the pain sensation is restored.
Two, Zhang, female, 58 years old, diabetes B 6 years, recent glycemic control was fine, and electromyogram prompt: lower limb feel mind Through exception.Patient's bilateral numbness of lower limbs shouting pain, is sent out cool, is more than 1 year powerless, and the pain sensation, temperature sensation slightly lower, double upper limbs occasionally have it is numb, Shouting pain is diagnosed as diabete peripheral herve pathology.After acupoint plaster is affixed on point st 36 treatment 14 days, above-mentioned symptom is relieved.
Although this specification is described in terms of embodiments, but not each embodiment only includes an independent skill Art scheme, this description of the specification is merely for the sake of clarity, and those skilled in the art should be using specification as one A entirety, the technical solutions in the various embodiments may also be suitably combined, formed it will be appreciated by those skilled in the art that other Embodiment.Therefore the foregoing is merely the preferred embodiments of the application, not are used to limit the practical range of the application；It is i.e. all according to The various equivalents that claims hereof range is done are the protection scope of the claim of this application.

Claims (9)

1. a kind of acupoint plaster for treating diabetic neuropathy, it is characterised in that: including for medicament-carried luffa carrier Layer (2) and the Chinese medicine (3) for being used to treat diabetic neuropathy being attached in luffa carrier layer；Wherein:
The Chinese medicine is prepared by following medicinal materials by mass parts: 8-12 parts of Radix Codonopsis, 8-12 parts of Radix Astragali, and 8-12 parts of Radix Angelicae Sinensis, Rhizoma Chuanxiong 8-12 parts, 8-12 parts of Radix Paeoniae Alba, 8-12 parts of ramulus cinnamomi, 4-8 parts of licorice, 15-25 parts of lycopodium calvatum, 15-25 parts of lopseed, evodia rutaecarpa 2- 4 parts, 8-12 parts of folium artemisiae argyi.
2. acupoint plaster according to claim 1, it is characterised in that: the Chinese medicine by following medicinal materials by mass parts prepare and At: 10 parts of Radix Codonopsis, 10 parts of Radix Astragali, 10 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiong, 10 parts of Radix Paeoniae Alba, 10 parts of ramulus cinnamomi, 6 parts of licorice, lycopodium calvatum 20 Part, 20 parts of lopseed, 3 parts of evodia rutaecarpa, 10 parts of folium artemisiae argyi.
3. acupoint plaster according to claim 1, it is characterised in that: the bottom of the luffa carrier layer (2) is equipped with substrate Layer (1).
4. acupoint plaster according to claim 3, it is characterised in that: the basal layer (1) is non-woven fabrics, stretch fabric, polyester-cotton blend One of cloth and chemical fabric.
5. acupoint plaster according to claim 1, it is characterised in that: anti-with what is be broken away when using on the Chinese medicine (3) Sheath (4).
6. the preparation method of acupoint plaster as described in claim 1, it is characterised in that: the following steps are included:
(1) drug is weighed according to the ratio and is placed in extraction vessel, and extracting solution is added and submerges medicinal material；
(2) heating extraction container makes 70-90 DEG C of extracting solution temperature, keeps the temperature 2-5h, repeats to extract multiple；
(3) leaching liquor is transferred in Rotary Evaporators, is concentrated under reduced pressure, recycling extracting solution to drug is in paste；
(4) luffa is flattened, staggeredly luffa carrier layer is made in compression, and cream drug is coated in luffa carrier layer Face is to get finished product.
7. preparation method according to claim 6, it is characterised in that: in step (1), the extracting solution is that mass fraction is The ethanol solution of 60-80%.
8. preparation method according to claim 6, it is characterised in that: in step (3), the revolving speed of the Rotary Evaporators is 20r/min, the temperature of the reduced pressure are 50-75 DEG C, and pressure is -0.09Mpa.
9. preparation method according to claim 6, it is characterised in that: in step (4), the thickness of the luffa carrier layer For 1-2mm.
CN201910721961.4A 2019-08-06 2019-08-06 Acupoint plaster for treating diabetic neuropathy and preparation method thereof Active CN110302270B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910721961.4A CN110302270B (en) 2019-08-06 2019-08-06 Acupoint plaster for treating diabetic neuropathy and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910721961.4A CN110302270B (en) 2019-08-06 2019-08-06 Acupoint plaster for treating diabetic neuropathy and preparation method thereof

Publications (2)

Publication Number Publication Date
CN110302270A true CN110302270A (en) 2019-10-08
CN110302270B CN110302270B (en) 2021-07-16

Family

ID=68083255

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910721961.4A Active CN110302270B (en) 2019-08-06 2019-08-06 Acupoint plaster for treating diabetic neuropathy and preparation method thereof

Country Status (1)

Country Link
CN (1) CN110302270B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112494546A (en) * 2020-12-22 2021-03-16 天津医科大学朱宪彝纪念医院 Light-excited acupoint-permeable medicament for treating diabetic neuropathy and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
武淑梅等: "益气活血化瘀为主中药浴治疗糖尿病周围神经病变临床体会", 《河北中医》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112494546A (en) * 2020-12-22 2021-03-16 天津医科大学朱宪彝纪念医院 Light-excited acupoint-permeable medicament for treating diabetic neuropathy and preparation method thereof

Also Published As

Publication number Publication date
CN110302270B (en) 2021-07-16

Similar Documents

Publication Publication Date Title
CN101979037B (en) Medicament for treating diabetic complications and preparation method thereof
CN101347536B (en) External-use preparation for treating traumatic injury
CN102847063A (en) Traditional Chinese medicinal composition for treating qi and blood deficiency blood stasis type diabetic feet, and its preparation method
CN102166278B (en) Chinese medicinal composition for treating pediatric rheumatoid arthritis and preparation method thereof
CN102861287B (en) Chinese medicinal composition for treating damp-heat invasion blood stasis diabetic foot and preparation method thereof
CN104689226A (en) Traditional Chinese medicine composition for treating children with rheumatoid arthritis and preparation method thereof
CN102697939A (en) Traditional Chinese medicine foot bath solution for preventing diabetic foot and preparation method thereof
CN102772712B (en) Traditional Chinese medicine composition for treating heat-toxicity, flourishing and blood stasis type diabetic foot
CN102872286B (en) Traditional Chinese medicine composition for curing lumbar interveterbral disc protrusion and preparation method thereof
CN104940810A (en) Traditional Chinese medicine composition for treating angina
CN102846955A (en) Chinese herbal medicine heightening insole
CN102145057A (en) Antispasmodic traditional Chinese medicine composition and preparation method thereof
CN110302270A (en) Acupoint plaster for treating diabetic neuropathy and preparation method thereof
CN103251878B (en) Anti-fatigue traditional Chinese medicine composition
CN103007159B (en) Chinese medicinal preparation for correcting pancreas islet function
CN104784538A (en) Chinese medicinal preparation for treating diabetes and preparation method
CN1772245A (en) Snake medicinal wine for health care massage and its application
CN102580030A (en) External traditional Chinese medicine composition having effect of reducing blood sugar, preparation prepared from the external traditional Chinese medicine composition, and their preparation method
CN102743440B (en) Traditional Chinese medicines for treating femoral head necrosis
CN102441131A (en) Chinese medicinal composition for treating traumatic injury
CN103182035B (en) Traditional Chinese medicine composition used for treating chronic arrhythmia of elderly people and preparation method of traditional Chinese medicine composition
CN104758439A (en) Traditional Chinese medicine composition for treating thoracic obstruction
CN104587345B (en) A kind of Chinese medicine preparation for treating Alzheimer disease and preparation method thereof
CN103768408A (en) Medicine for preventing and treating pains after operations due to anorectal diseases
CN105902644A (en) Traditional Chinese medicinal composition for treating cervical spondylopathy, and preparation methods thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant