CN102357125B - Chinese herbal medicine composition for treating early occlusive peripheral atherosclerosis - Google Patents
Chinese herbal medicine composition for treating early occlusive peripheral atherosclerosis Download PDFInfo
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Abstract
The invention belongs to the medicine category, and in particular discloses a Chinese herbal medicine composition for treating early occlusive peripheral atherosclerosis. The composition comprises the following raw material drugs in parts by weight: 10-60 parts of astragalus mongholicus, 5-30 parts of ginseng, 3-10 parts of cassia twig, 5-10 parts of lumbricus, 2-5 parts of scorpion, 1.5-3 parts of leech, 3-10 parts of pangolin scales, 6-15 parts of medicinal cyathula root, 3-10 parts of long-noded pit viper, 3-10 parts of safflower carthamus, 3-10 parts of frankincense and 3-10 parts of rhizoma corydalis. The composition disclosed by the invention has the effects of supplementing qi and activating blood, breaking blood stasis, dredging collaterals and relieving pain; according to composition disclosed by the invention, blood circulation of lower limbs can be effectively improved, limbs pain is obviously relieved or effectively eliminated, intermittent claudication is relieved or eliminated, skin is changed to normal skin color from black brown, lower limb crural muscular atrophy can be retarded or controlled, healing effect of later-stage toe, foot or crural ulcer is promoted, the disadvantage of not effectively preventing disease process from gradually developing and deteriorating which is caused owing to merely using western medicine to carry out symptomatic treatment is solved, and an effective treatment measure is provided for a new subject.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly a kind of atherosis Chinese medicine composition of early stage occlusive peripheral arterial for the treatment of.
Background technology
The category of the occlusive peripheral arterial is atherosis genus motherland's medical science " passages through which vital energy circulates " pathological changes and " vascular " pathological changes.Therefore peripheral vascular disease is referred to as " vascular disorders ".Its pathogenesis is: diseases caused by exogenous pathogenic factor six climate exopathogens, tobacco poisoning, wound or diet delicious food, feelings will internal injury, internal organs meridian function are lacked of proper care, the hyperamization arteries and veins stasis of bloods such as impairment caused by overstrain is deficient, blood stasis, phlegm retention stagnate, blood operation is obstructed, cause that pain increased the weight of when lower limb were sent out cold, numbness, pain, lifting affected limb, intermittent claudication, also pain during rest when serious, increase the weight of night, skin color becomes pitchy, amyotrophy, and the later stage can produce the ulcer of toe, foot or shank or dry gangrene etc. and be primary symptom.
The occlusive peripheral arterial is atherosis, is the new subject that just grows up in recent years, and everybody is stranger to this, and misdiagnosis rate is higher.Lose valuable opportunity if can not get in early days correct treatment, some patient has just lost limbs becomes lifelong deformity, even threat to life.And when using merely the western medicine primary disease, can only adopt to the ill supporting treatment, effect is relatively poor, can not effectively stop the deterioration of the state of an illness.
Summary of the invention
For overcoming the deficiencies in the prior art part, the object of the present invention is to provide a kind of atherosis Chinese medicine composition of early stage occlusive peripheral arterial for the treatment of.Said composition has the effect of benefiting QI for activating blood circulation, removing blood stasis with potent drugs collateral dredging, pain relieving, and its clinical efficacy is remarkable.
For achieving the above object, the technical scheme taked of the present invention is as follows:
A kind of atherosis Chinese medicine composition of early stage occlusive peripheral arterial for the treatment of is made by each crude drug of following portions by weight: 10 ~ 60 parts of the Radixs Astragali, 5 ~ 30 parts of Radix Ginsengs, 3 ~ 10 parts of Ramulus Cinnamomi, 5 ~ 10 parts of Pheretimas, 2 ~ 5 parts of Scorpios, 1.5 ~ 3 parts of Hirudos, 3 ~ 10 parts of Squama Maniss, 6 ~ 15 parts of Radix Cyathulaes, 3 ~ 10 parts of Agkistrodons, 3 ~ 10 parts on Flos Carthami, 3 ~ 10 parts of Olibanums, 3 ~ 10 parts of Rhizoma Corydalis.
Further, the parts by weight of described each crude drug are preferably: 30 parts of the Radixs Astragali, 15 parts of Radix Ginsengs, 10 parts of Ramulus Cinnamomi, 10 parts of Pheretimas, 5 parts of Scorpios, 2 parts of Hirudos, 6 parts of Squama Maniss, 10 parts of Radix Cyathulaes, 9 parts of Agkistrodons, 9 parts on Flos Carthami, 6 parts of Olibanums, 10 parts of Rhizoma Corydalis.
Preferably, Squama Manis is Squama Manis preparata, and Olibanum is Olibanum (processed).
Make according to a conventional method any clinically acceptable preparation, such as can be decoct, pill, capsule, granule or concentrated pill.Can according to the needs of different preparations, choose and add corresponding conventional adjuvant.
Preparation method and using method:
The progression of disease phase: 1. in weight/volume, take by weighing the Radix Astragali 10 ~ 60g, Radix Ginseng 5 ~ 30g, Ramulus Cinnamomi 3 ~ 10g, Pheretima 5 ~ 10g, Scorpio 2 ~ 5g, Hirudo 1.5 ~ 3g, Squama Manis 3 ~ 10g, Radix Cyathulae 6 ~ 15g, Agkistrodon 3 ~ 10g, Flos Carthami 3 ~ 10g, Olibanum 3 ~ 10g, Rhizoma Corydalis 3 ~ 10g, then this 12 flavor crude drug is put into marmite, first fries in shallow oil and adds water 600ml and soaked 30 minutes, after boiling with high heat first, used instead 30 minutes at a simmer, taking liquid is 350ml approximately again; Second fries in shallow oil and adds water 500ml, uses instead 25 minutes at a simmer after boiling with high heat first again, and taking liquid is 350ml approximately; Two boil medicine liquid mix after clothes at twice, morning and evening service once, decoction being taken warmly.Or, 2. the present invention's 12 flavor crude drug are utilized the agent of prior art granulation, be distributed into bag, every bag of 10g each serving 1 bag, takes warm boiled water every day three times.
The stable disease phase: by weight ratio, take by weighing the Radix Astragali 10 ~ 60g, Radix Ginseng 5 ~ 30g, Ramulus Cinnamomi 3 ~ 10g, Pheretima 5 ~ 10g, Scorpio 2 ~ 5g, Hirudo 1.5 ~ 3g, Squama Manis 3 ~ 10g, Radix Cyathulae 6 ~ 15g, Agkistrodon 3 ~ 10g, Flos Carthami 3 ~ 10g, Olibanum 3 ~ 10g, Rhizoma Corydalis 3 ~ 10g, then cross 120 mesh sieves after this 12 flavor Chinese medicine being pulverized, after making superfine medicated powder: 1. medicated powder and honey are made honeyed pill by the 1:1.5 mass ratio, every ball 3g, each serving 6g, take warm boiled water every day three times; Or, the Capsules of 2. medicated powder being packed into, every 0.3g, each serving 6, every day three times, warm boiled water; Or, 3. utilize prior art to make concentrated pill the present invention's 12 flavor crude drug, each serving 6g, take warm boiled water every day three times.
Pharmacology of the present invention:
The Radix Astragali: sweet in the mouth, slightly warm in nature enters spleen, lung meridian, has the effects such as benefiting QI for activating blood circulation, promoting pus discharge and tissue regeneration strengthening." Mingyi Bielu " meaning this product " by stagnant blood between the five internal organs ".Modern pharmacological research proves: this product truly has the good merit of invigorating blood circulation, and can reduce whole blood contrast viscosity and plasma viscosity, shortens erythrocyte electrophoretic time, reduces packed cell volume, improves hemorheological property.Can obviously reduce the platelet cofactor Ⅰ procoagulant activity.And coronary artery and peripheral blood vessel there are direct dilating effect, coronary flow is increased.Other has the effect of remarkable anti-experimental character thrombosis, energy anticoagulant etc.Be widely used in especially clinically for many years the stagnant person of the multiple blood vessels stasis of bloods such as artery thrombosis, coronary heart disease, cerebral thrombosis.This shows, the Radix Astragali can not only pass through QI invigorating, makes gas prosperous in promoting the circulation of blood, and the good merit of invigorating blood circulation is arranged.
Radix Ginseng: sweet in the mouth, slightly warm in nature enters lung, spleen, the heart, kidney channel, has strongly invigorating primordial QI, the functions such as enriching blood and promoting secretion of body fluid.This product is for saving danger emergency treatment of collapse key medicine, and the merit of its strongly invigorating primordial QI can generation without medicine, is suitable for most because of vigour fictitious pole due to losing blood greatly etc. and wants to take off the critical disease of faint pulse being about to disappear.This product can QI invigorating with hemopoietic, certain merit of enriching blood is arranged again; Can QI invigorating with promoting the circulation of blood, certain merit of invigorating blood circulation is arranged again, therefore availablely control blood deficiency disease and the blood vessels stasis of blood all diseases that stagnates.In recent years multiplex in the disease of the multiple blood-vessel obstructives such as treatment cardiovascular and cerebrovascular disease and peripheral arterial thrombosis.Pharmacological research proves: Radix Ginseng has the peripheral vascular resistance of reduction and blood pressure lowering, anti-hypoxia and protection cardiac muscle, improves hemorheology and antithrombotic formation, atherosclerosis, anti-stress, raising immunologic function, strengthens the effects such as hemopoietic function, cholesterol regulating metabolism, blood fat reducing, blood sugar lowering.
Ramulus Cinnamomi: acrid-sweet flavor, warm in nature, enter lung, kidney, the heart, spleen channel, have the effect of warm promoting blood circulation, warm aid yang qi.Cold coagulation in can the loose blood of temperature can be declared again and lead blood circulation promoting medicine, the effect of promoting blood circulation to strengthen blood stasis dispelling.The clinical heart arteries and veins stasis blocking that is usually used in due to the flaccidity of the heart-yang, and because of the arthromyodynia due to the rheumatism.Other has clinical report: Ramulus Cinnamomi also can be used for controlling Raynaud disease etc.
Pheretima: salty in the mouth is cold in nature, enters liver, spleen, urinary bladder channel, has the effects such as endogenous wind stopping relieving convulsion, collateral dredging.Kind control that blood stagnancy due to deficiency of QI after the apoplexy, muscle arteries and veins lose and support, the unfavorable all diseases of meridians and rheumatism with the passing of time, Yu Xue Bi resistance passages through which vital energy circulates, podomere or the whole body.The kind current meridians of Pheretima, pharmacological research proves: the Pheretima decoct has anti thrombotic action, and the thrombolytic composition is protease, energy direct hydrolysis fibrin, and have the activation of plasminogen.By anticoagulant, anticoagulation, reduction blood viscosity, thereby stop thrombosis, promote thromboembolism.
Scorpio: acrid in the mouth is flat, returns Liver Channel, has the functions such as endogenous wind stopping relieving convulsion, resolving mass and removing the obstruction of the collateral.This product has the good effect of expel wind to dredge collateral.With the passing of time do not heal with controlling anemofrigid-damp arthralgia, the contracture of muscle arteries and veins, brothers' erectile problem, very then the insensitive impediment effect of joint deformity is rather good." beautiful Chinese catalpa medicine solution ": " wearing muscle deep, by the wet wind that removes ".Modern pharmacological research confirms: this product has antithrombotic to form, reduce platelet adhesion rate, delay hemagglutinative function.
Hirudo: salty in the mouth is bitter, and property is flat, enters Liver Channel, enters blood, removing blood stasis power is strong, can cure the wound by the meridian dredging ， Xiao wei.Shennong's Herbal: " master pursues stagnant blood, blood stasis, removing blood stasis abdominal mass, gathers ... ".This product mainly contains in protein, heparin, antithrombase, the fresh Hirudo saliva and contains a kind of anticoagulative substance-hirudin.In addition, still contain the various trace elements such as sodium, potassium, calcium.Pharmacological research proves: this product has anti thrombotic action, can not only prevent the formation of tampon, can also thrombus, can suppress Fibrinogen and be converted into fibrin, and the activity of energy factor anticoagulant and the platelet response of thrombin induction, very strong anticoagulation is arranged.Can reduce surface activity of blood platelet, anticoagulant can improve hemorheology; the energy blood fat reducing, the atheromatous plaque that disappears alleviates the surrounding tissue inflammatory reaction; improve blood circulation, the protection cerebral tissue increases the effects such as Nutritional myocardium blood flow amount and promotion neurological functional recovery.
Squama Manis: the salty in the mouth cold nature, enter liver, stomach warp, have the functions such as the Xiao of invigorating blood circulation wei, dredge the meridian passage.This moral character is apt to away alter, and the stasis of blood of can promoting the circulation of blood dividing stagnates and the wei that disappears, dredge the meridian passage.Be used for controlling the chronic ulcer of the lower limb stagnant disease of meridian stasis such as do not close up for a long time.Modern pharmacological research confirms: this product can significantly increase femoral artery blood flow, reduces Peripheral resistance, and blood vessel wall is had direct dilating effect.Can obviously prolong clotting time, blood viscosity lowering." Records of Tradition Chinese and Western Medicine in Combination ": " Squama Manis, lightly seasoned property is flat, gas raw meat and altering, the property that it walks to alter, very careful, therefore can declare logical internal organs, implement meridians, thoroughly reach the pass key, all blood clotting blood is poly-to be disease, all can open it ".
Radix Cyathulae: bitter in the mouth, sweet, sour, property is flat, enters liver, kidney channel, has the effects such as promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, conducting blood to flow downwards.This product is longer than promoting blood circulation to restore menstrual flow, clinical disease and damp and hot one-tenth flaccidity for multiple blood stasis, the soft person of sufficient knee joint flaccidity." Records of Tradition Chinese and Western Medicine in Combination ": " kind bleed blood is made a bet, and is to want its lower passerby with medication, permanent take as tying-in, therefore control the lumbago and skelalgia of suffering from a deficiency of the kidney, or knee joint is painful can not bend and stretch or the lower limb flaccidity can not be appointed ground ".Pharmacological research proves: this product can reduce the rat whole blood viscosity, packed cell volume, erythrocyte aggregation index, and anticoagulation is arranged.In addition, the effects such as blood fat reducing, blood sugar lowering, antiinflammatory, enhancing immunologic function are still arranged." Chinese pharmacopoeia (version in 2000) record: Radix Cyathulae " eliminating blood stasis and inducing menstruation, easing joint movement ... be used for arthralgia, the flaccidity of the lower limbs clonic spasm of the muscle ... ".
Agkistrodon: sweet-salty is warm in nature, enters Liver Channel, has the effects such as wind-damp dispelling, the meridian dredging.This product has the property of walking to alter, and collateral dredging warm in nature is walked internal organs in the energy, reaches the flesh table outward and the deep wind of searching is the wind-damp dispelling key medicine; Again can collateral dredging, all rheumatic Bi syndromes without unsuitable it, outstanding kind rheumatoid arthritis stubborn of curing the disease deeply with the passing of time, blockage of main and collateral channels, numbness contracture etc.Compendium of Material Medica: " can the deep wind of searching, cut and frightenedly surely jerk, for migratory arthralgia, frightenedly jerk, favus, malignant boil key medicine.Get and walk internal organs in it, outer thorough skin is nowhere less than also ".Modern pharmacological research confirms: this product has significant hypotensive effect, and its water extract can activate fibrinolytic system, the effect that has stronger prevention artery and vein thrombosis to form.
Flos Carthami: acrid in the mouth is warm in nature, and GUIXIN, Liver Channel have the effect of promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.The hot loose temperature of this product is logical, specially enters blood system, is the key medicine of promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.Can blood circulation promoting and blood stasis dispelling, the stasis of blood is gone new life, and warm venting QI-blood is used for controlling that meridian stasis stagnates swells and ache the diseases such as traumatic injury." book on Chinese herbal medicine converges and says ": " Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood also.”
Olibanum: acrid in the mouth bitterness temperature, return liver, the heart, spleen channel, have invigorate blood circulation, the effect of circulation of qi promoting, pain relieving, detumescence and promoting granulation.The hot loose temperature of this product is logical, can the blood-activating and qi-promoting pain relieving, again can blood stasis dispelling, stretch muscle, and exempt from numbness, therefore diseases such as the limbs pain due to dispelling the wind and dampness pathogens arthralgia pain and the stagnation of blood stasis, numbnesses.And internal energy a surname of this product is led to internal organs, and external enwergy reaches meridians thoroughly, can blood circulation promoting and blood stasis dispelling, can manage it again the loose gas that stagnates, and the merit of pain relieving is more outstanding.Can " decide pain of all warps " " pearl sac ", the kind pain of controlling stagnation of QI and blood." property of medicine is cut usefulness ": " relaxing muscles and tendons to promote blood circulation, wind-expelling pain-stopping is for controlling the active special medicine of numbness ".
Olibanum: acrid in the mouth bitterness temperature, return liver, the heart, spleen channel, have invigorate blood circulation, the effect of circulation of qi promoting, pain relieving, detumescence and promoting granulation.The hot loose temperature of this product is logical, can the blood-activating and qi-promoting pain relieving, again can blood stasis dispelling, stretch muscle, and exempt from numbness, therefore diseases such as the limbs pain due to dispelling the wind and dampness pathogens arthralgia pain and the stagnation of blood stasis, numbnesses.And internal energy a surname of this product is led to internal organs, and external enwergy reaches meridians thoroughly, can blood circulation promoting and blood stasis dispelling, can manage it again the loose gas that stagnates, and the merit of pain relieving is more outstanding.Can " decide pain of all warps " " pearl sac ", the kind pain of controlling stagnation of QI and blood." property of medicine is cut usefulness ": " relaxing muscles and tendons to promote blood circulation, wind-expelling pain-stopping is for controlling the active special medicine of numbness ".
Rhizoma Corydalis: acrid in the mouth bitterness temperature, return liver, spleen, heart channel, have invigorate blood circulation, the effect of promoting the circulation of QI to relieve pain.The hot temperature of faling apart of this product is logical, and " stagnation of QI in the promoting the circulation of blood, therefore stasis in the gas is all pain Compendium of Material Medica about specially controlling all over the body for energy.This product is the pain relieving key medicine, which kind of pain disease no matter, but all compatibility is used, and especially qi depression to blood stasis person is better.
Above all medicine compatibilities are played the effect of benefiting QI for activating blood circulation, removing blood stasis with potent drugs collateral dredging, pain relieving altogether.Pain increases the weight of when being used for the treatment of the hyperamization arteries and veins stasis of bloods such as, blood stasis deficient because of diseases caused by exogenous pathogenic factor six climate exopathogens, tobacco poisoning, wound or diet delicious food, feelings will internal injury, the imbalance of internal organs meridian function, impairment caused by overstrain, phlegm retention stagnate, blood operation is obstructed to be caused lower limb and sending out cold, numbness, pain, lifting affected limb, intermittent claudication, also pain during rest when serious, increase the weight of night, skin color becomes pitchy, and the early stage occlusive peripheral arterial of the diseases such as amyotrophy is atherosis.
The present composition has the effect of benefiting QI for activating blood circulation, removing blood stasis with potent drugs removing obstruction in the collateral to relieve pain, can effectively improve the blood circulation of lower limb, significantly alleviate or effectively eliminate limbs pain, alleviate or the elimination intermittent claudication, make skin gradually transfer the normal colour of skin to by pitchy, can delay or control the atrophy of lower limb muscle of leg, and treatment more early, curative effect is just more remarkable.Chinese medicine composition of the present invention can impel the healing of toe in late period, foot or calf ulcer, has remedied the simple Western medicine symptomatic treatment of using, the drawback that can not effectively stop the state of an illness to be made progress gradually to worsen, and provide an effective treatment approach for this new subject.
The specific embodiment
Below in conjunction with specific embodiment technical scheme of the present invention is done to introduce in detail further, but protection scope of the present invention is not limited to this.
Embodiment 1
Radix Astragali 10g, Radix Ginseng 30g, Ramulus Cinnamomi 3g, Pheretima 7g, Scorpio 2g, Hirudo 3g, Squama Manis preparata 3g, Radix Cyathulae 15g, Agkistrodon 3g, Flos Carthami 7g, Olibanum (processed) 10g, Rhizoma Corydalis 3g.
Preparation method and using method:
The progression of disease phase: 1. above-mentioned 12 flavor crude drug are put into marmite, first fries in shallow oil and adds water 600ml and soaked 30 minutes, after boiling with high heat first, uses instead 30 minutes at a simmer again, and taking liquid is 350ml approximately; Second fries in shallow oil and adds water 500ml, uses instead 25 minutes at a simmer after boiling with high heat first again, and taking liquid is 350ml approximately; Two boil medicine liquid mix after clothes at twice, morning and evening service once, decoction being taken warmly.Or, 2. above-mentioned 12 flavor crude drug are utilized the agent of prior art granulation, be distributed into bag, every bag of 10g each serving 1 bag, takes warm boiled water every day three times.
The stable disease phase: will be above-mentioned 12 flavor Chinese medicines cross 120 mesh sieves after pulverizing, make superfine medicated powder after: 1. medicated powder and honey are made honeyed pill by the 1:1.5 mass ratio, every ball 3g is each serving taking 6g, every day warm boiled water three times; Or, the Capsules of 2. medicated powder being packed into, every 0.3g, each serving 6, every day three times, warm boiled water; Or, 3. utilize prior art to make concentrated pill the present invention's 12 flavor crude drug, each serving 6g, take warm boiled water every day three times.
Embodiment 2
Radix Astragali 30g, Radix Ginseng 15g, Ramulus Cinnamomi 10g, Pheretima 10g, Scorpio 5g, Hirudo 2g, Squama Manis preparata 6g, Radix Cyathulae 10g, Agkistrodon 9g, Flos Carthami 9g, Olibanum (processed) 6g, Rhizoma Corydalis 10g.
Preparation method and using method are with embodiment 1.
Embodiment 3
Radix Astragali 60g, Radix Ginseng 5g, Ramulus Cinnamomi 7g, Pheretima 5g, Scorpio 3g, Hirudo 1.5g, Squama Manis preparata 10g, Radix Cyathulae 6g, Agkistrodon 6g, Flos Carthami 3g, Olibanum (processed) 3g, Rhizoma Corydalis 7g.
Preparation method and using method are with embodiment 1.
Clinical trial
1.1 physical data
From year August in January, 2005 to 2011, accept atherosis patient's 120 examples of early stage occlusive peripheral arterial for medical treatment.All cases is all through health check-up, check pulsation of foot dorsal artery intensity, the test of finger pressure nail matrix, survey the ankle systolic arterial pressure and the multiple inspections such as brachial artery systolic pressure ratio and laboratory auxiliary examination are made a definite diagnosis, and bad without severe cardiac, liver, renal function.Be divided at random treatment group 60 examples, male 39 examples wherein, women 21 examples, 36 ~ 65 years old age, 55 years old mean age, suffer from diabetes 33 examples, suffer from hypertension 60 examples, suffer from 60 Cases of Hyperlipidemia.Matched group 60 examples, male 40 examples wherein, women 20 examples, 38 ~ 67 years old age, 56 years old mean age, suffer from 32 Patients with Diabetes, suffer from hypertension 60 examples, suffer from 60 Cases of Hyperlipidemia.Two groups at aspects such as sex, age, the state of an illness all without significant difference (P〉0.05), have comparability, see table 1 for details.
1.2 diagnostic criteria
The diagnostic criteria formulation for 367 pages of the professional internal medicine such as 8 years systems and 7 years clinical medicine processed with reference to Wang Jiyao chief editor.
1. the age is many more than 50 years old; 2. hyperlipemia, diabetes or hypertension history are arranged; 3. intermittent claudication, acroesthesia companion artery of lower extremity beat weaken, disappearance, asymmetric, ankle/brachial artery systolic pressure index＜1.0; 4. Doppler checks the positive.
1.3 Therapeutic Method
Matched group: adopt the routine of western medicine treatment: the control blood fat is with simvastatin or fenofibrate, control blood glucose is with glipizide or insulin, the control blood pressure improves the blood samples of patients circulation and uses low molecular dextran with enalapril, Nifedipine sustained release tablets, and other takes symptomatic treatment.
Treatment group: the basis for the treatment of with routine of western medicine at matched group adds the embodiment of the invention 2 prescriptions and preparation method thereof, using method.
Two groups treated respectively for 8 weeks after, observe the improvement situations such as clinical symptoms and every auxiliary examination.
1.4 therapeutic evaluation
Produce effects: clinical symptom disappearance, finger pressure nail matrix capillary filling time shortens, and survey ankle/upper arm index approaches or equals 1; Pulsation of foot dorsal artery approaches normal or normal; The blood fat and blood pressure glycemic control is normal.
Effectively: clinical symptoms disappears substantially, and finger pressure nail matrix capillary filling time slightly prolongs or approaches normally, surveys ankle/upper arm index greater than more than 0.7; Pulsation of foot dorsal artery approaches normal; Blood fat and blood pressure blood glucose all is controlled at and approaches normally.
Invalid: clinical symptoms and finger pressure nail matrix capillary filling time are surveyed ankle/upper arm index below 0.5 all without obviously improving; Pulsation of foot dorsal artery weakens or disappears.
1.5 statistical method
Data represent with rate, adopt X
2Check has statistical significance take P＜0.05 as difference.
1.6 result
1.6.1 two groups of doing well,improving situations relatively before and after the treatment
Treatment group adds Chinese medicine composition of the present invention at matched group with routine of western medicine treatment basis, and clinical symptoms improvement rate (91.5%) significantly is better than matched group merely with clinical symptoms improvement rate (49.8%) after the routine of western medicine treatment, sees table 2 for details.
1.6.2 two groups of auxiliary examination results improve comparison before and after the treatment
Treatment group is after matched group adds Chinese medicine composition of the present invention with routine of western medicine treatment basis, pulsation of foot dorsal artery strengthens improvement rate (86.6%), shorten improvement rate (91.6%) with finger compressing nail matrix capillary filling time, survey ankle/brachial artery systolic pressure index improvement rate (83.3%), blood glucose improvement rate (90.9%), blood pressure improvement rate (95%), blood fat and improving rate (96.6%) significantly is better than matched group merely with after the routine of western medicine treatment, pulsation of foot dorsal artery strengthens improvement rate (65%), with finger compressing nail matrix capillary filling time improvement rate (68.3%), survey ankle/brachial artery systolic pressure index improvement rate (65%), blood glucose improvement rate (84.3%), blood pressure improvement rate (60%), blood fat and improving rate (53.3%) sees table 3 for details.
1.6.2 untoward reaction
Matched group has 7 examples dry cough to occur, has 3 examples hypoglycemia to occur dizzy.Treatment group has no obvious adverse reaction.
Model case
Case 1
Feng so-and-so, the man, 52 years old, the peasant was East St people from village, area just outside a city gate town, on August 16th, 2007, comes the inventor to locate to go to a doctor with " the occlusive peripheral arterial is atherosis ".The patient had hypertension history more than 10 years.Two lower limb pains appear after 2 years causes are suffered from cold, once alleviation after the locality treatment is taken medicine, and two lower limb pains after the appearance fatigue are slightly alleviated after the rest then, and pruritus causes because scratching, and two shank shins are front to reach inboard ulcer, fusion in flakes.More do not turn the treatment of Puyang the People's Hospital through county people's hospital's treatment, use the hirudiod external, heavy when light when festering, repeatedly outbreak changes the inventor place over to for asking further treatment.Disease is seen: the slight atrophy of two lower limb muscles, and the colour of skin is purple dark, reaches two medial legs before the shin and festers, merge in flakes, the skin ulcer face oozes out, pain, the activity postemphasis also bitterly, is tucked and is comforted foot during rest, shallow complexion, lip is purple dark, and purplish tongue is dark, and tongue is white, thready pulse without strength, finger pressure nail matrix capillary filling time prolongs, and surveys ankle/upper arm index 0.6, T:37.6 ℃, P:86 time/minute, R:20 time/minute, BP:160/95mmHg, blood glucose 4.6mmol/L, blood fat: triglyceride 2.9 mmol/L, cholesterol 6.1 mmol/L, remaining (-).
Dialectical analysis: prolonged illness is felt frustrated, the deficiency of vital energy is without mechanical resistance blood operation, therefore hyperamization liquid stasis blocking passages through which vital energy circulates, limbs lose and support that the meeting color is sallow, purple dark, the two lower limb muscles atrophy of lip, purple dark, the pain of the colour of skin, tucks and comforts foot.Overexertion leading to consumption of QI, the movable rear pain of event increase the weight of.Because scratching the damage skin, multiple sense poison is evil, therefore shin is anterior and two medial legs fester, merges in flakes gradually, and the skin ulcer face oozes out.Purplish tongue is dark, and tongue is greasy in vain, and thready and weak pulse without strength is resembling of blood stasis due to qi deficiency.
Diagnosis: vascular disorders (blood stasis due to qi deficiency)
The rule for the treatment of: benefiting QI for activating blood circulation, removing blood stasis with potent drugs removing obstruction in the collateral to relieve pain.
Side's medicine: the embodiment of the invention 2 prescriptions and preparation method thereof, using method.
Western medicine: the control blood pressure is controlled the blood fat fenofibrate with Nifedipine sustained release tablets, enalapril, improves the microcirculation low molecular dextran, other symptomatic treatment.
After treating for 8 weeks, the two lower limb pains of patient disappear, and it is normal that the colour of skin is gradually recovered, form a scab with inboard rotten position before the two shank shins, and the healing that comes off gradually, finger pressure nail matrix capillary filling time transfers to normally, surveying ankle/upper arm index is 1, and blood pressure, blood fat, blood glucose all are controlled within normal range.Advise the capsule preparations 6 months that continues to take the embodiment of the invention 2 prescriptions, after the drug withdrawal, through repeatedly following up a case by regular visits to, so far without recurrence.
Case 2
Pay so-and-so, the man, 60 years old, the cadre was first villages and small towns Shi Gu people from village, on June 19th, 2008, comes the inventor to locate to go to a doctor with " the occlusive peripheral arterial is atherosis ".The patient has hypertension and coronary heart disease, atrial fibrillation medical history more than 30 years, through common medicine.Occur two lower limb over nearly 3 years and send out cold, numbness, movable rear pain.Once in county people's hospital's treatment, effect was not good enough, turned the diagnosis and treatment of Puyang the People's Hospital, still without being clearly better, located and change the inventor over to.Disease is seen: two lower limb pains, and the activity postemphasis, slightly light after the rest, the colour of skin is purple dark, and two Calf muscle atrophys have festering of diameter 3cm before the left leg shin, wound surface depression is oozed out, and has palpitation, breathes hard, asthenia, dim complexion, light red tongue are dark, irregularly intermittent and regularly intermittent pulse, and finger pressure nail matrix capillary filling time prolongs, survey ankle/upper arm index 0.5, T:37 ℃, P:90 time/minute, R:22 time/minute, BP:170/95mmHg, blood glucose 5.0mmol/L, blood fat: triglyceride 1.2mmol/L, cholesterol 6.7 mmol/L, remaining (-).
Dialectical analysis: the prolonged illness QI and blood is two loses, and causes the qi and blood stagnation passages through which vital energy circulates, and limbs lose supports, therefore see two Calf muscle atrophys, the colour of skin is purple dark.Stagnation of QI-blood can not be gone up flourish in face, therefore the meeting color is dark and gloomy.Impaired because of the wound skin, multiple sense poison is evil, thus fester before the left leg shin, Qi and blood deficiency of a specified duration, then the wound surface depression is oozed out.Insufficiency of vital energy and blood, the heart is become homeless foster, therefore see nervously, breathes hard asthenia.Light red tongue is dark, and irregularly intermittent and regularly intermittent pulse is deficiency of qi and blood, the stagnant disease of the passages through which vital energy circulates stasis of blood.
Diagnosis: vascular disorders (deficiency of qi and blood, the passages through which vital energy circulates stasis of blood stagnates)
The rule for the treatment of: vigorate qi and replenish the blood, removing blood stasis with potent drugs removing obstruction in the collateral to relieve pain.
Side's medicine: the embodiment of the invention 3 prescriptions and preparation method thereof, using method.
Western medicine: the control blood pressure is controlled the blood fat simvastatin with Nifedipine sustained release tablets, valsartan, improves the blood circulation low molecular dextran, and other adopts symptomatic treatment.
After treating for 8 weeks, patient's two lower limb pains disappear, and the left leg rotten position heals, Calf muscle is front plentiful, and the colour of skin gradually transfers to normally, the alleviation of having palpitation, breathe hard, finger pressure nail matrix capillary filling time shortens, and surveys ankle/upper arm index 0.9, and blood pressure, blood fat, blood glucose all are controlled in normal range.Advise and continue to take the made capsule of the embodiment of the invention 3 prescriptions and consolidated curative effect in 6 months, through repeatedly following up a case by regular visits to, so far without recurrence.
Case 3
The field so-and-so, the woman, 67 years old, the peasant was Gu Jin Lou Xiang Pingyi people from village, in JIUYUE in 2006 28 days, came the inventor to locate to go to a doctor with " the occlusive peripheral arterial is atherosis ".Two lower limb pains appear in the patient after 3 years causes are caught cold, once had no improvement in county people's hospital's diagnosis and treatment, then arrive Puyang the People's Hospital treatment, leave hospital after making pain relief.In nearly March, two lower limb pains increase the weight of and change the inventor over to and locate.Disease is seen: two lower limb have an intense pain, and tuck and comfort foot, and skin is pitchy, two Calf muscle atrophys, asthenia, poor appetite, have palpitation, breathe hard, pale tongue with white fur, weak pulse be unable.T:36.8 ℃, P:80 time/minute, R:22 time/minute, BP:160/90mmHg.Two pulsation of foot dorsal arteries weaken, and finger pressure nail matrix capillary filling time prolongs, and survey ankle/upper arm index 0.6, blood glucose 9.2mmol/L, blood fat: triglyceride 3.2mmol/L, cholesterol 5.3 mmol/L, remaining (-).
Dialectical analysis: the cold-evil stagnates, and makes blood-vessel obstructive obstructed, and again because prolonged illness causes deficiency of qi and blood, limbs lose supports, and, also can not alleviate amyotrophy, skin darkish complexion during rest therefore two lower limb have an intense pain.Insufficiency of vital energy and blood, heart arteries and veins lose to be supported, therefore see nervously, breathe hard.Pale tongue with white fur, weak pulse is unable, is resembling of blood stasis due to qi deficiency.
Diagnosis: vascular disorders (blood stasis due to qi deficiency)
The rule for the treatment of: benefiting QI for activating blood circulation, removing blood stasis with potent drugs, pain relieving.
Side's medicine: the embodiment of the invention 1 prescription and preparation method thereof, using method.
Western medicine: the control blood pressure is controlled the blood glucose glipizide with Nifedipine sustained release tablets, enalapril, and control blood fat fenofibrate improves the blood circulation low molecular dextran, and other adopts symptomatic treatment.
After treating for 8 weeks, patient's two lower limb pains disappear, and skin color approaches normal, and two Calf muscles are plentiful gradually, diet still can, the alleviation of having palpitation, breathe hard.Blood pressure, blood glucose, blood fat etc. all are controlled within normal range.Advise and continue to take the drug withdrawal in more than 6 months of the made capsule of the embodiment of the invention 1 prescription, through repeatedly following up a case by regular visits to, so far without recurrence.
Claims (7)
1. treat the atherosis Chinese medicine composition of early stage occlusive peripheral arterial for one kind, it is characterized in that being made by each crude drug of following portions by weight: 10 ~ 60 parts of the Radixs Astragali, 5 ~ 30 parts of Radix Ginsengs, 3 ~ 10 parts of Ramulus Cinnamomi, 5 ~ 10 parts of Pheretimas, 2 ~ 5 parts of Scorpios, 1.5 ~ 3 parts of Hirudos, 3 ~ 10 parts of Squama Maniss, 6 ~ 15 parts of Radix Cyathulaes, 3 ~ 10 parts of Agkistrodons, 3 ~ 10 parts on Flos Carthami, 3 ~ 10 parts of Olibanums, 3 ~ 10 parts of Rhizoma Corydalis.
2. the atherosis Chinese medicine composition of the early stage occlusive peripheral arterial for the treatment of as claimed in claim 1 is characterized in that being made by each crude drug of following portions by weight: 30 parts of the Radixs Astragali, 15 parts of Radix Ginsengs, 10 parts of Ramulus Cinnamomi, 10 parts of Pheretimas, 5 parts of Scorpios, 2 parts of Hirudos, 6 parts of Squama Maniss, 10 parts of Radix Cyathulaes, 9 parts of Agkistrodons, 9 parts on Flos Carthami, 6 parts of Olibanums, 10 parts of Rhizoma Corydalis.
3. the atherosis Chinese medicine composition of the early stage occlusive peripheral arterial for the treatment of as claimed in claim 1 or 2, it is characterized in that: Squama Manis is Squama Manis preparata.
4. the atherosis Chinese medicine composition of the early stage occlusive peripheral arterial for the treatment of as claimed in claim 1 or 2, it is characterized in that: Olibanum is Olibanum (processed).
5. the atherosis Chinese medicine composition of the early stage occlusive peripheral arterial for the treatment of as claimed in claim 1 or 2 is characterized in that: make according to a conventional method any clinically acceptable preparation.
6. the atherosis Chinese medicine composition of the early stage occlusive peripheral arterial for the treatment of as claimed in claim 5, it is characterized in that: described preparation is decoct, pill, capsule or granule.
7. the atherosis Chinese medicine composition of the early stage occlusive peripheral arterial for the treatment of as claimed in claim 6, it is characterized in that: described preparation is concentrated pill.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011103306462A CN102357125B (en) | 2011-10-27 | 2011-10-27 | Chinese herbal medicine composition for treating early occlusive peripheral atherosclerosis |
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| CN2011103306462A CN102357125B (en) | 2011-10-27 | 2011-10-27 | Chinese herbal medicine composition for treating early occlusive peripheral atherosclerosis |
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